LOCUS       NM_006700               2633 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TRAF-type zinc finger domain containing 1 (TRAFD1),
            transcript variant 2, mRNA.
ACCESSION   NM_006700
VERSION     NM_006700.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2633)
  AUTHORS   Gupta,S., Singh,P., Tasneem,A., Almatroudi,A., Rahmani,A.H.,
            Dohare,R. and Parveen,S.
  TITLE     Integrative Multiomics and Regulatory Network Analyses Uncovers the
            Role of OAS3, TRAFD1, miR-222-3p, and miR-125b-5p in Hepatitis E
            Virus Infection
  JOURNAL   Genes (Basel) 14 (1), 42 (2022)
   PUBMED   36672782
  REMARK    GeneRIF: Integrative Multiomics and Regulatory Network Analyses
            Uncovers the Role of OAS3, TRAFD1, miR-222-3p, and miR-125b-5p in
            Hepatitis E Virus Infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2633)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2633)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   4  (bases 1 to 2633)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2633)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2633)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   7  (bases 1 to 2633)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 2633)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   9  (bases 1 to 2633)
  AUTHORS   Mashima,R., Saeki,K., Aki,D., Minoda,Y., Takaki,H., Sanada,T.,
            Kobayashi,T., Aburatani,H., Yamanashi,Y. and Yoshimura,A.
  TITLE     FLN29, a novel interferon- and LPS-inducible gene acting as a
            negative regulator of toll-like receptor signaling
  JOURNAL   J Biol Chem 280 (50), 41289-41297 (2005)
   PUBMED   16221674
  REMARK    GeneRIF: FLN29 is a new negative feedback regulator of TLR
            signaling
REFERENCE   10 (bases 1 to 2633)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK312601.1, BC003553.2 and CA314188.1.
            
            On Nov 24, 2018 this sequence version replaced NM_006700.2.
            
            Summary: The innate immune system confers host defense against
            viral and microbial infection, and TRAFD1 is a negative feedback
            regulator that controls excessive immune responses (Sanada et al.,
            2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.46222.1,
                                           SRR3476690.536433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412615.7/ ENSP00000396526.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AK312601.1         16-74
            60-2628             BC003553.2         1-2569
            2629-2633           CA314188.1         18-22               c
FEATURES             Location/Qualifiers
     source          1..2633
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..2633
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /note="TRAF-type zinc finger domain containing 1"
                     /db_xref="GeneID:10906"
                     /db_xref="HGNC:HGNC:24808"
                     /db_xref="MIM:613197"
     exon            1..59
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     exon            60..118
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1820
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /note="FLN29 gene product"
                     /codon_start=1
                     /product="TRAF-type zinc finger domain-containing protein
                     1"
                     /protein_id="NP_006691.1"
                     /db_xref="CCDS:CCDS9160.1"
                     /db_xref="GeneID:10906"
                     /db_xref="HGNC:HGNC:24808"
                     /db_xref="MIM:613197"
                     /translation="MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKE
                     PFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKL
                     KEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQD
                     GIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQ
                     ERQERNRGQQPPKEGGEESANLDFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGP
                     RSLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEP
                     DVIFQNFLQQAASNQLDSLMGLSNSHPVEESIIIPCEFCGVQLEEEVLFHHQDQCDQR
                     PATATNHVTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDTKQETANGPTSCLP
                     PSRPINNMTATYNQLSRSTSGPRPGCQPSSPCVPKLSNSDSQDIQGRNRDSQNGAIAP
