LOCUS       NM_147686               5833 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript
            variant 2, mRNA.
ACCESSION   NM_147686 NM_015524
VERSION     NM_147686.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5833)
  AUTHORS   Che,J., DePalma,T.J., Sivakumar,H., Mezache,L.S., Tallman,M.M.,
            Venere,M., Swindle-Reilly,K., Veeraraghavan,R. and Skardal,A.
  TITLE     alphaCT1 peptide sensitizes glioma cells to temozolomide in a
            glioblastoma organoid platform
  JOURNAL   Biotechnol Bioeng 120 (4), 1108-1119 (2023)
   PUBMED   36544242
  REMARK    GeneRIF: alphaCT1 peptide sensitizes glioma cells to temozolomide
            in a glioblastoma organoid platform.
REFERENCE   2  (bases 1 to 5833)
  AUTHORS   Wang,S., Kuai,Y., Lin,S., Li,L., Gu,Q., Zhang,X., Li,X., He,Y.,
            Chen,S., Xia,X., Ruan,Z., Lin,C., Ding,Y., Zhang,Q., Qi,C., Li,J.,
            He,X., Pathak,J.L., Zhou,W., Liu,S., Wang,L. and Zheng,L.
  TITLE     NF-kappaB Activator 1 downregulation in macrophages activates STAT3
            to promote adenoma-adenocarcinoma transition and immunosuppression
            in colorectal cancer
  JOURNAL   BMC Med 21 (1), 115 (2023)
   PUBMED   36978108
  REMARK    GeneRIF: NF-kappaB Activator 1 downregulation in macrophages
            activates STAT3 to promote adenoma-adenocarcinoma transition and
            immunosuppression in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5833)
  AUTHORS   Yan,Q. and Li,B.
  TITLE     TRAF3IP2 regulated by FOXO4 affects fibroblast proliferation,
            migration, and extracellular matrix deposition in keloid through
            the TGF-beta1/Smad pathway
  JOURNAL   J Cosmet Dermatol 21 (10), 5148-5155 (2022)
   PUBMED   35441794
  REMARK    GeneRIF: TRAF3IP2 regulated by FOXO4 affects fibroblast
            proliferation, migration, and extracellular matrix deposition in
            keloid through the TGF-beta1/Smad pathway.
REFERENCE   4  (bases 1 to 5833)
  AUTHORS   De Benedittis,G., Latini,A., Conigliaro,P., Triggianese,P.,
            Bergamini,A., Novelli,L., Ciccacci,C., Chimenti,M.S. and
            Borgiani,P.
  TITLE     A multilocus genetic study evidences the association of
            autoimmune-related genes with Psoriatic Arthritis in Italian
            patients
  JOURNAL   Immunobiology 227 (4), 152232 (2022)
   PUBMED   35642993
  REMARK    GeneRIF: A multilocus genetic study evidences the association of
            autoimmune-related genes with Psoriatic Arthritis in Italian
            patients.
REFERENCE   5  (bases 1 to 5833)
  AUTHORS   Debackere,K., Marcelis,L., Demeyer,S., Vanden Bempt,M., Mentens,N.,
            Gielen,O., Jacobs,K., Broux,M., Verhoef,G., Michaux,L., Graux,C.,
            Wlodarska,I., Gaulard,P., de Leval,L., Tousseyn,T., Cools,J. and
            Dierickx,D.
  TITLE     Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell
            receptor signaling in peripheral T-cell lymphoma, not otherwise
            specified
  JOURNAL   Nat Commun 12 (1), 3705 (2021)
   PUBMED   34140493
  REMARK    GeneRIF: Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T
            cell receptor signaling in peripheral T-cell lymphoma, not
            otherwise specified.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5833)
  AUTHORS   Xia,Y.F., Li,Y.D., Li,X. and Geng,J.G.
  TITLE     Identification of alternatively spliced Act1 and implications for
            its roles in oncogenesis
  JOURNAL   Biochem Biophys Res Commun 296 (2), 406-412 (2002)
   PUBMED   12163033
  REMARK    GeneRIF: Data indicate that the newly identified alternatively
            spliced Act1 is a major transcript of the molecule and that Act1
            may play important roles in oncogenesis.
