LOCUS       NM_014831              10479 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens tetratricopeptide repeat and ankyrin repeat containing
            1 (TRANK1), transcript variant 2, mRNA.
ACCESSION   NM_014831 XM_047357 XM_940627
VERSION     NM_014831.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10479)
  AUTHORS   Lai,J., Zhang,P., Jiang,J., Mou,T., Li,Y., Xi,C., Wu,L., Gao,X.,
            Zhang,D., Chen,Y., Huang,H., Li,H., Cai,X., Li,M., Zheng,P. and
            Hu,S.
  TITLE     New Evidence of Gut Microbiota Involvement in the Neuropathogenesis
            of Bipolar Depression by TRANK1 Modulation: Joint Clinical and
            Animal Data
  JOURNAL   Front Immunol 12, 789647 (2021)
   PUBMED   34992606
  REMARK    GeneRIF: New Evidence of Gut Microbiota Involvement in the
            Neuropathogenesis of Bipolar Depression by TRANK1 Modulation: Joint
            Clinical and Animal Data.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10479)
  AUTHORS   Lai,J., Jiang,J., Zhang,P., Xi,C., Wu,L., Gao,X., Fu,Y., Zhang,D.,
            Chen,Y., Huang,H., Zhu,Y. and Hu,S.
  TITLE     Impaired blood-brain barrier in the microbiota-gut-brain axis:
            Potential role of bipolar susceptibility gene TRANK1
  JOURNAL   J Cell Mol Med 25 (14), 6463-6469 (2021)
   PUBMED   34014031
  REMARK    GeneRIF: Impaired blood-brain barrier in the microbiota-gut-brain
            axis: Potential role of bipolar susceptibility gene TRANK1.
            Review article
REFERENCE   3  (bases 1 to 10479)
  AUTHORS   Li,W., Cai,X., Li,H.J., Song,M., Zhang,C.Y., Yang,Y., Zhang,L.,
            Zhao,L., Liu,W., Wang,L., Shao,M., Zhang,Y., Zhang,C., Cai,J.,
            Zhou,D.S., Li,X., Hui,L., Jia,Q.F., Qu,N., Zhong,B.L., Zhang,S.F.,
            Chen,J., Xia,B., Li,Y., Song,X., Fan,W., Tang,W., Tang,W., Tang,J.,
            Chen,X., Yue,W., Zhang,D., Fang,Y., Xiao,X., Li,M., Lv,L. and
            Chang,H.
  TITLE     Independent replications and integrative analyses confirm TRANK1 as
            a susceptibility gene for bipolar disorder
  JOURNAL   Neuropsychopharmacology 46 (6), 1103-1112 (2021)
   PUBMED   32791513
  REMARK    GeneRIF: Independent replications and integrative analyses confirm
            TRANK1 as a susceptibility gene for bipolar disorder.
REFERENCE   4  (bases 1 to 10479)
  AUTHORS   Ambati,A., Hillary,R., Leu-Semenescu,S., Ollila,H.M., Lin,L.,
            During,E.H., Farber,N., Rico,T.J., Faraco,J., Leary,E.,
            Goldstein-Piekarski,A.N., Huang,Y.S., Han,F., Sivan,Y.,
            Lecendreux,M., Dodet,P., Honda,M., Gadoth,N., Nevsimalova,S.,
            Pizza,F., Kanbayashi,T., Peraita-Adrados,R., Leschziner,G.D.,
            Hasan,R., Canellas,F., Kume,K., Daniilidou,M., Bourgin,P., Rye,D.,
            Vicario,J.L., Hogl,B., Hong,S.C., Plazzi,G., Mayer,G.,
            Landtblom,A.M., Dauvilliers,Y., Arnulf,I. and Mignot,E.J.
  TITLE     Kleine-Levin syndrome is associated with birth difficulties and
            genetic variants in the TRANK1 gene loci
  JOURNAL   Proc Natl Acad Sci U S A 118 (12) (2021)
   PUBMED   33737391
  REMARK    GeneRIF: Kleine-Levin syndrome is associated with birth
            difficulties and genetic variants in the TRANK1 gene loci.
