LOCUS       NM_145725               7806 bp    mRNA    linear   PRI 23-FEB-2025
DEFINITION  Homo sapiens TNF receptor associated factor 3 (TRAF3), transcript
            variant 1, mRNA.
ACCESSION   NM_145725
VERSION     NM_145725.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7806)
  AUTHORS   Li,M.Y., Chong,L.C., Duns,G., Lytle,A., Woolcock,B., Jiang,A.,
            Telenius,A., Ben-Neriah,S., Nawaz,W., Slack,G.W., Elisia,I.,
            Vigano,E., Aoki,T., Healy,S., Krystal,G., Venturutti,L., Scott,D.W.
            and Steidl,C.
  TITLE     TRAF3 loss-of-function reveals the noncanonical NF-kappaB pathway
            as a therapeutic target in diffuse large B cell lymphoma
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2320421121 (2024)
   PUBMED   38662551
  REMARK    GeneRIF: TRAF3 loss-of-function reveals the noncanonical NF-kappaB
            pathway as a therapeutic target in diffuse large B cell lymphoma.
REFERENCE   2  (bases 1 to 7806)
  AUTHORS   Liang,Y., Han,D., Zhang,S. and Sun,L.
  TITLE     FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation
            of psoriatic keratinocytes through the NF-kB signaling via
            transcriptionally activating TRAF3
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (4), 119689 (2024)
   PUBMED   38367916
  REMARK    GeneRIF: FOSL1 regulates hyperproliferation and NLRP3-mediated
            inflammation of psoriatic keratinocytes through the NF-kB signaling
            via transcriptionally activating TRAF3.
REFERENCE   3  (bases 1 to 7806)
  AUTHORS   Wang,W., Wang,S., Wang,M., Ma,Y., Hu,W., Wu,B., Li,C. and Zhang,D.
  TITLE     Effects of TRAF3 on the proliferation and migration of lung
            adenocarcinoma depend partly on pyroptosis
  JOURNAL   BMC Cancer 23 (1), 942 (2023)
   PUBMED   37798663
  REMARK    GeneRIF: Effects of TRAF3 on the proliferation and migration of
            lung adenocarcinoma depend partly on pyroptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7806)
  AUTHORS   Li,Y., Zhang,J.K., Yu,Z.T., Jiang,J.W., Tang,H., Tu,G.L. and Xia,Y.
  TITLE     LncRNA XIST Exacerbates Oxygen-Glucose
            Deprivation/Reoxygenation-Induced Cerebral Injury Through the
            miR-25-3p/TRAF3 Axis
  JOURNAL   Mol Neurobiol 60 (10), 6109-6120 (2023)
   PUBMED   37422573
  REMARK    GeneRIF: LncRNA XIST Exacerbates Oxygen-Glucose
            Deprivation/Reoxygenation-Induced Cerebral Injury Through the
            miR-25-3p/TRAF3 Axis.
REFERENCE   5  (bases 1 to 7806)
  AUTHORS   Li,Y., Zhu,L., Ko,C.J., Yang,J.Y., Wang,H., Manyam,G., Wang,J.,
            Cheng,X., Zhao,S. and Jie,Z.
  TITLE     TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center
            responses
  JOURNAL   J Exp Med 220 (8) (2023)
   PUBMED   37097293
  REMARK    GeneRIF: TRAF3-EWSR1 signaling axis acts as a checkpoint on
            germinal center responses.
            Erratum:[J Exp Med. 2023 Aug 7;220(8):e2022148307122023c. doi:
            10.1084/jem.2022148307122023c.. PMID: 37462917]
REFERENCE   6  (bases 1 to 7806)
  AUTHORS   Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V.
  TITLE     TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF
            receptor 1 signal transduction pathways
  JOURNAL   Cell 84 (2), 299-308 (1996)
   PUBMED   8565075
REFERENCE   7  (bases 1 to 7806)
  AUTHORS   Cheng,G., Cleary,A.M., Ye,Z.S., Hong,D.I., Lederman,S. and
            Baltimore,D.
