LOCUS       NM_001042462            5508 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens trafficking protein particle complex subunit 5
            (TRAPPC5), transcript variant 3, mRNA.
ACCESSION   NM_001042462
VERSION     NM_001042462.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5508)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5508)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5508)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5508)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 5508)
  AUTHORS   Kim,J.J., Lipatova,Z. and Segev,N.
  TITLE     TRAPP Complexes in Secretion and Autophagy
  JOURNAL   Front Cell Dev Biol 4, 20 (2016)
   PUBMED   27066478
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5508)
  AUTHORS   Scrivens,P.J., Noueihed,B., Shahrzad,N., Hul,S., Brunet,S. and
            Sacher,M.
  TITLE     C4orf41 and TTC-15 are mammalian TRAPP components with a role at an
            early stage in ER-to-Golgi trafficking
  JOURNAL   Mol Biol Cell 22 (12), 2083-2093 (2011)
   PUBMED   21525244
REFERENCE   7  (bases 1 to 5508)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM841051.1, BU736689.1 and AC008763.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001042462.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB155196.1, SRR1803617.155745.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000596148.3/ ENSP00000470262.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-498               BM841051.1         1-498
            499-660             BU736689.1         27-188              c
            661-667             BU736689.1         19-25               c
            668-5508            AC008763.9         113675-118515
FEATURES             Location/Qualifiers
     source          1..5508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..5508
                     /gene="TRAPPC5"
                     /gene_synonym="TRS31"
                     /note="trafficking protein particle complex subunit 5"
                     /db_xref="GeneID:126003"
                     /db_xref="HGNC:HGNC:23067"
     exon            1..46
                     /gene="TRAPPC5"
                     /gene_synonym="TRS31"
                     /inference="alignment:Splign:2.1.0"
     exon            47..5508
                     /gene="TRAPPC5"
                     /gene_synonym="TRS31"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..625
                     /gene="TRAPPC5"
                     /gene_synonym="TRS31"
                     /note="trafficking protein particle complex 5"
                     /codon_start=1
                     /product="trafficking protein particle complex subunit 5"
                     /protein_id="NP_001035927.1"
                     /db_xref="CCDS:CCDS42490.1"
                     /db_xref="GeneID:126003"
                     /db_xref="HGNC:HGNC:23067"
                     /translation="MEARFTRGKSALLERALARPRTEVSLSAFALLFSELVQHCQSRV
                     FSVAELQSRLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEA
                     DKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKV
                     TAHWHKGTTLMIKFEEAVIARDRALEGR"
     regulatory      636..641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAPPC5"
                     /gene_synonym="TRS31"
                     /note="hexamer: GATAAA"
     polyA_site      659
                     /gene="TRAPPC5"
                     /gene_synonym="TRS31"
                     /note="major polyA site"
     regulatory      832..837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAPPC5"
                     /gene_synonym="TRS31"
                     /note="hexamer: AATAAA"