REFERENCE   5  (bases 1 to 10479)
  AUTHORS   Ruderfer,D.M., Fanous,A.H., Ripke,S., McQuillin,A., Amdur,R.L.,
            Gejman,P.V., O'Donovan,M.C., Andreassen,O.A., Djurovic,S.,
            Hultman,C.M., Kelsoe,J.R., Jamain,S., Landen,M., Leboyer,M.,
            Nimgaonkar,V., Nurnberger,J., Smoller,J.W., Craddock,N., Corvin,A.,
            Sullivan,P.F., Holmans,P., Sklar,P. and Kendler,K.S.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Bipolar Disorder Working Group of the Psychiatric Genomics
            Consortium; Cross-Disorder Working Group of the Psychiatric
            Genomics Consortium
  TITLE     Polygenic dissection of diagnosis and clinical dimensions of
            bipolar disorder and schizophrenia
  JOURNAL   Mol Psychiatry 19 (9), 1017-1024 (2014)
   PUBMED   24280982
REFERENCE   6  (bases 1 to 10479)
  AUTHORS   Muhleisen,T.W., Leber,M., Schulze,T.G., Strohmaier,J.,
            Degenhardt,F., Treutlein,J., Mattheisen,M., Forstner,A.J.,
            Schumacher,J., Breuer,R., Meier,S., Herms,S., Hoffmann,P.,
            Lacour,A., Witt,S.H., Reif,A., Muller-Myhsok,B., Lucae,S.,
            Maier,W., Schwarz,M., Vedder,H., Kammerer-Ciernioch,J., Pfennig,A.,
            Bauer,M., Hautzinger,M., Moebus,S., Priebe,L., Czerski,P.M.,
            Hauser,J., Lissowska,J., Szeszenia-Dabrowska,N., Brennan,P.,
            McKay,J.D., Wright,A., Mitchell,P.B., Fullerton,J.M.,
            Schofield,P.R., Montgomery,G.W., Medland,S.E., Gordon,S.D.,
            Martin,N.G., Krasnow,V., Chuchalin,A., Babadjanova,G.,
            Pantelejeva,G., Abramova,L.I., Tiganov,A.S., Polonikov,A.,
            Khusnutdinova,E., Alda,M., Grof,P., Rouleau,G.A., Turecki,G.,
            Laprise,C., Rivas,F., Mayoral,F., Kogevinas,M.,
            Grigoroiu-Serbanescu,M., Propping,P., Becker,T., Rietschel,M.,
            Nothen,M.M. and Cichon,S.
  TITLE     Genome-wide association study reveals two new risk loci for bipolar
            disorder
  JOURNAL   Nat Commun 5, 3339 (2014)
   PUBMED   24618891
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 10479)
  AUTHORS   Chen,D.T., Jiang,X., Akula,N., Shugart,Y.Y., Wendland,J.R.,
            Steele,C.J., Kassem,L., Park,J.H., Chatterjee,N., Jamain,S.,
            Cheng,A., Leboyer,M., Muglia,P., Schulze,T.G., Cichon,S.,
            Nothen,M.M., Rietschel,M., McMahon,F.J., Farmer,A., McGuffin,P.,
            Craig,I., Lewis,C., Hosang,G., Cohen-Woods,S., Vincent,J.B.,
            Kennedy,J.L. and Strauss,J.
  CONSRTM   BiGS
  TITLE     Genome-wide association study meta-analysis of European and
            Asian-ancestry samples identifies three novel loci associated with
            bipolar disorder
  JOURNAL   Mol Psychiatry 18 (2), 195-205 (2013)
   PUBMED   22182935
  REMARK    GeneRIF: The results of this study suggested that significant novel
            association signals near the genes TRANK1 and provide supportive
            evidence for the previously reported association signals near ANK3
            and within the 3p21.1 locus.
            Erratum:[Mol Psychiatry. 2013 Feb;18(2):264-6. Farmer, A [added];
            McGuffin, P [added]; Craig, I [added]; Lewis, C [added]; Hosang, G
            [added]; Cohen-Woods, S [added]; Vincent, J B [added]; Kennedy, J L
            [added]; Strauss, J [added]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN482191.1, AC011816.17, CD698859.1, EG328358.1, EG328357.1,
            BG960452.1, BG750754.1, AB002340.3, AC097360.2, AC105749.2 and
            BQ024165.1.
