LOCUS       NM_015049               6389 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens trafficking kinesin protein 2 (TRAK2), mRNA.
ACCESSION   NM_015049
VERSION     NM_015049.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6389)
  AUTHORS   Fenton,A.R., Jongens,T.A. and Holzbaur,E.L.F.
  TITLE     Mitochondrial adaptor TRAK2 activates and functionally links
            opposing kinesin and dynein motors
  JOURNAL   Nat Commun 12 (1), 4578 (2021)
   PUBMED   34321481
  REMARK    GeneRIF: Mitochondrial adaptor TRAK2 activates and functionally
            links opposing kinesin and dynein motors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6389)
  AUTHORS   Wang,F., Ye,B.G., Liu,J.Z. and Kong,D.L.
  TITLE     miR-487b and TRAK2 that form an axis to regulate the aggressiveness
            of osteosarcoma, are potential therapeutic targets and prognostic
            biomarkers
  JOURNAL   J Biochem Mol Toxicol 34 (8), e22511 (2020)
   PUBMED   32267991
  REMARK    GeneRIF: miR-487b and TRAK2 that form an axis to regulate the
            aggressiveness of osteosarcoma, are potential therapeutic targets
            and prognostic biomarkers.
REFERENCE   3  (bases 1 to 6389)
  AUTHORS   Lake,N.J., Taylor,R.L., Trahair,H., Harikrishnan,K.N., Curran,J.E.,
            Almeida,M., Kulkarni,H., Mukhamedova,N., Hoang,A., Low,H.,
            Murphy,A.J., Johnson,M.P., Dyer,T.D., Mahaney,M.C., Goring,H.H.H.,
            Moses,E.K., Sviridov,D., Blangero,J., Jowett,J.B.M. and Bozaoglu,K.
  TITLE     TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux
            and HDL biogenesis
  JOURNAL   Eur Heart J 38 (48), 3579-3587 (2017)
   PUBMED   28655204
  REMARK    GeneRIF: TRAK2 is a novel regulator of LXR-mediated ABCA1
            expression, cholesterol efflux, and HDL biogenesis. TRAK2 may
            therefore be an important target in the development of
            anti-atherosclerotic therapies.
REFERENCE   4  (bases 1 to 6389)
  AUTHORS   Mills,K.M., Brocardo,M.G. and Henderson,B.R.
  TITLE     APC binds the Miro/Milton motor complex to stimulate transport of
            mitochondria to the plasma membrane
  JOURNAL   Mol Biol Cell 27 (3), 466-482 (2016)
   PUBMED   26658612
  REMARK    GeneRIF: Full-length APC promotes assembly of the Miro-1/Milton-2
            complex.
REFERENCE   5  (bases 1 to 6389)
  AUTHORS   Loss,O. and Stephenson,F.A.
  TITLE     Localization of the kinesin adaptor proteins trafficking kinesin
            proteins 1 and 2 in primary cultures of hippocampal pyramidal and
            cortical neurons
  JOURNAL   J Neurosci Res 93 (7), 1056-1066 (2015)
   PUBMED   25653102
  REMARK    GeneRIF: This study showed that the TRAK2 was more prevalent in
            dendrites of hippocampal neurons. In cortical neurons, TRAK2 was
            equally distributed between axons and dendrites.
REFERENCE   6  (bases 1 to 6389)
  AUTHORS   Iyer,S.P., Akimoto,Y. and Hart,G.W.
  TITLE     Identification and cloning of a novel family of coiled-coil domain
            proteins that interact with O-GlcNAc transferase
  JOURNAL   J Biol Chem 278 (7), 5399-5409 (2003)
   PUBMED   12435728
REFERENCE   7  (bases 1 to 6389)
  AUTHORS   Beck,M., Brickley,K., Wilkinson,H.L., Sharma,S., Smith,M.,
            Chazot,P.L., Pollard,S. and Stephenson,F.A.
  TITLE     Identification, molecular cloning, and characterization of a novel
            GABAA receptor-associated protein, GRIF-1
  JOURNAL   J Biol Chem 277 (33), 30079-30090 (2002)
   PUBMED   12034717
  REMARK    GeneRIF: identification, molecular cloning and characterization
REFERENCE   8  (bases 1 to 6389)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6389)
  AUTHORS   Hadano,S., Yanagisawa,Y., Skaug,J., Fichter,K., Nasir,J.,
            Martindale,D., Koop,B.F., Scherer,S.W., Nicholson,D.W.,
            Rouleau,G.A., Ikeda,J. and Hayden,M.R.
