LOCUS       NM_001329998           10611 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens tetratricopeptide repeat and ankyrin repeat containing
            1 (TRANK1), transcript variant 1, mRNA.
ACCESSION   NM_001329998 XM_006713432
VERSION     NM_001329998.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10611)
  AUTHORS   Lai,J., Zhang,P., Jiang,J., Mou,T., Li,Y., Xi,C., Wu,L., Gao,X.,
            Zhang,D., Chen,Y., Huang,H., Li,H., Cai,X., Li,M., Zheng,P. and
            Hu,S.
  TITLE     New Evidence of Gut Microbiota Involvement in the Neuropathogenesis
            of Bipolar Depression by TRANK1 Modulation: Joint Clinical and
            Animal Data
  JOURNAL   Front Immunol 12, 789647 (2021)
   PUBMED   34992606
  REMARK    GeneRIF: New Evidence of Gut Microbiota Involvement in the
            Neuropathogenesis of Bipolar Depression by TRANK1 Modulation: Joint
            Clinical and Animal Data.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10611)
  AUTHORS   Lai,J., Jiang,J., Zhang,P., Xi,C., Wu,L., Gao,X., Fu,Y., Zhang,D.,
            Chen,Y., Huang,H., Zhu,Y. and Hu,S.
  TITLE     Impaired blood-brain barrier in the microbiota-gut-brain axis:
            Potential role of bipolar susceptibility gene TRANK1
  JOURNAL   J Cell Mol Med 25 (14), 6463-6469 (2021)
   PUBMED   34014031
  REMARK    GeneRIF: Impaired blood-brain barrier in the microbiota-gut-brain
            axis: Potential role of bipolar susceptibility gene TRANK1.
            Review article
REFERENCE   3  (bases 1 to 10611)
  AUTHORS   Li,W., Cai,X., Li,H.J., Song,M., Zhang,C.Y., Yang,Y., Zhang,L.,
            Zhao,L., Liu,W., Wang,L., Shao,M., Zhang,Y., Zhang,C., Cai,J.,
            Zhou,D.S., Li,X., Hui,L., Jia,Q.F., Qu,N., Zhong,B.L., Zhang,S.F.,
            Chen,J., Xia,B., Li,Y., Song,X., Fan,W., Tang,W., Tang,W., Tang,J.,
            Chen,X., Yue,W., Zhang,D., Fang,Y., Xiao,X., Li,M., Lv,L. and
            Chang,H.
  TITLE     Independent replications and integrative analyses confirm TRANK1 as
            a susceptibility gene for bipolar disorder
  JOURNAL   Neuropsychopharmacology 46 (6), 1103-1112 (2021)
   PUBMED   32791513
  REMARK    GeneRIF: Independent replications and integrative analyses confirm
            TRANK1 as a susceptibility gene for bipolar disorder.
REFERENCE   4  (bases 1 to 10611)
  AUTHORS   Ambati,A., Hillary,R., Leu-Semenescu,S., Ollila,H.M., Lin,L.,
            During,E.H., Farber,N., Rico,T.J., Faraco,J., Leary,E.,
            Goldstein-Piekarski,A.N., Huang,Y.S., Han,F., Sivan,Y.,
            Lecendreux,M., Dodet,P., Honda,M., Gadoth,N., Nevsimalova,S.,
            Pizza,F., Kanbayashi,T., Peraita-Adrados,R., Leschziner,G.D.,
            Hasan,R., Canellas,F., Kume,K., Daniilidou,M., Bourgin,P., Rye,D.,
            Vicario,J.L., Hogl,B., Hong,S.C., Plazzi,G., Mayer,G.,
            Landtblom,A.M., Dauvilliers,Y., Arnulf,I. and Mignot,E.J.
  TITLE     Kleine-Levin syndrome is associated with birth difficulties and
            genetic variants in the TRANK1 gene loci
  JOURNAL   Proc Natl Acad Sci U S A 118 (12) (2021)
   PUBMED   33737391
  REMARK    GeneRIF: Kleine-Levin syndrome is associated with birth
            difficulties and genetic variants in the TRANK1 gene loci.