            
            On Jun 2, 2019 this sequence version replaced NM_014831.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               CN482191.1         4-126
            124-126             AC011816.17        94587-94589         c
            127-420             CN482191.1         131-424
            421-459             CD698859.1         383-421
            460-496             EG328358.1         530-566             c
            497-1042            EG328357.1         1-546
            1043-1082           AC011816.17        23893-23932         c
            1083-1418           BG960452.1         98-433              c
            1419-1593           AC011816.17        10579-10753         c
            1594-1619           BG750754.1         1-26
            1620-2494           AB002340.3         1-875
            2495-3514           AC097360.2         162878-163897       c
            3515-9349           AB002340.3         1896-7730
            9350-9350           AC105749.2         192040-192040       c
            9351-10478          AB002340.3         7732-8859
            10479-10479         BQ024165.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..10479
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..10479
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /note="tetratricopeptide repeat and ankyrin repeat
                     containing 1"
                     /db_xref="GeneID:9881"
                     /db_xref="HGNC:HGNC:29011"
                     /db_xref="MIM:619316"
     exon            1..268
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..9023
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /note="isoform 2 is encoded by transcript variant 2; lupus
                     brain antigen 1 homolog; TPR and ankyrin repeat-containing
                     protein 1"
                     /codon_start=1
                     /product="TPR and ankyrin repeat-containing protein 1
                     isoform 2"
                     /protein_id="NP_055646.2"
                     /db_xref="CCDS:CCDS46789.2"
                     /db_xref="GeneID:9881"
                     /db_xref="HGNC:HGNC:29011"
                     /db_xref="MIM:619316"
                     /translation="MWDPRAARVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQW
                     DPTYVKGYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMSSD
                     SIVLQSFLPCFDHIFTTGFPTEVWQSVIEKLAKKGLWHSFLLLSAKKDRLPRNIHVPE
                     LSLKSLFEKYVFIGLYEKMEQVPKLVQWLISIGASVETIGPYPLHALMRLCIQARENH
                     LFRWLMDHKPEWKGRINQKDGDGCTVLHVVAAHSPGYLVKRQTEDVQMLLRFGADPTL
                     LDRQSRSVVDVLKRNKNFKAIEKINSHLEKLATCSKDLSGFSNGDGPTSENDIFRKVL
                     EQLVKYMNSGNRLLHKNFLKQEVVQRFLRLLSTLQEIPPDLVCDINQDCATTVFKFLL
                     EKQRWPEVLLLLTRKVSGEPPLGDCLIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCL
                     IDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISLTEGDTPLHAALHI
                     FLEIKADIGFSFLSHLLDLFWSNPTEFDYLNPNVQDSNGNTLMHILFQKGMLKRVKKL
                     LDLLVKFDINFNLKNKEGKDARHRIKKNDSLLLAWNKALMENRRRSRQDSAAHLGKLS
                     KSTAPGHTSQLKSQGSFKSVPCGATARTLPEGSAVPDSWETLPGTQVTRKEPGALRPC
                     SLRDCLMQDITVLIQQVEVDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCS
                     EVGEGHAQVGLGALQLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEM
                     LKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLDKGARML
                     WELAIDFSPRCSENPEKIIATEQNTCAMEKSGRIYTEIIRIWDIVLDHCKLADSIKAI
