LOCUS       NM_004620               7885 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens TNF receptor associated factor 6 (TRAF6), transcript
            variant 2, mRNA.
ACCESSION   NM_004620
VERSION     NM_004620.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7885)
  AUTHORS   Cheng,M., Xu,B., Sun,Y., Wang,J., Lu,Y., Shi,C., Pan,T., Zhao,W.,
            Li,X., Song,X., Wang,J., Wang,N., Yang,W., Jiang,Y., Huang,H.,
            Yang,G., Zeng,Y., Yang,D., Wang,C. and Cao,X.
  TITLE     ASB3 expression aggravates inflammatory bowel disease by targeting
            TRAF6 protein stability and affecting the intestinal microbiota
  JOURNAL   mBio 15 (9), e0204324 (2024)
   PUBMED   39162488
  REMARK    GeneRIF: ASB3 expression aggravates inflammatory bowel disease by
            targeting TRAF6 protein stability and affecting the intestinal
            microbiota.
REFERENCE   2  (bases 1 to 7885)
  AUTHORS   Luo,R.C., Wu,X.Y., Yu,W.W., Zheng,Y.J. and Wang,D.
  TITLE     [Research progress on the relationship between TRAF6 and
            neurodegenerative diseases]
  JOURNAL   Sheng Li Xue Bao 76 (4), 653-662 (2024)
   PUBMED   39192797
  REMARK    GeneRIF: [Research progress on the relationship between TRAF6 and
            neurodegenerative diseases].
            Review article
REFERENCE   3  (bases 1 to 7885)
  AUTHORS   Wang,J., Shen,S., You,J., Wang,Z., Li,Y., Chen,Y., Tuo,Y., Chen,D.,
            Yu,H., Zhang,J., Wang,F., Pang,X., Xiao,Z., Lan,Q. and Wang,Y.
  TITLE     PRMT6 facilitates EZH2 protein stability by inhibiting
            TRAF6-mediated ubiquitination degradation to promote glioblastoma
            cell invasion and migration
  JOURNAL   Cell Death Dis 15 (7), 524 (2024)
   PUBMED   39043634
  REMARK    GeneRIF: PRMT6 facilitates EZH2 protein stability by inhibiting
            TRAF6-mediated ubiquitination degradation to promote glioblastoma
            cell invasion and migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7885)
  AUTHORS   Matsui,S., Ri,C., Bolanos,L.C., Choi,K., Shibamiya,A., Ishii,A.,
            Takaishi,K., Oshima-Hasegawa,N., Tsukamoto,S., Takeda,Y.,
            Mimura,N., Yoshimi,A., Yokote,K., Starczynowski,D.T., Sakaida,E.
            and Muto,T.
  TITLE     Metabolic reprogramming regulated by TRAF6 contributes to the
            leukemia progression
  JOURNAL   Leukemia 38 (5), 1032-1045 (2024)
   PUBMED   38609495
  REMARK    GeneRIF: Metabolic reprogramming regulated by TRAF6 contributes to
            the leukemia progression.
REFERENCE   5  (bases 1 to 7885)
  AUTHORS   Ling,L. and Goeddel,D.V.
  TITLE     T6BP, a TRAF6-interacting protein involved in IL-1 signaling
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9567-9572 (2000)
   PUBMED   10920205
REFERENCE   6  (bases 1 to 7885)
  AUTHORS   Wong,B.R., Josien,R., Lee,S.Y., Vologodskaia,M., Steinman,R.M. and
            Choi,Y.
  TITLE     The TRAF family of signal transducers mediates NF-kappaB activation
            by the TRANCE receptor
  JOURNAL   J Biol Chem 273 (43), 28355-28359 (1998)
   PUBMED   9774460
REFERENCE   7  (bases 1 to 7885)
  AUTHORS   Deacon,K. and Blank,J.L.
