LOCUS       NM_032271               3683 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens TNF receptor associated factor 7 (TRAF7), mRNA.
ACCESSION   NM_032271
VERSION     NM_032271.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3683)
  AUTHORS   Herrera,C.M., McMahon,E., Swaney,D.L., Sherry,J., Pha,K.,
            Adams-Boone,K., Johnson,J.R., Krogan,N.J., Stevers,M., Solomon,D.,
            Elwell,C. and Engel,J.
  TITLE     The Chlamydia trachomatis Inc Tri1 interacts with TRAF7 to displace
            native TRAF7 interacting partners
  JOURNAL   Microbiol Spectr 12 (7), e0045324 (2024)
   PUBMED   38814079
  REMARK    GeneRIF: The Chlamydia trachomatis Inc Tri1 interacts with TRAF7 to
            displace native TRAF7 interacting partners.
REFERENCE   2  (bases 1 to 3683)
  AUTHORS   Kelam,J., Kelam,N., Filipovic,N., Komic,L., Racetin,A., Komic,D.,
            Kostic,S., Kuzmic Prusac,I. and Vukojevic,K.
  TITLE     Expression of Congenital Anomalies of the Kidney and Urinary Tract
            (CAKUT) Candidate Genes EDA2R, PCDH9, and TRAF7 in Normal Human
            Kidney Development and CAKUT
  JOURNAL   Genes (Basel) 15 (6), 702 (2024)
   PUBMED   38927638
  REMARK    GeneRIF: Expression of Congenital Anomalies of the Kidney and
            Urinary Tract (CAKUT) Candidate Genes EDA2R, PCDH9, and TRAF7 in
            Normal Human Kidney Development and CAKUT.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3683)
  AUTHORS   Colleran,J.A., Daykin,E.C., Hernandez,C., Ray,J. and Morand,M.
  TITLE     Novel mosaic TRAF7 likely pathogenic variant in an African American
            family
  JOURNAL   Am J Med Genet A 191 (7), 1990-1993 (2023)
   PUBMED   37067385
  REMARK    GeneRIF: Novel mosaic TRAF7 likely pathogenic variant in an African
            American family.
REFERENCE   4  (bases 1 to 3683)
  AUTHORS   Zou,L., Fang,Y. and He,W.
  TITLE     TRAF7 inhibits glycolysis to potentiate growth inhibition and
            apoptosis of myeloid leukemia cells via regulating the KLF2-PFKFB3
            axis
  JOURNAL   Mol Cell Probes 69, 101911 (2023)
   PUBMED   37003349
  REMARK    GeneRIF: TRAF7 inhibits glycolysis to potentiate growth inhibition
            and apoptosis of myeloid leukemia cells via regulating the
            KLF2-PFKFB3 axis.
REFERENCE   5  (bases 1 to 3683)
  AUTHORS   Mishra-Gorur,K., Barak,T., Kaulen,L.D., Henegariu,O., Jin,S.C.,
            Aguilera,S.M., Yalbir,E., Goles,G., Nishimura,S., Miyagishima,D.,
            Djenoune,L., Altinok,S., Rai,D.K., Viviano,S., Prendergast,A.,
            Zerillo,C., Ozcan,K., Baran,B., Sencar,L., Goc,N., Yarman,Y.,
            Ercan-Sencicek,A.G., Bilguvar,K., Lifton,R.P., Moliterno,J.,
            Louvi,A., Yuan,S., Deniz,E., Brueckner,M. and Gunel,M.
  TITLE     Pleiotropic role of TRAF7 in skull-base meningiomas and congenital
            heart disease
  JOURNAL   Proc Natl Acad Sci U S A 120 (16), e2214997120 (2023)
   PUBMED   37043537
  REMARK    GeneRIF: Pleiotropic role of TRAF7 in skull-base meningiomas and
            congenital heart disease.
REFERENCE   6  (bases 1 to 3683)
  AUTHORS   Li,S., Wang,L., Berman,M., Kong,Y.Y. and Dorf,M.E.
