LOCUS       NM_005658               4351 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TNF receptor associated factor 1 (TRAF1), transcript
            variant 1, mRNA.
ACCESSION   NM_005658
VERSION     NM_005658.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4351)
  AUTHORS   Dean,B., Seymour,N. and Gibbons,A.
  TITLE     Lower levels of TRAF1 in Brodmann's area 24, but not 46, in bipolar
            disorders are not detectable in major depressive disorders
  JOURNAL   J Affect Disord 356, 316-322 (2024)
   PUBMED   38583598
  REMARK    GeneRIF: Lower levels of TRAF1 in Brodmann's area 24, but not 46,
            in bipolar disorders are not detectable in major depressive
            disorders.
REFERENCE   2  (bases 1 to 4351)
  AUTHORS   Yu,M., Yang,Y., Zhang,J., Liu,R., Huang,L., Wu,J., Kang,Z., Zhou,J.
            and Yang,Z.
  TITLE     Association between TRAF1/C5 Gene Polymorphisms and IgA Vasculitis
            in Chinese Children
  JOURNAL   Immunol Invest 53 (2), 281-293 (2024)
   PUBMED   38117213
  REMARK    GeneRIF: Association between TRAF1/C5 Gene Polymorphisms and IgA
            Vasculitis in Chinese Children.
REFERENCE   3  (bases 1 to 4351)
  AUTHORS   Mirzaesmaeili,A., Zangiabadi,S., Raspanti,J., Akram,A., Inman,R.D.
            and Abdul-Sater,A.A.
  TITLE     Cutting Edge: Negative Regulation of Inflammasome Activation by
            TRAF1 Can Limit Gout
  JOURNAL   J Immunol 210 (5), 531-535 (2023)
   PUBMED   36637223
  REMARK    GeneRIF: Cutting Edge: Negative Regulation of Inflammasome
            Activation by TRAF1 Can Limit Gout.
REFERENCE   4  (bases 1 to 4351)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   5  (bases 1 to 4351)
  AUTHORS   Xia,F., Yang,L. and Zhu,X.
  TITLE     Knockdown of circ_0038467 alleviates lipopolysaccharides-induced
            16HBE cell injury by regulating the miR-545-3p/TRAF1 axis in
            neonatal pneumonia
  JOURNAL   Microb Pathog 173 (Pt A), 105819 (2022)
   PUBMED   36216207
  REMARK    GeneRIF: Knockdown of circ_0038467 alleviates
            lipopolysaccharides-induced 16HBE cell injury by regulating the
            miR-545-3p/TRAF1 axis in neonatal pneumonia.
            Erratum:[Microb Pathog. 2023 Jun;179:106091. doi:
            10.1016/j.micpath.2023.106091.. PMID: 37045695]
REFERENCE   6  (bases 1 to 4351)
  AUTHORS   Hsu,H., Huang,J., Shu,H.B., Baichwal,V. and Goeddel,D.V.
  TITLE     TNF-dependent recruitment of the protein kinase RIP to the TNF
            receptor-1 signaling complex
  JOURNAL   Immunity 4 (4), 387-396 (1996)
   PUBMED   8612133
REFERENCE   7  (bases 1 to 4351)
  AUTHORS   Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V.
  TITLE     TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF
            receptor 1 signal transduction pathways
  JOURNAL   Cell 84 (2), 299-308 (1996)
   PUBMED   8565075
REFERENCE   8  (bases 1 to 4351)
  AUTHORS   Mosialos,G., Birkenbach,M., Yalamanchili,R., VanArsdale,T., Ware,C.
            and Kieff,E.
  TITLE     The Epstein-Barr virus transforming protein LMP1 engages signaling
            proteins for the tumor necrosis factor receptor family
  JOURNAL   Cell 80 (3), 389-399 (1995)
   PUBMED   7859281
REFERENCE   9  (bases 1 to 4351)
  AUTHORS   Hu,H.M., O'Rourke,K., Boguski,M.S. and Dixit,V.M.