  TITLE     Characterization of the mitogen-activated protein kinase kinase 4
            (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated
            by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not
            cause activation of p38 kinase in vivo
  JOURNAL   J Biol Chem 272 (22), 14489-14496 (1997)
   PUBMED   9162092
REFERENCE   8  (bases 1 to 7885)
  AUTHORS   Malinin,N.L., Boldin,M.P., Kovalenko,A.V. and Wallach,D.
  TITLE     MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95
            and IL-1
  JOURNAL   Nature 385 (6616), 540-544 (1997)
   PUBMED   9020361
REFERENCE   9  (bases 1 to 7885)
  AUTHORS   Ishida,T., Mizushima,Si., Azuma,S., Kobayashi,N., Tojo,T.,
            Suzuki,K., Aizawa,S., Watanabe,T., Mosialos,G., Kieff,E.,
            Yamamoto,T. and Inoue,J.
  TITLE     Identification of TRAF6, a novel tumor necrosis factor
            receptor-associated factor protein that mediates signaling from an
            amino-terminal domain of the CD40 cytoplasmic region
  JOURNAL   J Biol Chem 271 (46), 28745-28748 (1996)
   PUBMED   8910514
REFERENCE   10 (bases 1 to 7885)
  AUTHORS   Cao,Z., Xiong,J., Takeuchi,M., Kurama,T. and Goeddel,D.V.
  TITLE     TRAF6 is a signal transducer for interleukin-1
  JOURNAL   Nature 383 (6599), 443-446 (1996)
   PUBMED   8837778
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292978.1, AC009656.11 and
            BQ187062.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004620.3.
            
            Summary: The protein encoded by this gene is a member of the TNF
            receptor associated factor (TRAF) protein family. TRAF proteins are
            associated with, and mediate signal transduction from, members of
            the TNF receptor superfamily. This protein has an amino terminal
            RING domain which is followed by four zinc-finger motifs, a central
            coiled-coil region and a highly conserved carboxyl terminal domain,
            known as the TRAF-C domain and mediates signaling from members of
            the TNF receptor superfamily as well as the Toll/IL-1 family.
            Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have
            been shown to be mediated by this protein. This protein also
            interacts with various protein kinases including IRAK1/IRAK, SRC
            and PKCzeta, which provides a link between distinct signaling
            pathways. This protein functions as a signal transducer in the
            NF-kappaB pathway that activates IkappaB kinase (IKK) in response
            to proinflammatory cytokines. The interaction of this protein with
            UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating
            enzymes catalyzing the formation of polyubiquitin chains, has been
            found to be required for IKK activation by this protein. This
            protein also interacts with the transforming growth factor (TGF)
            beta receptor complex and is required for Smad-independent
            activation of the JNK and p38 kinases. The protein encoded by this
            gene is a key molecule in antiviral innate and antigen-specific
            immune responses. [provided by RefSeq, Nov 2021].