  TITLE     Involvement of CRAF1, a relative of TRAF, in CD40 signaling
  JOURNAL   Science 267 (5203), 1494-1498 (1995)
   PUBMED   7533327
REFERENCE   8  (bases 1 to 7806)
  AUTHORS   Mosialos,G., Birkenbach,M., Yalamanchili,R., VanArsdale,T., Ware,C.
            and Kieff,E.
  TITLE     The Epstein-Barr virus transforming protein LMP1 engages signaling
            proteins for the tumor necrosis factor receptor family
  JOURNAL   Cell 80 (3), 389-399 (1995)
   PUBMED   7859281
REFERENCE   9  (bases 1 to 7806)
  AUTHORS   Sato,T., Irie,S. and Reed,J.C.
  TITLE     A novel member of the TRAF family of putative signal transducing
            proteins binds to the cytosolic domain of CD40
  JOURNAL   FEBS Lett 358 (2), 113-118 (1995)
   PUBMED   7530216
REFERENCE   10 (bases 1 to 7806)
  AUTHORS   Hu,H.M., O'Rourke,K., Boguski,M.S. and Dixit,V.M.
  TITLE     A novel RING finger protein interacts with the cytoplasmic domain
            of CD40
  JOURNAL   J Biol Chem 269 (48), 30069-30072 (1994)
   PUBMED   7527023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL132801.5, U21092.1,
            BX247977.1, AL117209.7 and BQ000015.1.
            
            On Aug 31, 2019 this sequence version replaced NM_145725.2.
            
            Summary: The protein encoded by this gene is a member of the TNF
            receptor associated factor (TRAF) protein family. TRAF proteins
            associate with, and mediate the signal transduction from, members
            of the TNF receptor (TNFR) superfamily. This protein participates
            in the signal transduction of CD40, a TNFR family member important
            for the activation of the immune response. This protein is found to
            be a critical component of the lymphotoxin-beta receptor (LTbetaR)
            signaling complex, which induces NF-kappaB activation and cell
            death initiated by LTbeta ligation. Epstein-Barr virus encoded
            latent infection membrane protein-1 (LMP1) can interact with this
            and several other members of the TRAF family, which may be
            essential for the oncogenic effects of LMP1. The protein also plays
            a role in the regulation of antiviral response. Mutations in this
            are associated with Encephalopathy, acute, infection-induced,
            herpes-specific 5. [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 3 both encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1953909.1,
                                           SRR11853564.9219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000392745.8/ ENSP00000376500.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AL132801.5         21916-21945         c
            31-111              U21092.1           4-84
            112-136             AL132801.5         21810-21834         c
            137-184             U21092.1           110-157
            185-2567            BX247977.1         1-2383
            2568-7801           AL117209.7         122476-127709
            7802-7806           BQ000015.1         18-22               c
FEATURES             Location/Qualifiers
