LOCUS       NM_001194986            7524 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TraB domain containing 2B (TRABD2B), mRNA.
ACCESSION   NM_001194986 XM_001132797 XM_001717552 XM_371250
VERSION     NM_001194986.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7524)
  AUTHORS   Yuan,X., Dong,B., Xu,Y., Dong,L., Huang,J., Zhang,J., Chen,Y.,
            Xue,W. and Huang,Y.
  TITLE     TIKI2 is upregulated and plays an oncogenic role in renal cell
            carcinoma
  JOURNAL   Oncotarget 7 (13), 17212-17219 (2016)
   PUBMED   26942462
  REMARK    GeneRIF: Results of the present study indicate that TIKI2 is
            upregulated in renal cell carcinoma tissues and plays an oncogenic
            role in renal cell carcinoma
REFERENCE   2  (bases 1 to 7524)
  AUTHORS   Zhang,X., MacDonald,B.T., Gao,H., Shamashkin,M., Coyle,A.J.,
            Martinez,R.V. and He,X.
  TITLE     Characterization of Tiki, a New Family of Wnt-specific
            Metalloproteases
  JOURNAL   J Biol Chem 291 (5), 2435-2443 (2016)
   PUBMED   26631728
  REMARK    GeneRIF: examination of the structural prediction and
            identification of the active site residues of human TIKI2
            Erratum:[J Biol Chem. 2020 Jan 31;295(5):1367. doi:
            10.1074/jbc.AAC120.012554.. PMID: 32005644]
REFERENCE   3  (bases 1 to 7524)
  AUTHORS   Li,R., Liu,J., Wu,H., Liu,L., Wang,L. and Zhang,S.
  TITLE     TIKI2 suppresses growth of osteosarcoma by targeting
            Wnt/beta-catenin pathway
  JOURNAL   Mol Cell Biochem 392 (1-2), 109-116 (2014)
   PUBMED   24771064
  REMARK    GeneRIF: provided evidence that reduced expression of TIKI family
            protein in osteosarcoma may participate in the progression of
            osteosarcoma and restoring its expression was able to impair the
            growth of osteosarcoma
REFERENCE   4  (bases 1 to 7524)
  AUTHORS   Reis,A.H., Macdonald,B., Feistel,K., Brito,J.M., Amado,N.G., Xu,C.,
            Abreu,J.G. and He,X.I.
  TITLE     Expression and evolution of the Tiki1 and Tiki2 genes in
            vertebrates
  JOURNAL   Int J Dev Biol 58 (5), 355-362 (2014)
   PUBMED   25354456
REFERENCE   5  (bases 1 to 7524)
  AUTHORS   Lopez,L.M., Bastin,M.E., Maniega,S.M., Penke,L., Davies,G.,
            Christoforou,A., Valdes Hernandez,M.C., Royle,N.A., Tenesa,A.,
            Starr,J.M., Porteous,D.J., Wardlaw,J.M. and Deary,I.J.
  TITLE     A genome-wide search for genetic influences and biological pathways
            related to the brain's white matter integrity
  JOURNAL   Neurobiol Aging 33 (8), 1847 (2012)
   PUBMED   22425255
REFERENCE   6  (bases 1 to 7524)
  AUTHORS   Zhang,X., Abreu,J.G., Yokota,C., MacDonald,B.T., Singh,S.,
            Coburn,K.L., Cheong,S.M., Zhang,M.M., Ye,Q.Z., Hang,H.C., Steen,H.
            and He,X.
  TITLE     Tiki1 is required for head formation via Wnt cleavage-oxidation and
            inactivation
  JOURNAL   Cell 149 (7), 1565-1577 (2012)
   PUBMED   22726442
REFERENCE   7  (bases 1 to 7524)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099679.3 and AL691459.25.
