LOCUS       NM_005879               2023 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens TRAF interacting protein (TRAIP), mRNA.
ACCESSION   NM_005879
VERSION     NM_005879.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2023)
  AUTHORS   Gu,Y. and Liang,C.
  TITLE     TRAIP suppressed apoptosis and cell cycle to promote prostate
            cancer proliferation via TRAF2-PI3K-AKT pathway activation
  JOURNAL   Int Urol Nephrol 56 (5), 1639-1648 (2024)
   PUBMED   38100027
  REMARK    GeneRIF: TRAIP suppressed apoptosis and cell cycle to promote
            prostate cancer proliferation via TRAF2-PI3K-AKT pathway
            activation.
REFERENCE   2  (bases 1 to 2023)
  AUTHORS   Scaramuzza,S., Jones,R.M., Sadurni,M.M., Reynolds-Winczura,A.,
            Poovathumkadavil,D., Farrell,A., Natsume,T., Rojas,P., Cuesta,C.F.,
            Kanemaki,M.T., Saponaro,M. and Gambus,A.
  TITLE     TRAIP resolves DNA replication-transcription conflicts during the
            S-phase of unperturbed cells
  JOURNAL   Nat Commun 14 (1), 5071 (2023)
   PUBMED   37604812
  REMARK    GeneRIF: TRAIP resolves DNA replication-transcription conflicts
            during the S-phase of unperturbed cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2023)
  AUTHORS   Chung,H.J., Lee,J.R., Kim,T.M., Kim,S., Park,K., Kim,M.J., Jung,E.,
            Kim,S., Lee,E.A., Ra,J.S., Hwang,S., Lee,J.Y., Scharer,O.D.,
            Kim,Y., Myung,K. and Kim,H.
  TITLE     ZNF212 promotes genomic integrity through direct interaction with
            TRAIP
  JOURNAL   Nucleic Acids Res 51 (2), 631-649 (2023)
   PUBMED   36594163
  REMARK    GeneRIF: ZNF212 promotes genomic integrity through direct
            interaction with TRAIP.
REFERENCE   4  (bases 1 to 2023)
  AUTHORS   Zheng,Y., Jia,H., Wang,P., Liu,L., Chen,Z., Xing,X., Wang,J.,
            Tan,X. and Wang,C.
  TITLE     Silencing TRAIP suppresses cell proliferation and
            migration/invasion of triple negative breast cancer via RB-E2F
            signaling and EMT
  JOURNAL   Cancer Gene Ther 30 (1), 74-84 (2023)
   PUBMED   36064576
  REMARK    GeneRIF: Silencing TRAIP suppresses cell proliferation and
            migration/invasion of triple negative breast cancer via RB-E2F
            signaling and EMT.
REFERENCE   5  (bases 1 to 2023)
  AUTHORS   Li,M., Wu,W., Deng,S., Shao,Z. and Jin,X.
  TITLE     TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and
            proliferation of osteosarcoma by promoting KANK1 degradation
  JOURNAL   Cell Death Dis 12 (8), 767 (2021)
   PUBMED   34349117
  REMARK    GeneRIF: TRAIP modulates the IGFBP3/AKT pathway to enhance the
            invasion and proliferation of osteosarcoma by promoting KANK1
            degradation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2023)
  AUTHORS   Besse,A., Campos,A.D., Webster,W.K. and Darnay,B.G.
  TITLE     TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin
            ligase
  JOURNAL   Biochem Biophys Res Commun 359 (3), 660-664 (2007)
   PUBMED   17544371
REFERENCE   7  (bases 1 to 2023)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   8  (bases 1 to 2023)
  AUTHORS   Regamey,A., Hohl,D., Liu,J.W., Roger,T., Kogerman,P., Toftgard,R.
            and Huber,M.