REFERENCE   5  (bases 1 to 10611)
  AUTHORS   Ruderfer,D.M., Fanous,A.H., Ripke,S., McQuillin,A., Amdur,R.L.,
            Gejman,P.V., O'Donovan,M.C., Andreassen,O.A., Djurovic,S.,
            Hultman,C.M., Kelsoe,J.R., Jamain,S., Landen,M., Leboyer,M.,
            Nimgaonkar,V., Nurnberger,J., Smoller,J.W., Craddock,N., Corvin,A.,
            Sullivan,P.F., Holmans,P., Sklar,P. and Kendler,K.S.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Bipolar Disorder Working Group of the Psychiatric Genomics
            Consortium; Cross-Disorder Working Group of the Psychiatric
            Genomics Consortium
  TITLE     Polygenic dissection of diagnosis and clinical dimensions of
            bipolar disorder and schizophrenia
  JOURNAL   Mol Psychiatry 19 (9), 1017-1024 (2014)
   PUBMED   24280982
REFERENCE   6  (bases 1 to 10611)
  AUTHORS   Muhleisen,T.W., Leber,M., Schulze,T.G., Strohmaier,J.,
            Degenhardt,F., Treutlein,J., Mattheisen,M., Forstner,A.J.,
            Schumacher,J., Breuer,R., Meier,S., Herms,S., Hoffmann,P.,
            Lacour,A., Witt,S.H., Reif,A., Muller-Myhsok,B., Lucae,S.,
            Maier,W., Schwarz,M., Vedder,H., Kammerer-Ciernioch,J., Pfennig,A.,
            Bauer,M., Hautzinger,M., Moebus,S., Priebe,L., Czerski,P.M.,
            Hauser,J., Lissowska,J., Szeszenia-Dabrowska,N., Brennan,P.,
            McKay,J.D., Wright,A., Mitchell,P.B., Fullerton,J.M.,
            Schofield,P.R., Montgomery,G.W., Medland,S.E., Gordon,S.D.,
            Martin,N.G., Krasnow,V., Chuchalin,A., Babadjanova,G.,
            Pantelejeva,G., Abramova,L.I., Tiganov,A.S., Polonikov,A.,
            Khusnutdinova,E., Alda,M., Grof,P., Rouleau,G.A., Turecki,G.,
            Laprise,C., Rivas,F., Mayoral,F., Kogevinas,M.,
            Grigoroiu-Serbanescu,M., Propping,P., Becker,T., Rietschel,M.,
            Nothen,M.M. and Cichon,S.
  TITLE     Genome-wide association study reveals two new risk loci for bipolar
            disorder
  JOURNAL   Nat Commun 5, 3339 (2014)
   PUBMED   24618891
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 10611)
  AUTHORS   Chen,D.T., Jiang,X., Akula,N., Shugart,Y.Y., Wendland,J.R.,
            Steele,C.J., Kassem,L., Park,J.H., Chatterjee,N., Jamain,S.,
            Cheng,A., Leboyer,M., Muglia,P., Schulze,T.G., Cichon,S.,
            Nothen,M.M., Rietschel,M., McMahon,F.J., Farmer,A., McGuffin,P.,
            Craig,I., Lewis,C., Hosang,G., Cohen-Woods,S., Vincent,J.B.,
            Kennedy,J.L. and Strauss,J.
  CONSRTM   BiGS
  TITLE     Genome-wide association study meta-analysis of European and
            Asian-ancestry samples identifies three novel loci associated with
            bipolar disorder
  JOURNAL   Mol Psychiatry 18 (2), 195-205 (2013)
   PUBMED   22182935
  REMARK    GeneRIF: The results of this study suggested that significant novel
            association signals near the genes TRANK1 and provide supportive
            evidence for the previously reported association signals near ANK3
            and within the 3p21.1 locus.