  TITLE     Cloning and characterization of three novel genes, ALS2CR1,
            ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis
            (ALS2) critical region at chromosome 2q33-q34: candidate genes for
            ALS2
  JOURNAL   Genomics 71 (2), 200-213 (2001)
   PUBMED   11161814
REFERENCE   10 (bases 1 to 6389)
  AUTHORS   Machado,R.D., Pauciulo,M.W., Fretwell,N., Veal,C., Thomson,J.R.,
            Vilarino Guell,C., Aldred,M., Brannon,C.A., Trembath,R.C. and
            Nichols,W.C.
  TITLE     A physical and transcript map based upon refinement of the critical
            interval for PPH1, a gene for familial primary pulmonary
            hypertension. The International PPH Consortium
  JOURNAL   Genomics 68 (2), 220-228 (2000)
   PUBMED   10964520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA414989.1, AB038951.1, DA314514.1, DA575492.1, CA396280.1,
            AB011121.1 and AC007256.5.
            
            On Nov 23, 2018 this sequence version replaced NM_015049.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB038951.1, SRR18074969.1085031.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332624.8/ ENSP00000328875.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               DA414989.1         139-557
            420-731             AB038951.1         493-804
            732-828             DA314514.1         463-559
            829-1195            AB038951.1         902-1268
            1196-1251           DA575492.1         88-143
            1252-1690           CA396280.1         30-468
            1691-3074           AB011121.1         48-1431
            3075-6389           AC007256.5         36949-40263
FEATURES             Location/Qualifiers
     source          1..6389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..6389
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /note="trafficking kinesin protein 2"
                     /db_xref="GeneID:66008"
                     /db_xref="HGNC:HGNC:13206"
                     /db_xref="MIM:607334"
     exon            1..109
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            110..399
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..3053
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /note="amyotrophic lateral sclerosis 2 (juvenile)
                     chromosome region, candidate 3; amyotrophic lateral
                     sclerosis 2 chromosomal region candidate gene 3 protein;
                     milton homolog 2; trafficking protein, kinesin binding 2;
                     gamma-aminobutyric acid(A) receptor-interacting factor;
                     O-linked N-acetylglucosamine transferase interacting
                     protein 98"
                     /codon_start=1
                     /product="trafficking kinesin-binding protein 2"
                     /protein_id="NP_055864.2"
                     /db_xref="CCDS:CCDS2347.1"
                     /db_xref="GeneID:66008"
                     /db_xref="HGNC:HGNC:13206"
                     /db_xref="MIM:607334"
                     /translation="MSQSQNAIFTSPTGEENLMNSNHRDSESITDVCSNEDLPEVELV
                     SLLEEQLPQYRLKVDTLFLYENQDWTQSPHQRQHASDALSPVLAEETFRYMILGTDRV
                     EQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQ
                     VNQLQHELCKKDELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQLEMLQEKLK
                     ELEEENMALRSKACHIKTETVTYEEKEQQLVSDCVKELRETNAQMSRMTEELSGKSDE
                     LIRYQEELSSLLSQIVDLQHKLKEHVIEKEELKLHLQASKDAQRQLTMELHELQDRNM
                     ECLGMLHESQEEIKELRSRSGPTAHLYFSQSYGAFTGESLAAEIEGTMRKKLSLDEES
                     SLFKQKAQQKRVFDTVRIANDTRGRSISFPALLPIPGSNRSSVIMTAKPFESGLQQTE
                     DKSLLNQGSSSEEVAGSSQKMGQPGPSGDSDLATALHRLSLRRQNYLSEKQFFAEEWQ
                     RKIQVLADQKEGVSGCVTPTESLASLCTTQSEITDLSSASCLRGFMPEKLQIVKPLEG
                     SQTLYHWQQLAQPNLGTILDPRPGVITKGFTQLPGDAIYHISDLEEDEEEGITFQVQQ
                     PLEVEEKLSTSKPVTGIFLPPITSAGGPVTVATANPGKCLSCTNSTFTFTTCRILHPS
                     DITQVTPSSGFPSLSCGSSGSSSSNTAVNSPALSYRLSIGESITNRRDSTTTFSSTMS
                     LAKLLQERGISAKVYHSPISENPLQPLPKSLAIPSTPPNSPSHSPCPSPLPFEPRVHL
                     SENFLASRPAETFLQEMYGLRPSRNPPDVGQLKMNLVDRLKRLGIARVVKNPGAQENG
                     RCQEAEIGPQKPDSAVYLNSGSSLLGGLRRNQSLPVIMGSFAAPVCTSSPKMGVLKED
                     "
     exon            400..594
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            595..671
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            672..788
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            789..998
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1077
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1208
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1283
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1421
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1501
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1705
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..2004
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2271
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2377
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..6389
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6363..6368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /note="hexamer: AATAAA"
     polyA_site      6389
                     /gene="TRAK2"
                     /gene_synonym="ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2;
                     OIP98"
                     /note="major polyA site"
ORIGIN      
        1 ggcagtggga gcagcggcag cagcttcggc tgctgctttc aggctgccgc tgcattaggg
       61 gcttcctgag gaagcgcggg cggacgacag aggatgccga accactccag tcatgactgt
      121 ccaaagtatg ataatcacat gagagtgctc gttgctacgg atgtcatttg actcatcaga
      181 gaaaatctgt ctaaaagaaa atatccatgt gaccaaatcc atttcattat tgaatggctt
      241 gatggatttc ctttactctg attcatacca aagctgtcct tctcaaccaa agcaagaaag
      301 gatcctgcat gagtcaatcc cagaatgcaa tttttacatc accaacaggt gaagaaaacc
      361 tcatgaatag caatcacaga gactcggaga gcatcactga tgtctgctcc aatgaggatc
      421 tccctgaagt tgagctggtg agtctgctag aagaacaact accacagtat aggctaaaag
      481 tagacactct ctttctatat gaaaatcaag actggactca gtctccacac cagcggcagc
      541 atgcatctga tgctctctct ccagtccttg ctgaagagac tttccgttac atgattctag
      601 gcacagacag ggtggagcag atgaccaaaa cttacaatga catcgacatg gttacacatc
      661 tcctggcaga gagggatcgt gatctggaac tcgctgctcg aattggacaa gctctcttaa
      721 agcggaacca tgtcttatct gagcagaacg aatccctgga ggagcaattg ggacaagcct
      781 ttgatcaagt taatcagctg cagcatgagc tatgcaagaa agatgagtta cttcgaatcg
      841 tctccattgc ttctgaagaa agtgaaactg attccagctg ttctacacct cttcggttca
      901 atgagtcctt tagcttatct caagggttgc tgcagttgga aatgctgcaa gaaaagctca