     source          1..7806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.32"
     gene            1..7806
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /note="TNF receptor associated factor 3"
                     /db_xref="GeneID:7187"
                     /db_xref="HGNC:HGNC:12033"
                     /db_xref="MIM:601896"
     exon            1..227
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     exon            228..366
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     exon            367..628
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..2090
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; CD40
                     binding protein; CD40 receptor associated factor 1; CD40
                     associated protein 1; RING-type E3 ubiquitin transferase
                     TRAF3; LMP1-associated protein 1"
                     /codon_start=1
                     /product="TNF receptor-associated factor 3 isoform 1"
                     /protein_id="NP_663777.1"
                     /db_xref="CCDS:CCDS9975.1"
                     /db_xref="GeneID:7187"
                     /db_xref="HGNC:HGNC:12033"
                     /db_xref="MIM:601896"
                     /translation="MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFV
                     KTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFK
                     DNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
                     DLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSEL
                     SAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSL
                     LQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELD
                     KEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQML
                     SVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYF
                     GYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHL
                     GDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLP
                     DP"
     exon            629..680
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     exon            681..785
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     exon            786..953
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1034
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1109
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1202
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1343
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1518
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..7806
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7783..7788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /note="hexamer: AATAAA"
     polyA_site      7806
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /note="major polyA site"
ORIGIN      
        1 gcggggctgc gtgagggagc gagggagcga gggagcgcgg cgcggccgcc gcgtgcgcga
       61 gccggggttg cagcccagcc gggactttcc agccggcggc agccgcggcg gccgccggct
      121 cttccccgcc ccccgccatg gggcagcccg gggagcagaa cgctgcggac cgcggcggag
      181 gacgcgcccg gcgcccctga gccggccgag cggcgacgga ccgcgagatg aggaaaatga
      241 ggcccaaaga agtgatgcca cttggttaag gtcccagagc aggtcagaat cagacctagg