            Erratum:[Mol Psychiatry. 2013 Feb;18(2):264-6. Farmer, A [added];
            McGuffin, P [added]; Craig, I [added]; Lewis, C [added]; Hosang, G
            [added]; Cohen-Woods, S [added]; Vincent, J B [added]; Kennedy, J L
            [added]; Strauss, J [added]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011816.17, AC097360.2 and AC105749.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001329998.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.556982.1,
                                           SRR14038195.503778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645898.2/ ENSP00000494480.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               AC011816.17        94445-94712         c
            269-400             AC011816.17        57981-58112         c
            401-527             AC011816.17        52807-52933         c
            528-678             AC011816.17        48767-48917         c
            679-797             AC011816.17        45298-45416         c
            798-881             AC011816.17        42559-42642         c
            882-1020            AC011816.17        41860-41998         c
            1021-1152           AC011816.17        39487-39618         c
            1153-1323           AC011816.17        23784-23954         c
            1324-1485           AC011816.17        13977-14138         c
            1486-1740           AC011816.17        10564-10818         c
            1741-1917           AC097360.2         165275-165451       c
            1918-4794           AC097360.2         161730-164606       c
            4795-4994           AC097360.2         158703-158902       c
            4995-5132           AC097360.2         158276-158413       c
            5133-5279           AC097360.2         153757-153903       c
            5280-5436           AC097360.2         152805-152961       c
            5437-5525           AC097360.2         149179-149267       c
            5526-5629           AC097360.2         145170-145273       c
            5630-5762           AC097360.2         144929-145061       c
            5763-5908           AC105749.2         198854-198999       c
            5909-8955           AC105749.2         194965-198011       c
            8956-9054           AC105749.2         193656-193754       c
            9055-10611          AC105749.2         190911-192467       c
FEATURES             Location/Qualifiers
     source          1..10611
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..10611
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /note="tetratricopeptide repeat and ankyrin repeat
                     containing 1"
                     /db_xref="GeneID:9881"
                     /db_xref="HGNC:HGNC:29011"
                     /db_xref="MIM:619316"
     exon            1..268
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..9155
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /note="isoform 1 is encoded by transcript variant 1; lupus
                     brain antigen 1 homolog; TPR and ankyrin repeat-containing
                     protein 1"
                     /codon_start=1
                     /product="TPR and ankyrin repeat-containing protein 1
                     isoform 1"
                     /protein_id="NP_001316927.1"
                     /db_xref="CCDS:CCDS87061.1"
                     /db_xref="GeneID:9881"
                     /db_xref="HGNC:HGNC:29011"
                     /db_xref="MIM:619316"
                     /translation="MWDPRAARMDLTAYAELLKESGNQVLKNGNFSLAIRKYDEAIQI
                     LLQLYQWGVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYS
                     LLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMSSDSIVLQSFLPCFDHI
                     FTTGFPTEVWQSVIEKLAKKGLWHSFLLLSAKKDRLPRNIHVPELSLKSLFEKYVFIG
