LOCUS       NM_025228               2234 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TRAF3 interacting protein 3 (TRAF3IP3), transcript
            variant 1, mRNA.
ACCESSION   NM_025228
VERSION     NM_025228.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2234)
  AUTHORS   Li,W., Jiang,H., Chen,X., Yang,K., Deng,X., Tang,Z., Hu,Z.,
            Zhang,X., Lin,S., Zou,Y. and Wu,H.
  TITLE     The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated
            with Graves' disease in the Chinese population
  JOURNAL   Medicine (Baltimore) 101 (45), e31501 (2022)
   PUBMED   36397361
  REMARK    GeneRIF: The variants in PTPRB, TRAF3IP3, and DISC1 genes were
            associated with Graves' disease in the Chinese population.
REFERENCE   2  (bases 1 to 2234)
  AUTHORS   Pommert,L., Burns,R., Furumo,Q., Pulakanti,K., Brandt,J.,
            Burke,M.J. and Rao,S.
  TITLE     Novel germline TRAF3IP3 mutation in a dyad with familial acute B
            lymphoblastic leukemia
  JOURNAL   Cancer Rep (Hoboken) 4 (3), e1335 (2021)
   PUBMED   33503336
  REMARK    GeneRIF: Novel germline TRAF3IP3 mutation in a dyad with familial
            acute B lymphoblastic leukemia.
REFERENCE   3  (bases 1 to 2234)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2234)
  AUTHORS   Yang,G., Tang,S., Zhang,J. and Qin,L.
  TITLE     High TRAF3IP3 Level Predicts Poor Prognosis of Patients with
            Gliomas
  JOURNAL   World Neurosurg 148, e436-e449 (2021)
   PUBMED   33444836
  REMARK    GeneRIF: High TRAF3IP3 Level Predicts Poor Prognosis of Patients
            with Gliomas.
REFERENCE   5  (bases 1 to 2234)
  AUTHORS   Yang,Y., Suzuki,A., Iwata,J. and Jun,G.
  TITLE     Secondary Genome-Wide Association Study Using Novel Analytical
            Strategies Disentangle Genetic Components of Cleft Lip and/or Cleft
            Palate in 1q32.2
  JOURNAL   Genes (Basel) 11 (11), 1280 (2020)
   PUBMED   33137956
  REMARK    GeneRIF: Secondary Genome-Wide Association Study Using Novel
            Analytical Strategies Disentangle Genetic Components of Cleft Lip
            and/or Cleft Palate in 1q32.2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2234)
  AUTHORS   Nasarre,P., Bonilla,I.V., Metcalf,J.S., Hilliard,E.G. and
            Klauber-DeMore,N.
  TITLE     TRAF3-interacting protein 3, a new oncotarget, promotes tumor
            growth in melanoma
  JOURNAL   Melanoma Res 28 (3), 185-194 (2018)
   PUBMED   29553967
  REMARK    GeneRIF: Tumor microarray analysis on 23 primary melanoma and nine
            positive lymph nodes revealed that 70% of human primary melanoma
            and 66% of lymph node metastases were positive for TRAF3IP3.
            Immunohistochemistry analysis of the tumors revealed that
            TRAF3IP3-shRNA tumors had increased apoptosis and reduced
            microvascular density.
REFERENCE   7  (bases 1 to 2234)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   8  (bases 1 to 2234)
  AUTHORS   Goudreault,M., D'Ambrosio,L.M., Kean,M.J., Mullin,M.J.,
            Larsen,B.G., Sanchez,A., Chaudhry,S., Chen,G.I., Sicheri,F.,
            Nesvizhskii,A.I., Aebersold,R., Raught,B. and Gingras,A.C.
  TITLE     A PP2A phosphatase high density interaction network identifies a
            novel striatin-interacting phosphatase and kinase complex linked to
            the cerebral cavernous malformation 3 (CCM3) protein
  JOURNAL   Mol Cell Proteomics 8 (1), 157-171 (2009)
   PUBMED   18782753
REFERENCE   9  (bases 1 to 2234)
  AUTHORS   Ma,X., Wang,X., Gao,X., Wang,L., Lu,Y., Gao,P., Deng,W., Yu,P.,
            Ma,J., Guo,J., Cheng,H., Zhang,C., Shi,T. and Ma,D.
