LOCUS       NM_001033910            3976 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens TNF receptor associated factor 5 (TRAF5), transcript
            variant 3, mRNA.
ACCESSION   NM_001033910
VERSION     NM_001033910.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3976)
  AUTHORS   Cheng,W.L., Chao,S.P., Zhao,F., Cai,H.H., Zeng,Z., Cao,J.L.,
            Jin,Z., Deng,K.Q., Hu,X., Wang,H. and Lu,Z.
  TITLE     Tumor necrosis factor receptor-associated factor 5 protects against
            intimal hyperplasia by regulation of macrophage polarization via
            directly targeting PPARgamma
  JOURNAL   Inflamm Res 73 (6), 929-943 (2024)
   PUBMED   38642079
  REMARK    GeneRIF: Tumor necrosis factor receptor-associated factor 5
            protects against intimal hyperplasia by regulation of macrophage
            polarization via directly targeting PPARgamma.
REFERENCE   2  (bases 1 to 3976)
  AUTHORS   Wu,G., Wu,F., Zhou,Y.Q., Lu,W., Hu,F.L. and Fan,X.
  TITLE     Silencing of TRAF5 enhances necroptosis in hepatocellular carcinoma
            by inhibiting LTBR-mediated NF-kappaB signaling
  JOURNAL   PeerJ 11, e15551 (2023)
   PUBMED   37366426
  REMARK    GeneRIF: Silencing of TRAF5 enhances necroptosis in hepatocellular
            carcinoma by inhibiting LTBR-mediated NF-kappaB signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3976)
  AUTHORS   Zhang,F., Luo,B.H., Wu,Q.H., Li,Q.L. and Yang,K.D.
  TITLE     LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation,
            migration and EMT of epithelial ovarian cancer by targeting
            miR-29a/b
  JOURNAL   Mol Med 28 (1), 2 (2022)
   PUBMED   34983361
  REMARK    GeneRIF: LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate
            proliferation, migration and EMT of epithelial ovarian cancer by
            targeting miR-29a/b.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3976)
  AUTHORS   Xu,S., Kong,J., Huang,L., Xie,H., Wang,F., Zhou,T., Zhang,X.,
            Yu,L., Xu,S. and Pan,F.
  TITLE     Single nucleotide polymorphisms of TRAF2 and TRAF5 gene in
            ankylosing spondylitis: a case-control study
  JOURNAL   Clin Exp Med 21 (4), 645-653 (2021)
   PUBMED   33997937
  REMARK    GeneRIF: Single nucleotide polymorphisms of TRAF2 and TRAF5 gene in
            ankylosing spondylitis: a case-control study.
REFERENCE   5  (bases 1 to 3976)
  AUTHORS   Xu,S., Gao,X., Ma,Y., Deng,J., Xu,S. and Pan,F.
  TITLE     Association of methylation level and transcript level in TRAF5 gene
            with ankylosing spondylitis: a case-control study
  JOURNAL   Genes Immun 22 (2), 101-107 (2021)
   PUBMED   34021268
  REMARK    GeneRIF: Association of methylation level and transcript level in
            TRAF5 gene with ankylosing spondylitis: a case-control study.
REFERENCE   6  (bases 1 to 3976)
  AUTHORS   Hsu,H., Solovyev,I., Colombero,A., Elliott,R., Kelley,M. and
            Boyle,W.J.
  TITLE     ATAR, a novel tumor necrosis factor receptor family member, signals
            through TRAF2 and TRAF5
  JOURNAL   J Biol Chem 272 (21), 13471-13474 (1997)
   PUBMED   9153189
REFERENCE   7  (bases 1 to 3976)
  AUTHORS   Tang,X.X., Pleasure,D.E. and Ikegaki,N.