      961 aggaactgga agaagagaat atggctcttc gatccaaggc ttgtcacata aagacagaaa
     1021 ctgttaccta tgaagaaaag gaacaacagc ttgtcagcga ctgtgttaaa gaacttcgtg
     1081 aaacaaatgc tcagatgtcc agaatgactg aagaattgtc agggaagagt gatgagctga
     1141 ttcgatacca agaagagctt tcctctcttt tgtcacagat tgtagacctt cagcacaaac
     1201 ttaaagaaca tgtgattgag aaggaagaac taaaacttca cctgcaagct tccaaagatg
     1261 cccaacggca actgacaatg gagctgcacg agttacaaga caggaatatg gagtgtctag
     1321 gaatgttaca tgaatcccaa gaagaaataa aggaacttcg tagtagatct ggccctactg
     1381 ctcatctcta cttctcccaa tcatatggag cttttactgg ggaatctttg gcagctgaga
     1441 ttgaggggac tatgcgtaaa aagctgagtt tggatgagga atcttctctc tttaaacaaa
     1501 aagcccaaca gaagcgggta tttgataccg tcaggattgc caatgacaca cggggccgct
     1561 ctatctcatt cccagctctg ttacccattc caggctccaa ccgttcaagt gtcatcatga
     1621 cagcaaaacc ttttgagtct ggtcttcagc aaacagagga caaatcactc ctgaaccagg
     1681 ggagcagctc agaggaggtt gcagggagct cccagaagat gggccaacca ggaccctcag
     1741 gagatagtga tttggctaca gcactgcatc gccttagctt gcgtcgacaa aactatttaa
     1801 gtgagaagca gttctttgct gaagaatggc agcggaagat ccaggttctg gcagaccaga
     1861 aggaaggagt tagtggctgt gtcaccccga cagagagcct tgcctctctc tgcaccaccc
     1921 agtcagagat cacagacctc agcagtgcca gttgccttcg aggttttatg ccagaaaaat
     1981 tacaaattgt caagcccctt gaaggatcac aaactctgta tcactggcag cagcttgctc
     2041 aaccaaactt gggaaccatc cttgatccac gaccaggtgt cattactaaa ggctttaccc
     2101 agttgcccgg ggatgctatt tatcacatct cagatttaga agaggatgaa gaggagggta
     2161 ttacttttca ggttcagcaa cctcttgaag tggaagagaa actttcaaca tccaagccag
     2221 taacagggat cttcctgcca cccattactt cagcaggtgg accagttaca gttgcaaccg
     2281 ccaacccagg aaagtgcctg tcgtgcacaa actcaacatt cactttcacc acctgtagaa
     2341 tattacatcc ctctgacatc actcaggtta cccccagctc tgggttccct tcattatcct
     2401 gtggaagtag cggtagcagt tcatccaaca cggctgtgaa ttctcctgcc ttgtcctata
     2461 gactcagcat tggtgagtcc atcaccaacc gacgagattc cactacaacc ttcagtagca
     2521 ccatgagctt ggccaaactt ctacaagagc gaggcatctc tgccaaagtg taccacagcc
     2581 caatttcaga gaaccccctc cagcctctcc ctaaatccct ggctatccct tccacaccac
     2641 caaattcacc atctcactca ccttgccctt ctcctttacc ctttgagcct cgagtgcatc
     2701 tctctgaaaa ttttttggcc tctcgaccag ctgagacatt cctccaggag atgtatggct
     2761 tgagaccctc ccggaaccct cctgatgttg gccagttgaa gatgaactta gtggacaggc
     2821 tgaagagact ggggatagcc agagtggtca agaaccctgg tgcccaagag aatggaagat
     2881 gccaggaggc agaaattggt cctcaaaaac cagattctgc tgtttattta aattcaggta
     2941 gcagtttatt aggtggacta aggaggaatc agagtcttcc agtcataatg ggtagctttg
     3001 ctgccccagt ttgcacatcc tcacccaaaa tgggtgtcct gaaggaggac tgaggttcag
     3061 cagttaactg accttttata caagttagca catgaaggat agatatgcac tgaaacatgt
     3121 ggtctggtct gacttgagag aaaaggaatg ttgcacaagg gttgtgaatg tgaaaggggg
     3181 aatggaggaa tggaaataaa attgggatga gccctaatgg aggaagtcgg gcaaattgaa
     3241 agtataaatg aatgggccat gagtgttcag agggagaaaa gaaaggttta atatactcct
     3301 tcagttgagt tttcttgtct tgaacataaa aagtgaatac aaataaattc agtaatacta
     3361 aaacatacag agatactgaa cttgctggca catttacttc tggtaagcat aaagcagaga
     3421 gaacccaggt tagaaggatg ggaagagaaa aggagcagtt ttattgctta tagaaagccg
     3481 ttctgagggg ttggtggggt aagctcagtc tattactgag acaatagtga gatggcttat
     3541 atgtttcccc tgttaatatc tggttaaatt atgtatccat caaatggtat gctcgcagca
     3601 ttagcaaaat taggagtttc atctttttca ttgaatcaca ggtggagact cctattttcc
     3661 tttctgtttt caggcctttg agcccctggg agcccaaata ccactcaatt attttgtatt