            
            Transcript Variant: This variant (2) lacks a segment in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2278096.1,
                                           SRR18074967.1910556.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000526995.6/ ENSP00000433623.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2104              AK292978.1         1-2104
            2105-7326           AC009656.11        97083-102304        c
            7327-7885           BQ187062.1         1-559
FEATURES             Location/Qualifiers
     source          1..7885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p12"
     gene            1..7885
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /note="TNF receptor associated factor 6"
                     /db_xref="GeneID:7189"
                     /db_xref="HGNC:HGNC:12036"
                     /db_xref="MIM:602355"
     exon            1..225
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /inference="alignment:Splign:2.1.0"
     exon            226..543
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1816
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /EC_number="2.3.2.27"
                     /note="RING finger protein 85; interleukin-1 signal
                     transducer; E3 ubiquitin-protein ligase TRAF6; TNF
                     receptor-associated factor 6, E3 ubiquitin protein ligase;
                     RING-type E3 ubiquitin transferase TRAF6"
                     /codon_start=1
                     /product="TNF receptor-associated factor 6"
                     /protein_id="NP_004611.1"
                     /db_xref="CCDS:CCDS7901.1"
                     /db_xref="GeneID:7189"
                     /db_xref="HGNC:HGNC:12036"
                     /db_xref="MIM:602355"
                     /translation="MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGN
                     LSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAG
                     HKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALM
                     DCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYC
                     NTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQA
                     VHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTI
                     RTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMR
                     LHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIM
                     DAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSL
                     RREGFQPRSTDAGV"
     exon            544..694
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /inference="alignment:Splign:2.1.0"
     exon            695..853
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /inference="alignment:Splign:2.1.0"
     exon            854..925
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1003
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..7885
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3586..3591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /note="hexamer: AATAAT"
     polyA_site      3611
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /note="major polyA site"
     regulatory      7870..7875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /note="hexamer: AATATA"
     polyA_site      7885
                     /gene="TRAF6"