  TITLE     cDNA cloning, chromosomal localization, and expression pattern of
            EPLG8, a new member of the EPLG gene family encoding ligands of
            EPH-related protein-tyrosine kinase receptors
  JOURNAL   Genomics 41 (1), 17-24 (1997)
   PUBMED   9126477
REFERENCE   8  (bases 1 to 3976)
  AUTHORS   Aizawa,S., Nakano,H., Ishida,T., Horie,R., Nagai,M., Ito,K.,
            Yagita,H., Okumura,K., Inoue,J. and Watanabe,T.
  TITLE     Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2
            are involved in CD30-mediated NFkappaB activation
  JOURNAL   J Biol Chem 272 (4), 2042-2045 (1997)
   PUBMED   8999898
REFERENCE   9  (bases 1 to 3976)
  AUTHORS   Ishida,T.K., Tojo,T., Aoki,T., Kobayashi,N., Ohishi,T.,
            Watanabe,T., Yamamoto,T. and Inoue,J.
  TITLE     TRAF5, a novel tumor necrosis factor receptor-associated factor
            family protein, mediates CD40 signaling
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9437-9442 (1996)
   PUBMED   8790348
REFERENCE   10 (bases 1 to 3976)
  AUTHORS   Nakano,H., Oshima,H., Chung,W., Williams-Abbott,L., Ware,C.F.,
            Yagita,H. and Okumura,K.
  TITLE     TRAF5, an activator of NF-kappaB and putative signal transducer for
            the lymphotoxin-beta receptor
  JOURNAL   J Biol Chem 271 (25), 14661-14664 (1996)
   PUBMED   8663299
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB290838.1, AB000509.1,
            U69108.1 and BU676629.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001033910.2.
            
            Summary: The scaffold protein encoded by this gene is a member of
            the tumor necrosis factor receptor-associated factor (TRAF) protein
            family and contains a meprin and TRAF homology (MATH) domain, a
            RING-type zinc finger, and two TRAF-type zinc fingers. TRAF
            proteins are associated with, and mediate signal transduction from
            members of the TNF receptor superfamily. This protein is one of the
            components of a multiple protein complex which binds to tumor
            necrosis factor (TNF) receptor cytoplasmic domains and mediates
            TNF-induced activation. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice junction compared to variant 4. The resulting isoform (b)
            has the same N- and C-termini but is shorter compared to isoform a.
            Variants 1, 2, and 3 all encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000509.1, SRR14038191.1806335.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261464.10/ ENSP00000261464.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               DB290838.1         28-561
            535-2188            AB000509.1         531-2184
            2189-2780           U69108.1           2072-2663
            2781-3971           AB000509.1         2777-3967
            3972-3976           BU676629.1         13-17               c
FEATURES             Location/Qualifiers
     source          1..3976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..3976
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /note="TNF receptor associated factor 5"
                     /db_xref="GeneID:7188"
                     /db_xref="HGNC:HGNC:12035"
                     /db_xref="MIM:602356"
     exon            1..57
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /inference="alignment:Splign:2.1.0"
     exon            58..276
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1732
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /note="isoform b is encoded by transcript variant 3; RING
                     finger protein 84"
                     /codon_start=1