  TITLE     The tumor suppressor CYLD interacts with TRIP and regulates
            negatively nuclear factor kappaB activation by tumor necrosis
            factor
  JOURNAL   J Exp Med 198 (12), 1959-1964 (2003)
   PUBMED   14676304
  REMARK    GeneRIF: CYLD interacts with TRIP and regulates negatively nuclear
            factor kappaB activation by tumor necrosis factor.
REFERENCE   9  (bases 1 to 2023)
  AUTHORS   Wilson,S.A., Brown,E.C., Kingsman,A.J. and Kingsman,S.M.
  TITLE     TRIP: a novel double stranded RNA binding protein which interacts
            with the leucine rich repeat of flightless I
  JOURNAL   Nucleic Acids Res 26 (15), 3460-3467 (1998)
   PUBMED   9671805
REFERENCE   10 (bases 1 to 2023)
  AUTHORS   Lee,S.Y., Lee,S.Y. and Choi,Y.
  TITLE     TRAF-interacting protein (TRIP): a novel component of the tumor
            necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes
            that inhibits TRAF2-mediated NF-kappaB activation
  JOURNAL   J Exp Med 185 (7), 1275-1285 (1997)
   PUBMED   9104814
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC139451.7, BX473682.1,
            BC019283.1 and BQ446539.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005879.2.
            
            Summary: This gene encodes a protein that contains an N-terminal
            RING finger motif and a putative coiled-coil domain. A similar
            murine protein interacts with TNFR-associated factor 1 (TRAF1),
            TNFR-associated factor 2 (TRAF2), and cylindromatosis. The
            interaction with TRAF2 inhibits TRAF2-mediated nuclear factor
            kappa-B, subunit 1 activation that is required for cell activation
            and protection against apoptosis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.268051.1, U77845.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331456.7/ ENSP00000328203.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC139451.7         12679-12683
            6-529               BX473682.1         9-532
            530-1655            BC019283.1         506-1631
            1656-2023           BQ446539.1         25-392              c
FEATURES             Location/Qualifiers
     source          1..2023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2023
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /note="TRAF interacting protein"
                     /db_xref="GeneID:10293"
                     /db_xref="HGNC:HGNC:30764"
                     /db_xref="MIM:605958"
     exon            1..209
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1521
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 206; RING-type E3 ubiquitin
                     transferase TRAIP"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRAIP"
                     /protein_id="NP_005870.2"
                     /db_xref="CCDS:CCDS2806.1"
                     /db_xref="GeneID:10293"
                     /db_xref="HGNC:HGNC:30764"
                     /db_xref="MIM:605958"
                     /translation="MPIRALCTICSDFFDHSRDVAAIHCGHTFHLQCLIQWFETAPSR
                     TCPQCRIQVGKRTIINKLFFDLAQEEENVLDAEFLKNELDNVRAQLSQKDKEKRDSQV
                     IIDTLRDTLEERNATVVSLQQALGKAEMLCSTLKKQMKYLEQQQDETKQAQEEARRLR
                     SKMKTMEQIELLLQSQRPEVEEMIRDMGVGQSAVEQLAVYCVSLKKEYENLKEARKAS
                     GEVADKLRKDLFSSRSKLQTVYSELDQAKLELKSAQKDLQSADKEIMSLKKKLTMLQE
                     TLNLPPVASETVDRLVLESPAPVEVNLKLRRPSFRDDIDLNATFDVDTPPARPSSSQH
                     GYYEKLCLEKSHSPIQDVPKKICKGPRKESQLSLGGQSCAGEPDEELVGAFPIFVRNA
                     ILGQKQPKRPRSESSCSKDVVRTGFDGLGGRTKFIQPTDTVMIRPLPVKPKTKVKQRV
                     RVKTVPSLFQAKLDTFLWS"
     exon            210..267
