LOCUS       NM_172367               3588 bp    mRNA    linear   PRI 25-SEP-2024
DEFINITION  Homo sapiens trafficking regulator of GLUT4 (SLC2A4) 1
            (gene/pseudogene) (TRARG1), mRNA.
ACCESSION   NM_172367
VERSION     NM_172367.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3588)
  AUTHORS   Duan,X., Norris,D.M., Humphrey,S.J., Yang,P., Cooke,K.C.,
            Bultitude,W.P., Parker,B.L., Conway,O.J., Burchfield,J.G.,
            Krycer,J.R., Brodsky,F.M., James,D.E. and Fazakerley,D.J.
  TITLE     Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate
  JOURNAL   Biochem J 479 (11), 1237-1256 (2022)
   PUBMED   35594055
  REMARK    GeneRIF: Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3
            substrate.
REFERENCE   2  (bases 1 to 3588)
  AUTHORS   Duan,X., Krycer,J.R., Cooke,K.C., Yang,G., James,D.E. and
            Fazakerley,D.J.
  TITLE     Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1)
  JOURNAL   Biochemistry 57 (26), 3606-3615 (2018)
   PUBMED   29787242
REFERENCE   3  (bases 1 to 3588)
  AUTHORS   Beaton,N., Rudigier,C., Moest,H., Muller,S., Mrosek,N., Roder,E.,
            Rudofsky,G., Rulicke,T., Ukropec,J., Ukropcova,B., Augustin,R.,
            Neubauer,H. and Wolfrum,C.
  TITLE     TUSC5 regulates insulin-mediated adipose tissue glucose uptake by
            modulation of GLUT4 recycling
  JOURNAL   Mol Metab 4 (11), 795-810 (2015)
   PUBMED   26629404
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3588)
  AUTHORS   Bubnov,V., Moskalev,E., Petrovskiy,Y., Bauer,A., Hoheisel,J. and
            Zaporozhan,V.
  TITLE     Hypermethylation of TUSC5 genes in breast cancer tissue
  JOURNAL   Exp Oncol 34 (4), 370-372 (2012)
   PUBMED   23302999
  REMARK    GeneRIF: Aberrant DNA hypermethylation of TUSC5 in breast cancer
            suggests epigenetic mechanism of cancer associated down-regulation
REFERENCE   5  (bases 1 to 3588)
  AUTHORS   Sallman Almen,M., Bringeland,N., Fredriksson,R. and Schioth,H.B.
  TITLE     The dispanins: a novel gene family of ancient origin that contains
            14 human members
  JOURNAL   PLoS One 7 (2), e31961 (2012)
   PUBMED   22363774
REFERENCE   6  (bases 1 to 3588)
  AUTHORS   Oort,P.J., Warden,C.H., Baumann,T.K., Knotts,T.A. and Adams,S.H.
  TITLE     Characterization of Tusc5, an adipocyte gene co-expressed in
            peripheral neurons
  JOURNAL   Mol Cell Endocrinol 276 (1-2), 24-35 (2007)
   PUBMED   17689857
  REMARK    GeneRIF: These findings may point to participation of Tusc5 in
            shared adipose-nervous system functions.
REFERENCE   7  (bases 1 to 3588)
  AUTHORS   Konishi,H., Sugiyama,M., Mizuno,K., Saito,H., Yatabe,Y.,
            Takahashi,T., Osada,H. and Takahashi,T.
  TITLE     Detailed characterization of a homozygously deleted region
            corresponding to a candidate tumor suppressor locus at distal
            17p13.3 in human lung cancer
  JOURNAL   Oncogene 22 (12), 1892-1905 (2003)
   PUBMED   12660825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC032044.28.
