LOCUS       NM_016292               2223 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens TNF receptor associated protein 1 (TRAP1), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_016292
VERSION     NM_016292.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2223)
  AUTHORS   Li,X., Chen,M., Chen,X., He,X., Li,X., Wei,H., Tan,Y., Min,J.,
            Azam,T., Xue,M., Zhang,Y., Dong,M., Yin,Q., Zheng,L., Jiang,H.,
            Huo,D., Wang,X., Chen,S., Ji,Y. and Chen,H.
  TITLE     TRAP1 drives smooth muscle cell senescence and promotes
            atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation
  JOURNAL   Eur Heart J 45 (39), 4219-4235 (2024)
   PUBMED   39088352
  REMARK    GeneRIF: TRAP1 drives smooth muscle cell senescence and promotes
            atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation.
REFERENCE   2  (bases 1 to 2223)
  AUTHORS   Bruno,G., Pietrafesa,M., Crispo,F., Piscazzi,A., Maddalena,F.,
            Giordano,G., Conteduca,V., Garofoli,M., Porras,A., Esposito,F. and
            Landriscina,M.
  TITLE     TRAP1 modulates mitochondrial biogenesis via PGC-1alpha/TFAM
            signalling pathway in colorectal cancer cells
  JOURNAL   J Mol Med (Berl) 102 (10), 1285-1296 (2024)
   PUBMED   39210159
  REMARK    GeneRIF: TRAP1 modulates mitochondrial biogenesis via
            PGC-1alpha/TFAM signalling pathway in colorectal cancer cells.
REFERENCE   3  (bases 1 to 2223)
  AUTHORS   Avolio,R., Agliarulo,I., Criscuolo,D., Sarnataro,D., Auriemma,M.,
            De Lella,S., Pennacchio,S., Calice,G., Ng,M.Y., Giorgi,C.,
            Pinton,P., Cooperman,B.S., Landriscina,M., Esposito,F. and
            Matassa,D.S.
  TITLE     Cytosolic and mitochondrial translation elongation are coordinated
            through the molecular chaperone TRAP1 for the synthesis and import
            of mitochondrial proteins
  JOURNAL   Genome Res 33 (8), 1242-1257 (2023)
   PUBMED   37487647
  REMARK    GeneRIF: Cytosolic and mitochondrial translation elongation are
            coordinated through the molecular chaperone TRAP1 for the synthesis
            and import of mitochondrial proteins.
REFERENCE   4  (bases 1 to 2223)
  AUTHORS   Dharaskar,S.P., Paithankar,K. and Amere Subbarao,S.
  TITLE     Analysis and functional relevance of the chaperone TRAP-1
            interactome in the metabolic regulation and mitochondrial integrity
            of cancer cells
  JOURNAL   Sci Rep 13 (1), 7584 (2023)
   PUBMED   37165028
  REMARK    GeneRIF: Analysis and functional relevance of the chaperone TRAP-1
            interactome in the metabolic regulation and mitochondrial integrity
            of cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2223)
  AUTHORS   Wurthner,J.U., Frank,D.B., Felici,A., Green,H.M., Cao,Z.,
            Schneider,M.D., McNally,J.G., Lechleider,R.J. and Roberts,A.B.
  TITLE     Transforming growth factor-beta receptor-associated protein 1 is a
            Smad4 chaperone
  JOURNAL   J Biol Chem 276 (22), 19495-19502 (2001)
   PUBMED   11278302
REFERENCE   6  (bases 1 to 2223)
  AUTHORS   Felts,S.J., Owen,B.A., Nguyen,P., Trepel,J., Donner,D.B. and
            Toft,D.O.
  TITLE     The hsp90-related protein TRAP1 is a mitochondrial protein with
            distinct functional properties
  JOURNAL   J Biol Chem 275 (5), 3305-3312 (2000)
   PUBMED   10652318
REFERENCE   7  (bases 1 to 2223)
  AUTHORS   Simmons,A.D., Musy,M.M., Lopes,C.S., Hwang,L.Y., Yang,Y.P. and
            Lovett,M.
