LOCUS       NM_152402               2023 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens translocation associated membrane protein 1 like 1
            (TRAM1L1), mRNA.
ACCESSION   NM_152402
VERSION     NM_152402.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2023)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2023)
  AUTHORS   Wang,H., St Julien,K.R., Stevenson,D.K., Hoffmann,T.J., Witte,J.S.,
            Lazzeroni,L.C., Krasnow,M.A., Quaintance,C.C., Oehlert,J.W.,
            Jelliffe-Pawlowski,L.L., Gould,J.B., Shaw,G.M. and O'Brodovich,H.M.
  TITLE     A genome-wide association study (GWAS) for bronchopulmonary
            dysplasia
  JOURNAL   Pediatrics 132 (2), 290-297 (2013)
   PUBMED   23897914
REFERENCE   3  (bases 1 to 2023)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   4  (bases 1 to 2023)
  AUTHORS   Kalsi,G., Kuo,P.H., Aliev,F., Alexander,J., McMichael,O.,
            Patterson,D.G., Walsh,D., Zhao,Z., Schuckit,M., Nurnberger,J. Jr.,
            Edenberg,H., Kramer,J., Hesselbrock,V., Tischfield,J.A.,
            Vladimirov,V., Prescott,C.A., Dick,D.M., Kendler,K.S. and
            Riley,B.P.
  TITLE     A systematic gene-based screen of chr4q22-q32 identifies
            association of a novel susceptibility gene, DKK2, with the
            quantitative trait of alcohol dependence symptom counts
  JOURNAL   Hum Mol Genet 19 (12), 2497-2506 (2010)
   PUBMED   20332099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock,
            Victor [added]; Tischfield, Jay A [added]]
REFERENCE   5  (bases 1 to 2023)
  AUTHORS   Cotsapas,C., Speliotes,E.K., Hatoum,I.J., Greenawalt,D.M.,
            Dobrin,R., Lum,P.Y., Suver,C., Chudin,E., Kemp,D., Reitman,M.,
            Voight,B.F., Neale,B.M., Schadt,E.E., Hirschhorn,J.N., Kaplan,L.M.
            and Daly,M.J.
  CONSRTM   GIANT Consortium
  TITLE     Common body mass index-associated variants confer risk of extreme
            obesity
  JOURNAL   Hum Mol Genet 18 (18), 3502-3507 (2009)
   PUBMED   19553259
  REMARK    Erratum:[Hum Mol Genet. 2010 Sep 15;19(18):3690-1]
REFERENCE   6  (bases 1 to 2023)
  AUTHORS   Stefanovic,B., Stefanovic,L., Schnabl,B., Bataller,R. and
            Brenner,D.A.
  TITLE     TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump
            Serca2b and is necessary for collagen type I synthesis
  JOURNAL   Mol Cell Biol 24 (4), 1758-1768 (2004)
   PUBMED   14749390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB099839.1, BX423039.2, BC030831.1 and CA415689.1.
            
            On May 17, 2019 this sequence version replaced NM_152402.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC030831.1, AK074617.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310754.5/ ENSP00000309402.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-568               DB099839.1         5-572
            569-1098            BX423039.2         506-1035
            1099-1923           BC030831.1         1099-1923
            1924-2023           CA415689.1         11-110              c
FEATURES             Location/Qualifiers
     source          1..2023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..2023
                     /gene="TRAM1L1"
                     /note="translocation associated membrane protein 1 like 1"
                     /db_xref="GeneID:133022"
                     /db_xref="HGNC:HGNC:28371"
                     /db_xref="MIM:617505"
     exon            1..2023
                     /gene="TRAM1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1293
                     /gene="TRAM1L1"
                     /codon_start=1
                     /product="translocating chain-associated membrane protein
                     1-like 1"
                     /protein_id="NP_689615.2"