      301 atcagaaacc tggctcctgg ctcctggctc cctactcttc taaggatcgc tgtcctgaca
      361 gaagagaact cctctttcct aaaatggagt cgagtaaaaa gatggactct cctggcgcgc
      421 tgcagactaa cccgccgcta aagctgcaca ctgaccgcag tgctgggacg ccagtttttg
      481 tccctgaaca aggaggttac aaggaaaagt ttgtgaagac cgtggaggac aagtacaagt
      541 gtgagaagtg ccacctggtg ctgtgcagcc cgaagcagac cgagtgtggg caccgcttct
      601 gcgagagctg catggcggcc ctgctgagct cttcaagtcc aaaatgtaca gcgtgtcaag
      661 agagcatcgt taaagataag gtgtttaagg ataattgctg caagagagaa attctggctc
      721 ttcagatcta ttgtcggaat gaaagcagag gttgtgcaga gcagttaatg ctgggacatc
      781 tgctggtgca tttaaaaaat gattgccatt ttgaagaact tccatgtgtg cgtcctgact
      841 gcaaagaaaa ggtcttgagg aaagacctgc gagaccacgt ggagaaggcg tgtaaatacc
      901 gggaagccac atgcagccac tgcaagagtc aggttccgat gatcgcgctg cagaaacacg
      961 aagacaccga ctgtccctgc gtggtggtgt cctgccctca caagtgcagc gtccagactc
     1021 tcctgaggag cgagttgagt gcacacttgt cagagtgtgt caatgccccc agcacctgta
     1081 gttttaagcg ctatggctgc gtttttcagg ggacaaacca gcagatcaag gcccacgagg
     1141 ccagctccgc cgtgcagcac gtcaacctgc tgaaggagtg gagcaactcg ctcgaaaaga
     1201 aggtttcctt gttgcagaat gaaagtgtag aaaaaaacaa gagcatacaa agtttgcaca
     1261 atcagatatg tagctttgaa attgaaattg agagacaaaa ggaaatgctt cgaaataatg
     1321 aatccaaaat ccttcattta cagcgagtga tagacagcca agcagagaaa ctgaaggagc
     1381 ttgacaagga gatccggccc ttccggcaga actgggagga agcagacagc atgaagagca
     1441 gcgtggagtc cctccagaac cgcgtgaccg agctggagag cgtggacaag agcgcggggc
     1501 aagtggctcg gaacacaggc ctgctggagt cccagctgag ccggcatgac cagatgctga
     1561 gtgtgcacga catccgccta gccgacatgg acctgcgctt ccaggtcctg gagaccgcca
     1621 gctacaatgg agtgctcatc tggaagattc gcgactacaa gcggcggaag caggaggccg
     1681 tcatggggaa gaccctgtcc ctttacagcc agcctttcta cactggttac tttggctata
     1741 agatgtgtgc cagggtctac ctgaacgggg acgggatggg gaaggggacg cacttgtcgc
     1801 tgttttttgt catcatgcgt ggagaatatg atgccctgct tccttggccg tttaagcaga
     1861 aagtgacact catgctgatg gatcaggggt cctctcgacg tcatttggga gatgcattca
     1921 agcccgaccc caacagcagc agcttcaaga agcccactgg agagatgaat atcgcctctg
     1981 gctgcccagt ctttgtggcc caaactgttc tagaaaatgg gacatatatt aaagatgata
     2041 caatttttat taaagtcata gtggatactt cggatctgcc cgatccctga taagtagctg
     2101 gggaggtgga tttagcagaa ggcaactcct ctgggggatt tgaaccggtc tgtcttcact
     2161 gaggtcctcg cgctcagaaa aggaccttgt gagacggagg aagcggcaga aggcggacgc
     2221 gtgccggcgg gaggagccac gcgtgagcac acctgacacg ttttataata gactagccac
     2281 acttcactct gaagaattat ttatccttca acaagataaa tattgctgtc agagaaggtt
     2341 ttcattttca tttttaaaga tctagttaat taaggtggaa aacatatatg ctaaacaaaa
     2401 gaaacatgat ttttcttcct taaacttgaa caccaaaaaa acacacacac acacacacgt
     2461 ggggatagct ggacatgtca gcatgttaag taaaaggaga atttatgaaa tagtaatgca
     2521 attctgatat cttctttcta aaattcaaga gtgcaatttt gtttcaaata cagtatattg
     2581 tctattttta aggcctcatc tggtctctgt tttaataatt tgtttgtcag aagaccctga
     2641 agtatatacc taggtctttt ttttgaaagt ctctaaattc agaatcattt tttaatttaa
     2701 agttctacaa ataattgtta ctgcaaacat tttattttaa aacgttgata gactgatatt
     2761 tcttggaaga aaatataaaa tatcaaacac tggttatcac ttgtgatagg aaagagaata