                     CNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKGREHVNPEYFPP
                     ASAVETEYNIMKFHSFSTNMAFNILNDTTATVEYPFRVGELEYAVIDLNPRPLEPIIL
                     IGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEE
                     EEEEEDEEEEDSIEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHL
                     HQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFVTSKQ
                     LLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEEAEVDGDYSEEDK
                     AVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPALIWKEIKSFLKGSFEALSCP
                     HGRLTEEVYKKLGRKRCPNFKEDRSEIYSLFSLYQQIRSQKGYFDEEDVLYNISRRLS
                     KLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSD
                     LRSLFHYASRNTIDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFD
                     RLPRDSGLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKEKI
                     PEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPTSTDSREENRPL
                     VEVPLDKPGSSQGRSLMVNPEMYKLLNGELKQLYTAITRARVNLWIFDENREKRAPAF
                     KYFIRRDFVQVVKTDENKDFDDSMFVKTSTPAEWIAQGDYYAKHQCWKVAAKCYQKGG
                     AFEKEKLALAHDTALSMKSKKVSPKEKQLEYLELAKTYLECKEPTLSLKCLSYAKEFQ
                     LSAQLCERLGKIRDAAYFYKRSQCYKDAFRCFEQIQEFDLALKMYCQEELFEEAAIAV
                     EKYEEMLKTKTLPISKLSYSASQFYLEAAAKYLSANKMKEMMAVLSKLDIEDQLVFLK
                     SRKRLAEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLGAARLNVAR
                     DSDIEHTKDILREALDICYQTGQLSGIAEAHFLQGVILRDFQKLRDAFFKFDTLNHSA
                     GVVEALYEAASQCEAEPEKILGLAPGGLEILLSLVRALKRVTNNAEKEMVKSCFEFFG
                     ISQVDAKYCQIAQNDPGPILRIIFDLDLNLREKKTKDHFLIMTDQVKLALNKHLLGRL
                     CQITRSLLGKTYRGVCMRFIVGLKCEDENCEHFHRPLRRCEAKCLVQSKMNLVAINGL
                     LLEAKKVFPKILAEELKEIDYILSTDMYGLCKSILDVLFPKHFHQRVLSENPMACKEI
                     LKPNYKSFRFYRFALKEYIHFLFENESARNRRESTDLWLSAMQAFLLSSNYPEEFEKL
                     LHQEEDNYNRELKALESEKDERGRGRGSRIKGIEGKFGMLAPNRDDENMDKTHLCFIR
                     LLENCIDQFYVYRNPEDYKRLFFRFMNVLIKRCKEPLIPSIGNTVALLEFQFIHCGVV
                     LARLWKNVILCLPKSYIALLHYWEFLFSKKDKELGDVFSIIQEYKPKDVTRAIQDFRF
                     HLSYLAKVLCGYENVNFNVLLDAFSEIDYVVSGEAERTLVLCLVMLVNAEEILQPYCK
                     PLLYRHFREIESRLQLMSMDCPGQVPERLLKVVKRVLVAVNVKSVAEALQDLLFERDE
                     EYLMDCDWRWDPVHTKGSIVRGLYYEEVRLNRLLCLDPVDYFAEPECEFGQDEMDELA
                     LEDRDHVLATILSQKQRKASIQRKLRRACLVVSLCISWRRRVGTQMERVREEAREPRA
                     GNFKKADVDRTQCDLCGVKFTRGPENYFSPSKAFEGAASEVAVLSRAELEREECQERN
                     SESYEQHIHLEHHQRQQVAYQKYSEFFHEKVDPAIDEGKLVVQDIEQSVWIHSHVGSK
                     EHSHMLQKVQEHIKRVSDMVEDLYRRKAWAGAEEAMTRLVNILILSVRDARDWLMKTE
                     TRLKKEGIVQEDDYENEVEDFGELRPRRRSRKCGKQRKY"
     exon            269..395
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..546
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..665
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..749
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            750..888
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1020
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1191
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1353
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1608
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1785
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..4662