  TITLE     A novel RING finger protein interacts with the cytoplasmic domain
            of CD40
  JOURNAL   J Biol Chem 269 (48), 30069-30072 (1994)
   PUBMED   7527023
REFERENCE   10 (bases 1 to 4351)
  AUTHORS   Rothe,M., Wong,S.C., Henzel,W.J. and Goeddel,D.V.
  TITLE     A novel family of putative signal transducers associated with the
            cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
  JOURNAL   Cell 78 (4), 681-692 (1994)
   PUBMED   8069916
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL832989.1, AK315476.1,
            U19261.1 and AC006430.22.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005658.4.
            
            Summary: The protein encoded by this gene is a member of the TNF
            receptor (TNFR) associated factor (TRAF) protein family. TRAF
            proteins associate with, and mediate the signal transduction from
            various receptors of the TNFR superfamily. This protein and TRAF2
            form a heterodimeric complex, which is required for
            TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
            protein complex formed by this protein and TRAF2 also interacts
            with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the
            anti-apoptotic signals from TNF receptors. The expression of this
            protein can be induced by Epstein-Barr virus (EBV). EBV infection
            membrane protein 1 (LMP1) is found to interact with this and other
            TRAF proteins; this interaction is thought to link LMP1-mediated B
            lymphocyte transformation to the signal transduction from TNFR
            family receptors. Three transcript variants encoding two different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832989.1, AK090468.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373887.8/ ENSP00000362994.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-637               AL832989.1         1974-2610
            638-1492            AK315476.1         618-1472
            1493-2326           U19261.1           1095-1928
            2327-4351           AC006430.22        16475-18499         c
FEATURES             Location/Qualifiers
     source          1..4351
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..4351
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /note="TNF receptor associated factor 1"
                     /db_xref="GeneID:7185"
                     /db_xref="HGNC:HGNC:12031"
                     /db_xref="MIM:601711"
     exon            1..247
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /inference="alignment:Splign:2.1.0"
     exon            248..613
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /inference="alignment:Splign:2.1.0"
     CDS             474..1724
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1;
                     Epstein-Bar virus-induced protein 6"
                     /codon_start=1
                     /product="TNF receptor-associated factor 1 isoform a"
                     /protein_id="NP_005649.1"
                     /db_xref="CCDS:CCDS6825.1"
                     /db_xref="GeneID:7185"
                     /db_xref="HGNC:HGNC:12031"
                     /db_xref="MIM:601711"
                     /translation="MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALCCAGCLSE
                     NPRNGEDQICPKCRGEDLQSISPGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQ
                     SVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDL
                     EVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATS
                     IHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNV
                     TRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYD
                     ALLPWPFRNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSK
                     LQSPKHAYVKDDTMFLKCIVETST"
     exon            614..701
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /inference="alignment:Splign:2.1.0"
     exon            702..767
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1178
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1356
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1505
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..4351
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2758..2763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /note="hexamer: AATAAT"
     polyA_site      2793
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /note="major polyA site"
     regulatory      4329..4334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /note="hexamer: AACAAA"
     polyA_site      4351
                     /gene="TRAF1"
                     /gene_synonym="EBI6; MGC:10353"
                     /note="major polyA site"
ORIGIN      
        1 gatttcatca gggctttcct gctccttctg gttgcctcag tcccaggcaa gatagggtcc
       61 cagaatctta cagcccagag gccacctgtt gcaacttctt ttttacagat ggagtcatca
      121 gaacccactg tgaggaagtg acttctcctt gaggtcaccc agacactcca aacagagcag
      181 agcaaaagcg cctagaactt gaaattttgg acctgtctcc aacaccctgg ggatttccac
      241 caggaagcct tcagtcacca tccaggggat ttttatcgcc acaaagggta attcctgctc
      301 catccctgct gtgactcagc tgtgacgttg aaccacacaa gccagagaga agaagataaa
      361 gtcatcagag ctcctactca ccagagagtg aggcccaggc caggactcca caaggctggt
      421 cccctgccct ggagcaactt aaacaggccc tctggccagc ctggaaccct gagatggcct
      481 ccagctcagg cagcagtcct cgcccggccc ctgatgagaa tgagtttccc tttgggtgcc
      541 ctcccaccgt ctgccaggac ccaaaggagc ccagggctct ctgctgtgca ggctgtctct
      601 ctgagaaccc gaggaatggc gaggatcaga tctgccccaa atgcagaggg gaagacctcc
      661 agtctataag cccaggaagc cgtcttcgaa ctcaggagaa ggctcacccc gaggtggctg
      721 aggctggaat tgggtgcccc tttgcaggtg tcggctgctc cttcaaggga agcccacagt
      781 ctgtgcaaga gcatgaggtc acctcccaga cctcccacct aaacctgctg ttggggttca
      841 tgaaacagtg gaaggcccgg ctgggctgtg gcctggagtc tgggcccatg gccctggagc
      901 agaacctgtc agacctgcag ctgcaggcag ccgtggaagt ggcgggggac ctggaggtcg
      961 attgctaccg ggcaccctgc tccgagagcc aggaggagct ggccctgcag cacttcatga
     1021 aggagaagct tctggctgag ctggagggga agctgcgtgt gtttgagaac attgttgctg
     1081 tcctcaacaa ggaggtggag gcctcccacc tggccctggc cacctctatc caccagagcc
     1141 agctggaccg tgagcgcatc ctgagcttgg agcagagggt ggtggagctt cagcagaccc
     1201 tggcccagaa agaccaggcc ctgggcaagc tggagcagag cttgcgcctc atggaggagg
     1261 cctccttcga tggcactttc ctgtggaaga tcaccaatgt caccaggcgg tgccatgagt
     1321 cggcctgtgg caggaccgtc agcctcttct ccccagcctt ctacactgcc aagtatggct
     1381 acaagttgtg cctgcggctg tacctgaatg gagatggcac tggaaagaga acccatctgt
     1441 cgctcttcat cgtgatcatg agaggggagt atgatgcgct gctgccgtgg cccttccgga
     1501 acaaggtcac cttcatgctg ctggaccaga acaaccgtga gcacgccatt gacgccttcc
     1561 ggcctgacct aagctcagcg tccttccaga ggccccagag tgaaaccaac gtggccagtg
