LOCUS       NM_004295               2894 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens TNF receptor associated factor 4 (TRAF4), mRNA.
ACCESSION   NM_004295
VERSION     NM_004295.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2894)
  AUTHORS   Nie,X.M., Dong,D.F., Lin,J.F., Wu,B.Y. and Cai,G.
  TITLE     [TRAF4 promotes lung cancer development by activating tyrosine
            kinase of EGFR]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 46 (10), 968-978 (2024)
   PUBMED   39414598
  REMARK    GeneRIF: [TRAF4 promotes lung cancer development by activating
            tyrosine kinase of EGFR].
REFERENCE   2  (bases 1 to 2894)
  AUTHORS   Liao,J., Qing,X., Li,X., Gan,Y., Wang,R., Han,S., Li,W. and Song,W.
  TITLE     TRAF4 regulates ubiquitination-modulated survivin turnover and
            confers radioresistance
  JOURNAL   Int J Biol Sci 20 (1), 182-199 (2024)
   PUBMED   38164179
  REMARK    GeneRIF: TRAF4 regulates ubiquitination-modulated survivin turnover
            and confers radioresistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2894)
  AUTHORS   Gu,Y., Zhong,K., Peng,L., Ding,W. and Zeng,X.
  TITLE     TRAF4 Silencing Induces Cell Apoptosis and Improves Retinoic Acid
            Sensitivity in Human Neuroblastoma
  JOURNAL   Neurochem Res 48 (7), 2116-2128 (2023)
   PUBMED   36795185
  REMARK    GeneRIF: TRAF4 Silencing Induces Cell Apoptosis and Improves
            Retinoic Acid Sensitivity in Human Neuroblastoma.
REFERENCE   4  (bases 1 to 2894)
  AUTHORS   Dong,X., Li,X., Gan,Y., Ding,J., Wei,B., Zhou,L., Cui,W. and Li,W.
  TITLE     TRAF4-mediated ubiquitination-dependent activation of JNK/Bcl-xL
            drives radioresistance
  JOURNAL   Cell Death Dis 14 (2), 102 (2023)
   PUBMED   36765039
  REMARK    GeneRIF: TRAF4-mediated ubiquitination-dependent activation of
            JNK/Bcl-xL drives radioresistance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2894)
  AUTHORS   Wang,Y., Luo,X., Wu,N., Liao,Q. and Wang,J.
  TITLE     USP7 mediates TRAF4 deubiquitination to facilitate the malignant
            phenotype of ovarian cancer via the RSK4/PI3K/AKT axis
  JOURNAL   J Cancer Res Ther 19 (1), 97-107 (2023)
   PUBMED   37006049
  REMARK    GeneRIF: USP7 mediates TRAF4 deubiquitination to facilitate the
            malignant phenotype of ovarian cancer via the RSK4/PI3K/AKT axis.
REFERENCE   6  (bases 1 to 2894)
  AUTHORS   Ye,X., Mehlen,P., Rabizadeh,S., VanArsdale,T., Zhang,H., Shin,H.,
            Wang,J.J., Leo,E., Zapata,J., Hauser,C.A., Reed,J.C. and
            Bredesen,D.E.
  TITLE     TRAF family proteins interact with the common neurotrophin receptor
            and modulate apoptosis induction
  JOURNAL   J Biol Chem 274 (42), 30202-30208 (1999)
   PUBMED   10514511
REFERENCE   7  (bases 1 to 2894)
  AUTHORS   Krajewska,M., Krajewski,S., Zapata,J.M., Van Arsdale,T.,
            Gascoyne,R.D., Berern,K., McFadden,D., Shabaik,A., Hugh,J.,
            Reynolds,A., Clevenger,C.V. and Reed,J.C.
  TITLE     TRAF-4 expression in epithelial progenitor cells. Analysis in
            normal adult, fetal, and tumor tissues
  JOURNAL   Am J Pathol 152 (6), 1549-1561 (1998)
   PUBMED   9626059
REFERENCE   8  (bases 1 to 2894)
  AUTHORS   Masson,R., Regnier,C.H., Chenard,M.P., Wendling,C., Mattei,M.G.,
            Tomasetto,C. and Rio,M.C.
  TITLE     Tumor necrosis factor receptor associated factor 4 (TRAF4)
            expression pattern during mouse development
  JOURNAL   Mech Dev 71 (1-2), 187-191 (1998)
   PUBMED   9507120
REFERENCE   9  (bases 1 to 2894)
  AUTHORS   Regnier,C.H., Tomasetto,C., Moog-Lutz,C., Chenard,M.P.,
            Wendling,C., Basset,P. and Rio,M.C.