                     /db_xref="CCDS:CCDS3707.1"
                     /db_xref="GeneID:133022"
                     /db_xref="HGNC:HGNC:28371"
                     /db_xref="MIM:617505"
                     /translation="MGLRKKSTKNPPVLSQEFILQNHADIVSCVGMFFLLGLVFEGTA
                     EASIVFLTLQHSVAVPAAEEQATGSKSLYYYGVKDLATVFFYMLVAIIIHATIQEYVL
                     DKINKRMQFTKAKQNKFNESGQFSVFYFFSCIWGTFILISENCLSDPTLIWKARPHSM
                     MTFQMKFFYISQLAYWFHAFPELYFQKTKKQDIPRQLVYIGLHLFHITGAYLLYLNHL
                     GLLLLVLHYFVELLSHMCGLFYFSDEKYQKGISLWAIVFILGRLVTLIVSVLTVGFHL
                     AGSQNRNPDALTGNVNVLAAKIAVLSSSCTIQAYVTWNLITLWLQRWVEDSNIQASCM
                     KKKRSRSSKKRTENGVGVETSNRVDCPPKRKEKSS"
     regulatory      1710..1715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAM1L1"
                     /note="hexamer: AATAAA"
     polyA_site      1739
                     /gene="TRAM1L1"
                     /note="major polyA site"
     regulatory      2001..2006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAM1L1"
                     /note="hexamer: ATTAAA"
     polyA_site      2023
                     /gene="TRAM1L1"
                     /note="major polyA site"
ORIGIN      
        1 atgctcagct cagctcggcc ctcgcctttg atttattttt tttctgggcg gccgctgcga
       61 cccgggactg acttcgggat gggaagtgga gcccccggag ctgctaccgt ggcggcggcg
      121 ctgtgaggag cagccagggg gaggcagctg cggctcgccg gtgagtatcc gggaagcgcc
      181 accatggggc tccgtaagaa gagcaccaag aacccccccg ttctcagcca ggaattcatc
      241 ctgcagaatc atgcggacat cgtctcctgc gtggggatgt tcttcctgct ggggcttgtg
      301 ttcgagggaa cagcagaagc atccatcgtg tttctcactc ttcagcacag tgttgctgtc
      361 cctgcagcag aggaacaagc cacgggctca aagtccctct attattatgg tgtcaaagat
      421 ttggccacgg ttttcttcta catgctggtg gcaatcatta ttcatgccac aattcaggaa
      481 tatgtgttgg ataaaattaa caagagaatg cagttcacca aagcgaaaca aaacaagttt
      541 aacgagtctg gtcagtttag tgtgttctac tttttttctt gtatttgggg cacattcatt
      601 ttaatctctg aaaactgcct gtcagaccca actcttatat ggaaggctcg tccccatagc
      661 atgatgacat ttcaaatgaa gtttttctac atatcccagt tggcttactg gtttcatgct
      721 tttcctgaac tctacttcca gaaaaccaaa aaacaagaca tccctcgtca acttgtctac
      781 attggtcttc acctcttcca cattactgga gcttatctct tgtacttgaa tcatttggga
      841 cttcttcttt tggtactgca ttattttgtt gaattacttt cccacatgtg cggcctgttt
      901 tactttagtg atgaaaagta ccagaaaggc atatctctgt gggccattgt gtttatcttg
      961 ggtagacttg tgactttaat tgtttccgta ctcactgttg ggtttcacct ggctggatcg
     1021 cagaatcgga atcctgatgc ccttactgga aatgtaaatg tgttggcagc taaaattgct
     1081 gttctgtcgt ccagttgcac gatccaagcc tacgtaacat ggaacttaat tactctctgg
     1141 cttcagaggt gggtagaaga ttctaatatt caggcctcat gtatgaaaaa gaaacggtcg
     1201 agatcttcta aaaaaagaac agaaaacgga gtgggagtgg aaacttcaaa tagagtagac
     1261 tgtccgccaa agaggaaaga gaaatcttca taatctttgc aagcgcattg attaatgtct
     1321 gcaaaggaat ctgctctttg aggtttcttt ctgcactaga gatttttctg tttttgaaaa
     1381 tagttcgtgc tcttcggttt ttgttattga actgtttcat gtatttttta aagacatttg
     1441 aggggaggag gattattatg aatgggaaaa aaagattttg gttgagacta aattactcat
     1501 cgtcaaaata atgtcaaaat agttttgggg atcaccacta tattttgttt tgatttttaa
     1561 cctttcaaca ttttcctaat gatttgcaga gataactgca caattttgca tatcaatgat
     1621 actggttctt actcccacca gtgtttcata atactaacaa gatggtctct cctagcaaga
     1681 ttatgtgttt aatgcttgct ttggggtaaa ataaaagtac gaaaaaggtg gaagtcaaat
     1741 cagtattctg taattgttag aatttatttt ttaagaactt acaactcaga aaagattgct
     1801 agactcacca aaataataaa tgttctttat tttacaggta gtgattatta gtgcttcatc
     1861 cccatttaaa aaaacacagt actaatgggt aacacatatg gaggtttgct gccatatata
     1921 ttgcatcaaa atatcattaa ttaatataaa aatattaaaa tcattcctgt ccattccact
     1981 tgtaaatggg aattcatgaa attaaatatt actttaaaaa gga
//
