LOCUS       NM_018275               2555 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens trafficking protein particle complex subunit 14
            (TRAPPC14), transcript variant 1, mRNA.
ACCESSION   NM_018275
VERSION     NM_018275.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2555)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2555)
  AUTHORS   Cuenca,A., Insinna,C., Zhao,H., John,P., Weiss,M.A., Lu,Q.,
            Walia,V., Specht,S., Manivannan,S., Stauffer,J., Peden,A.A. and
            Westlake,C.J.
  TITLE     The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8
            for preciliary vesicle tethering at the mother centriole during
            ciliogenesis
  JOURNAL   J Biol Chem 294 (42), 15418-15434 (2019)
   PUBMED   31467083
  REMARK    GeneRIF: C7orf43 directly binds to Rabin8 and that C7orf43
            knockdown diminishes Rabin8 preciliary centrosome accumulation.
REFERENCE   3  (bases 1 to 2555)
  AUTHORS   Perez,Y., Bar-Yaacov,R., Kadir,R., Wormser,O., Shelef,I.,
            Birk,O.S., Flusser,H. and Birnbaum,R.Y.
  TITLE     Mutations in the microtubule-associated protein MAP11 (C7orf43)
            cause microcephaly in humans and zebrafish
  JOURNAL   Brain 142 (3), 574-585 (2019)
   PUBMED   30715179
REFERENCE   4  (bases 1 to 2555)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073842.5, HY066862.1, BC015722.2 and BC094727.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018275.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094727.1, BC015722.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316937.8/ ENSP00000324741.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC073842.5         45971-45972
            3-44                HY066862.1         1-42
            45-2034             BC015722.2         1-1990
            2035-2555           BC094727.1         1996-2516
FEATURES             Location/Qualifiers
     source          1..2555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2555
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /note="trafficking protein particle complex subunit 14"
                     /db_xref="GeneID:55262"
                     /db_xref="HGNC:HGNC:25604"
                     /db_xref="MIM:618350"
     exon            1..635
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1967
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C7orf43; microtubule associated
                     protein 11; trafficking protein particle complex 14"
                     /codon_start=1
                     /product="trafficking protein particle complex subunit 14
                     isoform 1"
                     /protein_id="NP_060745.3"
                     /db_xref="CCDS:CCDS5687.1"
                     /db_xref="GeneID:55262"
                     /db_xref="HGNC:HGNC:25604"
                     /db_xref="MIM:618350"
                     /translation="MESQCDYSMYFPAVPLPPRAELAGDPGRYRALPRRNHLYLGETV
                     RFLLVLRCRGGAGSGTGGGPGLGSRGAWAELATALAALASVSAGGGMPGGGGAGDQDS
                     EPPGGGDPGGGGLFRGCSPLLTHGPGPATSGGATTLPVEEPIVSTDEVIFPLTVSLDR
                     LPPGTPKAKIVVTVWKREIEAPEVRDQGYLRLLQTRSPGETFRGEQSAFKAQVSTLLT
                     LLPPPVLRCRQFTVAGKHLTVLKVLNSSSQEEISIWDIRILPNFNASYLPVMPDGSVL
                     LVDNVCHQSGEVSMGSFCRLPGTSGCFPCPLNALEEHNFLFQLRGGEQPPPGAKEGLE
                     VPLIAVVQWSTPKLPFTQSIYTHYRLPSVRLDRPCFVMTASCKSPVRTYERFTVTYTL
                     LNNLQDFLAVRLVWTPEHAQAGKQLCEEERRAMQAALDSVVCHTPLNNLGFSRKGSAL
                     TFSVAFQALRTGLFELSQHMKLKLQFTASVSHPPPEARPLSRKSSPSSPAVRDLVERH
                     QASLGRSQSFSHQQPSRSHLMRSGSVMERRAITPPVASPVGRPLYLPPDKAVLSLDKI
                     AKRECKVLVVEPVK"
     exon            636..731
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /inference="alignment:Splign:2.1.0"
     exon            732..861