  TITLE     Presence of a new conserved domain in CART1, a novel member of the
            tumor necrosis factor receptor-associated protein family, which is
            expressed in breast carcinoma
  JOURNAL   J Biol Chem 270 (43), 25715-25721 (1995)
   PUBMED   7592751
REFERENCE   10 (bases 1 to 2894)
  AUTHORS   Tomasetto,C., Regnier,C., Moog-Lutz,C., Mattei,M.G., Chenard,M.P.,
            Lidereau,R., Basset,P. and Rio,M.C.
  TITLE     Identification of four novel human genes amplified and
            overexpressed in breast carcinoma and localized to the q11-q21.3
            region of chromosome 17
  JOURNAL   Genomics 28 (3), 367-376 (1995)
   PUBMED   7490069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR990949.1, BC001769.1 and
            AC010761.10.
            
            On Nov 22, 2018 this sequence version replaced NM_004295.3.
            
            Summary: This gene encodes a member of the TNF receptor associated
            factor (TRAF) family. TRAF proteins are associated with, and
            mediate signal transduction from members of the TNF receptor
            superfamily. The encoded protein has been shown to interact with
            neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR
            induced cell death and NF-kappa B activation. This protein has been
            found to bind to p47phox, a cytosolic regulatory factor included in
            a multi-protein complex known as NAD(P)H oxidase. This protein
            thus, is thought to be involved in the oxidative activation of
            MAPK8/JNK. Alternatively spliced transcript variants have been
            observed but the full-length nature of only one has been
            determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.752357.1, BC001769.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262395.10/ ENSP00000262395.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CR990949.1         28-37
            11-2018             BC001769.1         1-2008
            2019-2894           AC010761.10        102233-103108
FEATURES             Location/Qualifiers
     source          1..2894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..2894
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /note="TNF receptor associated factor 4"
                     /db_xref="GeneID:9618"
                     /db_xref="HGNC:HGNC:12034"
                     /db_xref="MIM:602464"
     exon            1..245
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1515
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /EC_number="2.3.2.27"
                     /note="tumor necrosis receptor-associated factor 4A;
                     malignant 62; cysteine-rich domain associated with ring
                     and TRAF domain; MLN 62; RING finger protein 83;
                     metastatic lymph node gene 62 protein; cysteine-rich
                     domain associated with RING and Traf domains protein 1"
                     /codon_start=1
                     /product="TNF receptor-associated factor 4"
                     /protein_id="NP_004286.2"
                     /db_xref="CCDS:CCDS11243.1"
                     /db_xref="GeneID:9618"
                     /db_xref="HGNC:HGNC:12034"
                     /db_xref="MIM:602464"
                     /translation="MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQ
                     EFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGH
                     LNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMC
                     PQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLP
                     VACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKP
                     HLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFS
                     PAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLD
                     QSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNY
                     VRDDAVFIRAAVELPRKILS"
     exon            246..297
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /inference="alignment:Splign:2.1.0"
     exon            298..402
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /inference="alignment:Splign:2.1.0"
     exon            403..564
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /inference="alignment:Splign:2.1.0"
     exon            565..726
