LOCUS       NM_001355204             744 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens trafficking protein particle complex subunit 2B
            (TRAPPC2B), mRNA.
ACCESSION   NM_001355204 NR_002166
VERSION     NM_001355204.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 744)
  AUTHORS   Kim,J.J., Lipatova,Z. and Segev,N.
  TITLE     TRAPP Complexes in Secretion and Autophagy
  JOURNAL   Front Cell Dev Biol 4, 20 (2016)
   PUBMED   27066478
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 744)
  AUTHORS   Tokunaga,M., Shiheido,H., Tabata,N., Sakuma-Yonemura,Y.,
            Takashima,H., Horisawa,K., Doi,N. and Yanagawa,H.
  TITLE     MIP-2A is a novel target of an anilinoquinazoline derivative for
            inhibition of tumour cell proliferation
  JOURNAL   PLoS One 8 (9), e76774 (2013)
   PUBMED   24098805
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 744)
  AUTHORS   Gecz,J., Shaw,M.A., Bellon,J.R. and de Barros Lopes,M.
  TITLE     Human wild-type SEDL protein functionally complements yeast Trs20p
            but some naturally occurring SEDL mutants do not
  JOURNAL   Gene 320, 137-144 (2003)
   PUBMED   14597397
REFERENCE   4  (bases 1 to 744)
  AUTHORS   Savarirayan,R., Thompson,E. and Gecz,J.
  TITLE     Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400)
  JOURNAL   Eur J Hum Genet 11 (9), 639-642 (2003)
   PUBMED   12939648
REFERENCE   5  (bases 1 to 744)
  AUTHORS   Sacher,M.
  TITLE     Membrane traffic fuses with cartilage development
  JOURNAL   FEBS Lett 550 (1-3), 1-4 (2003)
   PUBMED   12935876
  REMARK    Review article
REFERENCE   6  (bases 1 to 744)
  AUTHORS   Ghosh,A.K., Steele,R. and Ray,R.B.
  TITLE     Modulation of human luteinizing hormone beta gene transcription by
            MIP-2A
  JOURNAL   J Biol Chem 278 (26), 24033-24038 (2003)
   PUBMED   12700240
  REMARK    GeneRIF: MBP-1 interacting protein-2A (MIP-2A) preferentially
            expresses in certain tissues, including the pituitary gland, and
            negatively regulates the LHbeta gene transcription (MBP-1
            interacting protein-2A)
REFERENCE   7  (bases 1 to 744)
  AUTHORS   Gavin,A.C., Bosche,M., Krause,R., Grandi,P., Marzioch,M., Bauer,A.,
            Schultz,J., Rick,J.M., Michon,A.M., Cruciat,C.M., Remor,M.,
            Hofert,C., Schelder,M., Brajenovic,M., Ruffner,H., Merino,A.,
            Klein,K., Hudak,M., Dickson,D., Rudi,T., Gnau,V., Bauch,A.,
            Bastuck,S., Huhse,B., Leutwein,C., Heurtier,M.A., Copley,R.R.,
            Edelmann,A., Querfurth,E., Rybin,V., Drewes,G., Raida,M.,
            Bouwmeester,T., Bork,P., Seraphin,B., Kuster,B., Neubauer,G. and
            Superti-Furga,G.
  TITLE     Functional organization of the yeast proteome by systematic
            analysis of protein complexes
  JOURNAL   Nature 415 (6868), 141-147 (2002)
   PUBMED   11805826
REFERENCE   8  (bases 1 to 744)
  AUTHORS   Ghosh,A.K., Majumder,M., Steele,R., White,R.A. and Ray,R.B.
  TITLE     A novel 16-kilodalton cellular protein physically interacts with
            and antagonizes the functional activity of c-myc promoter-binding
            protein 1
  JOURNAL   Mol Cell Biol 21 (2), 655-662 (2001)
   PUBMED   11134351
REFERENCE   9  (bases 1 to 744)
  AUTHORS   Gecz,J., Hillman,M.A., Gedeon,A.K., Cox,T.C., Baker,E. and
            Mulley,J.C.
  TITLE     Gene structure and expression study of the SEDL gene for
            spondyloepiphyseal dysplasia tarda
  JOURNAL   Genomics 69 (2), 242-251 (2000)
   PUBMED   11031107
REFERENCE   10 (bases 1 to 744)
  AUTHORS   Gedeon,A.K., Colley,A., Jamieson,R., Thompson,E.M., Rogers,J.,
            Sillence,D., Tiller,G.E., Mulley,J.C. and Gecz,J.