                     /gene_synonym="MGC:3310; RNF85"
                     /note="major polyA site"
ORIGIN      
        1 agcagagaag gcggaagcag tggcgtccgc agctggggct tggcctgcgg gcggccagcg
       61 aaggtggcga aggctcccac tggatccaga gtttgccgtc caagcagcct cgtctcggcg
      121 cgcagtgtct gtgtccgtcc tctaccagcg ccttggctga gcggagtcgt gcggttggtg
      181 ggggagccct gccctcctgg ttcggcctcc ccgcgcacta gaacgagcaa gtgataatca
      241 agttactatg agtctgctaa actgtgaaaa cagctgtgga tccagccagt ctgaaagtga
      301 ctgctgtgtg gccatggcca gctcctgtag cgctgtaaca aaagatgata gtgtgggtgg
      361 aactgccagc acggggaacc tctccagctc atttatggag gagatccagg gatatgatgt
      421 agagtttgac ccacccctgg aaagcaagta tgaatgcccc atctgcttga tggcattacg
      481 agaagcagtg caaacgccat gcggccatag gttctgcaaa gcctgcatca taaaatcaat
      541 aagggatgca ggtcacaaat gtccagttga caatgaaata ctgctggaaa atcaactatt
      601 tccagacaat tttgcaaaac gtgagattct ttctctgatg gtgaaatgtc caaatgaagg
      661 ttgtttgcac aagatggaac tgagacatct tgaggatcat caagcacatt gtgagtttgc
      721 tcttatggat tgtccccaat gccagcgtcc cttccaaaaa ttccatatta atattcacat
      781 tctgaaggat tgtccaagga gacaggtttc ttgtgacaac tgtgctgcat caatggcatt
      841 tgaagataaa gagatccatg accagaactg tcctttggca aatgtcatct gtgaatactg
      901 caatactata ctcatcagag aacagatgcc taatcattat gatctagact gccctacagc
      961 cccaattcca tgcacattca gtacttttgg ttgccatgaa aagatgcaga ggaatcactt
     1021 ggcacgccac ctacaagaga acacccagtc acacatgaga atgttggccc aggctgttca
     1081 tagtttgagc gttatacccg actctgggta tatctcagag gtccggaatt tccaggaaac
     1141 tattcaccag ttagagggtc gccttgtaag acaagaccat caaatccggg agctgactgc
     1201 taaaatggaa actcagagta tgtatgtaag tgagctcaaa cgaaccattc gaacccttga
     1261 ggacaaagtt gctgaaatcg aagcacagca gtgcaatgga atttatattt ggaagattgg
     1321 caactttgga atgcatttga aatgtcaaga agaggagaaa cctgttgtga ttcatagccc
     1381 tggattctac actggcaaac ccgggtacaa actgtgcatg cgcttgcacc ttcagttacc
     1441 gactgctcag cgctgtgcaa actatatatc cctttttgtc cacacaatgc aaggagaata
     1501 tgacagccac ctcccttggc ccttccaggg tacaatacgc cttacaattc ttgatcagtc
     1561 tgaagcacct gtaaggcaaa accacgaaga gataatggat gccaaaccag agctgcttgc
     1621 tttccagcga cccacaatcc cacggaaccc aaaaggtttt ggctatgtaa cttttatgca
     1681 tctggaagcc ctaagacaaa gaactttcat taaggatgac acattattag tgcgctgtga
     1741 ggtctccacc cgctttgaca tgggtagcct tcggagggag ggttttcagc cacgaagtac
     1801 tgatgcaggg gtatagcttg ccctcacttg ctcaaaaaca actacctgga gaaaacagtg
     1861 cctttccttg ccctgttctc aataacatgc aaacaaacaa gccacgggaa atatgtaata
     1921 tctactagtg agtgttgtta gagaggtcac ttactatttc ttcctgttac aaatgatctg
     1981 aggcagtttt ttcctgggaa tccacacgtt ccatgctttt tcagaaatgt taggcctgaa
     2041 gtgcctgtgg catgttgcag cagctatttt gccagttagt atacctcttt gttgtacttt
     2101 cttgggcttt tgctctggtg tattttattg tcagaaagtc cagactcaag agtactaaac
     2161 ttttaataat aatggatttt ccttaaaact tcagtctttt tgtagtatta tatgtaatat
     2221 attaaaagtg aaaatcacta ccgccttgtg ctagtgccct cgagaagagt tattgctcta
     2281 gaaagttgag ttctcatttt tttaacctgt tatagatttc agaggatttg aaccataatc
     2341 cttggaaaac ttaagttctc attcacccca gtttttcctc caggttgtta ctaaggatat
     2401 tcagggatga gtttaaaccc taaatataac cttaattatt tagtgtaaac atgtctgttg
     2461 aataatactt gtttaagtgt tccttctgcc ttgcttactt atttccttga ggttacgaag
     2521 tagcatcttc cccagagttt ataatgctga gaaccacgtg gataccaact gctcattgtt