     2821 ttcaacctgt tgttatttct cgttagaaat gtaaaccttc aaatatctgt cgtagttaat
     2881 gacacgactt cacaattctg aacggagcct cgctcatgga tgctgtgcat cattttcaga
     2941 tttataattg ttttcaccct aaaatagggc atccgttgaa ctttggagtt ctaaacaaaa
     3001 tcctgtaggt gtttggattc tgccccatgt gttcggacga gctctctgtt gctgacagca
     3061 ccggccttcg gtctccatgt caggggtggg cgggtgactg ctgagggagg cccgcaggtg
     3121 tgtttctcca tcccgtcatc ttgctgcatg ccgtcaacgg tctccgaaag caacgttgtg
     3181 cgtagagctg gtggcatacg gcccacgtgc cttagatggg acatgctgct tctccaccct
     3241 gggtttgcat tgagcatcat tctagaaagt gctagtttaa ccagactttt ctctccacca
     3301 ctagatcttt gtctctacaa gggccctcag acacctctgc acctgctgag gggaagccag
     3361 gctccaccgt cggcttctgg agcctccgct gcttaattac cacagattcc aaatctctag
     3421 gccccacgag tgagccgcct ggtccaagta cggcctggtc ccaccctgag ggaggcaggt
     3481 gtggaacaga agccgagcct ctccgtgtcc ccaccggggc cgtgggcacc cccacagccc
     3541 gaagcagaac cctctgagca ttccagagac cgctgctcgg gggcctgccc aggctgacca
     3601 acgggcgctc ctgaccacca ccctggcggg aagggtggcc acggggcccg tcgtcccagc
     3661 ctgtgcctgc ccagatggca ttttctcaac tcactgttta ctgtctctca gtgtccaact
     3721 gtgattagaa gcctggagcc tgccccctgc accccttttg ctatgcacca cgcttcatgg
     3781 tgctcttacc actgatgggt gctacacgcg acgggtgctt cttaggcaaa accaatgtgt
     3841 gcgaactgtc acacctgtgc cactcgccca caagccgcgc ccacaattgg ccagctgggc
     3901 cgtgcacgtc agactgcctg cctcggctct ccccgtggcc gcgcggggac agcttggtgg
     3961 gtgcccggtg gcccacctgt ctctggtgct gccatctgtc ctgggtgtgc cttcgcccca
     4021 gtgcctgctg gaagtgccct ccgtcgcacc cctgtgccct gagctcccgt gaggggcccg
     4081 ccgcgccctt tcgcggtcga agcgttccgt tgttcttatc tgcctttcct ttccccgctc
     4141 tcctgggatt actttggggg aatgagtatc cttggttctg ccctgtgagg gagtcgtgtg
     4201 tccctgctca taaaggaagg acttcctgca gaagctgcgg aaaactactg ttccctcgaa
     4261 ggtgtccccc acctgaggcc tgtcccctac ctgccctcag gtagttttcc tgaggccagg
     4321 ggttaacaac agggacatcc ctgcaacttc cccttcacaa aatgtataat attagatgaa
     4381 ggatatgcaa catcttggtc tagtaagaac cgtttcctcc cctctgggtt gaagtcctgg
     4441 tgtggccccc agaagcagca gtgcgtgtca ctgggacgtc tccagtagcc cttcccaggc
     4501 agacgctcct ggcgggacgc catggggccc acctgagggt cccacagacg taacctgagt
     4561 gacaggagtc cttgaggatg ggatggccta tgtcacacac tttgtccttg aacctgagtg
     4621 atgggggtcc ttgaggatgg gatggcctgt gtcacgcgct ttgtctttgt gtttggttgt
     4681 atcggggtct ctgttctgag tgtgtcttcc tctcatgtac tcaacacagt gggcagcagc
     4741 ctgggacggc gtcccctctc ccggcggcgg gcaagccttg cgctgctcca ccctcggcct
     4801 gggcaccctc acttggcgct ggccacctgg gccagcctgg ggccatggtc tctctgcagc
     4861 tgaggcccag tggccccttg ggcagtgatc ggccctcccc gcatcacagg gccctggcag
     4921 caagcgggaa atgggggcgc acactgtgtg cttgggggtg ctgcttgttt accacacatg
     4981 accagactcc cagcaggaca gagctgctca gtactttaca gaaaccaact gagtcgtttg
     5041 tgcatgaatt aagccggtct gcttccccgt caccttcgta acaaaacaac gtcccctctc
     5101 ccctcgcctc gagcagtttc ttcaggacac cgtggctcgg gctgctccct gctgccaggc
     5161 acgctggttg gctggcctgg gcccggctca cgtgaagggc actggctctt gtgaccacac
     5221 tgagccacgt gcaagccgca gccgggcctg gaagcctgac cctctggttc tagggcttgt
