LOCUS       NM_001270891             758 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens trafficking protein particle complex subunit 6A
            (TRAPPC6A), transcript variant 2, mRNA.
ACCESSION   NM_001270891
VERSION     NM_001270891.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 758)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 758)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 758)
  AUTHORS   Mohamoud,H.S., Ahmed,S., Jelani,M., Alrayes,N., Childs,K.,
            Vadgama,N., Almramhi,M.M., Al-Aama,J.Y., Goodbourn,S. and Nasir,J.
  TITLE     A missense mutation in TRAPPC6A leads to build-up of the protein,
            in patients with a neurodevelopmental syndrome and dysmorphic
            features
  JOURNAL   Sci Rep 8 (1), 2053 (2018)
   PUBMED   29391579
  REMARK    GeneRIF: Missense mutation in TRAPPC6A identified in patients with
            a neurodevelopmental syndrome, affects stability of the TRAPP
            complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 758)
  AUTHORS   Zhu,P., Liang,L., Shao,X., Luo,W., Jiang,S., Zhao,Q., Sun,N.,
            Zhao,Y., Li,J., Wang,J., Zhou,Y., Zhang,J., Wang,G., Jiang,L.,
            Chen,H. and Li,C.
  TITLE     Host Cellular Protein TRAPPC6ADelta Interacts with Influenza A
            Virus M2 Protein and Regulates Viral Propagation by Modulating M2
            Trafficking
  JOURNAL   J Virol 91 (1), e01757-16 (2016)
   PUBMED   27795429
  REMARK    GeneRIF: Host cellular protein TRAPPC6ADelta interacts with
            influenza A virus M2 protein and regulates viral propagation by
            modulating M2 trafficking.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 758)
  AUTHORS   Kim,J.J., Lipatova,Z. and Segev,N.
  TITLE     TRAPP Complexes in Secretion and Autophagy
  JOURNAL   Front Cell Dev Biol 4, 20 (2016)
   PUBMED   27066478
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 758)
  AUTHORS   Westlake,C.J., Baye,L.M., Nachury,M.V., Wright,K.J., Ervin,K.E.,
            Phu,L., Chalouni,C., Beck,J.S., Kirkpatrick,D.S., Slusarski,D.C.,
            Sheffield,V.C., Scheller,R.H. and Jackson,P.K.
  TITLE     Primary cilia membrane assembly is initiated by Rab11 and transport
            protein particle II (TRAPPII) complex-dependent trafficking of
            Rabin8 to the centrosome
  JOURNAL   Proc Natl Acad Sci U S A 108 (7), 2759-2764 (2011)
   PUBMED   21273506
REFERENCE   7  (bases 1 to 758)
  AUTHORS   Kummel,D., Oeckinghaus,A., Wang,C., Krappmann,D. and Heinemann,U.
  TITLE     Distinct isocomplexes of the TRAPP trafficking factor coexist
            inside human cells
  JOURNAL   FEBS Lett 582 (27), 3729-3733 (2008)
   PUBMED   18930054
REFERENCE   8  (bases 1 to 758)
  AUTHORS   Kummel,D., Muller,J.J., Roske,Y., Henke,N. and Heinemann,U.
  TITLE     Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form
            trimeric complexes with Bet3 and Mum2
  JOURNAL   J Mol Biol 361 (1), 22-32 (2006)
   PUBMED   16828797
REFERENCE   9  (bases 1 to 758)
  AUTHORS   Gwynn,B., Smith,R.S., Rowe,L.B., Taylor,B.A. and Peters,L.L.
  TITLE     A mouse TRAPP-related protein is involved in pigmentation
  JOURNAL   Genomics 88 (2), 196-203 (2006)
   PUBMED   16697553
  REMARK    GeneRIF: Mapping and characterization of mouse Trappc6a, along with
            a description of the human homolog.
REFERENCE   10 (bases 1 to 758)
  AUTHORS   Kim,M.S., Yi,M.J., Lee,K.H., Wagner,J., Munger,C., Kim,Y.G.,
            Whiteway,M., Cygler,M., Oh,B.H. and Sacher,M.
  TITLE     Biochemical and crystallographic studies reveal a specific
            interaction between TRAPP subunits Trs33p and Bet3p
  JOURNAL   Traffic 6 (12), 1183-1195 (2005)
   PUBMED   16262728
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN256687.1, AF161407.1 and
            BC001907.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001270891.1.