     polyA_site      850
                     /gene="TRAPPC5"
                     /gene_synonym="TRS31"
     regulatory      5484..5489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAPPC5"
                     /gene_synonym="TRS31"
                     /note="hexamer: AATAAA"
     polyA_site      5508
                     /gene="TRAPPC5"
                     /gene_synonym="TRS31"
ORIGIN      
        1 acggcgccgt aaagcagctc ggccgagcag actgctgcgg ttcctgggtg gcggcggcat
       61 ggaggcgcgc ttcacgcgcg ggaagtcggc gctgctggag cgcgcgctgg cgcggccgcg
      121 caccgaggtg agcctgagcg ccttcgcact gctgttctcc gagctggtac agcactgcca
      181 gagccgcgtc ttctccgtgg ccgagctgca gtcgcgcctg gccgcgctgg gccgccaggt
      241 gggcgcgcgc gtgctggatg cgctggtggc gcgcgaaaag ggtgcccggc gtgagaccaa
      301 ggtgctaggc gcgttgctct tcgtcaaggg cgccgtgtgg aaggcgctct tcggcaagga
      361 ggcggacaag ctggagcagg ccaacgatga cgcgcgcacc ttctacatca tcgagcgcga
      421 gccgctcatc aacacctaca tctccgtgcc caaggagaac agcacgctca actgcgccag
      481 cttcacggcg ggcatcgtgg aggcggtgct cacacacagc ggcttccctg ccaaggtcac
      541 ggcgcactgg cacaagggca ccacgctcat gatcaagttc gaggaggcag tcatcgctcg
      601 agaccgggcc ctggagggcc gctgaccctg ccggagataa aggatacaga gagcccctcc
      661 ccacgtgtgt cttgtgtctt gtgtggcggc cttagatcca ctcagtacct tgagccacag
      721 ccctgcccca ggctggggag ggaggccagg tccgaatgtg tttacagtag agtgggggcg
      781 ggtctggcca tagggttggg gggttgagtg agaccaggag tggtggggag aaataaaccc
      841 ggcaaaagga gttggtggga aatgctggca ggttctggaa tcacggttgg aggctgtctg
      901 caggctggag ggggcatggg gtcctgggag acgcatcagg ctgagacaga cgcctttaga
      961 ctgggggtgg gcaaactgcg caaagtgcca gatgggcaat attttatgcc atgtggtctt
     1021 tattattatt ttttttattt gttgagatag agtcttgctc tgtcgcccag gctggagtgc
     1081 agtggcacca tctcacctca ctgcaaacct ccaccttggg ttcacgtgat tctcctgcct
     1141 cagcttccca agtagctggg attacaggtg cctcccacca cacccggcta atttttgtat
     1201 ttttagtaga gatggggttt caccatgttg gtcaggctgg tctcgaactc ctcatctcag
     1261 gtgatccgcc cacttcagcc tcccaaagtg ctgggattac aggcgtgagc cactgctgtg
     1321 ccgccatgtg ctcttgcccc attactccgc tgatgtactg aatgcaacca cagacaacat
     1381 gtaaaggagt gggtgtcacc gtgtgcctag aaaacaggca gagggagatt gtttgccttc
     1441 ttccctcatt tattatattt ttcagagaca gggttttgtt ctgtcgccca ggctggagtg
     1501 cagtggcagc atctcggctt cggctcactg caagctccgc ctcccgggtt catgtcattc
     1561 tcctgcccca gcctcccgag tagctggaac tacaggtgcc caccaccaca cctggctaat
     1621 ttttcgtatt tttagtagag acggggtttc accatgttag ccaggatggt ctcgatctcc
     1681 tcacctcgtg atctgcccac ctcggcttcc caaagtgctg ggattacagg cgtgagccat
     1741 ggcgcccagc catgcccagc taatttttaa aaaatttttg tagagatggg ggctcttatt
     1801 aggttgccca ggctggtctc aaactcttgg cctcaagcaa tccttccacc ttggcctccg
     1861 taagtgctgg ggttacaggc gtgagccaaa tcaaagtgtg ttctgtagat cagcagtagc
     1921 agcatcaact gggagttggt ccataatgca gtctcaggcc caccccagag ctgctgaatc
     1981 tgagggtgca ttttagcgag gcccccaggg gattcctggg gaccttagat tgagatgcag
     2041 gctttagggt atcagaatca ccaggagggg ccacgtgcgg tggctcacgc ctgtaatccc
     2101 agcactttgg gaggctgagg caggtggatc acctgaagtc aggagttcga gaccagcctg
     2161 gctaacatgg caaaaccccg tctctactaa aaatagaaaa cattagccgg gtgtggtggc
     2221 acatgcctgt aatcccagct acttgggagg ctgaggcagg agaatcgctc caacccggga
     2281 ggtggaggtt gcagtgagcc gagattgcac cattgcactc cagcctgggc aacaagagcg
     2341 aaactccatc taaaaaacaa aaaggtcagg cgcggtggct cacgcctata atcccagcac
     2401 tttgggaggc cgaggcaggc ggatcacgag gtcaggagtt cgagccagcc tggccaatat
     2461 ggtgaaaccc tgtctctact aaaaatacaa aaattagctg ggcatggagg tgcattcctg
     2521 tagtcccagc tacctaattt tttgtatttt tagtagagat gaggtttcac tgtgttggcc