                     LYEKMEQVPKLVQWLISIGASVETIGPYPLHALMRLCIQARENHLFRWLMDHKPEWKG
                     RINQKDGDGCTVLHVVAAHSPGYLVKRQTEDVQMLLRFGADPTLLDRQSRSVVDVLKR
                     NKNFKAIEKINSHLEKLATCSKDLSGFSNGDGPTSENDIFRKVLEQLVKYMNSGNRLL
                     HKNFLKQEVVQRFLRLLSTLQEIPPDLVCDINQDCATTVFKFLLEKQRWPEVLLLLTR
                     KVSGEPPLGDCLIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCLIDSGALPDGLQESQ
                     ERPVVTCLKHEDFELAFLLLTKGADPRAISLTEGDTPLHAALHIFLEIKADIGFSFLS
                     HLLDLFWSNPTEFDYLNPNVQDSNGNTLMHILFQKGMLKRVKKLLDLLVKFDINFNLK
                     NKEGKDARHRIKKNDSLLLAWNKALMENRRRSRQDSAAHLGKLSKSTAPGHTSQLKSQ
                     GSFKSVPCGATARTLPEGSAVPDSWETLPGTQVTRKEPGALRPCSLRDCLMQDITVLI
                     QQVEVDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCSEVGEGHAQVGLGAL
                     QLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIK
                     KKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLDKGARMLWELAIDFSPRCSEN
                     PEKIIATEQNTCAMEKSGRIYTEIIRIWDIVLDHCKLADSIKAICNAYNRGLSCVLRK
                     KLKGINKGQVSANMKIQKRIPRCYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFH
                     SFSTNMAFNILNDTTATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLY
                     RLWKKFHVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDSIE
                     VETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIFVTKNHVLCQE
                     VQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFF
                     LRNEDGSLKRTIIGWSAQEESTIPSWQEDEEEAEVDGDYSEEDKAVEMRTGDSDPRVY
                     VTFEVFKNEIWPKMTKGRTAYNPALIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGR
                     KRCPNFKEDRSEIYSLFSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYG
                     DEIQDFTQAELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTID
                     KQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKP
                     TVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKEKIPEELGLALVLTIYE
                     AKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPTSTDSREENRPLVEVPLDKPGSSQGR
                     SLMVNPEMYKLLNGELKQLYTAITRARVNLWIFDENREKRAPAFKYFIRRDFVQVVKT
                     DENKDFDDSMFVKTSTPAEWIAQGDYYAKHQCWKVAAKCYQKGGAFEKEKLALAHDTA
                     LSMKSKKVSPKEKQLEYLELAKTYLECKEPTLSLKCLSYAKEFQLSAQLCERLGKIRD
                     AAYFYKRSQCYKDAFRCFEQIQEFDLALKMYCQEELFEEAAIAVEKYEEMLKTKTLPI
                     SKLSYSASQFYLEAAAKYLSANKMKEMMAVLSKLDIEDQLVFLKSRKRLAEAADLLNR
                     EGRREEAALLMKQHGCLLEAARLTADKDFQASCLLGAARLNVARDSDIEHTKDILREA
                     LDICYQTGQLSGIAEAHFLQGVILRDFQKLRDAFFKFDTLNHSAGVVEALYEAASQCE
                     AEPEKILGLAPGGLEILLSLVRALKRVTNNAEKEMVKSCFEFFGISQVDAKYCQIAQN
                     DPGPILRIIFDLDLNLREKKTKDHFLIMTDQVKLALNKHLLGRLCQITRSLLGKTYRG
                     VCMRFIVGLKCEDENCEHFHRPLRRCEAKCLVQSKMNLVAINGLLLEAKKVFPKILAE
                     ELKEIDYILSTDMYGLCKSILDVLFPKHFHQRVLSENPMACKEILKPNYKSFRFYRFA
                     LKEYIHFLFENESARNRRESTDLWLSAMQAFLLSSNYPEEFEKLLHQEEDNYNRELKA
                     LESEKDERGRGRGSRIKGIEGKFGMLAPNRDDENMDKTHLCFIRLLENCIDQFYVYRN
                     PEDYKRLFFRFMNVLIKRCKEPLIPSIGNTVALLEFQFIHCGVVLARLWKNVILCLPK
                     SYIALLHYWEFLFSKKDKELGDVFSIIQEYKPKDVTRAIQDFRFHLSYLAKVLCGYEN
                     VNFNVLLDAFSEIDYVVSGEAERTLVLCLVMLVNAEEILQPYCKPLLYRHFREIESRL
                     QLMSMDCPGQVPERLLKVVKRVLVAVNVKSVAEALQDLLFERDEEYLMDCDWRWDPVH
                     TKGSIVRGLYYEEVRLNRLLCLDPVDYFAEPECEFGQDEMDELALEDRDHVLATILSQ
                     KQRKASIQRKLRRACLVVSLCISWRRRVGTQMERVREEAREPRAGNFKKADVDRTQCD
                     LCGVKFTRGPENYFSPSKAFEGAASEVAVLSRAELEREECQERNSESYEQHIHLEHHQ