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4663..4862
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4863..5000
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5001..5147
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5148..5304
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5305..5393
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5394..5497
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5498..5630
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5631..5776
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5777..8823
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8824..8922
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8923..10479
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10456..10461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /note="hexamer: TATAAA"
     polyA_site      10479
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /note="major polyA site"
ORIGIN      
        1 ggaataggtc tgcggctgca caccgcccgg acgccggggt tcctgcgtcc cccgccccct
       61 ctgatcgcgg ctgggtagcc gagccgcagg cagctggggg cccccgaacg ccgcctctgc
      121 atcgcgccgc ccctgccccg ggctccggta gctttcgggc ttccgcactg cccgccgcgc
      181 cctgcccaca gggaagcgct tccccaggcg gcggcggtcc tggtgcggac cctccggccg
      241 cagccatgtg ggacccgcgg gcagctaggg ttcccccgag ggacttggct gtgctgctgt
      301 gcaacaaatc aaatgcattt ttcagccttg ggaagtggaa tgaggcattt gttgctgcca
      361 aggaatgtct ccaatgggat ccaacctacg tgaagggata ctaccgagct ggttattcct
      421 tgctgaggtt gcaccagcct tacgaagccg ctcgcatgtt ttttgagggt ctgcgacttg
      481 tgcagagaag ccaagaccag gcaccggttg ctgatttcct tgttggagtc ttcaccacta
      541 tgagcagtga ctccattgtt ttgcaaagtt tcttgccttg ctttgatcat attttcacaa
      601 ctggattccc aacagaagtg tggcaatctg taatagaaaa gttggcaaag aaaggattat
      661 ggcattcatt tctgcttctg tcagcaaaaa aagaccgatt accaagaaat attcatgtcc
      721 cagagttatc actgaaaagt ctctttgaga aatacgtttt cattggactt tatgagaaga
      781 tggaacaagt gcccaagtta gtccagtggc tcatctccat tggtgcaagt gttgagacta
      841 taggaccgta tccccttcat gccctcatgc gactctgtat ccaagccaga gaaaaccatc
      901 ttttccggtg gttaatggat cacaagcccg agtggaaagg ccgcattaac cagaaggatg
      961 gggatggctg cactgtcctg cacgtcgtcg ctgcccactc cccaggatac ctcgttaagc
     1021 gacaaacaga ggatgtgcag atgctcctgc gctttggggc agatcccact ttgctggatc
     1081 gacagtctcg gtctgttgtg gatgtcctga agaggaataa gaacttcaaa gccatcgaga
     1141 aaatcaacag tcacttagaa aagctagcta cgtgttctaa ggacctatca ggattcagca
     1201 atggtgatgg acccactagt gaaaacgaca ttttcaggaa ggtcttggag cagctggtga
     1261 agtatatgaa ctcaggaaac cggttattgc ataaaaactt tctgaagcag gaagtagttc
     1321 agaggttctt gcgtctcctt tctactctgc aagaaattcc tcctgacctg gtctgtgata
     1381 ttaatcaaga ctgtgccacc accgtcttca aattcttatt ggaaaaacag agatggcctg
     1441 aggtgcttct gctgctgacc cgcaaagtaa gtggagaacc accgcttggg gattgcctca
     1501 tcaaagactg caacttctca gacctcgaca tctgtaccat catcccccat ctcagcacct
     1561 gggaccagcg gaagaaacag cttctgggct gcctgataga cagtggagcc ttgcctgatg
     1621 gtcttcagga gagccaggag aggccagttg tcacgtgcct gaaacatgag gacttcgagt
     1681 tggctttcct tctcttgacc aagggcgcag acccccgtgc tatttctctc acggaaggtg
     1741 atactccttt gcatgcagca ctccacatct ttctagagat taaagctgac attggtttta
     1801 gcttcctcag ccatctgttg gatctgtttt ggtccaaccc cactgaattc gactacctca
     1861 accccaatgt ccaggacagc aatgggaaca cgctgatgca catcctcttc cagaagggca
     1921 tgctaaagcg cgtgaagaag ctgttagacc tgctggtgaa gtttgacatc aacttcaatc
     1981 tgaagaacaa agagggcaaa gatgcacggc accggattaa gaagaacgac tctctgctct
