LOCUS       NM_006073               4627 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens triadin (TRDN), transcript variant 1, mRNA.
ACCESSION   NM_006073
VERSION     NM_006073.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4627)
  AUTHORS   Clemens,D.J., Ye,D., Wang,L., Kim,C.S.J., Zhou,W., Dotzler,S.M.,
            Tester,D.J., Marty,I., Knollmann,B.C. and Ackerman,M.J.
  TITLE     Cellular and electrophysiological characterization of triadin
            knockout syndrome using induced pluripotent stem cell-derived
            cardiomyocytes
  JOURNAL   Stem Cell Reports 18 (5), 1075-1089 (2023)
   PUBMED   37163978
  REMARK    GeneRIF: Cellular and electrophysiological characterization of
            triadin knockout syndrome using induced pluripotent stem
            cell-derived cardiomyocytes.
REFERENCE   2  (bases 1 to 4627)
  AUTHORS   Sulu,A., Karacan,M. and Ergul,Y.
  TITLE     A very rare cause of sudden cardiac arrest in children: triadin
            knockout syndrome
  JOURNAL   Cardiol Young 33 (1), 130-132 (2023)
   PUBMED   35481495
REFERENCE   3  (bases 1 to 4627)
  AUTHORS   Zhao,Y., Riching,A.S., Knight,W.E., Chi,C., Broadwell,L.J., Du,Y.,
            Abdel-Hafiz,M., Ambardekar,A.V., Irwin,D.C., Proenza,C., Xu,H.,
            Leinwand,L.A., Walker,L.A., Woulfe,K.C., Bristow,M.R.,
            Buttrick,P.M. and Song,K.
  TITLE     Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative
            Splicing of the Triadin Gene in the Heart
  JOURNAL   Circulation 146 (9), 699-714 (2022)
   PUBMED   35862102
  REMARK    GeneRIF: Cardiomyocyte-Specific Long Noncoding RNA Regulates
            Alternative Splicing of the Triadin Gene in the Heart.
REFERENCE   4  (bases 1 to 4627)
  AUTHORS   Thevenon,D., Smida-Rezgui,S., Chevessier,F., Groh,S.,
            Henry-Berger,J., Beatriz Romero,N., Villaz,M., DeWaard,M. and
            Marty,I.
  TITLE     Human skeletal muscle triadin: gene organization and cloning of the
            major isoform, Trisk 51
  JOURNAL   Biochem Biophys Res Commun 303 (2), 669-675 (2003)
   PUBMED   12659871
  REMARK    GeneRIF: gene organization and cloning of the major isoform
REFERENCE   5  (bases 1 to 4627)
  AUTHORS   Kobayashi,Y.M., Alseikhan,B.A. and Jones,L.R.
  TITLE     Localization and characterization of the calsequestrin-binding
            domain of triadin 1. Evidence for a charged beta-strand in
            mediating the protein-protein interaction
  JOURNAL   J Biol Chem 275 (23), 17639-17646 (2000)
   PUBMED   10748065
REFERENCE   6  (bases 1 to 4627)
  AUTHORS   Zhang,L., Kelley,J., Schmeisser,G., Kobayashi,Y.M. and Jones,L.R.
  TITLE     Complex formation between junctin, triadin, calsequestrin, and the
            ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic
            reticulum membrane
  JOURNAL   J Biol Chem 272 (37), 23389-23397 (1997)
   PUBMED   9287354
REFERENCE   7  (bases 1 to 4627)
  AUTHORS   Taske,N.L., Eyre,H.J., O'Brien,R.O., Sutherland,G.R.,
            Denborough,M.A. and Foster,P.S.
  TITLE     Molecular cloning of the cDNA encoding human skeletal muscle
            triadin and its localisation to chromosome 6q22-6q23
  JOURNAL   Eur J Biochem 233 (1), 258-265 (1995)
   PUBMED   7588753
REFERENCE   8  (bases 1 to 4627)
  AUTHORS   Guo,W. and Campbell,K.P.