                     RQQVAYQKYSEFFHEKVDPAIDEGKLVVQDIEQSVWIHSHVGSKEHSHMLQKVQEHIK
                     RVSDMVEDLYRRKAWAGAEEAMTRLVNILILSVRDARDWLMKTETRLKKEGIVQEDDY
                     ENEVEDFGELRPRRRSRKCGKQRKY"
     exon            269..400
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..527
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..678
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..797
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..881
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1020
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1152
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1323
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1485
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1740
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1917
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..4794
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4795..4994
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4995..5132
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5133..5279
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5280..5436
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5437..5525
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5526..5629
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5630..5762
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5763..5908
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5909..8955
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8956..9054
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            9055..10611
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10588..10593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /note="hexamer: TATAAA"
     polyA_site      10611
                     /gene="TRANK1"
                     /gene_synonym="LBA1"
                     /note="major polyA site"
ORIGIN      
        1 ggaataggtc tgcggctgca caccgcccgg acgccggggt tcctgcgtcc cccgccccct
       61 ctgatcgcgg ctgggtagcc gagccgcagg cagctggggg cccccgaacg ccgcctctgc
      121 atcgcgccgc ccctgccccg ggctccggta gctttcgggc ttccgcactg cccgccgcgc
      181 cctgcccaca gggaagcgct tccccaggcg gcggcggtcc tggtgcggac cctccggccg
      241 cagccatgtg ggacccgcgg gcagctagga tggacctgac agcttacgct gagctgctga
      301 aagaatccgg caaccaggtt cttaagaatg ggaacttctc tttggccatc agaaagtacg
      361 atgaagccat ccagattctc ctgcagttat accagtgggg ggttcccccg agggacttgg
      421 ctgtgctgct gtgcaacaaa tcaaatgcat ttttcagcct tgggaagtgg aatgaggcat
      481 ttgttgctgc caaggaatgt ctccaatggg atccaaccta cgtgaaggga tactaccgag
      541 ctggttattc cttgctgagg ttgcaccagc cttacgaagc cgctcgcatg ttttttgagg
      601 gtctgcgact tgtgcagaga agccaagacc aggcaccggt tgctgatttc cttgttggag
      661 tcttcaccac tatgagcagt gactccattg ttttgcaaag tttcttgcct tgctttgatc
      721 atattttcac aactggattc ccaacagaag tgtggcaatc tgtaatagaa aagttggcaa
      781 agaaaggatt atggcattca tttctgcttc tgtcagcaaa aaaagaccga ttaccaagaa
      841 atattcatgt cccagagtta tcactgaaaa gtctctttga gaaatacgtt ttcattggac
      901 tttatgagaa gatggaacaa gtgcccaagt tagtccagtg gctcatctcc attggtgcaa
      961 gtgttgagac tataggaccg tatccccttc atgccctcat gcgactctgt atccaagcca
     1021 gagaaaacca tcttttccgg tggttaatgg atcacaagcc cgagtggaaa ggccgcatta
     1081 accagaagga tggggatggc tgcactgtcc tgcacgtcgt cgctgcccac tccccaggat
     1141 acctcgttaa gcgacaaaca gaggatgtgc agatgctcct gcgctttggg gcagatccca
     1201 ctttgctgga tcgacagtct cggtctgttg tggatgtcct gaagaggaat aagaacttca
     1261 aagccatcga gaaaatcaac agtcacttag aaaagctagc tacgtgttct aaggacctat
     1321 caggattcag caatggtgat ggacccacta gtgaaaacga cattttcagg aaggtcttgg
     1381 agcagctggt gaagtatatg aactcaggaa accggttatt gcataaaaac tttctgaagc
     1441 aggaagtagt tcagaggttc ttgcgtctcc tttctactct gcaagaaatt cctcctgacc
     1501 tggtctgtga tattaatcaa gactgtgcca ccaccgtctt caaattctta ttggaaaaac