  TITLE     Mapping a dynamic innate immunity protein interaction network
            regulating type I interferon production
  JOURNAL   Immunity 35 (3), 426-440 (2011)
   PUBMED   21903422
  REMARK    Erratum:[Immunity. 2011 Oct 28;35(4):647-8]
REFERENCE   7  (bases 1 to 3683)
  AUTHORS   Zotti,T., Uva,A., Ferravante,A., Vessichelli,M., Scudiero,I.,
            Ceccarelli,M., Vito,P. and Stilo,R.
  TITLE     TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB
            kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA
            protein and represses NF-kappaB activation
  JOURNAL   J Biol Chem 286 (26), 22924-22933 (2011)
   PUBMED   21518757
  REMARK    GeneRIF: this study identifies TRAF7 as a NEMO- and p65-interacting
            molecule and brings important information on the ubiquitination
            events that control NF-kappaB transcriptional activity.
REFERENCE   8  (bases 1 to 3683)
  AUTHORS   Joslyn,G., Ravindranathan,A., Brush,G., Schuckit,M. and White,R.L.
  TITLE     Human variation in alcohol response is influenced by variation in
            neuronal signaling genes
  JOURNAL   Alcohol Clin Exp Res 34 (5), 800-812 (2010)
   PUBMED   20201926
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 3683)
  AUTHORS   Xu,L.G., Li,L.Y. and Shu,H.B.
  TITLE     TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces
            apoptosis
  JOURNAL   J Biol Chem 279 (17), 17278-17282 (2004)
   PUBMED   15001576
  REMARK    GeneRIF: TRAF7 potentiates MEKK3-induced AP1 and CHOP activation
            and induces apoptosis
REFERENCE   10 (bases 1 to 3683)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009065.8, AK090624.1, AL136921.1 and AW245178.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032271.2.
            
            Summary: Tumor necrosis factor (TNF; see MIM 191160)
            receptor-associated factors, such as TRAF7, are signal transducers
            for members of the TNF receptor superfamily (see MIM 191190). TRAFs
            are composed of an N-terminal cysteine/histidine-rich region
            containing zinc RING and/or zinc finger motifs; a coiled-coil
            (leucine zipper) motif; and a homologous region that defines the
            TRAF family, the TRAF domain, which is involved in self-association
            and receptor binding.[supplied by OMIM, Apr 2004].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY569455.1, AK090624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326181.11/ ENSP00000318944.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC009065.8         121615-121630       c
            17-1643             AK090624.1         15-1641
            1644-3678           AL136921.1         1524-3558
            3679-3683           AW245178.1         10-14               c
FEATURES             Location/Qualifiers
     source          1..3683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3683
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /note="TNF receptor associated factor 7"
                     /db_xref="GeneID:84231"
                     /db_xref="HGNC:HGNC:20456"
                     /db_xref="MIM:606692"
     exon            1..77
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            78..196
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2128
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /EC_number="2.3.2.27"
                     /note="ring finger and WD repeat domain 1; RING finger
                     protein 119; RING finger and WD repeat-containing protein
                     1; TNF receptor-associated factor 7, E3 ubiquitin protein
                     ligase; RING-type E3 ubiquitin transferase TRAF7"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRAF7"
                     /protein_id="NP_115647.2"
                     /db_xref="CCDS:CCDS10461.1"
                     /db_xref="GeneID:84231"