     2041 tggcctggaa caaagctctg atggagaaca ggaggaggag ccggcaggac tctgctgccc
     2101 acctggggaa gctctcaaag tccactgccc ctggtcacac atctcagctc aagtcccagg
     2161 gttcattcaa gtcagtgcca tgtggtgcca ctgccagaac actgcctgaa ggaagtgcag
     2221 tccctgacag ctgggagact ctcccaggta cccaggtgac caggaaggag cctggagctc
     2281 tcaggccctg ctcgctgaga gactgcctta tgcaggacat cacagttttg attcagcagg
     2341 ttgaagtgga tccgtctttc ccagaggact gtcttcagag ctctgagcct ctggaggcag
     2401 gagctggcaa agaaggaaag aaagatgaca agccgactct gggtgcaggg gcccctgact
     2461 gtagtgaggt gggggaagga catgctcagg tgggccttgg ggccttgcag cttgtgcctg
     2521 atgataacag ggggaaggag ggcaatgatg atcaggatga ctggagcacg caggagattg
     2581 aggcctgcct ccaggacttc gataacatga cctgggagat cgagtgcact tcagaaatgc
     2641 tgaagaagct gtctagtaag gtaatgacca aggtcatcaa gaagaaaatc atccttgcca
     2701 ttcagcagct gggaaatggc gagtggaccc agggcctgca gaagcgactg aagcacctga
     2761 aaggaagcat ccagctcttc gaagctaagc tggacaaagg agcccggatg ctctgggagc
     2821 tcgccattga cttctcccct cgatgcagtg agaaccctga gaagatcatt gccacggagc
     2881 agaacacgtg tgcaatggag aaatcagggc ggatctacac ggaaatcatc cggatttggg
     2941 acatcgtctt agatcactgc aaactggctg attccatcaa ggccatctgc aatgcctaca
     3001 accggggctt gtcctgtgtc ctgcggaaga agctgaaagg tatcaataaa ggccaagtgt
     3061 cagctaacat gaaaattcaa aagcgtatac ctcgctgcta tgtggaggac acagaggccg
     3121 agaagggcag ggagcatgtc aatcctgagt actttccccc agccagtgca gtggagacag
     3181 aatataacat catgaagttc cacagcttca gcaccaacat ggcctttaac atcctcaatg
     3241 acacgacagc cacagtggag taccccttcc gggtgggtga gcttgagtac gcggtgatcg
     3301 acctcaatcc caggccactg gagcccatca tccttattgg gcgaagtggc actgggaaga
     3361 caacctgctg cttgtacaga ttgtggaaga aattccacgt ttactgggaa aaagctgagc
     3421 aggcaggaag cccattgctg gccaaacagg tctggctgaa gagaaggttg gaagtggaac
     3481 ccggaaaaga gagtccaggt ggggaggaag aggaggagga agaggacgag gaagaggaag
     3541 attctattga agtggaaaca gtagaaagca tagatgagca ggagtatgaa gcctgcgcag
     3601 gaggagccgg tgtggagcca gcaggggacg gccaagctgc agaagtatgt gcaccagaac
     3661 atccccacca gctggagcat ttacatcaga tctttgtgac caagaaccat gtgctgtgcc
     3721 aggaggtaca aaggaatttc attgagcttt ccaagtccac caaggccact agtcattaca
     3781 aaccactgga ccccaacatt cacaaactcc aggacctgag ggacgagaac tttcctctgt
     3841 ttgtcacttc caagcagctg cttcttctgc ttgatgcttc tctgcccaaa ccattttttc
     3901 tgagaaacga agatggaagc ttgaaaagaa ccatcatagg atggtctgca caggaagagt
     3961 caaccattcc tagttggcaa gaggatgaag aggaggctga ggtggatggg gactacagtg
     4021 aggaggataa agctgtagaa atgcgtacgg gtgacagtga cccccgggtg tacgtgacgt
     4081 ttgaggtgtt caaaaatgaa atatggccca aaatgaccaa agggaggact gcctacaacc
     4141 ctgcactgat ttggaaagaa ataaaatctt ttctaaaggg ttcttttgag gccctcagct
     4201 gtccccatgg gagactcact gaagaagtat ataagaaatt agggaggaaa cggtgcccca
     4261 atttcaagga agaccggagt gagatctaca gcctcttcag tctgtatcag caaatcaggt
     4321 cccagaaagg ttattttgat gaagaggatg ttctgtacaa catatcccgg aggctgtcga
     4381 agctcagggt gctcccatgg tccatccacg agctctatgg tgatgagatt caagacttta
     4441 cccaggccga gctggcgctg ctgatgaaat gcatcaatga ccccaactct atgttcctca
     4501 cgggggacac ggcccagagc atcatgaagg gcgtggcctt ccgcttcagc gatctgcgct
     4561 ctctgttcca ttatgccagc agaaacacca tagacaagca gtgtgctgtc cggaagccca
     4621 agaagatcca ccagctgtac cagaattaca ggtcccactc aggaatcctc aatctggcat
     4681 ctggagtggt ggatttactt cagttctatt tcccagaatc ttttgatcgc cttccaaggg
     4741 attctggcct ctttgatggt cctaagccaa ctgttctgga gtcttgtagt gtaagcgact
     4801 tggcaatttt gctacgaggg aataaaagga aaactcagcc cattgaattt ggagcccacc