     1561 agagatggcc tgaggtgctt ctgctgctga cccgcaaagt aagtggagaa ccaccgcttg
     1621 gggattgcct catcaaagac tgcaacttct cagacctcga catctgtacc atcatccccc
     1681 atctcagcac ctgggaccag cggaagaaac agcttctggg ctgcctgata gacagtggag
     1741 ccttgcctga tggtcttcag gagagccagg agaggccagt tgtcacgtgc ctgaaacatg
     1801 aggacttcga gttggctttc cttctcttga ccaagggcgc agacccccgt gctatttctc
     1861 tcacggaagg tgatactcct ttgcatgcag cactccacat ctttctagag attaaagctg
     1921 acattggttt tagcttcctc agccatctgt tggatctgtt ttggtccaac cccactgaat
     1981 tcgactacct caaccccaat gtccaggaca gcaatgggaa cacgctgatg cacatcctct
     2041 tccagaaggg catgctaaag cgcgtgaaga agctgttaga cctgctggtg aagtttgaca
     2101 tcaacttcaa tctgaagaac aaagagggca aagatgcacg gcaccggatt aagaagaacg
     2161 actctctgct cttggcctgg aacaaagctc tgatggagaa caggaggagg agccggcagg
     2221 actctgctgc ccacctgggg aagctctcaa agtccactgc ccctggtcac acatctcagc
     2281 tcaagtccca gggttcattc aagtcagtgc catgtggtgc cactgccaga acactgcctg
     2341 aaggaagtgc agtccctgac agctgggaga ctctcccagg tacccaggtg accaggaagg
     2401 agcctggagc tctcaggccc tgctcgctga gagactgcct tatgcaggac atcacagttt
     2461 tgattcagca ggttgaagtg gatccgtctt tcccagagga ctgtcttcag agctctgagc
     2521 ctctggaggc aggagctggc aaagaaggaa agaaagatga caagccgact ctgggtgcag
     2581 gggcccctga ctgtagtgag gtgggggaag gacatgctca ggtgggcctt ggggccttgc
     2641 agcttgtgcc tgatgataac agggggaagg agggcaatga tgatcaggat gactggagca
     2701 cgcaggagat tgaggcctgc ctccaggact tcgataacat gacctgggag atcgagtgca
     2761 cttcagaaat gctgaagaag ctgtctagta aggtaatgac caaggtcatc aagaagaaaa
     2821 tcatccttgc cattcagcag ctgggaaatg gcgagtggac ccagggcctg cagaagcgac
     2881 tgaagcacct gaaaggaagc atccagctct tcgaagctaa gctggacaaa ggagcccgga
     2941 tgctctggga gctcgccatt gacttctccc ctcgatgcag tgagaaccct gagaagatca
     3001 ttgccacgga gcagaacacg tgtgcaatgg agaaatcagg gcggatctac acggaaatca
     3061 tccggatttg ggacatcgtc ttagatcact gcaaactggc tgattccatc aaggccatct
     3121 gcaatgccta caaccggggc ttgtcctgtg tcctgcggaa gaagctgaaa ggtatcaata
     3181 aaggccaagt gtcagctaac atgaaaattc aaaagcgtat acctcgctgc tatgtggagg
     3241 acacagaggc cgagaagggc agggagcatg tcaatcctga gtactttccc ccagccagtg
     3301 cagtggagac agaatataac atcatgaagt tccacagctt cagcaccaac atggccttta
     3361 acatcctcaa tgacacgaca gccacagtgg agtacccctt ccgggtgggt gagcttgagt
     3421 acgcggtgat cgacctcaat cccaggccac tggagcccat catccttatt gggcgaagtg
     3481 gcactgggaa gacaacctgc tgcttgtaca gattgtggaa gaaattccac gtttactggg
     3541 aaaaagctga gcaggcagga agcccattgc tggccaaaca ggtctggctg aagagaaggt
     3601 tggaagtgga acccggaaaa gagagtccag gtggggagga agaggaggag gaagaggacg
     3661 aggaagagga agattctatt gaagtggaaa cagtagaaag catagatgag caggagtatg
     3721 aagcctgcgc aggaggagcc ggtgtggagc cagcagggga cggccaagct gcagaagtat
     3781 gtgcaccaga acatccccac cagctggagc atttacatca gatctttgtg accaagaacc
     3841 atgtgctgtg ccaggaggta caaaggaatt tcattgagct ttccaagtcc accaaggcca
     3901 ctagtcatta caaaccactg gaccccaaca ttcacaaact ccaggacctg agggacgaga
     3961 actttcctct gtttgtcact tccaagcagc tgcttcttct gcttgatgct tctctgccca
     4021 aaccattttt tctgagaaac gaagatggaa gcttgaaaag aaccatcata ggatggtctg
     4081 cacaggaaga gtcaaccatt cctagttggc aagaggatga agaggaggct gaggtggatg
     4141 gggactacag tgaggaggat aaagctgtag aaatgcgtac gggtgacagt gacccccggg
     4201 tgtacgtgac gtttgaggtg ttcaaaaatg aaatatggcc caaaatgacc aaagggagga
     4261 ctgcctacaa ccctgcactg atttggaaag aaataaaatc ttttctaaag ggttcttttg
     4321 aggccctcag ctgtccccat gggagactca ctgaagaagt atataagaaa ttagggagga
     4381 aacggtgccc caatttcaag gaagaccgga gtgagatcta cagcctcttc agtctgtatc
     4441 agcaaatcag gtcccagaaa ggttattttg atgaagagga tgttctgtac aacatatccc
     4501 ggaggctgtc gaagctcagg gtgctcccat ggtccatcca cgagctctat ggtgatgaga