  TITLE     Identification of five human novel genes associated with cell
            proliferation by cell-based screening from an expressed cDNA ORF
            library
  JOURNAL   Life Sci 81 (14), 1141-1151 (2007)
   PUBMED   17868742
  REMARK    GeneRIF: TRAF3IP3 stimulated cell growth by modulating the c-Jun
            N-terminal kinase (JNK) pathway
REFERENCE   10 (bases 1 to 2234)
  AUTHORS   Dadgostar,H., Doyle,S.E., Shahangian,A., Garcia,D.E. and Cheng,G.
  TITLE     T3JAM, a novel protein that specifically interacts with TRAF3 and
            promotes the activation of JNK(1)
  JOURNAL   FEBS Lett 553 (3), 403-407 (2003)
   PUBMED   14572659
  REMARK    GeneRIF: This paper provides an alignment of the mouse and human
            proteins.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL558384.3, AK312755.1 and
            BX648450.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_025228.3.
            
            Summary: The gene encodes a protein that mediates cell growth by
            modulating the c-Jun N-terminal kinase signal transduction pathway.
            The encoded protein may also interact with a large multi-protein
            assembly containing the phosphatase 2A catalytic subunit.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 4 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225762.1, AK122792.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367025.8/ ENSP00000355992.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL558384.3         22-106
            86-475              AK312755.1         1-390
            476-2234            BX648450.1         476-2234
FEATURES             Location/Qualifiers
     source          1..2234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..2234
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /note="TRAF3 interacting protein 3"
                     /db_xref="GeneID:80342"
                     /db_xref="HGNC:HGNC:30766"
                     /db_xref="MIM:608255"
     exon            1..257
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            258..358
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            359..761
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..2072
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /note="isoform 1 is encoded by transcript variant 1; TRAF3
                     interacting Jun N terminal kinase (JNK) activating
                     modulator"
                     /codon_start=1
                     /product="TRAF3-interacting JNK-activating modulator
                     isoform 1"
                     /protein_id="NP_079504.2"
                     /db_xref="CCDS:CCDS1490.2"
                     /db_xref="GeneID:80342"
                     /db_xref="HGNC:HGNC:30766"
                     /db_xref="MIM:608255"
                     /translation="MISPDPRPSPGLARWAESYEAKCERRQEIRESRRCRPNVTTCRQ
                     VGKTLRIQQREQLQRARLQQFFRRRNLELEEKGKAQHPQAREQGPSRRPGQVTVLKEP
                     LSCARRISSPREQVTGTSSEVFPAQHPPPSGICRDLSDHLSSQAGGLPPQDTPIKKPP
                     KHHRGTQTKAEGPTIKNDASQQTNYGVAVLDKEIIQLSDYLKEALQRELVLKQKMVIL
                     QDLLSTLIQASDSSWKGQLNEDKLKGKLRSLENQLYTCTQKYSPWGMKKVLLEMEDQK
                     NSYEQKAKESLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGT
                     QHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSLDT
                     QDLQDQLKRSEAEKLTLVTRVQQLQGLLQNQSLQLQEQEKLLTKKDQALPVWSPKSFP
                     NEVEPEGTGKEKDWDLRDQLQKKTLQLQAKEKECRELHSELDNLSDEYLSCLRKLQHC
                     REELNQSQQLPPRRQCGRWLPVLMVVIAAALAVFLANKDNLMI"
     exon            762..909
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            910..967
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            968..992
