LOCUS       NM_016388               1831 bp    mRNA    linear   PRI 26-APR-2024
DEFINITION  Homo sapiens T cell receptor associated transmembrane adaptor 1
            (TRAT1), transcript variant 1, mRNA.
ACCESSION   NM_016388
VERSION     NM_016388.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1831)
  AUTHORS   Guo,Q., Wang,S.H., Ji,Y.M., Tong,S., Li,D., Ding,X.C. and Wu,C.Y.
  TITLE     The Roles and Mechanisms of TRAT1 in the Progression of Non-Small
            Cell Lung Cancer
  JOURNAL   Curr Med Sci 42 (6), 1186-1200 (2022)
   PUBMED   36184729
  REMARK    GeneRIF: The Roles and Mechanisms of TRAT1 in the Progression of
            Non-Small Cell Lung Cancer.
REFERENCE   2  (bases 1 to 1831)
  AUTHORS   Alloush,J. and Weisleder,N.
  TITLE     TRIM proteins in therapeutic membrane repair of muscular dystrophy
  JOURNAL   JAMA Neurol 70 (7), 928-931 (2013)
   PUBMED   23699904
  REMARK    Review article
REFERENCE   3  (bases 1 to 1831)
  AUTHORS   Jarvis,L.B., Goodall,J.C. and Gaston,J.S.
  TITLE     Human leukocyte antigen class I-restricted immunosuppression by
            human CD8+ regulatory T cells requires CTLA-4-mediated interaction
            with dendritic cells
  JOURNAL   Hum Immunol 69 (11), 687-695 (2008)
   PUBMED   18817831
  REMARK    GeneRIF: TRIM acts to chaperone CTLA-4 transport to the cell
            surface; this function would be required to account for the
            phenotypic and functional properties of CD8(+) Tregs.
REFERENCE   4  (bases 1 to 1831)
  AUTHORS   Tedoldi,S., Paterson,J.C., Hansmann,M.L., Natkunam,Y., Rudiger,T.,
            Angelisova,P., Du,M.Q., Roberton,H., Roncador,G., Sanchez,L.,
            Pozzobon,M., Masir,N., Barry,R., Pileri,S., Mason,D.Y.,
            Marafioti,T. and Horejsi,V.
  TITLE     Transmembrane adaptor molecules: a new category of lymphoid-cell
            markers
  JOURNAL   Blood 107 (1), 213-221 (2006)
   PUBMED   16160011
REFERENCE   5  (bases 1 to 1831)
  AUTHORS   Koyasu,S.
  TITLE     The role of PI3K in immune cells
  JOURNAL   Nat Immunol 4 (4), 313-319 (2003)
   PUBMED   12660731
  REMARK    Review article
REFERENCE   6  (bases 1 to 1831)
  AUTHORS   Kirchgessner,H., Dietrich,J., Scherer,J., Isomaki,P., Korinek,V.,
            Hilgert,I., Bruyns,E., Leo,A., Cope,A.P. and Schraven,B.
  TITLE     The transmembrane adaptor protein TRIM regulates T cell receptor
            (TCR) expression and TCR-mediated signaling via an association with
            the TCR zeta chain
  JOURNAL   J Exp Med 193 (11), 1269-1284 (2001)
   PUBMED   11390434
REFERENCE   7  (bases 1 to 1831)
  AUTHORS   Zhang,W. and Samelson,L.E.
  TITLE     The role of membrane-associated adaptors in T cell receptor
            signalling
  JOURNAL   Semin Immunol 12 (1), 35-41 (2000)
   PUBMED   10723796
  REMARK    Review article
REFERENCE   8  (bases 1 to 1831)
  AUTHORS   Hubener,C., Mincheva,A., Lichter,P., Schraven,B. and Bruyns,E.
  TITLE     Genomic organization and chromosomal localization of the human gene
            encoding the T-cell receptor-interacting molecule (TRIM)
  JOURNAL   Immunogenetics 51 (2), 154-158 (2000)
   PUBMED   10663578
REFERENCE   9  (bases 1 to 1831)
  AUTHORS   Bruyns,E., Marie-Cardine,A., Kirchgessner,H., Sagolla,K.,
            Shevchenko,A., Mann,M., Autschbach,F., Bensussan,A., Meuer,S. and
            Schraven,B.
  TITLE     T cell receptor (TCR) interacting molecule (TRIM), a novel
            disulfide-linked dimer associated with the TCR-CD3-zeta complex,
            recruits intracellular signaling proteins to the plasma membrane
  JOURNAL   J Exp Med 188 (3), 561-575 (1998)
   PUBMED   9687533
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK291991.1, BC025713.1 and AV735609.1.