     4561 ttcaagactt tacccaggcc gagctggcgc tgctgatgaa atgcatcaat gaccccaact
     4621 ctatgttcct cacgggggac acggcccaga gcatcatgaa gggcgtggcc ttccgcttca
     4681 gcgatctgcg ctctctgttc cattatgcca gcagaaacac catagacaag cagtgtgctg
     4741 tccggaagcc caagaagatc caccagctgt accagaatta caggtcccac tcaggaatcc
     4801 tcaatctggc atctggagtg gtggatttac ttcagttcta tttcccagaa tcttttgatc
     4861 gccttccaag ggattctggc ctctttgatg gtcctaagcc aactgttctg gagtcttgta
     4921 gtgtaagcga cttggcaatt ttgctacgag ggaataaaag gaaaactcag cccattgaat
     4981 ttggagccca ccaggtaatc cttgtggcca atgaaacggc aaaggagaaa attccagaag
     5041 agctggggtt agcacttgtg ctaacaattt atgaagcaaa aggcttagaa tttgatgatg
     5101 tcctccttta caactttttt actgattctg aggcttataa ggaatggaag atcatttcct
     5161 cattcacacc tacctcaact gactccagag aggaaaaccg gccattggtt gaagtacccc
     5221 tggacaaacc aggctcttct cagggtcgat ctctcatggt gaatccagaa atgtacaagc
     5281 tcctcaacgg agagctgaag cagctgtaca ccgccatcac acgggctcgg gtcaacctct
     5341 ggatctttga tgaaaaccga gagaaacggg ctcccgcatt caaatatttc attagaagag
     5401 attttgtcca agttgtaaag acagatgaaa ataaagactt tgatgatagc atgttcgtta
     5461 agacctcaac tcctgcggag tggattgcac agggagatta ctacgccaag caccagtgct
     5521 ggaaggttgc agccaagtgt taccagaaag gaggtgcatt tgagaaggag aagttggccc
     5581 tggcccatga cactgccctg agcatgaaat ccaagaaagt cagccccaag gaaaagcagt
     5641 tggaatattt ggaattggct aagacctatt tggagtgcaa agagccaaca ctgtccctta
     5701 agtgtctgag ctatgccaag gagttccagc tctctgccca gctgtgcgag aggctgggaa
     5761 agataagaga tgctgcctat ttctataagc gaagccagtg ctacaaagac gctttcagat
     5821 gctttgagca gattcaggaa tttgatctag cactcaaaat gtactgccaa gaggagcttt
     5881 ttgaagaagc tgctattgca gtggaaaagt atgaagaaat gctaaagact aagacccttc
     5941 ccatttccaa gctctcctat tctgccagtc agttttactt ggaagctgca gcaaagtatc
     6001 tgagtgcaaa taagatgaag gaaatgatgg ctgtcctctc aaagctagac atagaagacc
     6061 agctggtgtt cttgaagtct cggaaacgct tagcagaagc tgcagacctg ctgaacaggg
     6121 aaggtaggag agaagaggct gccctgctga tgaagcaaca tggctgcctc ctggaggctg
     6181 ccaggctcac tgccgacaag gacttccagg cctcatgtct gctgggggcc gcccgcctca
     6241 atgtggccag ggattccgac atagaacaca ccaaggacat tctgagagaa gcacttgata
     6301 tctgctatca aactggccag ttgtctggca ttgcggaggc ccacttcctg caaggggtaa
     6361 tcctgagaga ctttcagaag ctcagggatg ccttcttcaa gtttgacacg ctcaaccact
     6421 cagctggagt ggtggaagca ctctacgaag cagccagcca gtgtgaggcc gagcctgaga
     6481 agattctggg cctggctcca gggggcttgg aaatcctcct cagtctggtc agggctctca
     6541 aaagagtgac caacaatgct gagaaggaaa tggtcaaatc ttgctttgag ttttttggga
     6601 tttcccaggt ggatgccaag tattgccaga tagctcagaa tgaccctggg cccatattaa
     6661 gaataatttt tgacctggat ttgaacttga gagagaaaaa aacaaaagat cattttttga
     6721 taatgactga ccaagtgaaa ttagccctaa acaaacacct tttgggcagg ctgtgtcaga
     6781 tcacacggag cctgcttggg aagacctacc gaggagtctg catgaggttt attgtaggct
     6841 taaaatgtga ggatgaaaac tgtgaacatt ttcacaggcc tctgcggcgt tgtgaagcca
     6901 agtgtttagt tcagtcgaaa atgaacttgg tggcaatcaa cgggttgctt ttggaagcca
     6961 aaaaagtatt ccctaaaatc ttagcagaag aacttaaaga aattgattat attttgtcta
     7021 cagatatgta tggcctttgc aagtccattc tggatgtcct tttccctaag catttccatc
     7081 agagagtgtt gtcagaaaac cccatggcat gcaaagaaat cctcaaacca aattacaaat
     7141 ccttccggtt ctacagattt gctttgaagg agtacatcca ctttctgttt gaaaatgaaa
     7201 gcgcacgcaa ccgccgggaa tccacagacc tgtggctgag tgccatgcaa gctttccttc
     7261 tctcttccaa ctacccggag gagtttgaaa agctgctcca ccaggaggag gacaactaca
     7321 acagggaact caaagctcta gagtctgaaa aggatgaaag gggcaggggg agaggcagca
     7381 ggataaaagg aatagaaggg aaatttggca tgctggcacc caacagggat gatgaaaata
     7441 tggacaagac ccacctgtgc ttcatccggc ttctggagaa ttgcattgat caattctacg
     7501 tgtacaggaa cccagaagac tacaagaggc tctttttccg tttcatgaat gtcctcatca