REFERENCE   7  (bases 1 to 5833)
  AUTHORS   Qian,Y., Zhao,Z., Jiang,Z. and Li,X.
  TITLE     Role of NF kappa B activator Act1 in CD40-mediated signaling in
            epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9386-9391 (2002)
   PUBMED   12089335
  REMARK    GeneRIF: Endogenous Act1 is recruited to the CD40 receptor in human
            intestinal (HT29) and cervical (HeLa) epithelial cells upon
            stimulation with CD40 ligand, indicating that Act1 is involved in
            this signaling pathway.
REFERENCE   8  (bases 1 to 5833)
  AUTHORS   Leonardi,A., Chariot,A., Claudio,E., Cunningham,K. and
            Siebenlist,U.
  TITLE     CIKS, a connection to Ikappa B kinase and stress-activated protein
            kinase
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10494-10499 (2000)
   PUBMED   10962033
REFERENCE   9  (bases 1 to 5833)
  AUTHORS   Li,X., Commane,M., Nie,H., Hua,X., Chatterjee-Kishore,M., Wald,D.,
            Haag,M. and Stark,G.R.
  TITLE     Act1, an NF-kappa B-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10489-10493 (2000)
   PUBMED   10962024
REFERENCE   10 (bases 1 to 5833)
  AUTHORS   Morelli,C., Magnanini,C., Mungall,A.J., Negrini,M. and
            Barbanti-Brodano,G.
  TITLE     Cloning and characterization of two overlapping genes in a
            subregion at 6q21 involved in replicative senescence and
            schizophrenia
  JOURNAL   Gene 252 (1-2), 217-225 (2000)
   PUBMED   10903453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF136406.1, AF136405.1,
            AL008730.1, AF136407.1, AW296296.1 and DA130363.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 14, 2018 this sequence version replaced NM_147686.3.
            
            Summary: This gene encodes a protein involved in regulating
            responses to cytokines by members of the Rel/NF-kappaB
            transcription factor family. These factors play a central role in
            innate immunity in response to pathogens, inflammatory signals and
            stress. This gene product interacts with TRAF proteins (tumor
            necrosis factor receptor-associated factors) and either I-kappaB
            kinase or MAP kinase to activate either NF-kappaB or Jun kinase.
            Several alternative transcripts encoding different isoforms have
            been identified. Another transcript, which does not encode a
            protein and is transcribed in the opposite orientation, has been
            identified. Overexpression of this transcript has been shown to
            reduce expression of at least one of the protein encoding
            transcripts, suggesting it has a regulatory role in the expression
            of this gene. [provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (2) encodes isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF136407.1, AF136406.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368761.11/ ENSP00000357750.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1079              AF136406.1         184-1262
            1080-2274           AF136405.1         1172-2366
            2275-2787           AL008730.1         61121-61633         c
            2788-4760           AF136407.1         2971-4943
            4761-4793           AW296296.1         181-213             c
            4794-5300           AL008730.1         58608-59114         c
            5301-5833           DA130363.1         27-559              c