            
            On May 17, 2019 this sequence version replaced NM_016388.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF161547.1, BC025713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295756.11/ ENSP00000295756.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AK291991.1         89-94
            7-1692              BC025713.1         1-1686
            1693-1831           AV735609.1         347-485
FEATURES             Location/Qualifiers
     source          1..1831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.13"
     gene            1..1831
                     /gene="TRAT1"
                     /gene_synonym="HSPC062; pp29/30; TCRIM; TRIM"
                     /note="T cell receptor associated transmembrane adaptor 1"
                     /db_xref="GeneID:50852"
                     /db_xref="HGNC:HGNC:30698"
                     /db_xref="MIM:604962"
     exon            1..149
                     /gene="TRAT1"
                     /gene_synonym="HSPC062; pp29/30; TCRIM; TRIM"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..703
                     /gene="TRAT1"
                     /gene_synonym="HSPC062; pp29/30; TCRIM; TRIM"
                     /note="isoform 1 is encoded by transcript variant 1; T
                     cell receptor interacting molecule; T-cell
                     receptor-associated transmembrane adapter 1"
                     /codon_start=1
                     /product="T-cell receptor-associated transmembrane adapter
                     1 isoform 1"
                     /protein_id="NP_057472.2"
                     /db_xref="CCDS:CCDS33813.1"
                     /db_xref="GeneID:50852"
                     /db_xref="HGNC:HGNC:30698"
                     /db_xref="MIM:604962"
                     /translation="MSGISGCPFFLWGLLALLGLALVISLIFNISHYVEKQRQDKMYS
                     YSSDHTRVDEYYIEDTPIYGNLDDMISEPMDENCYEQMKARPEKSVNKMQEATPSAQA
                     TNETQMCYASLDHSVKGKRRKPRKQNTHFSDKDGDEQLHAIDASVSKTTLVDSFSPES
                     QAVEENIHDDPIRLFGLIRAKREPIN"
     exon            150..260
                     /gene="TRAT1"
                     /gene_synonym="HSPC062; pp29/30; TCRIM; TRIM"
                     /inference="alignment:Splign:2.1.0"
     exon            261..294
                     /gene="TRAT1"
                     /gene_synonym="HSPC062; pp29/30; TCRIM; TRIM"
                     /inference="alignment:Splign:2.1.0"
     exon            295..356
                     /gene="TRAT1"
                     /gene_synonym="HSPC062; pp29/30; TCRIM; TRIM"
                     /inference="alignment:Splign:2.1.0"
     exon            357..445
                     /gene="TRAT1"
                     /gene_synonym="HSPC062; pp29/30; TCRIM; TRIM"
                     /inference="alignment:Splign:2.1.0"
     exon            446..1831
                     /gene="TRAT1"
                     /gene_synonym="HSPC062; pp29/30; TCRIM; TRIM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1674..1679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAT1"
                     /gene_synonym="HSPC062; pp29/30; TCRIM; TRIM"
                     /note="hexamer: ATTAAA"
     polyA_site      1697
                     /gene="TRAT1"
                     /gene_synonym="HSPC062; pp29/30; TCRIM; TRIM"
                     /note="major polyA site"
ORIGIN      
        1 ggcacagata aagataagtt ttactgtcat gctgctttta acataacaga gcaacatcac
       61 ctaggaaaaa agtttgtagg aggattttta atccatatat ttgtcttatg gctagataaa
      121 gatttctctg aaaaaaagaa gcatgtcagg aatctctggg tgcccctttt tcctctgggg
      181 acttctagca ttgttgggct tggctttggt tatatcactg atcttcaata tttcccacta
      241 tgtggaaaag caacgacaag ataaaatgta cagctactcc agtgaccaca ccagggttga
      301 tgagtattat attgaagaca caccaattta tggtaactta gatgatatga tttcagaacc
      361 aatggatgaa aattgctatg aacaaatgaa agcccgacca gagaaatctg taaataagat
      421 gcaggaagcc accccatctg cacaggcaac caatgaaaca cagatgtgct acgcctcact
      481 tgatcacagc gttaagggga agcgtagaaa gcccaggaaa cagaatactc atttctcaga
      541 caaggatgga gatgagcaac tacatgcaat agatgccagc gtttctaaga ccaccttagt
      601 agacagtttc tccccagaaa gccaggcagt agaggaaaac attcatgatg atcccatcag
      661 actgtttgga ttgatccgtg ctaagagaga acctataaac tagctggacc atgatctagt
      721 tcaatgattt ggctcctatt gaagatggct tctaagaaaa caagatgcac agaggacaca
      781 gaaggacttg gcagcagggt gatgacctga tcatttgttg atgggatggt ggcttacctc
      841 ttattcacag cttacactta tgcatgccaa atgtaaggcc atgaaaatca gtatttcaaa
      901 taacttaaaa aatgctttac tactaaaatg taaaaaatta atgtgctcac ctcggcagca
      961 catatactaa aaattaataa gacccagctt gaaaattgag cctgataaca agattacaaa
     1021 ttcacaatac ctaatactta gggaaatata aaaatttaag catgaatgtg ttctggaaca
     1081 cgttagaaga aaaataaaag ccaatgagtt tttttttaat tctcctttct caccaatggg
     1141 caatagccca taattgaaat aaatttctga ttgaaaggta taggaaacat taaaatgcat
     1201 tactaagaga agtaatataa ttttcttaca aagtattttt cccaaagata gctttactat
     1261 ttcaaaaatt gtcaaattaa tgcatgctcc ttacaacaaa caaatatcaa aaagagttta
     1321 ggaattctac tagccagaga tagtcacttg gagaaacttt ctatatatcc ttctaaatat
     1381 ttttctgggc atgcttatgt atgtacatca gttgtttctt tttattttga accaaaaatg
     1441 tggtttcttt tgtacacatt acttaaactt tctttccagt caacaatata ttgtggattt
     1501 attttcactg ttatatttaa ctatatataa atacgcatat attgtaattt taatgtctgc
     1561 ttagcacccc actgataacc aaatcacagt ttatttaaat aattttaatg acttttcaaa
     1621 aacaatttat tgatgcaaaa agcaaggttg agatgacaat gtttctttca ataattaaaa
     1681 aatactgctt cactgtcttc tctctgtttc atcagaaaca catactataa tacttgtctc
     1741 tgtccttaag tgtgatacac gctatttttc tgattgttaa gactttcctt attactggtt
     1801 ctaatttgat tataatatgc caaggtatgg t
//