  TITLE     A direct interaction between EXT proteins and glycosyltransferases
            is defective in hereditary multiple exostoses
  JOURNAL   Hum Mol Genet 8 (12), 2155-2164 (1999)
   PUBMED   10545594
REFERENCE   8  (bases 1 to 2223)
  AUTHORS   Charng,M.J., Zhang,D., Kinnunen,P. and Schneider,M.D.
  TITLE     A novel protein distinguishes between quiescent and activated forms
            of the type I transforming growth factor beta receptor
  JOURNAL   J Biol Chem 273 (16), 9365-9368 (1998)
   PUBMED   9545258
REFERENCE   9  (bases 1 to 2223)
  AUTHORS   Chen,C.F., Chen,Y., Dai,K., Chen,P.L., Riley,D.J. and Lee,W.H.
  TITLE     A new member of the hsp90 family of molecular chaperones interacts
            with the retinoblastoma protein during mitosis and after heat shock
  JOURNAL   Mol Cell Biol 16 (9), 4691-4699 (1996)
   PUBMED   8756626
REFERENCE   10 (bases 1 to 2223)
  AUTHORS   Song,H.Y., Dunbar,J.D., Zhang,Y.X., Guo,D. and Donner,D.B.
  TITLE     Identification of a protein with homology to hsp90 that binds the
            type 1 tumor necrosis factor receptor
  JOURNAL   J Biol Chem 270 (8), 3574-3581 (1995)
   PUBMED   7876093
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB452880.1, BC018950.2 and
            AF154108.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016292.2.
            
            Summary: This gene encodes a mitochondrial chaperone protein that
            is member of the heat shock protein 90 (HSP90) family. The encoded
            protein has ATPase activity and interacts with tumor necrosis
            factor type I. This protein may function in regulating cellular
            stress responses. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005522.1, SRR3476690.1145766.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000246957.10/
                                                  ENSP00000246957.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DB452880.1         74-82
            10-2218             BC018950.2         1-2209
            2219-2223           AF154108.1         2207-2211
FEATURES             Location/Qualifiers
     source          1..2223
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2223
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /note="TNF receptor associated protein 1"
                     /db_xref="GeneID:10131"
                     /db_xref="HGNC:HGNC:16264"
                     /db_xref="MIM:606219"
     exon            1..104
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..2131
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; heat shock protein 75 kDa, mitochondrial;
                     TNFR-associated protein 1; tumor necrosis factor type 1
                     receptor-associated protein; testicular tissue protein Li
                     209; heat shock protein family C member 5"
                     /codon_start=1
                     /product="heat shock protein 75 kDa, mitochondrial isoform
                     1 precursor"
                     /protein_id="NP_057376.2"
                     /db_xref="CCDS:CCDS10508.1"
                     /db_xref="GeneID:10131"
                     /db_xref="HGNC:HGNC:16264"
                     /db_xref="MIM:606219"
                     /translation="MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLG
                     PRRNPAWSLQAGRLFSTQTAEDKEEPLHSIISSTESVQGSTSKHEFQAETKKLLDIVA
                     RSLYSEKEVFIRELISNASDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTG
                     IGMTQEELVSNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVY
                     SRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTK
                     YSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTD
                     APLNIRSIFYVPDMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVD
                     SEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMRE
                     GIVTATEQEVKEDIAKLLRYESSALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLA
                     EHSPYYEAMKKKDTEVLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFED
                     RSPAAECLSEKETEELMAWMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRM
                     QQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGL
                     VDDPRAMVGRLNELLVKALERH"
     exon            105..263
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..346
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..487
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..559
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..720
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..830
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..904
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1060
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1181
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1251
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1399
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1585
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1724
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1810
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1956
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2029
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2223
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2223
                     /gene="TRAP1"
                     /gene_synonym="HSP 75; HSP75; HSP90L; TRAP-1"
                     /note="major polyA site"
ORIGIN      
        1 gctctgggag tacgacatgg cgcgcgagct gcgggcgctg ctgctgtggg gccgccgcct
       61 gcggcctttg ctgcgggcgc cggcgctggc ggccgtgccg ggaggaaaac caattctgtg
      121 tcctcggagg accacagccc agttgggccc caggcgaaac ccagcctgga gcttgcaggc
      181 aggacgactg ttcagcacgc agaccgccga ggacaaggag gaacccctgc actcgattat
      241 cagcagcaca gagagcgtgc agggttccac ttccaaacat gagttccagg ccgagacaaa
      301 gaagcttttg gacattgttg cccggtccct gtactcagaa aaagaggtgt ttatacggga
      361 gctgatctcc aatgccagcg atgccttgga aaaactgcgt cacaaactgg tgtctgacgg
      421 ccaagcactg ccagaaatgg agattcactt gcagaccaat gccgagaaag gcaccatcac
      481 catccaggat actggtatcg ggatgacaca ggaagagctg gtgtccaacc tggggacgat
      541 tgccagatcg gggtcaaagg ccttcctgga tgctctgcag aaccaggctg aggccagcag
      601 caagatcatc ggccagtttg gagtgggttt ctactcagct ttcatggtgg ctgacagagt
      661 ggaggtctat tcccgctcgg cagccccggg gagcctgggt taccagtggc tttcagatgg
      721 ttctggagtg tttgaaatcg ccgaagcttc gggagttaga accgggacaa aaatcatcat
      781 ccacctgaaa tccgactgca aggagttttc cagcgaggcc cgggtgcgag atgtggtaac
      841 gaagtacagc aacttcgtca gcttcccctt gtacttgaat ggaaggcgga tgaacacctt
      901 gcaggccatc tggatgatgg accccaagga tgtccgtgag tggcaacatg aggagttcta
      961 ccgctacgtc gcgcaggctc acgacaagcc ccgctacacc ctgcactata agacggacgc
     1021 accgctcaac atccgcagca tcttctacgt gcccgacatg aaaccgtcca tgtttgatgt
     1081 gagccgggag ctgggctcca gcgttgcact gtacagccgc aaagtcctca tccagaccaa
     1141 ggccacggac atcctgccca agtggctgcg cttcatccga ggtgtggtgg acagtgagga
     1201 cattcccctg aacctcagcc gggagctgct gcaggagagc gcactcatca ggaaactccg
     1261 ggacgtttta cagcagaggc tgatcaaatt cttcattgac cagagtaaaa aagatgctga
     1321 gaagtatgca aagttttttg aagattacgg cctgttcatg cgggagggca ttgtgaccgc
     1381 caccgagcag gaggtcaagg aggacatagc aaagctgctg cgctacgagt cctcggcgct
     1441 gccctccggg cagctaacca gcctctcaga atacgccagc cgcatgcggg ccggcacccg
     1501 caacatctac tacctgtgcg cccccaaccg tcacctggca gagcactcac cctactatga
     1561 ggccatgaag aagaaagaca cagaggttct cttctgcttt gagcagtttg atgagctcac
     1621 cctgctgcac cttcgtgagt ttgacaagaa gaagctgatc tctgtggaga cggacatagt
     1681 cgtggatcac tacaaggagg agaagtttga ggacaggtcc ccagccgccg agtgcctatc
     1741 agagaaggag acggaggagc tcatggcctg gatgagaaat gtgctggggt cgcgtgtcac
     1801 caacgtgaag gtgaccctcc gactggacac ccaccctgcc atggtcaccg tgctggagat
     1861 gggggctgcc cgccacttcc tgcgcatgca gcagctggcc aagacccagg aggagcgcgc
     1921 acagctcctg cagcccacgc tggagatcaa ccccaggcac gcgctcatca agaagctgaa
     1981 tcagctgcgc gcaagcgagc ctggcctggc tcagctgctg gtggatcaga tatacgagaa
     2041 cgccatgatt gctgctggac ttgttgacga ccctagggcc atggtgggcc gcttgaatga
     2101 gctgcttgtc aaggccctgg agcgacactg acagccaggg ggccagaagg actgacacca
     2161 cagatgacag ccccacctcc ttgagcttta tttacctaaa tttaaaggta tttcttaacc
     2221 cga
//