     7561 agaggtgcaa agaaccactc atccccagca ttggaaacac agtagccctc ctggagttcc
     7621 agttcatcca ctgtggggtg gtgctggccc gcctctggaa gaatgtcatt ctatgcctcc
     7681 ccaagagcta cattgcactc ttgcactact gggagttcct gtttagcaag aaggacaagg
     7741 agcttgggga tgtgttctcc atcattcagg aatacaaacc caaggacgtg acaagagcca
     7801 ttcaggattt ccggttccat ctctcctacc tcgccaaggt gctatgtggc tatgagaatg
     7861 tgaacttcaa cgtcctgctt gatgccttca gtgaaataga ctatgtggtc tcgggtgagg
     7921 ctgagcggac actggtgctg tgcttggtga tgctagtgaa tgctgaggag atcctgcagc
     7981 catactgcaa gcctctcctg tatcgccact tccgggagat tgagtcaagg ctgcagctca
     8041 tgagcatgga ctgccctggc caggttcccg agaggctcct gaaggtggtg aagcgggtct
     8101 tggtggcagt caatgtgaag tctgtggctg aggcactgca ggacctgctc tttgagcggg
     8161 atgaagagta cctaatggac tgtgactggc ggtgggaccc tgtgcacacc aaagggtcca
     8221 tagtccgtgg cctctattat gaggaggtca gactaaaccg cctgctctgt ttggaccctg
     8281 tggactactt tgctgaacct gagtgtgagt ttggccagga tgagatggat gaactggcat
     8341 tagaagaccg agaccacgtc ctggccacca ttctttccca aaagcaacgg aaggcctcca
     8401 tacagcggaa gttgaggagg gcatgcctgg tggtgtctct gtgcatcagt tggaggagaa
     8461 gagtgggcac ccagatggag cgtgtcaggg aggaggccag ggagcccagg gctgggaact
     8521 tcaaaaaggc agacgtggac aggacccagt gtgacctatg tggagtgaag tttacccgtg
     8581 gcccagagaa ctatttcagc cccagcaaag cgtttgaggg ggcagcttcc gaggtggcag
     8641 tcctttccag ggctgagctg gaaagggagg agtgtcagga gaggaacagc gagtcttacg
     8701 agcagcatat ccatctagaa caccaccaga ggcagcaagt ggcctaccag aaatactcag
     8761 aatttttcca cgagaaggtg gacccggcca ttgatgaagg caagctggtg gtgcaggaca
     8821 tcgagcaaag tgtatggatc cacagtcacg tgggctccaa ggagcacagc cacatgctgc
     8881 agaaggtcca ggagcacatc aagagggttt cggatatggt ggaggacctc tacaggcgga
     8941 aggcctgggc tggcgcggag gaggcgatga ctcggctggt caacattctg atcctgtcag
     9001 tcagggatgc acgagactgg ttgatgaaaa cagagacccg cttaaagaag gaaggtattg
     9061 ttcaggaaga tgattatgaa aatgaagttg aagactttgg tgagcttcgg cctagaaggc
     9121 gttctcggaa atgtggaaag cagagaaaat actaatgtcc acacagctgc agcctcctca
     9181 tccttcggaa cattccattc tgacttagaa ttctgagcgc tggggcagaa gacaaaaaga
     9241 atgtgaatta gcattttaaa aataggggag tctaacaaca ccattgcttt ttattctcat
     9301 tacttctctt tcagtggctt aggatctgat tgctccctca cctctaaagt gtttccaagt
     9361 agagtctggc agtattagtt tcccccacaa acaaattcag gtagagaagt tgtagtcgaa
     9421 gggaatgttg ggactcctca ctgcatggtc cctggggtgt ctggctcatc cccatcatga
     9481 catgagttgg tagcagagga ctaggtgtta ggacagactc tcctcacctc agttgctgct
     9541 gctctgggcc aggaaatctc tctatggatt ccctcatctc ctgccacact gctgcagcat
     9601 caagtgtgct atgagagctg tatgtgccca ggggtgggcc ctgccactgg ccaccccgag
     9661 cccaggacgc attctggtca tctctgagcc cacttgtagt gtagcttctt ctgttagaga
     9721 tgttagcctt ttctctctgt ggcgactttt ctgccttccc ttcttctgtt ttttgtgatc
     9781 attcttagct acctgtgcca agtcacagtt agactacctc agaatgtagt caagaattca
     9841 cccagtgttc tttggatgtc ccttccctag ggggaaaggc tggggaatgt tgctgggagc
     9901 attcccagct gcctctccaa agtggtccta actctgcctt ggctatggtg cagacattcc
     9961 aaaaagtgtt ttgtatacag ccctgtacat ctagttttct tggttctccc tggcaagttc
    10021 gctaccctag cttaggctga cgttctgatg agtctctgct tgctgagctc atcactgtgg
    10081 gatggtgacc tgcagagctg cagattggag caagtggaca gaggagggag ccagctaagc
    10141 caaatccgtc actgccactt ggctggcagg ccttataaga gggcggatct gggcccgttt
    10201 gcaggaggcc attgcctacc ctctccccac agtgagccag cagccatcag ctgatcccac
    10261 ctgggaaacc ttcatgcctc tctgatggtt actgcccacc cttaccccac ccctcagctc
    10321 agcctggtat ggaaagcaag gtgcacgttg gtctttgatt gttctgtcct cacagcagag
    10381 ccagctttcc ccccatgttg ctgctgcttt tgctgctcat gctgcttgtt gttttctctt
    10441 ccttatcttt ccaaattgtt tccttgaaat gcttgtttcc aatttttctt agattatgtt
    10501 tctaattttt attccaggtg tttttttttc ttacttgaca gaaaaaaaga aaaccccaac
    10561 aatatcttgc tgtattatca cattttttat aaagttaaag catttctctt a
//
