LOCUS       NM_021210                812 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens trafficking protein particle complex subunit 1
            (TRAPPC1), transcript variant 1, mRNA.
ACCESSION   NM_021210
VERSION     NM_021210.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 812)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 812)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 812)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 812)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 812)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 812)
  AUTHORS   Westlake,C.J., Baye,L.M., Nachury,M.V., Wright,K.J., Ervin,K.E.,
            Phu,L., Chalouni,C., Beck,J.S., Kirkpatrick,D.S., Slusarski,D.C.,
            Sheffield,V.C., Scheller,R.H. and Jackson,P.K.
  TITLE     Primary cilia membrane assembly is initiated by Rab11 and transport
            protein particle II (TRAPPII) complex-dependent trafficking of
            Rabin8 to the centrosome
  JOURNAL   Proc Natl Acad Sci U S A 108 (7), 2759-2764 (2011)
   PUBMED   21273506
REFERENCE   7  (bases 1 to 812)
  AUTHORS   Kummel,D., Muller,J.J., Roske,Y., Henke,N. and Heinemann,U.
  TITLE     Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form
            trimeric complexes with Bet3 and Mum2
  JOURNAL   J Mol Biol 361 (1), 22-32 (2006)
   PUBMED   16828797
  REMARK    GeneRIF: Mum2 binds to the alpha1-alpha2 loop of the Bet3-Tpc6B
            heterodimer.
REFERENCE   8  (bases 1 to 812)
  AUTHORS   Oka,T. and Krieger,M.
  TITLE     Multi-component protein complexes and Golgi membrane trafficking
  JOURNAL   J Biochem 137 (2), 109-114 (2005)
   PUBMED   15749823
  REMARK    Review article
REFERENCE   9  (bases 1 to 812)
  AUTHORS   Gavin,A.C., Bosche,M., Krause,R., Grandi,P., Marzioch,M., Bauer,A.,
            Schultz,J., Rick,J.M., Michon,A.M., Cruciat,C.M., Remor,M.,
            Hofert,C., Schelder,M., Brajenovic,M., Ruffner,H., Merino,A.,
            Klein,K., Hudak,M., Dickson,D., Rudi,T., Gnau,V., Bauch,A.,
            Bastuck,S., Huhse,B., Leutwein,C., Heurtier,M.A., Copley,R.R.,
            Edelmann,A., Querfurth,E., Rybin,V., Drewes,G., Raida,M.,
            Bouwmeester,T., Bork,P., Seraphin,B., Kuster,B., Neubauer,G. and
            Superti-Furga,G.
  TITLE     Functional organization of the yeast proteome by systematic
            analysis of protein complexes
  JOURNAL   Nature 415 (6868), 141-147 (2002)
   PUBMED   11805826
  REMARK    GeneRIF: This paper studies human as well as yeast TRAPP subunits.
REFERENCE   10 (bases 1 to 812)
  AUTHORS   Chiari,R., Foury,F., De Plaen,E., Baurain,J.F., Thonnard,J. and
            Coulie,P.G.
  TITLE     Two antigens recognized by autologous cytolytic T lymphocytes on a
            melanoma result from a single point mutation in an essential
            housekeeping gene
  JOURNAL   Cancer Res 59 (22), 5785-5792 (1999)
   PUBMED   10582700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104581.22 and BC032717.1.
            
            On May 17, 2019 this sequence version replaced NM_021210.4.
            
            Summary: This gene product plays a role in vesicular transport of
            proteins to the Golgi apparatus from the endoplasmic reticulum. The
            encoded protein is a component of the multisubunit transport
            protein particle (TRAPP) complex. Alternative splicing results in
            multiple transcript variants.[provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.165702.1,
                                           SRR3476690.124091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303731.9/ ENSP00000302783.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC104581.22        95178-95183         c
            7-812               BC032717.1         12-817
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..812
                     /gene="TRAPPC1"
                     /gene_synonym="BET5; MUM2"
                     /note="trafficking protein particle complex subunit 1"
                     /db_xref="GeneID:58485"
                     /db_xref="HGNC:HGNC:19894"
                     /db_xref="MIM:610969"
     exon            1..216
                     /gene="TRAPPC1"
                     /gene_synonym="BET5; MUM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..555
                     /gene="TRAPPC1"
                     /gene_synonym="BET5; MUM2"
                     /note="multiple myeloma protein 2; melanoma ubiquitous
                     mutated 2; MUM-2; BET5 homolog; trafficking protein
                     particle complex 1"
                     /codon_start=1
                     /product="trafficking protein particle complex subunit 1"
                     /protein_id="NP_067033.1"
                     /db_xref="CCDS:CCDS11125.1"
                     /db_xref="GeneID:58485"
                     /db_xref="HGNC:HGNC:19894"
                     /db_xref="MIM:610969"
                     /translation="MTVHNLYLFDRNGVCLHYSEWHRKKQAGIPKEEEYKLMYGMLFS
                     IRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGIKVVMNTDLGVGPIRDVLHHIYS
                     ALYVELVVKNPLCPLGQTVQSELFRSRLDSYVRSLPFFSARAG"
     exon            217..287
                     /gene="TRAPPC1"
                     /gene_synonym="BET5; MUM2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..426
                     /gene="TRAPPC1"
                     /gene_synonym="BET5; MUM2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..812
                     /gene="TRAPPC1"
                     /gene_synonym="BET5; MUM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      792..797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAPPC1"
                     /gene_synonym="BET5; MUM2"
                     /note="hexamer: AATAAA"
     polyA_site      812
                     /gene="TRAPPC1"
                     /gene_synonym="BET5; MUM2"
                     /note="major polyA site"
ORIGIN      
        1 agttccggtg agtccgtggg tggggtcccc acctggttgg aaggctgtgg gtccgggaac
       61 ccgagcccaa ggagtggggg cggccccgga gcgaggctca cactccctgc cctgcagatg
      121 actgtccaca acctgtacct gtttgaccgg aatggagtgt gtctgcacta cagcgaatgg
      181 caccgcaaga agcaagcagg gattcccaag gaggaggagt ataagctgat gtacgggatg
      241 ctcttctcta tccgctcgtt tgtcagcaag atgtccccgc tagacatgaa ggatggcttc
      301 ctggccttcc aaactagccg ttacaaactc cattactacg agacgcccac tgggatcaaa
      361 gttgtcatga atactgactt gggcgtggga cccatccgag atgtgctgca ccacatctac
      421 agtgcgctgt atgtggagct ggtggtgaag aatcccctgt gcccgctggg ccaaactgtg
      481 caaagtgagc tctttcgctc ccgactggac tcctatgttc gctctctgcc cttcttctcc
      541 gcccgggctg gctgaagcaa cctacctcaa gtctcaggag aattcatgtc tgcctggggc
      601 ccttccgaac ctgtgccaac taagggcccc cactgtaagc ccccgcaccc ccaccccctg
      661 cccagagcaa cagcctaaag gcctgccctg atgctctcct cctaccagag tgaagcccac
      721 agagtccctc cacctccaca ccaggccctc tctccagttt tatcccctgc ctaatgctgc
      781 gagaagcaca gaataaactt tttgtcactc tc
//