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /inference="alignment:Splign:2.1.0"
     exon            862..948
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1069
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1217
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1300
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1464
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1619
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1813
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2555
                     /gene="TRAPPC14"
                     /gene_synonym="C7orf43; MAP11; MCPH25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttcctgtt tctctccagt cattcggctc agtaccccgg ttccggcgct gccgggtctc
       61 ggttcgggtt cgttgccccg gtgccgggac cgggccggtc tctccggccg ccccagccgg
      121 gcgcagcagc cggaggtgtc gggaccctct ggacccaccc tagcgggccc cgccggcggt
      181 cggcctccgg tccgggctcc cagtcgcgcc gtcctcgccg ccccatggag tcccagtgcg
      241 actactcgat gtacttcccg gccgtgccgc tgccgccgcg cgcggagctg gcaggggatc
      301 cgggccggta ccgggcgctg ccccggcgca accatctgta cttgggggag actgtccgtt
      361 ttctgctggt gttgcgctgc cggggcggtg cggggtccgg caccgggggc ggcccgggct
      421 tgggctccag aggagcctgg gcagaactgg caaccgccct ggccgccctg gcctcggtca
      481 gcgccggagg cgggatgccg gggggcggcg gcgccggcga ccaggattcg gagcccccag
      541 ggggagggga tcctgggggt gggggtttgt tccgaggctg cagccccctt ctcacccacg
      601 gcccgggccc tgctacctca gggggagcga ccacgctgcc tgtggaggaa ccgattgtgt
      661 ccacagatga ggtcatcttc ccactcaccg tttcactgga tagactgccc ccagggacac
      721 ctaaggccaa gattgtagtg actgtgtgga agcgggagat tgaggcacca gaggtcagag
      781 atcaaggcta cctgcgattg ctgcagaccc gatctcctgg ggagacattc cggggcgagc
      841 agagcgcttt caaggcccaa gtgagcacgc tgctgactct gctgccccct ccggttctga
      901 gatgccggca gttcactgtg gctggaaaac acttgaccgt gctcaaggtg ctgaacagct
      961 cctctcagga ggaaatctcc atctgggata tccgaatcct ccccaacttc aacgccagtt
     1021 atctacctgt catgcccgat ggctctgtgc tgctggtgga caatgtctgt caccagtctg
     1081 gggaagtctc catgggctcc ttctgccgcc tacccgggac ctctggctgc ttcccctgcc
     1141 cgctgaatgc cctggaggaa cacaacttcc tgtttcagct gagagggggt gagcagcccc
     1201 ctccaggggc caaggagggc ctggaagttc ccctgattgc tgtggttcag tggtctaccc
     1261 caaagctgcc cttcactcag agcatctaca cccactaccg cctgcccagt gtccgcttgg
     1321 accgcccgtg ttttgtgatg accgcttctt gtaagtcccc tgttcggacc tacgagcgtt
     1381 tcactgtcac ctacacgctg cttaacaatc tccaagactt ccttgctgtg aggctcgtgt
     1441 ggaccccaga gcatgcacag gctggaaagc agctgtgtga ggaggagcgc cgggccatgc
     1501 aggctgccct ggactccgtc gtctgccaca cgcccctcaa caaccttggc ttttcccgga
     1561 agggcagcgc gctcaccttc agtgtggcct tccaggctct gaggacgggg ctcttcgagc
     1621 taagccagca catgaaactg aagctgcagt tcaccgccag cgtgtcccac cctccacccg
     1681 aggcccggcc cctctcccgc aagagcagcc ccagcagccc tgctgtccgg gacttggtgg
     1741 agaggcatca ggctagcctg ggccgctccc agtccttctc ccaccagcag ccttcccgaa
     1801 gccacctcat gaggtcgggc agtgtgatgg agcgcagagc catcacgccc cctgtggcct
     1861 ctcctgttgg ccgccccctc tacctgcccc cggacaaggc tgtgttgtct ctggacaaga
     1921 ttgccaagcg cgagtgcaag gtcctggtgg tggaacccgt caagtagcac cgtgccagct
     1981 ctgttccctc ttacactcca gagacccaac gcccccagag gggatccctg ctcccgggct
     2041 gtgcctcccc tgggatgcct cccagacggg ggtgaagagg cctggcagag ctgcctgtct
     2101 tgtgtctgct gatgagggat gggggaagaa gctgtgaagt gggcgggcat ggctgggact
     2161 aagccaccag tattccccga gttcctgtgg ggggggctgg ccccacccct aggccagggc
     2221 aagggttccc agagctccct tgtccccggc cctttaccct ggttctgagt ttacaaagtc
     2281 tcttcctcat tcccgttgag ttctttccca cctctgacat tccctccctc cctcccgcag
     2341 ggctgagatt agagggtggt gatggctaag ggcccctgac agtgaccttc ctgtctcagg
     2401 ggttggggac agggccaggt agcctcctgc cccttatgtt tacgtttgca gcctgaagca
     2461 ctttaatttt tttttttttg gtctgttcct gtaacttatt ttccaactat tgcttccaac
     2521 tgaaataaga ctattaaatg cctgttcagg aggga
//