  TITLE     Association of triadin with the ryanodine receptor and
            calsequestrin in the lumen of the sarcoplasmic reticulum
  JOURNAL   J Biol Chem 270 (16), 9027-9030 (1995)
   PUBMED   7721813
REFERENCE   9  (bases 1 to 4627)
  AUTHORS   Napolitano,C., Mazzanti,A., Bloise,R. and Priori,S.G.
  TITLE     Catecholaminergic Polymorphic Ventricular Tachycardia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301466
REFERENCE   10 (bases 1 to 4627)
  AUTHORS   Groffen,A.J., Bikker,H. and Christiaans,I.
  TITLE     Long QT Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301308
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA401295.1, U18985.1,
            AK307619.1, BC012590.1, AL357352.11, AL603902.4, BM678702.1 and
            AI375093.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006073.3.
            
            Summary: This gene encodes an integral membrane protein found in
            skeletal and cardiac muscle. The encoded protein plays a role in
            skeletal muscle excitation-contraction coupling as part of the
            calcium release complex and is required for normal skeletal muscle
            strength. This protein indirectly links triads and microtubules in
            skeletal muscle. Mutations in this gene are associated with cardiac
            arrythmia syndrome and some variants in this gene may be associated
            with sudden cardiac death. [provided by RefSeq, May 2022].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U18985.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2142680 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334268.9/ ENSP00000333984.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AA401295.1         154-306
            154-775             U18985.1           1-622
            776-776             AK307619.1         596-596
            777-1362            U18985.1           624-1209
            1363-1363           BC012590.1         1370-1370
            1364-1487           U18985.1           1211-1334
            1488-1488           AL357352.11        57483-57483         c
            1489-2874           U18985.1           1336-2721
            2875-4246           AL603902.4         97878-99249         c
            4247-4624           BM678702.1         19-396              c
            4625-4627           AI375093.1         13-15               c
FEATURES             Location/Qualifiers
     source          1..4627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..4627
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /note="triadin"
                     /db_xref="GeneID:10345"
                     /db_xref="HGNC:HGNC:12261"
                     /db_xref="MIM:603283"
     exon            1..197
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..2365
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /note="isoform 1 is encoded by transcript variant 1;
                     triadin in skeletal muscle"
                     /codon_start=1
                     /product="triadin isoform 1"
                     /protein_id="NP_006064.2"
                     /db_xref="CCDS:CCDS55053.1"
                     /db_xref="GeneID:10345"
                     /db_xref="HGNC:HGNC:12261"
                     /db_xref="MIM:603283"
                     /translation="MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDIVTTF
                     SSPAAWLLVIALIITWSAVAIVMFDLVDYKNFSASSIAKIGSDPLKLVRDAMEETTDW
                     IYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQT
                     KVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKT
                     KKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDI
                     FVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKED
                     IKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQP
                     KGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKT
                     TKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVK
                     PKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVK
                     AVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKE
                     KADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQ
                     KSPISFFQCVYLDGYNGYGFQFPFTPADRPGESSGQANSPGQKQQGQ"
     exon            198..407