            
            On Nov 24, 2018 this sequence version replaced NM_001194986.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JQ653416.1, ERR3218371.390816.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000606738.3/ ENSP00000476820.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-698               AC099679.3         37420-38117         c
            699-1262            AC099679.3         34766-35329         c
            1263-1409           AL691459.25        133185-133331       c
            1410-1584           AL691459.25        126298-126472       c
            1585-1675           AL691459.25        110166-110256       c
            1676-1945           AL691459.25        106882-107151       c
            1946-7524           AL691459.25        92240-97818         c
FEATURES             Location/Qualifiers
     source          1..7524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..7524
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /note="TraB domain containing 2B"
                     /db_xref="GeneID:388630"
                     /db_xref="HGNC:HGNC:44200"
                     /db_xref="MIM:614913"
     exon            1..698
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             597..2150
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /note="UPF0632 protein A; TRAB domain-containing protein
                     2B; metalloprotease TIKI2; heart, kidney and
                     adipose-enriched transmembrane protein homolog"
                     /codon_start=1
                     /product="metalloprotease TIKI2 precursor"
                     /protein_id="NP_001181915.1"
                     /db_xref="CCDS:CCDS58000.1"
                     /db_xref="GeneID:388630"
                     /db_xref="HGNC:HGNC:44200"
                     /db_xref="MIM:614913"
                     /translation="MHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWT
                     IRRDPPAYLFGTIHVPYTRVWDFIPDNSKAAFQASTRVYFELDLTDPYTISALASCQL
                     LPHGENLQDVLPHELYWRLKRHLDYVKLMMPSWMTPAQRGKGLYADYLFNAIAGNWER
                     KRPVWVMLMVNSLTERDVRFRGVPVLDLYLAQQAEKMKKTTGAVEQVEEQCHPLNNGL
                     NFSQVLFALNQTLLQQESVRAGSLQASYTTEDLIKHYNCGDLSAVIFNHDTSQLPNFI
                     NTTLPPHEQVTAQEIDSYFRQELIYKRNERMGKRVMALLRENEDKICFFAFGAGHFLG
                     NNTVIDILRQAGLEVDHTPAGQAIHSPAPQSPAPSPEGTSTSPAPVTPAAAVPEAPSV
                     TPTAPPEDEDPALSPHLLLPDSLSQLEEFGRQRKWHKRQSTHQRPRQFNDLWVRIEDS
                     TTASPPPLPLQPTHSSGTAKPPFQLSDQLQQQDPPGPASSSAPTLGLLPAIATTIAVC
                     FLLHSLGPS"
     exon            699..1262
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1409
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1584
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1675
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1945
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..7524
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2387..2392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /note="hexamer: AAGAAA"
     polyA_site      2416
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /note="major polyA site"
     regulatory      7502..7507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /note="hexamer: AATAAA"
     polyA_site      7524
                     /gene="TRABD2B"
                     /gene_synonym="TIKI2"
                     /note="major polyA site"
ORIGIN      
        1 ctctctccct ccctcccggc cgcggagcag catggcggag cccgggcagc ggccgcgcgg
       61 ccgcccgccg cccctctgag ccgggctcgg gggcagccgg tcgccccaga gccgcccccc
      121 acccctgccg cgccttccgc cgcacttgtc ccactgcgcg cctcctggag cgccgcgcac
      181 ccctgggacc cttgcgtgcc ccgggtgccc agcataaccc cgggaccctt gcgcaccccg
      241 ggttctcggt tctgccccag gaaccccgcg cgcccctgga ccgcgacgca gctccgggac
      301 cccgcgcgcc cccggacccc aacacgccct cagcacccgg gggctcggcc agcgaggttg
      361 agcgcccggg ggaggggccc agccctagag ggtctccctc ttccaacaga cggagcccgg
      421 ccccagagaa acccccaggt ccgacaggga cagtcagcca cgccccagag ggcgcccagc
      481 atcctgcggc tggagccccg tgctccagag gaaactccgt gcccaactgg gggctccccg
      541 ccccgctgag gggcgccgcc caggagggtc ccccgcgccc cgcgggccct ggcaggatgc
      601 acgccgccct ggcggggccg ctgctcgccg ccctcctcgc caccgctcgc gcccgcccgc
      661 agcccccgga cggaggacag tgccggccgc ccggatcgca gagggacttg aactccttcc
      721 tgtggacgat tcggcgtgat cctccggcct acctgtttgg cactattcac gtcccctaca