FEATURES             Location/Qualifiers
     source          1..5833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..5833
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /note="TRAF3 interacting protein 2"
                     /db_xref="GeneID:10758"
                     /db_xref="HGNC:HGNC:1343"
                     /db_xref="MIM:607043"
     exon            1..103
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /inference="alignment:Splign:2.1.0"
     exon            104..940
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1809
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     connection to IKK and SAPK/JNK; NFkB-activating protein
                     ACT1; adapter protein CIKS; nuclear factor NF-kappa-B
                     activator 1; symbol withdrawn, see C6orf4; E3
                     ubiquitin-protein ligase CIKS; E3 ubiquitin ligase
                     TRAF3IP2"
                     /codon_start=1
                     /product="E3 ubiquitin ligase TRAF3IP2 isoform 2"
                     /protein_id="NP_679211.2"
                     /db_xref="CCDS:CCDS5093.1"
                     /db_xref="GeneID:10758"
                     /db_xref="HGNC:HGNC:1343"
                     /db_xref="MIM:607043"
                     /translation="MNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAP
                     NSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVTCLRTQVLEDSEDSFCRRHPGL
                     GKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSD
                     QSLPNASADSLGGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPL
                     TSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPWNYHYHCPGSPDHQVP
                     YGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSF
                     PGLPRHQDQPHHQPPNRAGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLK
                     TSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERY
                     LRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMMQIEFIKQGSMNFRFI
                     PVLFPNAKKEHVPTWLQNTHVYSWPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL"
     exon            941..1133
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1312
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1401
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1470
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1587
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1662
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..5833
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2251..2256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /note="hexamer: AATAAA"
     polyA_site      2274
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /note="major polyA site"
     regulatory      5811..5816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /note="hexamer: AATAAA"
     polyA_site      5833
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
ORIGIN      
        1 gttcttctac ttacctgggc ccggagaagg tggagggaga cgagaagccg ccgagagccg
       61 actaccctcc gggcccagtc tgtctgtccg tggtggatct aagaaactag aatgaaccga
      121 agcattcctg tggaggttga tgaatcagaa ccatacccaa gtcagttgct gaaaccaatc
      181 ccagaatatt ccccggaaga ggaatcagaa ccacctgctc caaatataag gaacatggca
      241 cccaacagct tgtctgcacc cacaatgctt cacaattcct ccggagactt ttctcaagct
      301 cactcaaccc tgaaacttgc aaatcaccag cggcctgtat cccggcaggt cacctgcctg