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            408..566
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            567..599
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            600..659
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            660..725
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            726..785
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            786..968
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1028
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1106
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1166
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1226
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1280
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1310
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1340
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1361
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1394
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1421
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1448
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1496
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1544
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1595
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1646
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1685
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1712
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1742
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1772
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1799
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1847
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1895
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1913
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..1958
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..1979
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2006
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2045
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2081
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2126
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2150
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2189
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2225
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..4627
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4532..4537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /note="hexamer: ATTAAA"
     polyA_site      4564
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /note="major polyA site"
     regulatory      4603..4608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /note="hexamer: AATAAA"
     polyA_site      4627
                     /gene="TRDN"
                     /gene_synonym="CARDAR; CPVT5; TDN; TRISK"
                     /note="major polyA site"
ORIGIN      
        1 agaggagagg caaagttcaa caggacaaca aagaagcagc agaaacagcc aggaaaacga
       61 agagccccca ggttttgaca cagaaccctc caccagagtt ctcaaatccc caaatactct
      121 gcaaagtgca acttgacggg aacttttcaa ctgactttta cttttgacga ccaccatgac
      181 tgagatcact gctgaaggaa atgcatctac aaccacaact gtgatagaca gcaaaaatgg
      241 atctgtgccc aaatcccccg gaaaagtgct gaagaggaca gtcacagaag acatagtgac
      301 gacgttcagc tcccctgcag cctggcttct ggtcattgcc ctgataatca cgtggtcagc
      361 tgttgccatc gttatgtttg atttagtgga ttacaaaaac ttttcagcaa gctctattgc
      421 caagattggc tcagatcctt taaaactggt acgtgatgct atggaggaaa ccacggactg
      481 gatctatggc ttcttttctt tgttatctga catcatctca tctgaagatg aagaagatga
      541 tgatggtgac gaagatactg ataaaggaga aatagatgag cctcccttga gaaaaaaaga
      601 aatacacaaa gataagactg aaaaacaaga gaaacctgaa aggaaaatac aaactaaagt
      661 tacacacaaa gaaaaagaaa aaggaaaaga aaaagtaaga gaaaaagaaa aacctgaaaa
      721 gaaagcaact cacaaggaaa aaattgagaa aaaagaaaaa ccagaaacaa agacactggc
      781 gaaagaacag aagaaagcta agactgcaga aaagagtgaa gaaaagacta aaaaggaagt
      841 gaaaggtgga aaacaggaga aagtgaagca aacagctgca aaagtaaaag aagtacagaa
      901 aacaccatca aaacccaaag aaaaggagga caaagagaaa gcagctgtgt caaagcatga
      961 acagaaagat cagtatgcat tctgtcgata tatgattgac atatttgtcc atggggattt
     1021 aaaaccagga caaagcccag ccattccacc tcccttaccg acagaacaag cttccagacc
     1081 cactccggca tcacctgccc ttgaagaaaa agaaggggaa aagaagaagg ctgagaagaa
     1141 agttacttct gaaacaaaaa agaaagaaaa agaagatatc aaaaagaaaa gtgagaagga