            
            Summary: This gene encodes a component of the trafficking protein
            particle complex, which tethers transport vesicles to the cis-Golgi
            membrane. Loss of expression of the related gene in mouse affects
            coat and eye pigmentation, suggesting that the encoded protein may
            be involved in melanosome biogenesis. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (2, also known as
            TRAPPC6Adelta29-42) uses an alternate in-frame splice site in the
            5' coding region, compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF161407.1, SRR7410570.655515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2152798
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000585934.1/ ENSP00000468612.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                CN256687.1         19-73
            56-313              AF161407.1         56-313
            314-758             BC001907.1         346-790
FEATURES             Location/Qualifiers
     source          1..758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..758
                     /gene="TRAPPC6A"
                     /gene_synonym="TRS33"
                     /note="trafficking protein particle complex subunit 6A"
                     /db_xref="GeneID:79090"
                     /db_xref="HGNC:HGNC:23069"
                     /db_xref="MIM:610396"
     exon            1..103
                     /gene="TRAPPC6A"
                     /gene_synonym="TRS33"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..499
                     /gene="TRAPPC6A"
                     /gene_synonym="TRS33"
                     /note="isoform 2 is encoded by transcript variant 2; TRAPP
                     complex subunit 6A; trafficking protein particle complex
                     6A"
                     /codon_start=1
                     /product="trafficking protein particle complex subunit 6A
                     isoform 2"
                     /protein_id="NP_001257820.1"
                     /db_xref="CCDS:CCDS59397.1"
                     /db_xref="GeneID:79090"
                     /db_xref="HGNC:HGNC:23069"
                     /db_xref="MIM:610396"
                     /translation="MADTVLFEFLHTEMVAELWAHDPDPGPGGQKMSLSVLEGMGFRV
                     GQALGERLPRETLAFREELDVLKFLCKDLWVAVFQKQMDSLRTNHQGTYVLQDNSFPL
                     LLPMASGLQYLEEAPKFLAFTCGLLRGALYTLGIESVVTASVAALPVCKFQVVIPKS"
     exon            104..171
                     /gene="TRAPPC6A"
                     /gene_synonym="TRS33"
                     /inference="alignment:Splign:2.1.0"
     exon            172..289
                     /gene="TRAPPC6A"
                     /gene_synonym="TRS33"
                     /inference="alignment:Splign:2.1.0"
     exon            290..373
                     /gene="TRAPPC6A"
                     /gene_synonym="TRS33"
                     /inference="alignment:Splign:2.1.0"
     exon            374..467
                     /gene="TRAPPC6A"
                     /gene_synonym="TRS33"
                     /inference="alignment:Splign:2.1.0"
     exon            468..758
                     /gene="TRAPPC6A"
                     /gene_synonym="TRS33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      737..742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAPPC6A"
                     /gene_synonym="TRS33"
                     /note="hexamer: AATAAA"
     polyA_site      758
                     /gene="TRAPPC6A"
                     /gene_synonym="TRS33"
                     /note="major polyA site"
ORIGIN      
        1 aggcgtgcga ggagggggca tggcggatac tgtgttgttt gagtttcttc acacggagat
       61 ggtggctgag ctgtgggctc acgaccccga ccccggcccg gggggacaga agatgagcct
      121 gtcggtcctg gagggtatgg ggttccgtgt gggccaggct ctaggcgaga ggctgccccg
      181 ggagacgctg gccttcaggg aggagctgga tgtcctcaag ttcttgtgca aagacctgtg
      241 ggtggcggtg ttccagaagc agatggacag cctgcgcacc aatcaccagg ggacctacgt
      301 cctgcaagac aacagcttcc ccctcctcct cccgatggcc tctggcctgc agtatctgga
      361 ggaagcaccc aagttcctgg ccttcacctg cggcctcctg cgcggcgccc tctataccct
      421 gggcattgag agcgtggtca ccgcctccgt ggcagccctg cccgtctgta agttccaggt
      481 ggtgattccg aaatcctaag cctgcctcgc acctgctgag ccgcactgct gcccctggcc
      541 tcaccggcct caggagacgg tggggccgct gcatttcggg gtggtcttgg gaatcccagg
      601 ccctaggggt cacatttgct caggaagtgg gtatcaaatt gaggtggggg tgtcagagga
      661 ggcaaagggg tcccagctgc ggtcaggact gtggtgggat tcccgcctcg gcagcgtcac
      721 tgcccagtag ctgctcaata aaggctgtgt gtgtggaa
//