     2581 atgctatgta accctttttg tctattcagt gcagagtgaa tttcacagct ctgcatatgt
     2641 cttcatttgt ttaatgctta caagacagga gatgcacaca tacaatcagc aacataaaaa
     2701 ttaaaagtga cccaagtagt cagcgcatgt ggcatctcat tggtggtgac agaagctatg
     2761 tgagccagaa gttttcagct cttttgaata ccctctggtt tatttcgatt aaaaagaaca
     2821 aaattgattt cctaaaatca gaatttttta aaacttggga gatgattgga gatacctagg
     2881 aggtcaccaa actaggatta gaagtcacag tggttgtatc acaacttagc ttgagtatgt
     2941 tgctgtagcc taacaactgc aggttctgag aaggatcctg tagaatcctg gaagtaacca
     3001 gattttccta atagggagat gatttttttg tgtgccatca tgtatttgtt aaaggcctat
     3061 atatagatat aaaatatcgt ggaatctagt tctcagggag acccgcaact agtataagct
     3121 tataaaggat ctaaagatcc atccaccatt taaagttgtc tggtaatgag agatgacatt
     3181 gtatccccca gagaggccaa atcagagtcg ccagccagcg ttctagatca gccttaattt
     3241 caagagaaag ccaaggacct catctgcagg ggagtgtggt tttcagcccc agcgagtgtc
     3301 actttgaact ttccctttgc ttttttctct cttctccctc cccacccacc cttaggctcc
     3361 tgatctggtg agtttgttat ggagtgaaaa taaaagtcaa gcagagacct tgtttcccgt
     3421 gccaccatta gtaccacaag ctcatggcta gttaccacat tacttcctgg cagtttgtgt
     3481 ccctcagctg tgccttccaa ccagcgcctg agaatcactg cataccaccc tctaggtagg
     3541 gaaacctaca ctgctgctgt tcctgtgatt attttacaat gaataaataa ttgtcaagtt
     3601 ccatttaaaa actgaacagt agtatttttg tatttgcgta gaaaaagcct gaaggaaata
     3661 tactaaactt tttgttggct tattttcctt tgcgcttgct tatatttttt acattttcta
     3721 caataaatgt gtacttttat cggagaaaaa aattaaatgt tgccacaaaa catttaatct
     3781 ccacgccccc agctcaaaaa aggaaatgat atttaaaagc ttcctggtca gatttctatt
     3841 aaaagcactg gctgtgcatt agatacaaag aggagtcatt tcctgccttg gtgatactat
     3901 ttttttctac taactcaaga gtctttatta aaaaaaaaag ttgttttgcc taatttcagc
     3961 ttttagcaag cttcccatct gtaaaatgat ttggaccaga tatttctaga gtcccctcca
     4021 gccataacat tctgtctcaa attaagttcc aaccagcaga acaatgacaa tacttaggaa
     4081 agtattttgc cagtataaaa tgtctttaac ttactctttg ctgacactga tactttcctc
     4141 taatttagtg tctatcagct gggtcacatc ttaagtaaaa tgagcaattt taacccccaa
     4201 catttggcat tttgtcataa accagccagt tattttatgc tggtcattca tcttgactac
     4261 aaagtagaat agtcaagctg tcattccaaa tagaaaactt tttacttcaa tcagaattaa
     4321 gccttaacct ggaaagttgg tttcttcctt acattttccc aatctcctac tctattctta
     4381 aacatgctag tttcactcag ttgggtatac aagcctttgg gctttatgtt gtatgttact
     4441 aaccaccttt taccatattt atcttttggc atcattctgg gacattgcta aattaaaaaa
     4501 gaaattgttt ccactttttt ctggagatgt tcaactaaag gttgttttgt tttgtttttt
     4561 gttttgagac agtctcaccc tgacgctcag gctggagtgc agtggtgcaa cctcggctca
     4621 ctgcaacctc cacctcccgg gctcaagcca ttctcctgcc tcagcctccc aagcagctgg
     4681 gattacaggc acccgccacc acgcccagct aatttttttg tattttgagt agagaccggg
     4741 tttcaccata ttggccagtc tcgtctggaa ctcctgacct cagatgatcc gcccgcctca
     4801 gcctcccaaa gtgctgggat tacaggcatg agccaccacg cccagcgtcc aacccactgt
     4861 tggatgaaac ttgctgcacg tcatacattt tgctgttggc aaacaagtct gaatgttgat
     4921 ttgaagtttg gtagtttatt actatctatt ggcagcaaag actgtttatt ggtatactac
     4981 aatatgattt aacttttatt ttggggataa atagtagaaa aaagtgaaac agaatgaagg
     5041 caggtgtttt ttattctaat gatggaataa tacagagata ctggacgatc tctagcagtt
     5101 aattattgtg acccatataa aattatacag gtcacagtat aattctctat taccgttttt
     5161 acaccagtaa gtcttagata aactaagcat gcttatgaat tatgtataca gttagaatgc