     1201 aactgccatt gatgtggaaa aaaaagagcc gggaaaagct tctgaaacca aacaagggac
     1261 tgtaaaaatt gcagcacaag cagcagctaa gaaggatgaa aagaaggaag attccaagaa
     1321 aacaaaaaaa cctgcagaag tagaacaacc caagggaaaa aaacaggaaa agaaagaaaa
     1381 acatgtggaa ccagcaaagt caccaaagaa agaacactca gttccaagtg acaaacaagt
     1441 aaaagcaaaa actgaacgag ccaaagagga gattggtgcg gtttcaatta aaaaagctgt
     1501 acctggaaag aaggaagaga aaacaaccaa gacagtggag caagaaatta gaaaagaaaa
     1561 atctgggaag acttcttcaa ttctgaaaga taaagaacct attaaaggga aagaagagaa
     1621 agttccagct tccctaaagg aaaaagaacc tgaaactaaa aaagatgaaa agatgtccaa
     1681 agcaggcaaa gaagtcaagc ctaaacctcc acaactacaa ggaaaaaagg aagagaagcc
     1741 agagccccaa attaaaaaag aagcaaaacc agctatatct gaaaaagtgc aaatacacaa
     1801 acaagacata gtgaaaccag aaaagactgt ttctcatggt aaaccagaag aaaaagttct
     1861 caagcaggta aaagctgtca caatagaaaa aacagccaag cccaaaccaa caaaaaaagc
     1921 tgaacatcga gaaagagaac ctccatctat aaaaacagac aaaccaaaac caactccaaa
     1981 aggaacatca gaagtcacag aatcaggaaa gaagaaaact gaaatatctg aaaaagaaag
     2041 taaagaaaaa gcagacatga agcatcttag agaagaaaaa gtctcaacaa gaaaagaaag
     2101 tcttcaatta cacaatgtga caaaagcaga aaaacctgca agagtatcaa aagatgttga
     2161 agatgtacca gcttcaaaga aagctaaaga aggaactgaa gatgtgtctc ccacaaagca
     2221 gaaaagtccc atcagtttct tccagtgtgt ctacttggat gggtacaatg gctatggatt
     2281 tcagtttcct ttcactcctg cagaccgccc tggagagagc tctggtcaag caaattctcc
     2341 aggacagaag caacaaggac agtaaacaca catgtatgac ccttacaagt gctttaagat
     2401 tttaaaaatg tgatgttttg tccacagtag ttcaggcaat taagaatatg caacccagag
     2461 aatttctgtg aaaacatttt gctctttggc ctggtgtgga cggaaagggt ggccaaatgg
     2521 attgagtgat gagcagacat gtttaagggt ctaagtctca agaatctgtt atgtgtgttt
     2581 gctgcggtgg gagggggtgc ttgtatttat cttatttcca gtcactataa ggttgtacac
     2641 aaactaattt aaagtttact taataatggt atctttaaaa taattgacac aattgcaaaa
     2701 tgaattcctg gcttcagtta gctattattt ttttaatgac aacatagact gtgctctaag
     2761 tttaaaagat ggggaagctt atataaaagt gacccttttg catcatatgg gtatctaaac
     2821 ttaatttacc caataagttg atgcttaatg attttatttt atttttgtct atttctattt
     2881 tagttgtggc tttgctctaa gaatgggtaa tagttgtact acagactgct ataaatttct
     2941 tgtgatactc ttttagagct caaaatatct ctgagcttta gacatggtaa ggtggagagt
     3001 aaatgcttga taaatcttta agatatgtct tgaatgataa ttaggacatt cagtccagtg
     3061 gaaatacacc attcaattag tcaggtctgg tgaatcgttt gtttaaaata ttagcaaatg
     3121 agatgtggaa ttctgaaatt tctccagact gtgtcttaat aaaaatgtca cctgggtgaa
     3181 attttagatc aatcactaaa tttgggtgac aaatataaaa atattttcat ttcactttaa
     3241 tacattcttt ctgtgaagta aaatgttttt ctttctcata atggcaaaat atgaatgcca
     3301 tcaaagttta aggaattcat tttagcctta aatgccttcg tgagatgtct tacttgtatt
     3361 ttaggtaact ggtcatcagt gccaatgaca tggataacaa tttttaatct actcgacagt
     3421 gcatccctgg gaatgactgt tatgtttttg tcatattcct ggtaatataa atactcgtgt
     3481 tctttactac attgttttta tcaactctaa aagtcatgcc tctgtgacct ttatcatgtt
     3541 tacaattgca actgaactta tgacaaatta actcaggaaa taaattgagt tatcctttct
     3601 agcattgtaa ttaccatcag caaggcctga gatagccaga gccaatacta gccaagtgat
     3661 ttattttcaa ggattgccac taactacggt tctttaggac caagatataa aacagtcact
     3721 aaaaatcatt aggctaggta tcagtaatac attcattact aataatgcat ttttggagac
     3781 ttttgtgaaa gaagttggtc tctgccaaaa gctggtggac cacattcaca ccacgaaagc
     3841 cagtgtcaca tgaaccagat taatgactct ctttatgggg tatgtgggac atcctggaag
     3901 tgtataattt caggaatgac cagacaatac catcttgcaa agccccttca ggtgacaatc
     3961 taaacttgtg ggtaggagag tgcataaagt ttattgctca actgctcctc cagcctgctg
     4021 aatttactga gtaaagaaat agcaaatatg atagatgttt tagatttcat agaacagaat
     4081 ggtttgtcca ttaattcttt cattcaatga ctgtttattg aatacctact cttttagggc
     4141 gctgtgttag gtgctgtatt gtacaagaaa aatataataa attagattcc cagcgctatt
     4201 ctgacatagt gaatgacctt gaaaaattta ctaaacatac tatgtttgtt tctccatgag
     4261 taaaataggg atatagggac aaacagtcta atatctcata gaaataccat ggagacaaat
     4321 aaaatatttt aatataaata tgatattaaa gtaaatttct gaagtaatac ttttgggtat
     4381 ggcactagtt tttcctctga ctattttact gtttctttca ctctcaatat aaaaactatt
     4441 tgataagata aaacgatata ttttattgta attagaattt agacaaatca gctataatgt
     4501 aaaaatgtta ataataatta cgttttatct gattaaagtt acaatgatca tagcacttta
     4561 aaaatattat ctgaactgtc atttgtttat atattaccgt ctaataaaat agttatagat
     4621 cttccaa
//