     1621 gatgcccact cttcttcccc ctcagcaaac tgcagtcacc caagcacgcc tacgtgaagg
     1681 acgacacaat gttcctcaag tgcattgtgg agaccagcac ttagggtggg cggggctcct
     1741 gagggagctc caactcagaa gggagctagc cagaggactg tgatgccctg cccttggcac
     1801 ccaagacctc agggcacaaa gatgggtgaa ggctggcatg atccaagcaa gactgagggg
     1861 tcgacttcgg gctggccatc tggttaggat ggcaggacgt gggctgggcc cacaaaggca
     1921 aagggtccag aaggagacag gcagagctgc tcccctctgc acggaccatg cgacactggg
     1981 aggccagtga gccactccgg ccccgaatgt tgaggtggac tctcaccaaa tgagaagaaa
     2041 atggaaccag gcttggaacc gtaggaccca agcagagaag ctctcgggct aggaagatct
     2101 ctgcagggcc gccagggaga cctggacaca ggcctgctct ctttttctcc agggtcagaa
     2161 acaggaccgg gtggaaggga tggggtgcca gtttgaatgc agtctgtcca ggctcgtcat
     2221 tggaggtgaa caagcaaacc cagacggctc cactaggact tcaaattggg ggttggattt
     2281 gaagactttt aagtttcctt ccagcccaga aagtctctca ttctaggcct cctggcccag
     2341 gtgagtccta gagctacagg ggttctggaa acattcagga gcttcctgtc ctcccagctc
     2401 ctcactcacc ttcagtaacc cccactggac tgacctggtc cacagggcac ctgccaccct
     2461 gggcctggca gctcagcttc cccaacacgc aggagcacac ccagccccca catcctgtgc
     2521 ctccatcagc taaacaccac gtcacttcat gcaggtgaaa cccagtcact gtgagctccc
     2581 aggtgcagcc agaggcacct caagaagaag aggggcataa actttcctct tcctgcctag
     2641 aggccccacc tttggtgctt tccagaatcc cgtaacacct gattaactga ggcatccact
     2701 tctttcagca gactgatcag gacctccaag ccactgagca atgtataacc ccaaagaaat
     2761 aatttttaga atctctttcg aagttttcct aaagtgtatg gtttgggagt tgtttgtact
     2821 gagccaggtt tgaaaaggcc attgctgagt ttgaggtggt gccaccagtt ttgcaggtgg
     2881 catcagaggc tggcatgctg gcaggaacat cccctcttag ccccagtctt ctcttttcta
     2941 taatgagacc caccccagct tgcctccctc cctggcttct ctgaccctca aaggagatgc
     3001 cacgcaggac agactggaga gagaagcctg ggcaatactg cccgcctgtc atggcctggt
     3061 ggtggcccac acctatcttc tcaccttgga ggccacaccc aactttccaa agaccctgag
     3121 acaagtcagg accctactac tctcccctgc tgctttcctg acagcttact cttcctccac
     3181 ctgctgagcc tgtgccagac tccattgctc aaatcgttag ggttgcttct ataaaaatgg
     3241 gtcagtagcc cttcctgttc tctccagccc agcatacagg aggatcaaag gaggtgacgg
     3301 agcatcgtgg cacggcagtc tcaatgggtc agaaacccag gccagctggg ctctaagcct
     3361 ggcatcctgt catgcttagt ccttcagctg aagatcagag gaagcctctc ccttgccctc
     3421 tccagctcta ggggttttca ggaggcccaa ctgcaataat ggagcactag tgcttttatg
     3481 tgcaatggtg tcgtccatgc acgacagcag caaacattct ggggctgctt tttattgttc
     3541 ccacggctga cagcgtggca gcggagactg tggaggcagt ggagactgac ttcttcctgc
     3601 tgacagctgg atgtcacaca tgaaggtctg gcctagcgag tgatgggtct aggccctgaa
     3661 actgatgtcc tagcaataac ctcttgatcc ctactcaccg agtgttgagc ccaagggggg
     3721 atttgtagaa caagccccca tgagaaacag ctgttactct acacttttga ttgcctattt
     3781 ctgatggcaa gagatacata ctctcttcaa agagcatgag atgcagccat tctttcagca
     3841 aagcttcatt gacacctgca cctgttaact gtgttcgaca ttgaagggag aaaggcaaga
     3901 tgtgcactct ggactcaaga aactcttagt tcagtggagg aaatgagcag ataagtagat
     3961 cattatgatt gagagtagga gaagcttaga gaaagcacag aatcccagat ccagctggtg
     4021 aaggagggaa ggcttcaggc ctttaagctc agcctgagaa tattgtgaaa tgcagaggat
     4081 ggggaaaagg gaagagtacc gacttgaaaa cggagagctg tcttggctga gggcagggtc
     4141 tgtgtggcag gatgggggag ggagtcagaa gggtcagatg aactggagtg tagacagcat
     4201 cagatgcagc agtgcccacc gccccccccc ccaccccccg ccctgcccac agagcacctg
     4261 ctggtaaccc tgggcctatt gaaagcagga tgagatgata atttaagaca ctgaatgatt
     4321 tcttttccaa caaagctcta tgttaagtgc a
//