                     /product="TNF receptor-associated factor 5 isoform b"
                     /protein_id="NP_001029082.1"
                     /db_xref="CCDS:CCDS1497.1"
                     /db_xref="GeneID:7188"
                     /db_xref="HGNC:HGNC:12035"
                     /db_xref="MIM:602356"
                     /translation="MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYK
                     CAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKRE
                     VLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSAS
                     CQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEA
                     EQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKES
                     KIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVN
                     QQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEE
                     RFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNG
                     DGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSF
                     KRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL"
     exon            277..334
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /inference="alignment:Splign:2.1.0"
     exon            335..436
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /inference="alignment:Splign:2.1.0"
     exon            437..601
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /inference="alignment:Splign:2.1.0"
     exon            602..679
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /inference="alignment:Splign:2.1.0"
     exon            680..754
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /inference="alignment:Splign:2.1.0"
     exon            755..847
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /inference="alignment:Splign:2.1.0"
     exon            848..988
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1157
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..3976
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3950..3955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /note="hexamer: AGTAAA"
     polyA_site      3976
                     /gene="TRAF5"
                     /gene_synonym="MGC:39780; RNF84"
                     /note="major polyA site"
ORIGIN      
        1 aggagcagca gccgcgcctg cagaccggcc tcgcggagcc cgcgcgccga gccccacaat
       61 ggcttattca gaagagcata aaggtatgcc ctgtggtttc atccgccaga attccggcaa
      121 ctccatttcc ttggactttg agcccagtat agagtaccag tttgtggagc ggttggaaga
      181 gcgctacaaa tgtgccttct gccactcggt gcttcacaac ccccaccaga caggatgtgg
      241 gcaccgcttc tgccagcact gcatcctgtc cctgagagaa ttaaacacag tgccaatctg
      301 ccctgtagat aaagaggtca tcaaatctca ggaggttttt aaagacaatt gttgcaaaag
      361 agaagtcctc aacttatatg tatattgcag caatgctcct ggatgtaatg ccaaggttat
      421 tctgggccgg taccaggatc accttcagca gtgcttattt caacctgtgc agtgttctaa
      481 tgagaagtgc cgggagccag tcctacggaa agacctgaaa gagcatttga gtgcatcctg
      541 tcagtttcga aaggaaaaat gcctttattg caaaaaggat gtggtagtca tcaatctaca
      601 gaatcatgag gaaaacttgt gtcctgaata cccagtattt tgtcccaaca attgtgcgaa
      661 gattattcta aaaactgagg tagatgaaca cctggctgta tgtcctgaag ctgagcaaga
      721 ctgtcctttt aagcactatg gctgtgctgt aacggataaa cggaggaacc tgcagcaaca
      781 tgagcattca gccttacggg agcacatgcg tttggtttta gaaaagaatg tccaattaga
      841 agaacagatt tctgacttac acaagagcct agaacagaaa gaaagtaaaa tccagcagct
      901 agcagaaact ataaagaaac ttgaaaagga gttcaagcag tttgcacagt tgtttggcaa
      961 aaatggaagc ttcctcccaa acatccaggt ttttgccagt cacattgaca agtcagcttg
     1021 gctagaagct caagtgcatc aattattaca aatggttaac cagcaacaaa ataaatttga