  TITLE     Identification of the gene (SEDL) causing X-linked
            spondyloepiphyseal dysplasia tarda
  JOURNAL   Nat Genet 22 (4), 400-404 (1999)
   PUBMED   10431248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF058918.1 and BU556832.1.
            
            On May 17, 2019 this sequence version replaced NM_001355204.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.452494.1,
                                           SRR1660805.319724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543226.2/ ENSP00000442778.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-692               AF058918.1         41-732
            693-744             BU556832.1         727-778
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..744
                     /gene="TRAPPC2B"
                     /gene_synonym="MIP-2A; MIP2A; SEDLP; SEDLP1; TRAPPC2P1"
                     /note="trafficking protein particle complex subunit 2B"
                     /db_xref="GeneID:10597"
                     /db_xref="HGNC:HGNC:10710"
                     /db_xref="MIM:620472"
     exon            1..153
                     /gene="TRAPPC2B"
                     /gene_synonym="MIP-2A; MIP2A; SEDLP; SEDLP1; TRAPPC2P1"
                     /inference="alignment:Splign:2.1.0"
     exon            154..744
                     /gene="TRAPPC2B"
                     /gene_synonym="MIP-2A; MIP2A; SEDLP; SEDLP1; TRAPPC2P1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..595
                     /gene="TRAPPC2B"
                     /gene_synonym="MIP-2A; MIP2A; SEDLP; SEDLP1; TRAPPC2P1"
                     /note="spondyloepiphyseal dysplasia, late, pseudogene;
                     MBP-1 interacting protein-2A; trafficking protein particle
                     complex 2 pseudogene 1; trafficking protein particle
                     complex 2B"
                     /codon_start=1
                     /product="trafficking protein particle complex subunit 2B"
                     /protein_id="NP_001342133.1"
                     /db_xref="CCDS:CCDS86812.1"
                     /db_xref="GeneID:10597"
                     /db_xref="HGNC:HGNC:10710"
                     /db_xref="MIM:620472"
                     /translation="MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHA
                     ALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDIRQEDGIKNFFTDV
                     YDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS"
     regulatory      617..622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAPPC2B"
                     /gene_synonym="MIP-2A; MIP2A; SEDLP; SEDLP1; TRAPPC2P1"
                     /note="hexamer: ATTATA"
     polyA_site      644
                     /gene="TRAPPC2B"
                     /gene_synonym="MIP-2A; MIP2A; SEDLP; SEDLP1; TRAPPC2P1"
                     /note="major polyA site"
     regulatory      671..676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAPPC2B"
                     /gene_synonym="MIP-2A; MIP2A; SEDLP; SEDLP1; TRAPPC2P1"
                     /note="hexamer: ATTAAA"
     polyA_site      698
                     /gene="TRAPPC2B"
                     /gene_synonym="MIP-2A; MIP2A; SEDLP; SEDLP1; TRAPPC2P1"
     regulatory      719..724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAPPC2B"
                     /gene_synonym="MIP-2A; MIP2A; SEDLP; SEDLP1; TRAPPC2P1"
                     /note="hexamer: AATGAA"
     polyA_site      744
                     /gene="TRAPPC2B"
                     /gene_synonym="MIP-2A; MIP2A; SEDLP; SEDLP1; TRAPPC2P1"
ORIGIN      
        1 gtacgcagag gcggtagtga cacaggcaca actgacagtg gcagaagctc agctgacaag
       61 gactggggac ggcggtgtcc ttgtcttgcc tttgtcgccc ccgcccctct cttccctggc
      121 tggacttgcg gagtccccgc cgaagaaccc gaggagccat atattgaaga ccatgtctgg
      181 aagcttctac tttgtaattg ttggtcacca tgataatcca gtttttgaaa tggagttttt
      241 gccagctggg aaggcagaat ccaaagacga ccatcgtcat ctgaaccagt tcatagctca
      301 tgctgctctc gacctcgtag atgagaacat gtggctgtcg aacaacatgt acttgaaaac
      361 tgtggacaag ttcaacgagt ggtttgtgtc agcatttgtc accgcggggc atatgaggtt
      421 tattatgctt catgacataa gacaagaaga tggaataaag aacttcttta ctgatgttta
      481 tgatttatat ataaaatttt caatgaatcc attttatgaa cccaattctc ctattcgatc
      541 aagtgcattt gacagaaaag ttcagtttct tgggaagaaa caccttttaa gctgaatgga
      601 gaaaattcca aaataaatta tatcaccaca atggtgtata ctcaggaatg tgtacattgt
      661 aaattacttg attaaatagc ctggaaatct tttgtgtatt ctcagcttat ctaaacttaa
      721 tgaaatttct tttatattta aaaa
//