                     /db_xref="HGNC:HGNC:20456"
                     /db_xref="MIM:606692"
                     /translation="MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTI
                     TKADGTSTYKQHCRTPSSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMS
                     LRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEK
                     CPVDNVKLTVVVNNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSA
                     RKDHEGSCDYRPVRCPNNPSCPPLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYE
                     THLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLE
                     LKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTF
                     VGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGC
                     KLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGT
                     ELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIA
                     VTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRS
                     LRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC"
     exon            197..254
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            255..346
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            347..463
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            464..556
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            557..590
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            591..774
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            775..909
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1127
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1201
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1250
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1378
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1461
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1501
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1618
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1741
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1861
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1993
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2113
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..3683
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2471..2476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /note="hexamer: AATAAA"
     polyA_site      2492
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /note="major polyA site"
     regulatory      3575..3580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /note="hexamer: AATAAT"
     regulatory      3594..3599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /note="hexamer: AATATA"
     polyA_site      3599
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
     polyA_site      3614
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /note="major polyA site"
     regulatory      3658..3663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
                     /note="hexamer: AATAAA"
     polyA_site      3683
                     /gene="TRAF7"
                     /gene_synonym="CAFDADD; RFWD1; RNF119"
ORIGIN      
        1 ccctttcccg gccggcggcc gagggggcat catgaagcgg gctggcggcg ctgccgctcc
       61 cgggcggccg cgggcgggag gtgcttccca aggaccgtag atgcctctct agagcatgag
      121 ctcaggcaag agtgcccgct acaaccgctt ctccgggggg cccagcaatc ttcccacccc
      181 agacgtcacc acagggacca gaatggaaac gaccttcgga cccgcctttt cagccgtcac
      241 caccatcaca aaagctgacg ggaccagcac ctacaagcag cactgcagga caccctcctc
      301 ctccagcacc cttgcctact ccccgcggga cgaggaggac agcatgcccc ccatcagcac
      361 tccccgccgc tccgactccg ccatctctgt ccgctccctg cactcagagt ccagcatgtc
      421 tctgcgctcc acattctcac tgcccgagga ggaggaggag ccggagccac tggtgtttgc
      481 ggagcagccc tcggtgaagc tgtgctgtca gctctgctgc agcgtcttca aagaccccgt
      541 gatcaccacg tgtgggcaca cgttctgtag gagatgcgcc ttgaagtcag agaagtgtcc
