LOCUS       NM_003789               1483 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TNFRSF1A associated via death domain (TRADD),
            transcript variant 1, mRNA.
ACCESSION   NM_003789
VERSION     NM_003789.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Chen,Y., Gu,Y., Xiong,X., Zheng,Y., Liu,X., Wang,W. and Meng,G.
  TITLE     Roles of the adaptor protein tumor necrosis factor receptor type
            1-associated death domain protein (TRADD) in human diseases
  JOURNAL   Biomed Pharmacother 153, 113467 (2022)
   PUBMED   36076575
  REMARK    GeneRIF: Roles of the adaptor protein tumor necrosis factor
            receptor type 1-associated death domain protein (TRADD) in human
            diseases.
            Review article
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Feoktistova,M., Makarov,R., Yazdi,A.S. and Panayotova-Dimitrova,D.
  TITLE     RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome
            Formation
  JOURNAL   Int J Mol Sci 22 (22), 12459 (2021)
   PUBMED   34830347
  REMARK    GeneRIF: RIPK1 and TRADD Regulate TNF-Induced Signaling and
            Ripoptosome Formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   Zhang,N., Kisiswa,L., Ramanujan,A., Li,Z., Sim,E.W., Tian,X.,
            Yuan,W., Ibanez,C.F. and Lin,Z.
  TITLE     Structural basis of NF-kappaB signaling by the p75 neurotrophin
            receptor interaction with adaptor protein TRADD through their
            respective death domains
  JOURNAL   J Biol Chem 297 (2), 100916 (2021)
   PUBMED   34175311
  REMARK    GeneRIF: Structural basis of NF-kappaB signaling by the p75
            neurotrophin receptor interaction with adaptor protein TRADD
            through their respective death domains.
            Erratum:[J Biol Chem. 2022 Nov;298(11):102583. doi:
            10.1016/j.jbc.2022.102583.. PMID: 36257251]
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Xu,D., Zhao,H., Jin,M., Zhu,H., Shan,B., Geng,J., Dziedzic,S.A.,
            Amin,P., Mifflin,L., Naito,M.G., Najafov,A., Xing,J., Yan,L.,
            Liu,J., Qin,Y., Hu,X., Wang,H., Zhang,M., Manuel,V.J., Tan,L.,
            He,Z., Sun,Z.J., Lee,V.M.Y., Wagner,G. and Yuan,J.
  TITLE     Modulating TRADD to restore cellular homeostasis and inhibit
            apoptosis
  JOURNAL   Nature 587 (7832), 133-138 (2020)
   PUBMED   32968279
  REMARK    GeneRIF: Modulating TRADD to restore cellular homeostasis and
            inhibit apoptosis.
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Park,A. and Baichwal,V.R.
  TITLE     Systematic mutational analysis of the death domain of the tumor
            necrosis factor receptor 1-associated protein TRADD
  JOURNAL   J Biol Chem 271 (16), 9858-9862 (1996)
   PUBMED   8621670
REFERENCE   7  (bases 1 to 1483)
  AUTHORS   Hsu,H., Huang,J., Shu,H.B., Baichwal,V. and Goeddel,D.V.
  TITLE     TNF-dependent recruitment of the protein kinase RIP to the TNF
            receptor-1 signaling complex
  JOURNAL   Immunity 4 (4), 387-396 (1996)
   PUBMED   8612133
REFERENCE   8  (bases 1 to 1483)
  AUTHORS   Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V.
  TITLE     TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF
            receptor 1 signal transduction pathways
  JOURNAL   Cell 84 (2), 299-308 (1996)
   PUBMED   8565075
REFERENCE   9  (bases 1 to 1483)
  AUTHORS   Hsu,H., Xiong,J. and Goeddel,D.V.
  TITLE     The TNF receptor 1-associated protein TRADD signals cell death and
            NF-kappa B activation
  JOURNAL   Cell 81 (4), 495-504 (1995)
   PUBMED   7758105
REFERENCE   10 (bases 1 to 1483)
  AUTHORS   Hasegawa,H.
  TITLE     [Nurses replies to expectations of the nursing profession]
  JOURNAL   Kango 27 (3), 66-80 (1975)
   PUBMED   1040062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA353575.1, BC004491.2 and
            CA426418.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003789.3.
            
            Summary: The protein encoded by this gene is a death domain
            containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and
            mediates programmed cell death signaling and NF-kappaB activation.