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            268..351
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            352..391
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            392..519
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            520..614
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            615..728
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            729..816
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            817..906
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            907..995
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1148
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1197
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1347
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1398
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..2023
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2006..2011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /note="hexamer: ATTAAA"
     polyA_site      2023
                     /gene="TRAIP"
                     /gene_synonym="RNF206; SCKL9; TRIP"
                     /note="major polyA site"
ORIGIN      
        1 aagtcgtgct gcggagccaa atttgaagca agcggaggcg cgggggcgcg tctacgaagc
       61 cggacctgta gcagtttctt tggctgcctg ggccccttga gtccagccat catgcctatc
      121 cgtgctctgt gcactatctg ctccgacttc ttcgatcact cccgcgacgt ggccgccatc
      181 cactgcggcc acaccttcca cttgcagtgc ctaattcagt ggtttgagac agcaccaagt
      241 cggacctgcc cacagtgccg aatccaggtt ggcaaaagaa ccattatcaa taagctcttc
      301 tttgatcttg cccaggagga ggagaatgtc ttggatgcag aattcttaaa gaatgaactg
      361 gacaatgtca gagcccagct ttcccagaaa gacaaggaga aacgagacag ccaggtcatc
      421 atcgacactc tgcgggatac gctggaagaa cgcaatgcta ctgtggtatc tctgcagcag
      481 gccttgggca aggccgagat gctgtgctcc acactgaaaa agcagatgaa gtacttagag
      541 cagcagcagg atgagaccaa acaagcacaa gaggaggccc gccggctcag gagcaagatg
      601 aagaccatgg agcagattga gcttctactc cagagccagc gccctgaggt ggaggagatg
      661 atccgagaca tgggtgtggg acagtcagcg gtggaacagc tggctgtgta ctgtgtgtct
      721 ctcaagaaag agtacgagaa tctaaaagag gcacggaagg cctcagggga ggtggctgac
      781 aagctgagga aggatttgtt ttcctccaga agcaagttgc agacagtcta ctctgaattg
      841 gatcaggcca agttagaact gaagtcagcc cagaaggact tacagagtgc tgacaaggaa
      901 atcatgagcc tgaaaaagaa gctaacgatg ctgcaggaaa ccttgaacct gccaccagtg
      961 gccagtgaga ctgtcgaccg cctggtttta gagagcccag cccctgtgga ggtgaatctg
     1021 aagctccgcc ggccatcctt ccgtgatgat attgatctca atgctacctt tgatgtggat
     1081 actcccccag cccggccctc cagctcccag catggttact acgaaaaact ttgcctagag
     1141 aagtcacact ccccaattca ggatgtcccc aagaagatat gcaaaggccc caggaaggag
     1201 tcccagctct cactgggtgg ccagagctgt gcaggagagc cagatgagga actggttggt
     1261 gccttcccta tttttgtccg gaatgccatc ctaggccaga aacagcccaa gaggcccagg
     1321 tcagagtcct cttgcagcaa agatgtggta aggacaggct tcgatgggct cggtggccgg
     1381 acaaaattca tccagcctac tgacacagtc atgatccgcc cattgcctgt taagcccaag
     1441 accaaggtta agcagagggt gagggtgaag acagtgcctt ctctcttcca ggccaagctg
     1501 gacaccttcc tgtggtcgtg agaacagtga gtctgaccaa tggccagaca catgcctgca
     1561 acttgtaggt caaggactgt ccaggcaggg gttttgtgga cagagcccca ctttcgggac
     1621 cagcctgagg tgtaagggca gacaaacagg tgagggtgag tgtggcaccc agagactgct
     1681 cttcctgccc tcaccctgcc ccactcctac gactgggagc tgacatgacc agcccactga
     1741 tcctgtcagc aggtcctgct cctgttgcca ggctcctgtt tatagccatg atcagatgtg
     1801 gtcagactct ttctgggcct ggagaccacg gtcacttgtt gactgtctct gtggaccaga
     1861 gtgcttgagg catctcaggc agcctcagcc caagcttcta cctgcctttg acttgcttct
     1921 aggcatagcc tgggccaagc agggtgggga atggaggata gcatgggatg tatggagagg
     1981 atggaagatt ttcatgtaaa ataaaattaa aaaaaaaaaa caa
//