     5221 attattttta cagaggaaca attgcttgta tgtactaaca ctgttctctt ggcttgcctc
     5281 aagttctact cattatttta tataaaatac tattaggctg ggcacggtgg ctcacgccta
     5341 taatcccagc actttgggag gtggaggctg gcggattact tgaagccagg agttcgagac
     5401 cagcctggcc aaaatggtga aaccccatct ctataaaaat acaaaaatta gccaggtgtc
     5461 atgatacatg cctgtaatcc cagcttcttg ggaggctgag gcacgggaat cgcttgaacc
     5521 cgggaagcac aggttgcagt gagccaagat catgccactg cacccccagc ctgggtgaca
     5581 gagtgcaaca ctgtctcaca aaacaaaaca aaaacatcag attctgtttg tgatgcctag
     5641 ttgcttacaa cctaaacagt gcaatgcctt aaggaaatga aaaggagcca taagtagtca
     5701 tttatatttt tattttgaag tgtgcttttt ctaaactccc agattgacat gatggactgt
     5761 aagttagttt ctctgtttct gtctttgtgc ctgtagagtg tacttggcac ttacaaattc
     5821 ccagtatcca gaaagatgat ctgatgaaat caaattggat ggatcttggc agactgtgac
     5881 actcaattac agccttcact ttcagtcaaa aacggacact tggcaaggag gtgcctggtt
     5941 gtttcactaa atgtcacttg tgtgtgtaat attttaaagc tttttcccca caggaaattc
     6001 gggtcataaa atcctgaaaa ataattctag gtgggaaaag cattttagga aatgagagat
     6061 gtggtgctgc ttttcttctc tcagagtgct ttctcagcag gacactagcc ctgcctttaa
     6121 gatggggaag ttggggcatg tgcctctgct cttactgtct gcagctctga aggtaggtgc
     6181 tgtcccactc ggacaatcgc ccaagcagca gtgaccatag ttctcttcta tgcaagtccc
     6241 caggagaagg taaactgtgt ggaatgggga tgtgttctgg ttgctgctga atcccctctt
     6301 cttaccacag tgcctggcac gttgcacaca ctcaaatacg taataatgaa catttattga
     6361 aagcagcagt tgaagctgac caatttctgg taccttgtca tgtaaatttt agatggtaag
     6421 gcgcagatgt tacttttttt gctttttttc ttcagcactt gatgaaattt cccaaacatg
     6481 cagaaatgtt gaaagacttg tatagtgaac atctacgacc tagaatctgc agtaatatta
     6541 tgttacattt gctttatcac ttgatagatg ttacttttaa tgagacttca agtttggttt
     6601 ctctaaacaa aatattctaa aataactgaa caactttaat caatttgtct taagttcttt
     6661 gggggaactt gggacatttg ctttgtaact ggaattgcag ccctcacgtt aagctaattt
     6721 taaactttgc aaatttgtta tgctgaattt cagtcttatt tattttgcct gaaggggtat
     6781 tttttgtaat ggatttattt gaaggtcctt gataaattgt gcagaatatt ctcgtgttct
     6841 ttttgcactt gataaattat ctaatttctg tggtgagaat gtaatttggg gcctattttg
     6901 tttatacaag cttccagaat tatgttctca gagggatgaa aaggtgtaat ttagcatata
     6961 ggtcactaaa ttaggagcta agacacattt tctcctgact gaccatgggt caatcagttt
     7021 tgtcttcgtg tccttttcct tgtaaagtag aaactagaat ttgaaattta aatattaaat
     7081 aatgggtaac attcattaat gtatgactct attaagaaag acactgtgaa tccagggagg
     7141 attctcataa ttctgtaaac tgtatgacaa gctgtggaat gaaatctgac ttttgaaaat
     7201 tgaaagacat ccagtggtct tatcacaaag cctgcttttc ctcagaactt aactattgcc
     7261 atggaatttg taagcagtta tcctaatcca tctggactct gaaaatgcat cctttatgag
     7321 agggagtgaa tgcaaagata agggtgggga aacactaatc atgaaaagaa tgaaaatcag
     7381 tgttcagttt taagagcagg ttgtattgaa ggaagggatt aaaggaatta tccagatttg
     7441 aggtggcaca tcttccacca ctccctgcac catcagcatg cacggagcgc ataaaacaag
     7501 ccctgctcct aatggcagtg aaacctcgga tggcctccat caggtcaata caactgaatt
     7561 gctgggctga cttaagattg aaggactcca ttttagtaag tagagaagtg tgacctttct
     7621 caacccaggt tgtgaatgtg gattcacact tatctcaaaa aggcacctgg agttttaact
     7681 ttatgtcatg tctcagtact ggttgcaagg tatgaccaaa agtgttcctt gaatggcacc
     7741 tttttgaata ttaatttaga agaaaacatg ccagactgac atacttaccc cctccgcact
     7801 gttactactt ccttaccagc cctatgtact gcatcaatgt ctacaagaaa gcactcttca
     7861 ttaaaatgaa atatatatat taaaa
//