     5281 cccgcggagc ctgcagagct agacgttggg gtgtgtccgt gatgatatgg gggccaggct
     5341 gggagtaggg cctttctagc agggttgggt ggctcagtga gggtgtggaa gtgggggacc
     5401 cacggggcct ggctttggga ctagacatgc cagccccagc tgggctggag ggagcctgag
     5461 tgagccccga catacgctgg gcctttcagc tcgccgtgct ctggtgacac acaggcggcc
     5521 aggttgggat ttgtgtcaat tctaggagcc atcaagcatg aatgtggttc tgtctcctga
     5581 gcgcaagcct cgccggaccc ctgggcgaag gcctggactt gcagatgtgt gttccctgtg
     5641 cgggtggaca gagggggccc ttatgaccca cattgcagcc ccattccacc accccttcct
     5701 ccccagagca gtctctgccg agggacagca cctgtgtccc ttcgatgcca caacagccag
     5761 ttgaacaggg gagccctttg ctcaggcagc ttctcctgcc tctccctcct ttctccttcc
     5821 ctgccccatc cccgtgccct tcttggcctg tggcgctggg gagccatggt gtggcatact
     5881 ggggctcctg ctccttgggc cacttcctca gcccgggccc cacaggccca ccacctgcca
     5941 gggctcccac tgcactggct gtggcaggag gcttccccat gaccccgtgt ggcccagctc
     6001 ggtgaggatg cagttctagg cacagcccct gggacagcca gctgcctccc agaccacgtc
     6061 agcctgctcc agggtcctca gtcaccctgg gccaggggcc acgtgtccca tggatgtcga
     6121 ccatgccaac gtcacattcc agcacccctt ttgcttgatg gcgtctggtg gtagtcagca
     6181 tggtggaccc acatcctaca gccagaggtg atgttggaca aaggaagggg agtctggatg
     6241 ggtccttaaa cgaccattct gtccgcagcg gggtcattcc ttgtcagccc aagggagggc
     6301 cggggagtac actgatccca acagctgggc tgacacctcc tttctcccct gcacggggag
     6361 gattggcctg aggaccgtca ccctgtgcac agccccagta gggtggcagt gccactgtct
     6421 ccttgggccg ttgcaggatt gggcgggtgc agactcccct tgcgggcccc ttgctcaatc
     6481 cccggccctc ccagactcct ccctctactg ggggtaattt gtgtgtcaga agggctctgg
     6541 cagagctgta aaatactgtt ttttaaaaat tttagtccag atctttactt attagactgc
     6601 agaaggagag ctagggagag tgggggaagc ccccttgctt ttgtatctgt gaggtgaatg
     6661 agggtctgtc acccaaatct acttctcagc ccatgaccat agttctgttt tccgtttgca
     6721 aatctcagta gctctgtttt ctccaaagta gaatgtgcgc accggggtcc tagccaggcg
     6781 aggtcagtgt cggcaggcta cctggtcatt attgctgcct cgtccaggct gatgctgatg
     6841 gtcacaggca cggtggcatc agggagccgg gccagcaggc ggcgtgaggc ggggccagca
     6901 gctcactgca agggcatttt ccacctgatc ctggtgtgcc ccacatgcgg tggcagggca
     6961 gacgtgtgaa gcctcggccg tctcggggct ggcaggtgtg cgggtgagga ggccccggtg
     7021 gccaagcaga gcctgcgttt catttctcct gctgcactgt gtctagtctg tcttgtgaac
     7081 tctcaccgtg aaaagaggct agaagtccag gatcgctgta ccgctcctgt aattaggtga
     7141 tgactggatt tgacaactta gtcccctcag acaagtaaga taccctccaa cagcaaattc
     7201 aatgacttaa ttggaaaaca cacaagctgg catgatgtcc ggtgatttct gtaagaaatg
     7261 cctgtaggag aaggtctgtg aagtgtggag ggcagtgtcg acgctgcaca gcatctgcag
     7321 attcgcagcc tcttctctgc cggtgcctct gttcggttct gttacccaaa aacaaagacc
     7381 aaagaaggcc aatctctcat ttgaccctgt ctttttaatc tgcctgtttt aaaagttgcg
     7441 tctgtagtag ccgcttgctg tgaagacaca tcttgacagt ccaagtgatt ttgtgaccag
     7501 tgatttgggt cctgttttcc gctcttctaa gaaaaaacaa aaagaccgtg agttattgcc
     7561 cagcaataat catgttgtta ctgtgagtta gcaacatgcc tgacttcctg atagcattac
     7621 tgttttctag ttttgtttat tgtatattat gtgtggtttt atttggtatt tatttgtgtt
     7681 ttgaggtctt gcaatgtttt tgtgtttctg atgctaataa ctaaagtttg taagactgta
     7741 gaatgcaaaa ctcggagatg ctaaactgtc ttattagagg aaaataaatc tgattatgga
     7801 gtctca
//