      601 cgtggacaac gtcaaactga ccgtggtggt gaacaacatc gcggtggccg agcagatcgg
      661 ggagctcttc atccactgcc ggcacggctg ccgggtagcg ggcagcggga agccccccat
      721 ctttgaggtg gacccccgag ggtgcccctt caccatcaag ctcagcgccc ggaaggacca
      781 cgagggcagc tgtgactaca ggcctgtgcg gtgtcccaac aaccccagct gccccccgct
      841 gctcaggatg aacctggagg cccacctcaa ggagtgcgag cacatcaaat gcccccactc
      901 caagtacggg tgcacgttca tcgggaacca ggacacttac gagacccacc tggagacttg
      961 ccgcttcgag ggcctgaagg agtttctgca gcagacggat gaccgcttcc acgagatgca
     1021 cgtggctctg gcccagaagg accaggagat cgccttcctg cgctccatgc tgggaaagct
     1081 ctcggagaag atcgaccagc tagagaagag cctggagctc aagtttgacg tcctggacga
     1141 aaaccagagc aagctcagcg aggacctcat ggagttccgg cgggacgcat ccatgttaaa
     1201 tgacgagctg tcccacatca acgcgcggct gaacatgggc atcctaggct cctacgaccc
     1261 tcagcagatc ttcaagtgca aagggacctt tgtgggccac cagggccctg tgtggtgtct
     1321 ctgcgtctac tccatgggtg acctgctctt cagtggctcc tctgacaaga ccatcaaggt
     1381 gtgggacaca tgtaccacct acaagtgtca gaagacactg gagggccatg atggcatcgt
     1441 gctggctctc tgcatccagg ggtgcaaact ctacagcggc tctgcagact gcaccatcat
     1501 tgtgtgggac atccagaacc tgcagaaggt gaacaccatc cgggcccatg acaacccggt
     1561 gtgcacgctg gtctcctcac acaacgtgct cttcagcggc tccctgaagg ccatcaaggt
     1621 ctgggacatc gtgggcactg agctgaagtt gaagaaggag ctcacaggcc tcaaccactg
     1681 ggtgcgggcc ctggtggctg cccagagcta cctgtacagc ggctcctacc agacaatcaa
     1741 gatctgggac atccgaaccc ttgactgcat ccacgtcctg cagacgtctg gtggcagcgt
     1801 ctactccatt gctgtgacaa atcaccacat tgtctgtggc acctacgaga acctcatcca
     1861 cgtgtgggac attgagtcca aggagcaggt gcggaccctc acgggccacg tgggcaccgt
     1921 gtatgccctg gcggtcatct cgacgccaga ccagaccaaa gtcttcagtg catcctacga
     1981 ccggtccctc agggtctgga gtatggacaa catgatctgc acgcagaccc tgctgcgtca
     2041 ccagggcagt gtcaccgcgc tggctgtgtc ccggggccga ctcttctcag gggctgtgga
     2101 tagcactgtg aaggtttgga cttgctaaca ggatccaggc caggctgtgg tttcccctga
     2161 accagccctg gacctttctg agccaggctg gccacatggg gtggtctcgg ggtttctgcc
     2221 tgccccgtgg gcataggtgg acaggctctg gcagccgggc agtgccctcc ccgtcccatg
     2281 ctcggcgagc ctccctctac tcggcactgt ccttgctgcc cagcccctct ctgggtgcca
     2341 ggtacgacgc ttgccccggc ccaccctcca tccccaccct ccatccccac cctagatgga
     2401 gcgagggcct ttttactcac cttttctacc gtttttagac tgtatgtaga tttggttacc
     2461 tcctggttga aataaatgct ccacagactg tggctgtgag tggggacagc tcctcgggac
     2521 aagggggctg tgtgtggcct tgaggttggt gtgcacaggc actggctgct gtgagtgggg
     2581 gggcatgggg cagtttcctt tggtggaccc caggacttcg gcccactccg gggcctcccc
     2641 tccctgctag gaggcaactc gtcacaccca agctgctggc ctccagtccc atctccccca
     2701 acacatgtgc ccccaaaaag tgagccaggc acctctgttt cctgctgttt attgacagcc
     2761 gacggcagcg ccttgcccag acctcccctg cccacctgct ggagcccagc ctgtgccgcc
     2821 ctctgaggag aggcctgggg ggacagctgg gcacgtccac tcgcagggaa acacggggtg
     2881 agacagcagg aaggggccct gcacgccggg acgccacctc cgccagccgc ctccacccgc
     2941 cccacaccac aatcgctggt tttcggcatt ttttaaattt tttttttaag aaacgtcaaa
     3001 gttgtgccca acactgtgga tcagcaaaca cgatagagga gaccagtcag tacttcttgg
     3061 agggggcagg aggagagagg aaaagggagg gcgagaatga ccacacaaca cagccttgga
     3121 ccatgagcag aagcgtccgt gggaactcca ctggggtgga tgggctgcct gcacagcccc
     3181 tggagagggg gccaggcaca ccctcagagg agctgcaagc ccgtggcctg gcctgctaca
     3241 tgccctgctt ccacgtggct gccacgctga cacacccaca ttcaccaaac ccacccgcgc
     3301 cctgggacgc agccacgcca ggaggaggac acggccgccg agagcaaggc acaacctcga
     3361 gttcttgggg cgcagagaac ttaggagaga agcacggagg agcccccggc agagcacccg
     3421 cccccgggcc ccagccttcc acctgtgcta gcagcctggg gcctccactc tggccggagg
     3481 aaggaccgca ggcagacagc ctgggcctct aacagctttt gtccggagct agacttcgtg
     3541 tcctttcagt tggtaaatgg ttttctatag aatcaataat atttctttct ttaaatatat
     3601 atttgttaaa gttatacctt tttgtttctc tggggaaatc cgcctcagct cattcccaat
     3661 aaattaatac tcttgatagc tta
//
