LOCUS       NM_021138               2266 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens TNF receptor associated factor 2 (TRAF2), mRNA.
ACCESSION   NM_021138 NM_145718
VERSION     NM_021138.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2266)
  AUTHORS   Zhou,N., Guo,C., Li,X., Tu,L., Du,J., Qian,Q., Li,J., Huang,D.,
            Xu,Q. and Zheng,X.
  TITLE     USP24 promotes hepatocellular carcinoma tumorigenesis through
            deubiquitinating and stabilizing TRAF2
  JOURNAL   Biochem Pharmacol 229, 116473 (2024)
   PUBMED   39127151
  REMARK    GeneRIF: USP24 promotes hepatocellular carcinoma tumorigenesis
            through deubiquitinating and stabilizing TRAF2.
REFERENCE   2  (bases 1 to 2266)
  AUTHORS   Wang,T., Zhang,Q., Xu,Y., Yan,R., Pan,Y., Xuan,Y., Shen,M.,
            Chen,X., Zhu,H., Ke,X., Qu,Y. and Zhang,X.
  TITLE     TRAF2 associates with cullin neddylation complex assembly
  JOURNAL   FEBS J 291 (20), 4473-4488 (2024)
   PUBMED   38978293
  REMARK    GeneRIF: TRAF2 associates with cullin neddylation complex assembly.
REFERENCE   3  (bases 1 to 2266)
  AUTHORS   Rathore,U., Haas,P., Easwar Kumar,V., Hiatt,J., Haas,K.M.,
            Bouhaddou,M., Swaney,D.L., Stevenson,E., Zuliani-Alvarez,L.,
            McGregor,M.J., Turner-Groth,A., Ochieng' Olwal,C., Bediako,Y.,
            Braberg,H., Soucheray,M., Ott,M., Eckhardt,M., Hultquist,J.F.,
            Marson,A., Kaake,R.M. and Krogan,N.J.
  TITLE     CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and
            UHRF1 as regulators of HIV latency in primary human T cells
  JOURNAL   mBio 15 (4), e0222223 (2024)
   PUBMED   38411080
  REMARK    GeneRIF: CRISPR-Cas9 screen of E3 ubiquitin ligases identifies
            TRAF2 and UHRF1 as regulators of HIV latency in primary human T
            cells.
REFERENCE   4  (bases 1 to 2266)
  AUTHORS   Wang,Z., Zhang,Y., Shen,Y., Zhou,H., Gao,Y., Zhu,C. and Qin,X.
  TITLE     Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated
            TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway
  JOURNAL   Biol Direct 19 (1), 18 (2024)
   PUBMED   38419066
  REMARK    GeneRIF: Unlocking hepatocellular carcinoma aggression:
            STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2266)
  AUTHORS   Jaeger-Ruckstuhl,C.A., Lo,Y., Fulton,E., Waltner,O.G.,
            Shabaneh,T.B., Simon,S., Muthuraman,P.V., Correnti,C.E.,
            Newsom,O.J., Engstrom,I.A., Kanaan,S.B., Bhise,S.S.,
            Peralta,J.M.C., Ruff,R., Price,J.P., Stull,S.M., Stevens,A.R.,
            Bugos,G., Kluesner,M.G., Voillet,V., Muhunthan,V., Morrish,F.,
            Olson,J.M., Gottardo,R., Sarthy,J.F., Henikoff,S., Sullivan,L.B.,
            Furlan,S.N. and Riddell,S.R.
  TITLE     Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell
            activation promotes memory-associated gene regulatory networks
  JOURNAL   Immunity 57 (2), 287-302 (2024)
   PUBMED   38354704
REFERENCE   6  (bases 1 to 2266)
  AUTHORS   Hsu,H., Huang,J., Shu,H.B., Baichwal,V. and Goeddel,D.V.
  TITLE     TNF-dependent recruitment of the protein kinase RIP to the TNF
            receptor-1 signaling complex
  JOURNAL   Immunity 4 (4), 387-396 (1996)
   PUBMED   8612133
REFERENCE   7  (bases 1 to 2266)
  AUTHORS   Lee,S.Y., Park,C.G. and Choi,Y.