     3721 tatgattaat aaaagttcat tttttaaatt tgtattttta tacaacctcc aaaaaaaaaa
     3781 acaactgggt agagggtggg agggatttac ttttaagagg caaaatgtga gtaaattgaa
     3841 accaagaaaa cttgttttta gaatatttcg tctgaataag tacagtagcc aaggaataca
     3901 aacataattg catgttttta aaaattcctt ggaggctgga aggggttaag ccagaagtgc
     3961 aatcaatagg aattagggaa tgttgtatat ttatatatgt aaactttttt tgtaagaaaa
     4021 gttggtgaca actaaaccaa ctttttccaa agtgcgctat gcatattttt aatgaaagat
     4081 gacatgtatt tgcacaaaaa ttctcaggca cattaaatta ttgtaaactg aagtaaaacc
     4141 cgggtgcttg ctttgagatt gtggtttttt cttcctaatg taaaataaaa taaaacacat
     4201 ctgccttctt gatatttata gaattagaga ataaactttt taatggggga gtcaaagctt
     4261 tttctttttc tctaaggttc ttttttttta ttcaaactgt atgaaatggc aaagtgaggc
     4321 tctggggtta gatttcagca ttcagcagtt gacacaggct aagaaatgga aagaagtaga
     4381 tctgtttttt ctcaatgttg ctgagcaaag tctgcttctc atcagatgac gtggctttgt
     4441 ctagacagca cgcagttcag aaagaaatgt ctttatacaa aagacatgat agagaaaaga
     4501 tgagagaggg gactaattat tttgtttatg aaaatggcaa gtaaattact tgatcttttt
     4561 ggtgcttaat ttgcaaatgt tttgttcctt tgtcctgact taaaggcagt tttctgaaga
     4621 actcttgact cttgctccta tggttcccat aggcacacct attcccaggc caaggagagt
     4681 ccttcctctc cccttttgag gcatccccgc catcccccca cttagagcta tgtgctcaaa
     4741 aagccaacat gaatgcagtg gtaaaaattt gttagtttct tatacttttt agaatctctc
     4801 aataaaattt ttctaaataa attccacaaa aacaaagggt gaagatggtc tctccctttc
     4861 gttccccttc actcagttgt gctgaggtca atagagtgta gagtttcaga aaggattcca
     4921 gcaggtttat atgtgaatat aagtgtccct gaatggggca ggcattaaat agaagaatcc
     4981 ctgctgttta aatttcccgc atattccaat tcacttttaa aaaataccat ttgaatttgt
     5041 atttcataaa gtgactctgg ggtgcttact ttagtcaatt cttaaaattt tttatttgtt
     5101 ccctaagaaa gtaattactg tttctgttgc ctggacagtt acagtttcca ggaaacatca
     5161 ggaagtagga aactgtaggg ccagagagta gtacaacgtt aaattgtccg atttatgtgt
     5221 attacttaaa gctataaatt gaactagatc ttgccgtgct ctgtattgag tataatttgt
     5281 atactttttt ataattaatg actaaatgat cactttggag gcagggtggt gggggtgtat
     5341 tagcagccaa ataagcacat ctgatcaaaa agaaccaggc ttagattttt tttaagtaca
     5401 ttgatgttga tgttccacca gaaacacctt aagtgtatac tgttgtgtaa tgtctctaga
     5461 aaggaatcct gtcttaaaac tgggttttgc tgttttttga agtttctacc taaaatcatt
     5521 tttggtatat cctgataatc tctataatac tagaattgtc tgcaaaatat agtaagaaga
     5581 attggagcct aatagctgat tcctcccaat ttatctgtta tgttttgtca ctattcacat
     5641 tttagtcttt tctacgataa aaattgtatg tgtactttca tgccagtata ggaaacctca
     5701 atcttttttt tttttcgcct ttaagaaggt tttcagtgat tatacctcag gtatttctga
     5761 gtgtcctatt gtctaatagg agaaatatct tcccgagctc agaattaaaa gttctcctaa
     5821 attatgaaga tcccaaatct tatgtaaata accttaggca tgagtcctta gggagaagtt
     5881 aatgaccatt gttaaagtgc ttttttagaa aatgttgtgc tgtatgttct tgatttgaca
     5941 taaatgaata gactttggca agggaggaaa taagttaaaa ggcagcttac aagagcctat
     6001 tccctataaa gggtataatt ttacacagta ctcaaagctt gttatctttt ctgaccattt
     6061 tagtacagaa ttagtacttg gtggttacta acatcaactt gtgacatcta gaactagggc
     6121 tcttagtgtt tagtgggcca cttctctgat gtcagatgca tgcagacctg tactccacat
     6181 gcaacccaac agcagtgcag tgtgataact gagcggtcgc atggcagagg acatccccct
     6241 cagagtgggc acaagtgccc tctagggcag ccaggggaat actattgttc gatacctggg
     6301 atttgacttt gtcaaacagc tctttgtgcc cctatctttg ttttgtcaaa tgtagatcag
     6361 ttaataaaca tgagtagctt gaattttca
//