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /inference="alignment:Splign:2.1.0"
     exon            727..882
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /inference="alignment:Splign:2.1.0"
     exon            883..2894
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1993..1998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /note="hexamer: AATAAA"
     polyA_site      2018
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /note="major polyA site"
     regulatory      2875..2880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
                     /note="hexamer: ATTAAA"
     polyA_site      2894
                     /gene="TRAF4"
                     /gene_synonym="CART1; MLN62; RNF83"
ORIGIN      
        1 agtcggcgcc gcccggagcc gggagcgccg ctccagcgag gcgcgggctg tggggccgcc
       61 gcgtgcctgg ccccgctcgc ccgtgccggc cgctcgcccg ccatgcctgg cttcgactac
      121 aagttcctgg agaagcccaa gcgacggctg ctgtgcccac tgtgcgggaa gcccatgcgc
      181 gagcctgtgc aggtttccac ctgcggccac cgtttctgcg atacctgcct gcaggagttc
      241 ctcagtgaag gagtcttcaa gtgccctgag gaccagcttc ctctggacta tgccaagatc
      301 tacccagacc cggagctgga agtacaagta ttgggcctgc ctatccgctg catccacagt
      361 gaggagggct gccgctggag tgggccacta cgtcatctac agggccacct gaatacctgc
      421 agcttcaatg tcattccctg ccctaatcgc tgccccatga agctgagccg ccgtgatcta
      481 cctgcacact tgcagcatga ctgccccaag cggcgcctca agtgcgagtt ttgtggctgt
      541 gacttcagtg gggaggccta tgagagccat gagggtatgt gcccccagga gagtgtctac
      601 tgtgagaata agtgtggtgc ccgcatgatg cggcggctgc tggcccagca tgccacctct
      661 gagtgcccca agcgcactca gccctgcacc tactgcacta aggagttcgt ctttgacacc
      721 atccagagcc accagtacca gtgcccaagg ctgcctgttg cctgccccaa ccaatgtggt
      781 gtgggcactg tggctcggga ggacctgcca ggccatctga aggacagctg taacaccgcc
      841 ctggtgctct gcccattcaa agactccggc tgcaagcaca ggtgccctaa gctggcaatg
      901 gcacggcatg tggaggagag tgtgaagcca catctggcca tgatgtgtgc cctggtgagc
      961 cggcaacggc aggagctgca ggagcttcgg cgagagctgg aggagctatc agtgggcagt
     1021 gatggcgtgc tcatctggaa gattggcagc tatggacggc ggctacagga ggccaaggcc
     1081 aagcccaacc ttgagtgctt cagcccagcc ttctacacac ataagtatgg ttacaagctg
     1141 caggtgtctg cattcctcaa tggcaatggc agtggtgagg gcacacacct ctcactgtac
     1201 attcgtgtgc tgcctggtgc ctttgacaat ctccttgagt ggccctttgc ccgccgtgtc
     1261 accttctccc tgctggatca gagcgaccct gggctggcta aaccacagca cgtcactgag
     1321 accttccacc ccgacccaaa ctggaagaat ttccagaagc caggcacgtg gcggggctcc
     1381 ctggatgaga gttctctggg ctttggttat cccaagttca tctcccacca ggacattcga
     1441 aagcgaaact atgtgcggga tgatgcagtc ttcatccgtg ctgctgttga actgccccgg
     1501 aagatcctca gctgagtgca ggtggggttc gaggggaaag gacgatgggg catgacctca
     1561 gtcaggcact ggctgaactt ggagaggggg ccggaccccc gtcagctgct tctgctgcct
     1621 aggttctgtt accccatcct ccctccccca gccaccaccc tcaggtgcct ccaattggtg
     1681 cttcagccct ggcccctgtg gggaacaggt cttggggtca tgaagggctg gaaacaagtg
     1741 accccagggc ctgtctccct tcttgggtag ggcagacatg ccttggtgcc ggtcacactc
     1801 tacacggact gaggtgcctg ctcaggtgct atgtcccaag agccataagg gggtgggaat
     1861 tggggaggga gaaagggtag ttcaaagagt ctgtcttgag atctgatttt ttcccccttt
     1921 acctagctgt gccccctctg gttatttatt tccttagtgc caggagggca cagcagggga
     1981 gccctgattt ttaataaatc cggaattgta tttattaatt tgcttccagc ctgacttacc
     2041 tgggttggtt aggtccctgg gaggctcaac caaactgaag gcaaagaaag gaccagtcag
     2101 agaagggccg ctgcctgggt ctggccccag gatccagctt acctgctggc tcgccctctg
     2161 atggacgccg ggaaaactgc atcgggcttt gtgtggaaga cggtccctgc cactgccctc
     2221 tgccgatgaa atgcgggaag tgtatggcct agatgtttca taaggctgga gtccctggtc
     2281 agccccacca gattagtgct tctaccctag gcagggcttt cttggtctaa tggtaataag
     2341 caccgacact gctaagcact ttacgtgcat tattatttca ttgaaaagaa ctgtcaagtg
     2401 aaatactttt tagcacagta actggctttg tgggctctag agaagagtta atgaggcagt
     2461 gcatgttctt ggcccagagt aagtgcttag tgaatgcttt ctaactccga accccagcca
     2521 catccaggga ctgggtgttg agcaaaaggg gccttcaaga tgttcaaggc acttggattt
     2581 tctcctgtct ctcatcggct tttcttaacg ggcctcagtg ggtgcatgtg attatccacg
     2641 tttcacctat gaaacatgaa cagaggagac tgacttatca gtgattcttc cgcgggttcg
     2701 gacagggcct cgattctgtt ttaaactcca gtagtcccta gaaattgtag ctccctctag
     2761 ttgtggcaat aggtgtgggt ccttgtgctt gcttttggca agtttctgag ctacacaggg
     2821 cctccattac cgtcactggt gaaatgcggc tcacctccca gatttgttgt aaagattaaa
     2881 tgaactggtc agca
//