  TITLE     T cell receptor-dependent cell death of T cell hybridomas mediated
            by the CD30 cytoplasmic domain in association with tumor necrosis
            factor receptor-associated factors
  JOURNAL   J Exp Med 183 (2), 669-674 (1996)
   PUBMED   8627180
REFERENCE   8  (bases 1 to 2266)
  AUTHORS   Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V.
  TITLE     TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF
            receptor 1 signal transduction pathways
  JOURNAL   Cell 84 (2), 299-308 (1996)
   PUBMED   8565075
REFERENCE   9  (bases 1 to 2266)
  AUTHORS   Hsu,H., Xiong,J. and Goeddel,D.V.
  TITLE     The TNF receptor 1-associated protein TRADD signals cell death and
            NF-kappa B activation
  JOURNAL   Cell 81 (4), 495-504 (1995)
   PUBMED   7758105
REFERENCE   10 (bases 1 to 2266)
  AUTHORS   Rothe,M., Wong,S.C., Henzel,W.J. and Goeddel,D.V.
  TITLE     A novel family of putative signal transducers associated with the
            cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
  JOURNAL   Cell 78 (4), 681-692 (1994)
   PUBMED   8069916
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC043492.1 and BC064662.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021138.3.
            
            Summary: The protein encoded by this gene is a member of the TNF
            receptor associated factor (TRAF) protein family. TRAF proteins
            associate with, and mediate the signal transduction from members of
            the TNF receptor superfamily. This protein directly interacts with
            TNF receptors, and forms a heterodimeric complex with TRAF1. This
            protein is required for TNF-alpha-mediated activation of MAPK8/JNK
            and NF-kappaB. The protein complex formed by this protein and TRAF1
            interacts with the inhibitor-of-apoptosis proteins (IAPs), and
            functions as a mediator of the anti-apoptotic signals from TNF
            receptors. The interaction of this protein with TRADD, a TNF
            receptor associated apoptotic signal transducer, ensures the
            recruitment of IAPs for the direct inhibition of caspase
            activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing
            ubiquitin ligase activity, can unbiquitinate and induce the
            degradation of this protein, and thus potentiate TNF-induced
            apoptosis. Multiple alternatively spliced transcript variants have
            been found for this gene, but the biological validity of only one
            transcript has been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043492.1, SRR1803611.110533.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247668.7/ ENSP00000247668.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1627              BC043492.1         4-1630
            1628-2266           BC064662.1         1626-2264
FEATURES             Location/Qualifiers
     source          1..2266
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..2266
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /note="TNF receptor associated factor 2"
                     /db_xref="GeneID:7186"
                     /db_xref="HGNC:HGNC:12032"
                     /db_xref="MIM:601895"
     exon            1..26
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            27..242
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1560
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /EC_number="2.3.2.27"
                     /note="tumor necrosis factor type 2 receptor associated
                     protein 3; E3 ubiquitin-protein ligase TRAF2; RING-type E3
                     ubiquitin transferase TRAF2"
                     /codon_start=1
                     /product="TNF receptor-associated factor 2"
                     /protein_id="NP_066961.2"
                     /db_xref="CCDS:CCDS7013.1"
                     /db_xref="GeneID:7186"
                     /db_xref="HGNC:HGNC:12032"
                     /db_xref="MIM:601895"
                     /translation="MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRP
                     FQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVES
                     LPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERS
                     LSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRF
                     HAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLE
                     KKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLA
                     MADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCL
                     RIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPD
                     VTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL"
     exon            243..321
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            322..420
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..582
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            583..657
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            658..732
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1014
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1192
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1341
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..2266
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2248..2253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /note="hexamer: ATTAAA"
     polyA_site      2266
                     /gene="TRAF2"
                     /gene_synonym="MGC:45012; RNF117; TRAP; TRAP3"
                     /note="major polyA site"
ORIGIN      
        1 agttccgggc gcgctgcgac cgttggggct ttgttcgcgg gggtcacagc tctcatggct
       61 gcagctagcg tgaccccccc tggctccctg gagttgctac agcccggctt ctccaagacc
      121 ctcctgggga ccaagctgga agccaagtac ctgtgctccg cctgcagaaa cgtcctccgc
      181 aggcccttcc aggcgcagtg tggccaccgg tactgctcct tctgcctggc cagcatcctc
      241 agctctgggc ctcagaactg tgctgcctgt gttcacgagg gcatatatga agaaggcatt
      301 tctattttag aaagcagttc ggccttccca gataatgctg cccgcaggga ggtggagagc
      361 ctgccggccg tctgtcccag tgatggatgc acctggaagg ggaccctgaa agaatacgag
      421 agctgccacg aaggccgctg cccgctcatg ctgaccgaat gtcccgcgtg caaaggcctg
      481 gtccgccttg gtgaaaagga gcgccacctg gagcacgagt gcccggagag aagcctgagc
      541 tgccggcatt gccgggcacc ctgctgcgga gcagacgtga aggcgcacca cgaggtctgc
      601 cccaagttcc ccttaacttg tgacggctgc ggcaagaaga agatcccccg ggagaagttt
      661 caggaccacg tcaagacttg tggcaagtgt cgagtccctt gcagattcca cgccatcggc
      721 tgcctcgaga cggtagaggg tgagaaacag caggagcacg aggtgcagtg gctgcgggag
      781 cacctggcca tgctactgag ctcggtgctg gaggcaaagc ccctcttggg agaccagagc
      841 cacgcggggt cagagctcct gcagaggtgc gagagcctgg agaagaagac ggccactttt
      901 gagaacattg tctgcgtcct gaaccgggag gtggagaggg tggccatgac tgccgaggcc
      961 tgcagccggc agcaccggct ggaccaagac aagattgaag ccctgagtag caaggtgcag
     1021 cagctggaga ggagcattgg cctcaaggac ctggcgatgg ctgacttgga gcagaaggtc
     1081 ttggagatgg aggcatccac ctacgatggg gtcttcatct ggaagatctc agacttcgcc
     1141 aggaagcgcc aggaagctgt ggctggccgc atacccgcca tcttctcccc agccttctac
     1201 accagcaggt acggctacaa gatgtgtctg cgtatctacc tgaacggcga cggcaccggg
     1261 cgaggaacac acctgtccct cttctttgtg gtgatgaagg gcccgaatga cgccctgctg
     1321 cggtggccct tcaaccagaa ggtgacctta atgctgctcg accagaataa ccgggagcac
     1381 gtgattgacg ccttcaggcc cgacgtgact tcatcctctt ttcagaggcc agtcaacgac
     1441 atgaacatcg caagcggctg ccccctcttc tgccccgtct ccaagatgga ggcaaagaat
     1501 tcctacgtgc gggacgatgc catcttcatc aaggccattg tggacctgac agggctctaa
     1561 ctgcccccta ctggtgtctg ggggttgggg gcagccaggc acagccggct cacggagggg
     1621 ccaccacgct gggccagggt ctcactgtac aagtgggcag gggccgcgct tgggcgcttg
     1681 ggagggtgtc ggcctgcagc caagttcact gtcacggggg aaggagccac cagccagtcc
     1741 tcagatttca gagactgcgg aggggcttgg cagacggtct tagccaaggg ctgtggtggc
     1801 attggccgag ggtcttcggg tgcttcccag cacaagctgc ccttgctgtc ctgtgcagtg
     1861 aagggagagg ccctgggtgg gggacactca gagtgggagc acatcccagc agtgcccatg
     1921 tagcaggagc acagtggatg gccttgtgtc cctcgggcat gacaggcaga aacgagggct
     1981 gctccaggag aagggcctcc tgctggccag agcaaggaag gctgagcagc ttggttctcc
     2041 cctctggccc ctggagagaa gggagcattc ctagacccct gggtgcttgt ctgcacagag
     2101 ctctggtctg tgccaccttg gccaggctgg ctgtgggaga gggtctggtc ccacgccgcc
     2161 tctgctcaga ccactgtgtg ggaggtgcac agcacagcct gcgggtaaag tgtgagagct
     2221 tgccatccag ctcacgaaga cagagttatt aaaccattca aatctc
//