                     GHVSVIRPPQNLYPENIVPSFSPGPSGRYGASGRSEGGRNSRVTPAAANYRSRTAKAK
                     PSKQQGAGDAEEEEEE"
     exon            119..254
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     exon            255..308
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     exon            309..714
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     exon            715..921
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     exon            922..998
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1229
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1350
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1690
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1763
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2633
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2610..2615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /note="hexamer: AATAAA"
     polyA_site      2633
                     /gene="TRAFD1"
                     /gene_synonym="FLN29"
                     /note="major polyA site"
ORIGIN      
        1 agaggaggct ccgtgtctgc agctagtgtg tcaactcagc gtttctcctc tcgtccctgg
       61 aagagctaaa gatggctgaa tttctagatg accaggaaac tcgactgtgt gacaactgca
      121 aaaaagaaat tcctgtgttt aactttacca tccatgagat ccactgtcaa aggaacattg
      181 gtatgtgtcc tacctgtaag gaaccatttc ccaaatctga catggagact cacatggctg
      241 cagaacactg tcaggtgacc tgcaaatgta acaagaagtt ggagaagagg ctgttaaaga
      301 agcatgagga gactgagtgc cctttgcggc ttgctgtctg ccagcactgt gatttagaac
      361 tttccattct caaactgaag gaacatgaag attattgtgg tgcccggacg gaactatgtg
      421 gcaactgtgg tcgcaatgtc cttgtgaaag atctgaagac tcaccctgaa gtttgtggga
      481 gagaggggga ggaaaagaga aatgaggttg ccatacctcc taatgcatat gatgaatctt
      541 ggggtcagga tggaatctgg attgcatccc aactcctcag acaaattgag gctctggacc
      601 cacccatgag gctgccgcga aggcccctga gagcctttga atcagatgtt ttccacaata
      661 gaactaccaa ccaaaggaac attacagccc aggtttcaat tcagaataat ctgtttgaag
      721 aacaagagag gcaggaaagg aatagaggcc aacagccccc caaagagggt ggtgaagaga
      781 gtgcaaactt ggacttcatg ttggccctaa gtctgcaaaa tgaaggccaa gcctccagtg
      841 tggcagagca ggacttctgg agggccgtat gtgaggccga ccagtctcat ggcggtccca
      901 ggtctctcag tgacataaag ggtgcagctg acgagatcat gttgccttgt gaattttgtg
      961 aggagctcta cccagaggaa ctgctgattg accatcagac aagctgtaac ccttcacgtg
     1021 ccttaccttc actcaatact ggcagctctt cccccagagg ggtggaggaa cctgatgtca
     1081 tcttccagaa cttcttgcaa caggctgcaa gtaaccagtt agactctttg atgggcctga
     1141 gcaattcaca ccctgtggag gagagcatca ttatcccatg tgaattctgt ggggtacagc
     1201 tggaagagga ggtgctgttc catcaccagg accagtgtga ccaacgccca gccactgcaa
     1261 ccaaccatgt gacagagggg attcctagac tggattccca gcctcaagag acctcaccag
     1321 agctgcccag gaggcgtgtc agacaccagg gagacctgtc ttctggttac ctggatgata
     1381 ctaagcagga aacagctaat gggcccacct cctgtctgcc tcccagccga cccattaaca
     1441 atatgacagc tacctataac cagctatcga gatcaacatc aggccccaga cctgggtgcc
     1501 agcccagctc tccttgtgtg ccgaagctca gcaactcaga cagccaggac atccaggggc
     1561 ggaatcgaga cagccagaat ggggccatag cccctgggca cgtttcagtg attcgccctc
     1621 ctcaaaatct ctacccagaa aacattgtgc cctctttctc ccctgggcct tcagggagat
     1681 acggagctag tggtaggagt gaaggtggca ggaattcccg ggtcacccct gcagctgcca
     1741 actaccgcag cagaactgca aaggcaaagc cttccaagca acagggagct ggggatgcag
     1801 aagaggaaga ggaggagtaa tggtgtctcc agagacttta catcggttcc tgtcttctgt
     1861 gcacagcagc acttgccgct gtgcaggccc acctctttgg ctctttgggt gggagagttt
     1921 ttccagattt tagatttttc taggttatgg ccattttgtg tcttttgagg ttgtgctgtg
     1981 ggggtttggg tttgagggaa gggagcaggg tggcggttga ggaacgcttc agccttagct
     2041 gctacctttc ggcagcagtg aaatacaagc tgcagcctcg gctgccaggg ctcccttttg
     2101 acttattgtc gccactgccc cttggtgctg tgtggtccca gtggaaggag gggaagattt
     2161 tggaaacctg gtagccacca gtaaggtgat tctctgccct gttggggcct aaatttgggg
     2221 gcttttgggc aacctctccg tgtactgcgt ctgtccacac tcgattgggc cccaggtgtg
     2281 tatgaggcgc tctggtaagg tgctcaggcc agttgcaatg tctgtcagta acgaggcttt
     2341 tgatgtgttg agctggaggt gagtggaccg ggggctgtgt tttaagctgc ttccttggca
     2401 tttggcatca ctgccttctg ttcccggggg agcatggatc ttttgtcctc actgctttct
     2461 aatggggagg gctgagggct ccctgtcccc acagcaggta tgttgggctc tgccccagcc
     2521 ccacacttgc tctgaaaacc aagtgtcaga gccccttccc cttgttttta ttttactgtt
     2581 ataataatta ttaacttcct tgtaatagaa ataaagtttg tacttggagt tca
//