            This protein binds adaptor protein TRAF2, reduces the recruitment
            of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus
            suppresses TRAF2 mediated apoptosis. This protein can also interact
            with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is
            involved in the Fas-induced cell death pathway. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.500582.1,
                                           SRR1163657.329789.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345057.9/ ENSP00000341268.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DA353575.1         1-23
            24-1468             BC004491.2         1-1445
            1469-1483           CA426418.1         14-28               c
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1483
                     /gene="TRADD"
                     /gene_synonym="Hs.89862"
                     /note="TNFRSF1A associated via death domain"
                     /db_xref="GeneID:8717"
                     /db_xref="HGNC:HGNC:12030"
                     /db_xref="MIM:603500"
     exon            1..72
                     /gene="TRADD"
                     /gene_synonym="Hs.89862"
                     /inference="alignment:Splign:2.1.0"
     exon            73..231
                     /gene="TRADD"
                     /gene_synonym="Hs.89862"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1019
                     /gene="TRADD"
                     /gene_synonym="Hs.89862"
                     /note="tumor necrosis factor receptor-1-associated
                     protein; TNFR1-associated death domain protein; tumor
                     necrosis factor receptor type 1 associated death domain
                     protein"
                     /codon_start=1
                     /product="tumor necrosis factor receptor type 1-associated
                     DEATH domain protein"
                     /protein_id="NP_003780.1"
                     /db_xref="CCDS:CCDS10829.1"
                     /db_xref="GeneID:8717"
                     /db_xref="HGNC:HGNC:12030"
                     /db_xref="MIM:603500"
                     /translation="MAAGQNGHEEWVGSAYLFVESSLDKVVLSDAYAHPQQKVAVYRA
                     LQAALAESGGSPDVLQMLKIHRSDPQLIVQLRFCGRQPCGRFLRAYREGALRAALQRS
                     LAAALAQHSVPLQLELRAGAERLDALLADEERCLSCILAQQPDRLRDEELAELEDALR
                     NLKCGSGARGGDGEVASAPLQPPVPSLSEVKPPPPPPPAQTFLFQGQPVVNRPLSLKD
                     QQTFARSVGLKWRKVGRSLQRGCRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAE
                     GRRATLQRLVEALEENELTSLAEDLLGLTDPNGGLA"
     exon            232..509
                     /gene="TRADD"
                     /gene_synonym="Hs.89862"
                     /inference="alignment:Splign:2.1.0"
     exon            510..708
                     /gene="TRADD"
                     /gene_synonym="Hs.89862"
                     /inference="alignment:Splign:2.1.0"
     exon            709..1483
                     /gene="TRADD"
                     /gene_synonym="Hs.89862"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1451..1456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRADD"
                     /gene_synonym="Hs.89862"
                     /note="hexamer: AATAAA"
     polyA_site      1483
                     /gene="TRADD"
                     /gene_synonym="Hs.89862"
                     /note="major polyA site"
ORIGIN      
        1 gcacacccgg aagcggcgga gtagagcgga gcctggcggg cgtgggaacc caggccccgc
       61 cgaggcggcc aggaggtgag atggcagctg ggcaaaatgg gcacgaagag tgggtgggca
      121 gcgcatacct gtttgtggag tcctcgctgg acaaggtggt cctgtcggat gcctacgcgc
      181 acccccagca gaaggtggca gtgtacaggg ctctgcaggc tgccttggca gagagcggcg
      241 ggagcccgga cgtgctgcag atgctgaaga tccaccgcag cgacccgcag ctgatcgtgc
      301 agctgcgatt ctgcgggcgg cagccctgtg gccgcttcct ccgcgcctac cgcgaggggg
      361 cgctgcgcgc cgcgctgcag aggagcctgg cggccgcgct cgcccagcac tcggtgccgc
      421 tgcaactgga gctgcgcgcc ggcgccgagc ggctggacgc tttgctggcg gacgaggagc
      481 gctgtttgag ttgcatccta gcccagcagc ccgaccggct ccgggatgaa gaactggctg
      541 agctggagga tgcgctgcga aatctgaagt gcggctcggg ggcccggggt ggcgacgggg
      601 aggtcgcttc ggcccccttg cagcccccgg tgccctctct gtcggaggtg aagccgccgc
      661 cgccgccgcc acctgcccag acttttctgt tccagggtca gcctgtagtg aatcggccgc
      721 tgagcctgaa ggaccaacag acgttcgcgc gctctgtggg tctcaaatgg cgcaaggtgg
      781 ggcgctcact gcagcgaggc tgccgggcgc tgcgggaccc ggcgctggac tcgctggcct
      841 acgagtacga gcgcgaggga ctgtacgagc aggccttcca gctgctgcgg cgcttcgtgc
      901 aggccgaggg ccgccgcgcc acgctgcagc gcctggtgga ggcactcgag gagaacgagc
      961 tcaccagcct ggcagaggac ttgctgggcc tgaccgatcc caatggcggc ctggcctaga
     1021 ccaggggtgc agccagcttt tggagaacct ggatggcctt agggttcctt ctgcggctat
     1081 tgctgaaccc ctgtccatcc acgggaccct gaaactccac ttggcctatc tgctggacct
     1141 gctggggcag agttgattgc cttccccagg agccagacca ctgggggtgc atcattgggg
     1201 attctgcctc aggtactttg atagagtgtg gggtgggggg gacctgcttt ggagatcagc
     1261 ctcaccttct cccatcccag aagcggggct tacagccagc ccttacagtt tcactcatga
     1321 agcaccttga tctttggtgt cctggacttc atcctgggtg ctgcagatac tgcagtgaag
     1381 taaaacagga atcaatcttg cctgccccca gctcacactc agcgtgggac cccgaatgtt
     1441 aagcaatgat aataaagtat aacacggatt ttgatgtgag aaa
//