     1081 cctgagacct ttgatggaag cagttgatac agtgaaacag aaaattaccc tgctagaaaa
     1141 caatgatcaa agattagccg ttttagaaga ggaaactaac aaacatgata cccacattaa
     1201 tattcataaa gcacagctga gtaaaaatga agagcgattt aaactgctgg agggtacttg
     1261 ctataatgga aagctcattt ggaaggtgac agattacaag atgaagaaga gagaggcggt
     1321 ggatgggcac acagtgtcca tcttcagcca gtccttctac accagccgct gtggctaccg
     1381 gctctgtgct agagcatacc tgaatgggga tgggtcaggg agggggtcac acctgtccct
     1441 atactttgtg gtcatgcgag gagagtttga ctcactgttg cagtggccat tcaggcagag
     1501 ggtgaccctg atgcttctgg accagagtgg caaaaagaac attatggaga ccttcaaacc
     1561 tgaccccaat agcagcagct ttaaaagacc tgatggggag atgaacattg catctggctg
     1621 tccccgcttt gtggctcatt ctgttttgga gaatgccaag aacgcctaca ttaaagatga
     1681 cactctgttc ttgaaagtgg ccgtggactt aactgacctg gaggatctct agtcactgtt
     1741 atggggtgat aagaggactt cttggggcca gaactgtgga ggagagcaca tttgattatc
     1801 atattgacct ggatttagac tcaaagcaca tttgtatttg cctttttcct taacgtttga
     1861 agtcagttta aaacttctga agtgctgtct ttttacattt tactctgtcc cagtttgaaa
     1921 cttaaaactc ttagaatatt ctcttattat ttatattttt atatttcttg aaagatggta
     1981 agtttcttga agtttttggg gcgtttctct tttactggtg cttagcgcag tgtctcgggc
     2041 actctaaata ttgagtgtta tggaggacac agaggtagca gaatcccagt tgaaaatgtt
     2101 ttgatatttt attgtttggc ctattgattc tagacctggc cttaagtctg caaaagccat
     2161 ctttataagg taggctgttc cagttaagta gtgggtgatg tagttacaaa gataatatgc
     2221 tcagtttgga cctttttttc agttaaatgc taaatatatg aaaattacta tacctctaag
     2281 tattttcatg aaattcacca gcagtttgca agcacagttt tgcaaggctg cataagaact
     2341 ggtgaatggg gtaagcattt tcattcttcc tgctgaagta aagcagaaag tactgcatag
     2401 tatatgagat atagccagct agctaaagtt cagattttgt taggttcaac cctatgaaaa
     2461 aaactatttt cataggtcaa aaatggtaaa aaattagcag tttcataaga ttcaaccaaa
     2521 taaatatata tatacacaca cacatacata tacacctata tatgtgtgta tacaaacagt
     2581 tcgaatgtat tttggtgaca gtaataaatc aatgtgagga tggatagaat ttagtatatg
     2641 atagagaaaa tgtcataaat ggataaaagg aatttacaac ttgaggagaa aacctttaca
     2701 atttcctatg ggtgtcagaa gtactctcag cgaaaactga tggctaaaac agtatctact
     2761 attctctgat aacttttttt ttgagacaga gtttcattgt cacccaggct ggagtacagt
     2821 ggcatgatct cagctcactg caaactctgc ctcccgaatt caagtgattc tcctgcctca
     2881 gcctcctgag tagctgggat tacaggcgcc cgtcaccaca cccaggtaat ttttgtattt
     2941 ttagtagaga cggagttttg ccatgttggc caagctgatc tcaaactcct gacctcaagt
     3001 gatctgcccg cctcggcctc ccaaagtgct gagattacag gcatgaccca ccgcgtcaag
     3061 cctctgacaa ctattgaatt tgtaagctgc tatgcaaatg ggcatttata taaacttgtg
     3121 atgtttcttg tcagaattct gagtactctg tgaagaacag aaatgatcat attcttatgc
     3181 atctatctgt atgggtctga aggtgtatat acaaactgag atgagtcctt atgactcttg
     3241 ataagcctga gtttaacaac aacaaaaatg ccaagttgtc ctgagccctt ctgcgttgtt
     3301 atgccacttc cctactgctc atatgcacgc tggctcccct gggcacgcaa ggatgagtat
     3361 gggccatggg cccctgtaga gctgcttacc tggtgatgac catgcacctt acaatttctg
     3421 aacagttaac cctatagaag catgctttat atgagtgtct tctgggaaga ggaaccttct
     3481 taatctcttc tgtgggattt tcaaaatgct aaagactcac actgcagcaa tcatcccaga
     3541 tgattaaatt caaagaaata ggttcacaac aggaatatac tgaagaacta gagtgtcact
     3601 gctggtgaac tgtggcacgg ttgctcaaca catcacctcg gacaaattca ggaagcattt
     3661 ctttagccca caagtccaga cccaggtgct ctgtatgttt gtttttaata ttcatcatat
     3721 ccaagttcac tctgtcttcc tgagcagtgg aagatcatat tgctgtaact tcttttaagt
     3781 agttgatgtg gaaaacattt taaagtgaat ttgtcaaaat gctggttttg tgttttatcc
     3841 aacttttgtg catatatata aagtatgtca tggcatggtt tgcttaggag ttcagagttc
     3901 cttcatcatc gaaatagtga ttaagtgatc ccagaacaag gaatactaga gtaaaaagca
     3961 cctctttttc acaaaa
//