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1022
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1118
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1190
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1331
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1469
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1605
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1668
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1728
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1865
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1979
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2234
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2214..2219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /note="hexamer: AATAAA"
     polyA_site      2234
                     /gene="TRAF3IP3"
                     /gene_synonym="T3JAM"
                     /note="major polyA site"
ORIGIN      
        1 agatgatacc agagagcaag agagaggaac tggggtttgc gaaccttgtg gctttgtctg
       61 tttcctgttt cagcaaggct gctgtgcaaa aagaaagacg gtaccaagaa gggacgtgtt
      121 aatggggccc agacctatgg attgaaagcg tgtgctttac ccatctgctg tcttgctcca
      181 tctgagacca gagccaagat ctgcccagga ctggaatgct ttcccgagtg gcttgagttg
      241 gagcctggga ctaggagcag ccttattgag gtacaattca tgtgcttgtg ggtttggatg
      301 gcacaatctg tgtctgggct aaggaaagca gacttggcac caacattaac cctgacagat
      361 ccaggcatct attccaggaa ctggaagcca agcgcaacag gtgcttggag gtcatcatga
      421 tcagcccaga ccccaggccc tcccctggct tggcccggtg ggctgagagc tatgaggcca
      481 agtgtgagcg caggcaagag atccgtgaaa gccgccgctg ccgtcccaat gtgaccactt
      541 gccgccaggt ggggaagacg ctgaggatcc aacagagaga gcagctccag agagctcgac
      601 tgcagcagtt cttcaggagg aggaacctgg agctagagga gaagggcaaa gcgcagcatc
      661 cccaggccag ggagcaaggg ccctccaggc ggccaggaca ggtgactgtc ctcaaggaac
      721 ccttgtcttg tgccagaagg atttcttctc ccagagagca ggtgacaggc accagctctg
      781 aagtctttcc agcccagcat cctcctccct caggcatctg cagggatctg tctgaccacc
      841 tctcctcaca ggctgggggc cttcctccac aggacactcc catcaagaag ccacccaaac
      901 accaccgtgg tactcagaca aaggcagaag gaccaacaat taagaacgat gccagtcagc
      961 aaaccaatta cggagttgca gttctggata aggaaatcat ccagctttct gattacctca
     1021 aagaggccct acaaagggag ctggtcctaa aacagaaaat ggtgattctc caagacctac
     1081 tgtccactct gattcaggcc tctgacagct cttggaaggg acagcttaat gaagacaaac
     1141 tgaaggggaa actgagatcc ttagaaaacc agctatacac ctgtacccag aaatactccc
     1201 cttggggaat gaaaaaagta ctactggaga tggaagacca gaaaaacagc tatgagcaga
     1261 aggccaagga gtcactgcag aaagtgctgg aggagaaaat gaatgcagag cagcaactac
     1321 agagcacaca gcgatccctg gccctggcag agcagaagtg tgaagagtgg aggagccagt
     1381 atgaggctct gaaggaggac tggaggaccc ttgggaccca gcacagggag ctggagagcc
     1441 aactccacgt gcttcagtcc aaactgcagg gagcagatag cagggactta cagatgaacc
     1501 aggccctgcg atttttggaa aatgagcacc agcaactgca ggccaagatt gaatgcctgc
     1561 aaggggacag agacctgtgc agcttggata cccaggacct acaagatcaa ctaaaaaggt
     1621 cagaggcaga gaaactcacc ctggtgacca gagtacagca gttgcagggt ttgcttcaaa
     1681 atcaatcctt acagcttcaa gaacaggaga aactcttaac aaagaaagat caggctttgc
     1741 ccgtgtggag tccaaagtcc ttccctaacg aagtggagcc tgagggtaca gggaaggaga
     1801 aagactggga tctcagagac cagctgcaaa agaagacttt gcagctccag gccaaggaaa
     1861 aggagtgcag agaactgcat tcagaattag acaacctcag tgacgagtat ctctcctgcc
     1921 tgcgtaagct gcagcactgt cgagaagagc tgaaccagag ccagcagctg cctcccagaa
     1981 ggcaatgtgg gcgatggctc ccagtgctga tggtggtgat tgctgcagca ctggcagtgt
     2041 tcctggccaa taaagacaac ctgatgatct gaataatttg tgacaactgc cttgggtgaa
     2101 aatcagaagc aagcaactca gcgaaaaact cagaaggttt gggtacatta cagcttgggt
     2161 tttccaactg acttaggatt tctgactttt tattaatttc ttaacctact gtaaataaac
     2221 ttcacctgac caga
//