     4861 aggtaatcct tgtggccaat gaaacggcaa aggagaaaat tccagaagag ctggggttag
     4921 cacttgtgct aacaatttat gaagcaaaag gcttagaatt tgatgatgtc ctcctttaca
     4981 acttttttac tgattctgag gcttataagg aatggaagat catttcctca ttcacaccta
     5041 cctcaactga ctccagagag gaaaaccggc cattggttga agtacccctg gacaaaccag
     5101 gctcttctca gggtcgatct ctcatggtga atccagaaat gtacaagctc ctcaacggag
     5161 agctgaagca gctgtacacc gccatcacac gggctcgggt caacctctgg atctttgatg
     5221 aaaaccgaga gaaacgggct cccgcattca aatatttcat tagaagagat tttgtccaag
     5281 ttgtaaagac agatgaaaat aaagactttg atgatagcat gttcgttaag acctcaactc
     5341 ctgcggagtg gattgcacag ggagattact acgccaagca ccagtgctgg aaggttgcag
     5401 ccaagtgtta ccagaaagga ggtgcatttg agaaggagaa gttggccctg gcccatgaca
     5461 ctgccctgag catgaaatcc aagaaagtca gccccaagga aaagcagttg gaatatttgg
     5521 aattggctaa gacctatttg gagtgcaaag agccaacact gtcccttaag tgtctgagct
     5581 atgccaagga gttccagctc tctgcccagc tgtgcgagag gctgggaaag ataagagatg
     5641 ctgcctattt ctataagcga agccagtgct acaaagacgc tttcagatgc tttgagcaga
     5701 ttcaggaatt tgatctagca ctcaaaatgt actgccaaga ggagcttttt gaagaagctg
     5761 ctattgcagt ggaaaagtat gaagaaatgc taaagactaa gacccttccc atttccaagc
     5821 tctcctattc tgccagtcag ttttacttgg aagctgcagc aaagtatctg agtgcaaata
     5881 agatgaagga aatgatggct gtcctctcaa agctagacat agaagaccag ctggtgttct
     5941 tgaagtctcg gaaacgctta gcagaagctg cagacctgct gaacagggaa ggtaggagag
     6001 aagaggctgc cctgctgatg aagcaacatg gctgcctcct ggaggctgcc aggctcactg
     6061 ccgacaagga cttccaggcc tcatgtctgc tgggggccgc ccgcctcaat gtggccaggg
     6121 attccgacat agaacacacc aaggacattc tgagagaagc acttgatatc tgctatcaaa
     6181 ctggccagtt gtctggcatt gcggaggccc acttcctgca aggggtaatc ctgagagact
     6241 ttcagaagct cagggatgcc ttcttcaagt ttgacacgct caaccactca gctggagtgg
     6301 tggaagcact ctacgaagca gccagccagt gtgaggccga gcctgagaag attctgggcc
     6361 tggctccagg gggcttggaa atcctcctca gtctggtcag ggctctcaaa agagtgacca
     6421 acaatgctga gaaggaaatg gtcaaatctt gctttgagtt ttttgggatt tcccaggtgg
     6481 atgccaagta ttgccagata gctcagaatg accctgggcc catattaaga ataatttttg
     6541 acctggattt gaacttgaga gagaaaaaaa caaaagatca ttttttgata atgactgacc
     6601 aagtgaaatt agccctaaac aaacaccttt tgggcaggct gtgtcagatc acacggagcc
     6661 tgcttgggaa gacctaccga ggagtctgca tgaggtttat tgtaggctta aaatgtgagg
     6721 atgaaaactg tgaacatttt cacaggcctc tgcggcgttg tgaagccaag tgtttagttc
     6781 agtcgaaaat gaacttggtg gcaatcaacg ggttgctttt ggaagccaaa aaagtattcc
     6841 ctaaaatctt agcagaagaa cttaaagaaa ttgattatat tttgtctaca gatatgtatg
     6901 gcctttgcaa gtccattctg gatgtccttt tccctaagca tttccatcag agagtgttgt
     6961 cagaaaaccc catggcatgc aaagaaatcc tcaaaccaaa ttacaaatcc ttccggttct
     7021 acagatttgc tttgaaggag tacatccact ttctgtttga aaatgaaagc gcacgcaacc
     7081 gccgggaatc cacagacctg tggctgagtg ccatgcaagc tttccttctc tcttccaact
     7141 acccggagga gtttgaaaag ctgctccacc aggaggagga caactacaac agggaactca
     7201 aagctctaga gtctgaaaag gatgaaaggg gcagggggag aggcagcagg ataaaaggaa
     7261 tagaagggaa atttggcatg ctggcaccca acagggatga tgaaaatatg gacaagaccc
     7321 acctgtgctt catccggctt ctggagaatt gcattgatca attctacgtg tacaggaacc
     7381 cagaagacta caagaggctc tttttccgtt tcatgaatgt cctcatcaag aggtgcaaag
     7441 aaccactcat ccccagcatt ggaaacacag tagccctcct ggagttccag ttcatccact
     7501 gtggggtggt gctggcccgc ctctggaaga atgtcattct atgcctcccc aagagctaca
     7561 ttgcactctt gcactactgg gagttcctgt ttagcaagaa ggacaaggag cttggggatg
     7621 tgttctccat cattcaggaa tacaaaccca aggacgtgac aagagccatt caggatttcc