            
            On Nov 22, 2018 this sequence version replaced NM_172367.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB090231.1, BC142615.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333813.4/ ENSP00000329548.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC032044.28        169670-169670       c
            2-727               AC032044.28        168944-169669       c
            728-860             AC032044.28        153709-153841       c
            861-3588            AC032044.28        148354-151081       c
FEATURES             Location/Qualifiers
     source          1..3588
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..3588
                     /gene="TRARG1"
                     /gene_synonym="BEC-1; DSPB1; IFITMD3; LOST1; TUSC5"
                     /note="trafficking regulator of GLUT4 (SLC2A4) 1
                     (gene/pseudogene)"
                     /db_xref="GeneID:286753"
                     /db_xref="HGNC:HGNC:29592"
                     /db_xref="MIM:612211"
     exon            1..727
                     /gene="TRARG1"
                     /gene_synonym="BEC-1; DSPB1; IFITMD3; LOST1; TUSC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..874
                     /gene="TRARG1"
                     /gene_synonym="BEC-1; DSPB1; IFITMD3; LOST1; TUSC5"
                     /note="interferon induced transmembrane protein domain
                     containing 3; tumor suppressor candidate 5; located at
                     seventeen p thirteen point three 1; protein located at
                     seventeen-p-thirteen point three 1; interferon-induced
                     transmembrane domain-containing protein D3; dispanin
                     subfamily B member 1; brain endothelial cell derived
                     gene-1"
                     /codon_start=1
                     /product="trafficking regulator of GLUT4 1"
                     /protein_id="NP_758955.2"
                     /db_xref="CCDS:CCDS42225.1"
                     /db_xref="GeneID:286753"
                     /db_xref="HGNC:HGNC:29592"
                     /db_xref="MIM:612211"
                     /translation="MAHPVQSEFPSAQEPGSAAFLDLPEMEILLTKAENKDDKTLNLS
                     KTLSGPLDLEQNSQGLPFKAISEGHLEAPLPRSPSRASSRRASSIATTSYAQDQEAPR
                     DYLILAVVACFCPVWPLNLIPLIISIMSRSSMQQGNVDGARRLGRLARLLSITLIIMG
                     IVIIMVAVTVNFTVQKK"
     exon            728..860
                     /gene="TRARG1"
                     /gene_synonym="BEC-1; DSPB1; IFITMD3; LOST1; TUSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            861..3588
                     /gene="TRARG1"
                     /gene_synonym="BEC-1; DSPB1; IFITMD3; LOST1; TUSC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3573..3578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRARG1"
                     /gene_synonym="BEC-1; DSPB1; IFITMD3; LOST1; TUSC5"
                     /note="hexamer: AATAAA"
     polyA_site      3588
                     /gene="TRARG1"
                     /gene_synonym="BEC-1; DSPB1; IFITMD3; LOST1; TUSC5"
                     /note="major polyA site"
ORIGIN      
        1 gcattcttct ctctgctctc tgagctttcc gttgcttccc tgcccatctg tgctctcagc
       61 agcaccagca aagttggcct caaacttgaa caaagctgca ggctccagcg tctttctggg
      121 agctccgcgg gggcagcagg caggccccag cctctgaact cagctggctt gagaagctca
      181 gcccaaccct tccagcaccc agccggccct ccgtctcctg agggacgccc ctgcccccga
      241 cctggaggcc ctcagtctgg gctggggaat ggcgcgctga ggtccctcca gagccccttg
      301 tcccagcctg gagctgcagc cgcgcaaggc ccaggccccc atggcccacc cggtgcagtc
      361 cgagtttcct tcagcacagg agccaggctc cgccgcattc ctggacctgc cggagatgga
      421 gatactcctc accaaggcag agaacaagga tgacaagacc ctgaatctgt ccaagaccct
      481 ctcggggcct ctggatctgg agcagaacag ccagggccta cccttcaagg ccatctccga