     2581 agtctggtca atactttaaa gttaatttta aagtccagga tgatacaaac acatttccct
     2641 tgttaaaaaa attttaaaat aagtggggtg cagtggtgca cacctggagt cccagctatt
     2701 caggaggccg aggcagaagg atcgcttgag gccaggggtt ggtgtccagc ctgggcaaca
     2761 tagtgagacc ttgtctaaaa gaatttgaaa taaggccagg cgtggcgact tatgtctgta
     2821 atcccagcac tttgagaggc cgaggtgggc agatcacttg aggccggaag tttgagacca
     2881 acctggtcaa catggcaaaa cccatcttta ctaaaaatac aaaaattagc tgggcgtggt
     2941 ggcaggcacc tgtaatccca gctacttggg aggctaaggc aggaggatca cttaaacctg
     3001 ggaggcggag gttgaagtga gccaagatca caccactggc actccagcct gagcaacaga
     3061 gtgagaccct gtcttaaaaa agaaaaaaaa agtaatgtat tacacctcag gcaattttcc
     3121 tttccctttt tgttcaccac acttggttcc tgataactcc tcctctcccc caaggaaagt
     3181 tcttccagat tttttggggg aaccatgatc caatcttccc tgcttccttt ccaccgcccc
     3241 ccagaatgtg aacagacagg tctgttcaga aaaggaactg cagggactgt cagctgggct
     3301 cccctcactg gttatgagaa gggccaaagg ggtcggtgtc acctctagat ttgtttagga
     3361 tgctctgttg gactgcctgg tggaccaggg ctgagggctt ggtcagggca gtctcagcca
     3421 tcctagcaag aggcattgag cagggtgggc ttcagcacac tggggagaag gtggcgtctc
     3481 taggatgaat gaaaccattg agcaaccacc acacatagcc ccagggctga tcctggaata
     3541 gctgttggct gttggaggtg gagggaggcg ccgggagagg gcttgggcag gatgatagcc
     3601 tgaatctgga atgaggggga ggcgtctagg gggccagcag atgcacaggt cttggggttt
     3661 ggggtctgga gttctggagg gaggtctggg cgtctgcaca gacacagaaa ccacagtcct
     3721 ggatggggga cggagggagg ggaacatggt gtctgagaag ctggatttca gagcaaaatg
     3781 caggacgctt tgggctaagc agccccaggc aggtcctctg agaccctggc gagaggggct
     3841 tccagggccg gccagggcag gggccattct tctgtccaga ggcggggctg tgagggatgt
     3901 cagagaaatc gggagggagg aagaggggct gcgggaattt gtaagctggg agtgcagggc
     3961 ccagggtctg ttcccacgcc ccatccccac cggccaccga gggtgagtta gggggcttga
     4021 ggagaaggga aaacgtttga acaagctgta gggttatgag gctgggcccg gggttggggc
     4081 aagggaggat gaagagaaag aagagcctgt ggttcggcag cttctgatca cagcagctct
     4141 aacttacggt gctctgggct gcaaggaagg tcttcccctg gaccctccag gtgggtgggt
     4201 gagaggaaga ggaggaggag gagccaggca ccagcccttg gtgagctggg caagcagcat
     4261 cagctcattt cacaggcagg ttccaaaaga agtcatgtgc ccatggtcac acagattaat
     4321 tattattatt attattattt agagatggag tctcactctg tcgcccaggc tggagtgcag
     4381 tggtgcgatc tcagatctca gcctcctggg ttcaagcaat tctcctgctt cagcctcctg
     4441 aatagttggg actataggca tccgccacca cacccagcta atttttgtat ttttagtgga
     4501 gacggggttt caccatgttg gccaggctgg tctggaactc ctgacctcaa gtgatctgcc
     4561 cgccttggcc tcccaaagtg ctaggattac aggcgtgagc caccgcacct ggctggcttt
     4621 ttctcttttc ttcttctttt tttttgagac aggttctcac tgtcgcccag gctgagagca
     4681 ggggcacaat cctcccacct cggcctccca agcagctggg accaagttgc ccatcactac
     4741 acctctagtt tttgtatttt ttgtagagat ggggcctcac tatgttgccc aggctggcct
     4801 caaactcctg aactcaagca gtcctcccac ctcagcctcc caaagcgctg ggatgacagg
     4861 catgagccac tgtgcgcagc tggctttggc cttttatctg agctggagga aacttctgga
     4921 aagggggcag tgaagagaga gccccgggcg gaggtgactg ctccagtcga ggcagtggca
     4981 gaaggggtga gcagtgagtg attgtgagcg ccgtttgaca gcagagccca ctggcatttc
     5041 ttatggtctt ggacctggag gtgttgtcag gggaaaggga agaggtgcaa tgaccccagt
     5101 gttggcctga gccactggta gaggagtgtg gagaggggac cctgtgctcc tggcctccct
     5161 cccgtggcct ccggcatggg tcgaccttgg ccgagcgtga ggctggtgcc acctcagcct
     5221 cccagaccct gagtagggtt aacacctcca gacccgaaat ggcctccggt tgaccgggcc
     5281 cactccccat cagcctgtcc agccagccag cacttactga gtgccttctg tgtactaagc
     5341 cctgctctgg gtacttccat gagtcaactc acgccctccc ggcctcaggg tgatccaccg
     5401 ccttccccta cagtattcca aggggccatt ggacctcaga ggcttcatgt cctgcacatt
     5461 ctccgtgtca tagagcagga aaaaataaaa acgggagatc gaattcta
//