     7681 ggttccatct ctcctacctc gccaaggtgc tatgtggcta tgagaatgtg aacttcaacg
     7741 tcctgcttga tgccttcagt gaaatagact atgtggtctc gggtgaggct gagcggacac
     7801 tggtgctgtg cttggtgatg ctagtgaatg ctgaggagat cctgcagcca tactgcaagc
     7861 ctctcctgta tcgccacttc cgggagattg agtcaaggct gcagctcatg agcatggact
     7921 gccctggcca ggttcccgag aggctcctga aggtggtgaa gcgggtcttg gtggcagtca
     7981 atgtgaagtc tgtggctgag gcactgcagg acctgctctt tgagcgggat gaagagtacc
     8041 taatggactg tgactggcgg tgggaccctg tgcacaccaa agggtccata gtccgtggcc
     8101 tctattatga ggaggtcaga ctaaaccgcc tgctctgttt ggaccctgtg gactactttg
     8161 ctgaacctga gtgtgagttt ggccaggatg agatggatga actggcatta gaagaccgag
     8221 accacgtcct ggccaccatt ctttcccaaa agcaacggaa ggcctccata cagcggaagt
     8281 tgaggagggc atgcctggtg gtgtctctgt gcatcagttg gaggagaaga gtgggcaccc
     8341 agatggagcg tgtcagggag gaggccaggg agcccagggc tgggaacttc aaaaaggcag
     8401 acgtggacag gacccagtgt gacctatgtg gagtgaagtt tacccgtggc ccagagaact
     8461 atttcagccc cagcaaagcg tttgaggggg cagcttccga ggtggcagtc ctttccaggg
     8521 ctgagctgga aagggaggag tgtcaggaga ggaacagcga gtcttacgag cagcatatcc
     8581 atctagaaca ccaccagagg cagcaagtgg cctaccagaa atactcagaa tttttccacg
     8641 agaaggtgga cccggccatt gatgaaggca agctggtggt gcaggacatc gagcaaagtg
     8701 tatggatcca cagtcacgtg ggctccaagg agcacagcca catgctgcag aaggtccagg
     8761 agcacatcaa gagggtttcg gatatggtgg aggacctcta caggcggaag gcctgggctg
     8821 gcgcggagga ggcgatgact cggctggtca acattctgat cctgtcagtc agggatgcac
     8881 gagactggtt gatgaaaaca gagacccgct taaagaagga aggtattgtt caggaagatg
     8941 attatgaaaa tgaagttgaa gactttggtg agcttcggcc tagaaggcgt tctcggaaat
     9001 gtggaaagca gagaaaatac taatgtccac acagctgcag cctcctcatc cttcggaaca
     9061 ttccattctg acttagaatt ctgagcgctg gggcagaaga caaaaagaat gtgaattagc
     9121 attttaaaaa taggggagtc taacaacacc attgcttttt attctcatta cttctctttc
     9181 agtggcttag gatctgattg ctccctcacc tctaaagtgt ttccaagtag agtctggcag
     9241 tattagtttc ccccacaaac aaattcaggt agagaagttg tagtcgaagg gaatgttggg
     9301 actcctcact gcatggtccc tggggtgtct ggctcatccc catcatgaca tgagttggta
     9361 gcagaggact aggtgttagg acagactctc ctcacctcag ttgctgctgc tctgggccag
     9421 gaaatctctc tatggattcc ctcatctcct gccacactgc tgcagcatca agtgtgctat
     9481 gagagctgta tgtgcccagg ggtgggccct gccactggcc accccgagcc caggacgcat
     9541 tctggtcatc tctgagccca cttgtagtgt agcttcttct gttagagatg ttagcctttt
     9601 ctctctgtgg cgacttttct gccttccctt cttctgtttt ttgtgatcat tcttagctac
     9661 ctgtgccaag tcacagttag actacctcag aatgtagtca agaattcacc cagtgttctt
     9721 tggatgtccc ttccctaggg ggaaaggctg gggaatgttg ctgggagcat tcccagctgc
     9781 ctctccaaag tggtcctaac tctgccttgg ctatggtgca gacattccaa aaagtgtttt
     9841 gtatacagcc ctgtacatct agttttcttg gttctccctg gcaagttcgc taccctagct
     9901 taggctgacg ttctgatgag tctctgcttg ctgagctcat cactgtggga tggtgacctg
     9961 cagagctgca gattggagca agtggacaga ggagggagcc agctaagcca aatccgtcac
    10021 tgccacttgg ctggcaggcc ttataagagg gcggatctgg gcccgtttgc aggaggccat
    10081 tgcctaccct ctccccacag tgagccagca gccatcagct gatcccacct gggaaacctt
    10141 catgcctctc tgatggttac tgcccaccct taccccaccc ctcagctcag cctggtatgg
    10201 aaagcaaggt gcacgttggt ctttgattgt tctgtcctca cagcagagcc agctttcccc
    10261 ccatgttgct gctgcttttg ctgctcatgc tgcttgttgt tttctcttcc ttatctttcc
    10321 aaattgtttc cttgaaatgc ttgtttccaa tttttcttag attatgtttc taatttttat
    10381 tccaggtgtt tttttttctt acttgacaga aaaaaagaaa accccaacaa tatcttgctg
    10441 tattatcaca ttttttataa agttaaagca tttctctta
//