      361 cgcactcaag ttctggagga cagtgaagac agtttctgca ggagacaccc aggcctgggc
      421 aaagctttcc cttctgggtg ctctgcagtc agcgagcctg cgtctgagtc tgtggttgga
      481 gccctccctg cagagcatca gttttcattt atggaaaaac gtaatcaatg gctggtatct
      541 cagctttcag cggcttctcc tgacactggc catgactcag acaaatcaga ccaaagttta
      601 cctaatgcct cagcagactc cttgggcggt agccaggaga tggtgcaacg gccccagcct
      661 cacaggaacc gagcaggcct ggatctgcca accatagaca cgggatatga ttcccagccc
      721 caggatgtcc tgggcatcag gcagctggaa aggcccctgc ccctcacctc cgtgtgttac
      781 ccccaggacc tccccagacc tctcaggtcc agggagttcc ctcagtttga acctcagagg
      841 tatccagcat gtgcacagat gctgcctccc aatctttccc cacatgctcc atggaactat
      901 cattaccatt gtcctggaag tcccgatcac caggtgccat atggccatga ctaccctcga
      961 gcagcctacc agcaagtgat ccagccggct ctgcctgggc agcccctgcc tggagccagt
     1021 gtgagaggcc tgcaccctgt gcagaaggtt atcctgaatt atcccagccc ctgggaccac
     1081 gaagagaggc ccgcacagag agactgctcc tttccggggc ttccaaggca ccaggaccag
     1141 ccacatcacc agccacctaa tagagctggt gctcctgggg agtccttgga gtgccctgca
     1201 gagctgagac cacaggttcc ccagcctccg tccccagctg ctgtgcctag accccctagc
     1261 aaccctccag ccagaggaac tctaaaaaca agcaatttgc cagaagaatt gcggaaagtc
     1321 tttatcactt attcgatgga cacagctatg gaggtggtga aattcgtgaa ctttttgttg
     1381 gtaaatggct tccaaactgc aattgacata tttgaggata gaatccgagg cattgatatc
     1441 attaaatgga tggagcgcta ccttagggat aagaccgtga tgataatcgt agcaatcagc
     1501 cccaaataca aacaggacgt ggaaggcgct gagtcgcagc tggacgagga tgagcatggc
     1561 ttacatacta agtacattca tcgaatgatg cagattgagt tcataaaaca aggaagcatg
     1621 aatttcagat tcatccctgt gctcttccca aatgctaaga aggagcatgt gcccacctgg
     1681 cttcagaaca ctcatgtcta cagctggccc aagaataaaa aaaacatcct gctgcggctg
     1741 ctgagagagg aagagtatgt ggctcctcca cgggggcctc tgcccaccct tcaggtggtt
     1801 cccttgtgac accgttcatc cccagatcac tgaggccagg ccatgtttgg ggccttgttc
     1861 tgacagcatt ctggctgagg ctggtcggta gcactcctgg ctggtttttt tctgttcctc
     1921 cccgagaggc cctctggccc ccaggaaacc tgttgtgcag agctcttccc cggagacctc
     1981 cacacaccct ggctttgaag tggagtctgt gactgctctg cattctctgc ttttaaaaaa
     2041 accattgcag gtgccagtgt cccatatgtt cctcctgaca gtttgatgtg tccattctgg
     2101 gcctctcagt gcttagcaag tagataatgt aagggatgtg gcagcaaatg gaaatgacta
     2161 caaacactct cctatcaatc acttcaggct acttttatga gttagccaga tgcttgtgta
     2221 tcctcagacc aaactgattc atgtacaaat aataaaatgt ttactctttt gtaagattat
     2281 gttttactta tctcaaagga gatacatata atttataatg atatgggcag ttgcttccag
     2341 ggacatcaac aaagctgctt agatataata ttagataaat ataacagacc actctgtatt
     2401 aatggattaa agccagctag ttaaacaacc ctttttaacc ataatcatgg aagctttatt
     2461 cttgcaataa agatttttag gctgggcgca gtgactcaca cctgtaatcc cagcactttg
     2521 ggaagctaag gcaggcagat catttgaggt caggagtttg agaccagcct ggccaacatg
     2581 gtgaaacccc atctctgcta aaattacaaa aaagttagcc gggcatggtg gtgtgcacct
     2641 gtaatcccag ctactcggga ggctgaggca ggagaatcac ttgaacccgg gaggcagagg
     2701 ttgcagtgag ccgagatcat gtcactgcac tctagcttgg gagacagagc gagactccgt
     2761 ctcaaaaaac aaacaaacaa ataaaaacac ccatttttaa caaaacaact ttatatagca
     2821 tacagccatg attctaaata gtatgattat ggttctcagg atctgactac ataggtaaaa
     2881 atatttgcat atgtgtatga agtgttgggg gatgtaggct agaattgtag tctgtgttct
     2941 aattttggtt ctaccaccaa ttagctgtat gacctttagc aagtccttta acttttctta
     3001 gattccaggg actcatttat aaaatgacat ggacaaaagc atctctaatc actctaaaag
     3061 atttgaagtc taggacctaa attctaaata ctcttttgag gagtgactga gttttcattt