      541 ggggcacctg gaggccccac tgcctcggtc cccctcccgg gccagctcaa ggagggcgtc
      601 ctccatcgcc accacctcct atgcccaaga ccaagaagcc cccagagatt acctcatcct
      661 ggccgtcgtc gcctgcttct gccccgtctg gcccctcaac ctcatccccc tcatcatttc
      721 catcatgtct cgaagcagca tgcaacaggg caacgtggac ggcgcccgga ggctgggccg
      781 cctggctcgg ctgctcagca ttaccctcat catcatgggc atcgtcatta tcatggtggc
      841 cgtgaccgtc aacttcacag ttcagaagaa ataaacttaa gcagggagct gggctagcag
      901 aggccggccc tggccatcgg gagagctctg acctgcacac cgcgggaggc cagggtgctg
      961 actgtcaagc atcccctgtc cccaagttcc aaaagcacag actcaaaggg aaacccccca
     1021 gtcacccact gtcagccccc atctgacaag aaagcctgga gcgaggaagg aaagcacagc
     1081 gaacccaatg ggtaacgtgg tttactctcc cggacgcgtc ctgggatctc aaccccagca
     1141 gtctggcttg tttctcattc ccacaatttc ctgggttcca ccaagcagcg aaaactgcca
     1201 ggatgaatga ggaaaaaacc cagccccaca aacgagacac acgctggcgg ggagagacgc
     1261 agcagagctc cttcctgtct gtggactcgg agcaaagacg tggggcccca tcttttgtgt
     1321 tttcctcaag cggggaaaga atggactgtt tgcatgcttc gtgccacacg cccgcggtga
     1381 tcccagccag ggccccgagc gcagaggcgg agctgtgctc agcacaggcc tgggacctcc
     1441 cccggcaggc acctgtgggg ggtgcagctc ccgggaagga ggcaactgcc tcacttaaca
     1501 tcctccgctg caaggtggtg gcgccgagag gcgtgtctgt gaagacaggt accaggatgg
     1561 caggacccgc acgcctcttc ccacacctgt cagcttcgga agcatctctc gaggactctg
     1621 gtcccaggat gtctcccagg acaagccagt ctgcctcttc ctcctacttc tgctgtagcc
     1681 tgggaccaga cctggccaag gtcagccagc ggggagggcc gaggtctgag ctctcgtcct
     1741 gccgtggccc ccgcgatggc ctggggtgca agcttggggc tccgtctggt gctgcttagg
     1801 tagtttcagg cttccagccc agccctatgc tctgtgcttg gccctgggcc cctggccatc
     1861 cacaaacagc agaggccttc cctggaggag gctttgggac cacccctggg gggacttccc
     1921 aaagggtccc aggctgtcag gggcgtttgc gccacctgca agggcgtggg tcagagagtt
     1981 tttatggggg tctgttgttt gaccgtcctg agaccgaggg aagggctcag ctgaaggacc
     2041 ccgtctgcag gagagtcggg ggaccaggtt tgggaataca cttgcatgta cagagcctgg
     2101 ggcctggacg ccacggcctc tcatcttagg acctaatggg acccccgaaa ggagccaagt
     2161 ggggccctcg gcctcttcct tcgttccagg cccatgattt tccctacact tctccctggc
     2221 ccaggctcca gccacaggca cctctcctgc ccccgcccac cctcctgacc gcagctccca
     2281 ggccctggag acctccaggc tttcctgccc tgggcagccc cacctcacag ccagagtcaa
     2341 tgccttcatg ggaagggctc ccagccacac ccagagtggc ccaaagctgt tgaagtcagc
     2401 atcctttgtc ccatcaggac cctcctgcct cctctccagg cccttgttcg cctccccacc
     2461 ctcctcagag gcccggggaa gggaagagca ggtcagtaca gaggttctgt ctacagggag
     2521 gggccctggg tctatgcaca gctggagctc tgagccttcc acagcccgtg tgactgctag
     2581 agggcagggg tgcagggctc agggggcccg ggctggtcct ttggggctgg tgttcctacg
     2641 tcagtcccca cctggggaat aaactccagc ctctcctgct catacagaag ggactggttg
     2701 ggtttgcttt atgggatctt tgagaccaaa acagatgctc ctgtttgctg ggggagggtg
     2761 tgagcacgga gtatttctgt ccctcgtgaa gtcacgtcac acaggggaga ggcgaggtcg
     2821 atggaactgg ccacgcacag gctctggctc tggaaggagg gatgatgagt gggcgttttc
     2881 ccggcaggcc cccggggtcc tcagcctcag caacccaggg agaggacaga aacgaaccga
     2941 tggttgaggg attgtcacgg gaggaacatg acacccgaag ggactctagg tgccctcgga
     3001 gtgccacaca tgcccagacc ttctcacacc cacacaaata ggctctgccg tgcactccta
     3061 cacacacaca cacacacaca cacgcttgtt cacactcaga acccaggaca gccacagcca
     3121 ccgcttaggg gaagccactg cagatgcccc tggaatgggc acagcacagc cagggcgctc
     3181 ttccaggcag gcgaggataa cttgagagtt tcctagggca ccagggacag agctcagagg
     3241 cccccgaggt gtgtgtagga ggcggaggcc cgcagagcac agagcaggag aagggcttgg
     3301 gccctggagg agaaagccat tctggacacc aggggacctg gacggagggt ccccacagcc
     3361 cgtgccccac gccgcctgga ggccagaggg gtcagtggcc ctgctgtccc ggctccatct
     3421 tggttctagc cgccacctgc atgaacacag tggcccggct taacgcacta acccagcctc
     3481 tccctgtgtc ccacagggag tagcaagacc caccccacac tgccttcacc atctacacca
     3541 gtgacgccgc tgtgtgtctt agcatggaaa taaataaacc tgaatgta
//