     3121 tcataattat gtctctcaga ggacaaattt acattttctt aacagagaca ttttcttctt
     3181 cttttttttt gtttgagaca gagtctcgct ctgtcgtcca ggctggagtg cagtgctgca
     3241 atcttggctc actgcaacct gcgcctcctg ggttcaagtg attcttctgc ctcaacctcc
     3301 caagtagcta gacctatagg cgcctgccac catgcccagc taatttttgt atttttagta
     3361 gagacagggt ttcatattgg ccagactggt ctcgaactcc tgaccttgtg atccgcccac
     3421 ctcggcctcc caaagtgctg ggattacagg tgtgagccac cacacccagc caacattttc
     3481 ctcttttaaa aaatatcttc tcacgcctgt aatcccagca ctttgggagg ctgaggcagg
     3541 cggatcatga ggtcaggaga tcaagaccat cctggctaac acggtgaaac tccatctcta
     3601 ctaaaaatac aaaaaaaata gccgggcgtg gtggcaggcg cctgtagtcc cagctactgg
     3661 ggaggctgag gcaggaaaat ggtgtcaacc cgggaggcgg agcttgcagt gagccgagat
     3721 tgcgccactg cactccagcc tgggcaatag agtgagactc cgtctcaaaa aaaaaaaaaa
     3781 aaaaaaaaac ttcaacaata ccctcaggtt gataattttg gatatctatc tgtatctata
     3841 tatcttgttt acctggtctc cagaaaaaga acacatacac atatccatat ataaaatatg
     3901 tatacatgta tcaaatctac gtaaactata aaggtgggat ggctttaatt atggcccaag
     3961 ctactaagac aatgaagact ttttggggct gcaagctact gcttcccttc tttatctact
     4021 agcctcttaa acaaggctca cttgtgctac aagacagtcc accgttttgt tttttttttc
     4081 ttttttttga gacagggtct cactctttcc caggctgcag tacagtgaca cagtctcagc
     4141 tcactgcagc tttgaccttg ccgggctcag gtgaccctta cacttcagcc tcccaagtag
     4201 cagggactat aggtgtgcac caacatgctt ggttaatttt tgtatttttt gtagagacag
     4261 ggttttgcca tgttgtccag gctagtctcg aattcctggg ctcaagtgat tcacctgcct
     4321 tggcctccca aagtgctagg attacagatg ggagccacca cgcccagccc agtccagctc
     4381 ttatatgtag cacagggaaa ggacaaatac ttgtcaacta taaataagaa acattgctaa
     4441 tgcattgcaa agaacactag tttcatttac tttataactt agatgtctac tgggtgagac
     4501 gaatgtcttt gttctttaaa aaataggaaa agagaagaaa aactagcata acataagtac
     4561 tcatttgtaa gactttctga catgtaacat tagttccgta gttttgagac ctggtagaac
     4621 tgactttcat atttggataa cctggaaaac acccaaacac aaacttcaag tcttctttct
     4681 cttttttcat tatctttttt agtctgaggt gacaccatca ttaaggattc gacacccgtt
     4741 tgtaaataaa atgacatcag caattactct gaaatgtttc tagtttgcaa agacttagca
     4801 atgtgatgtt attaaccctt cctcccttca gagacctgtc ctaagctctg aaccactcat
     4861 tccttccact cttcttaccc caggtggttg atgagcagtg gtccctggtg ttccacaaag
     4921 agtcattaaa gtgttacagc tggtagcact ggtagcaaaa aaacaaacca aaaagtacac
     4981 acagacacac acacacacac gcacacatac acacacacac gcacttggcc aagtgacaaa
     5041 agcttggccc ctgaaatttc tatgagatcc gatgaccacc aacatcaaag catttttttt
     5101 tttttttttt tgagacgtag tctcgctctg tcacccaggc tagagtgcag tggtgcaatc
     5161 acagctcact gcaacctcca cctcccgggt tcaagcgatt ctcctgcctc agcctctcga
     5221 gtagctgtga ctacaggcac ctgccaccat gcccggctaa ttttttgtat ttttagtaga
     5281 gacggggttt caccgtgtta gccaggatgg tcttgatctc ctgacctcgt gatccatccg
     5341 cctcggcctc ccaaattgct gggattacag gcatgagcca ccacgcccgg cccatcaaag
     5401 gaattgtaac aactatttga gagcactgac aataagatta acactcggtt gatttagatg
     5461 ttatgctggt cctcaggcat tcatctttag atatttttgg ggtggaagtg gggtagggct
     5521 gacttagtaa aaataacctc ttagcccaaa ggctttattc agacttacac cgatttgagg
     5581 ggtgggtttg tggaatgcaa ggttaggttc ttacctaata tttgatgact aatttagaat
     5641 tttaaatgta attttaaatt ttagtgactg gtttcaaatc tattttaact tctagattgt
     5701 tcaaagaggt ctcagtacat ggctacaatc aaagtattag actagctatt tctcagctca
     5761 gtgctcagaa aaattattac tgttgatacc tttttctttg tttcctgtta aataaatcac
     5821 ctctttaaag aca
//