      781 cccgcgtctg ggacttcatc ccggacaact ccaaggcagc cttccaggct agcacccgtg
      841 tctactttga gctggacctt acagacccct acaccatctc ggccctggcc agctgccagc
      901 tgctgccgca cggggaaaac ctgcaggacg tgctgcccca cgagctttac tggcgcttga
      961 agcgccacct ggactacgtg aagttgatga tgccctcctg gatgacgccc gctcagcggg
     1021 gcaaggggct ctatgctgac tacctattca atgccatcgc gggcaactgg gagcgcaaga
     1081 ggcccgtctg ggtgatgctc atggtaaact cgctcacaga gagggacgtg cgcttccgtg
     1141 gtgtgcccgt gctcgacctc tacctggccc agcaggctga gaagatgaag aagaccacag
     1201 gggctgtgga gcaggtggag gagcagtgcc atcccctcaa caacgggctc aacttctccc
     1261 aggtgctgtt tgccctgaac caaaccctgc tgcagcagga gagtgtgcgg gccgggagcc
     1321 tgcaggcctc ctacaccacg gaggacctca tcaagcacta caactgcgga gacctcagcg
     1381 cagtcatctt caaccacgac acatcccagc tgcccaactt tatcaacacc accctcccgc
     1441 cacacgagca ggtgacggcc caggagattg acagctactt ccgccaggag ctcatctaca
     1501 agaggaatga gcgcatgggg aagagggtca tggcgcttct acgggagaac gaggacaaga
     1561 tctgcttctt tgccttcgga gcaggtcact ttctggggaa caacacagtc atcgacatcc
     1621 tgcggcaggc agggctggag gtggaccaca cacccgccgg gcaggccata cacagccctg
     1681 ccccccagag cccagcgccc tctcctgagg ggacctcgac gagcccggcc ccagtgaccc
     1741 cagctgccgc tgtccccgaa gcaccctctg tgacccccac cgccccacca gaggatgagg
     1801 atccagccct gtccccacac ctcctgctcc ccgacagcct cagccagctg gaggagtttg
     1861 gccggcagag gaagtggcac aagaggcaga gcacacacca gcggccgcgg cagttcaatg
     1921 acctctgggt ccgcatcgag gacagcacca ccgcctcacc acccccgctg cccctgcagc
     1981 ccacccacag ctcggggacc gccaagcccc ccttccagct ttcagaccag ctacaacagc
     2041 aggacccgcc agggcccgcc agcagctcgg cacccaccct gggccttctc cccgccatcg
     2101 ccaccaccat cgctgtctgc ttcctgctgc atagccttgg gccctcctga cctcggccac
     2161 cccaagtgga gaagccagag aaatgacaca ggggtcttcg gccacaccca actgctcctg
     2221 ccaccacctc cagggggtgc ccaacacgtc gagggcagtc cacatgggat tggctagaca
     2281 ctctagagct ttactgtacc caagttacat cttctttttt gtagaaggat cttaatttcc
     2341 catagtgcta tggggctctt ttgtaaaata cgtgtccata ttaaaaaaga aaaatgtatt
     2401 tattctaccg ataaaactat tcttatgtgg cctgtgttat aaccccctag ccctagtgct
     2461 ggcccgggag gggaacccgg gacatcagtg acctcctgtg gactgtggct ctggactggc
     2521 ttgctcttgg atcaccgaag cctcctgggt ctgggtttgg cttctccgac tgtggggccc
     2581 tcagcaggag gggcaggcag gcaggcttag cctttgtgaa gctggatttg ggagccagag
     2641 gtgtgaacgt tggccatcct cccctctgct ggatgcaccc gcggcctggg aagataattt
     2701 aggaaagaga atgctgctat tgtgaaaccc ctgagtgtct atctggccct ccagagctct
     2761 tggtaagtgt tttcaaccaa agcgctgggg tggggtggga ggtgggatac tggtgctgag
     2821 gaaagcagtc cccaccccac agaacaaatg aataaactga gatccagaga gaaccaggtg
     2881 ggtagcccaa ggtcacacgg caagtgggag agtgaggaca taaatccaga cctctctgtt
     2941 ctggtgtcat gaatccagct tgggttaaag gagaggctgt tgaagtcctg gctaaatgga
     3001 ttgagctggg ccgagggact ggagtgggca caggagggca gttttagaga caggggctta
     3061 ggcctcacat gatgttaata gtaatgagag ctgccatttt tccaaagcct gcagcgtggc
     3121 aagcactttg cacacttgct tcactgattc ttgcgctagt tctgtgagat gtgactatcc
     3181 ccatttcaca gatgaggaaa ctgagccccc caaagaggcg aagggacttg ctgaagatcc
     3241 cccagccagg atgtggcccc agatcagtgt gatgcaaaac aattcctgcc tcctgttccc
     3301 tgttctgcca cgttctctct gcaagggagc agatctcacc caaactgggg ccagcacaag
     3361 ctttcactcc accaagaaac cttttggccg gctgcttatg ttgacccctc tggccaaagg
     3421 gctctggcaa ctgcatgtgc catgtgtcgc atgtcctgac ttgccagatc ttggagccca
     3481 cgagaagctt tcctgccaaa tcaaaggctg agaggtgggc acagctgtgg ggcacctggg
     3541 gaggcacagc agccaagtgg ggaggcaggt gacagggact ccgagagact ttagcccctc
     3601 ggctcctcaa ggtggtggtt gaggagacag aggacccagg tgggctaact cccacctggg
     3661 aggcctgaaa ccctatgggg caggtgcctc agtaattaca gagtcctgga acctgacagc
     3721 agaaaggacc cttcacttga tggataatag taacagtagg aggaataata aggcccacag
     3781 agaggagaca cttctccaag gctgcacagc cgggtgggcc tgctgactcc cagcccagtg
     3841 caccccaact ttatagcttc gtgggtttcc ctggcaggct tgatggcagc taattggccc
     3901 cagtgccatc ttgcccagct tggcagctat ctcccttctg agacggcaag ttctgggcag
     3961 ctcatgggat ggtcaggagt cccacgggca tcttggcagg cagctgaatt ctttacagct
     4021 cagccctgat ggacgtgttt gagcttgaga cctggcagga gactggagct ctgccttaga
     4081 gggcccagcc agccctgtgg gcaccatgct ctaaactgaa cttgacctca atccaggctg
     4141 gagttggttt atccttggca aaaatgtgac ttcctatttc tgagcgggaa ggggcttagc
     4201 tgacttataa agcaggctca gaagttggac atcaaacgga tcgtgcagtg cactatttgg
     4261 atgagataag tgtaaaggaa ttagaagcac acaggccaga ttcctctctg tttggggcag
     4321 agtatggcgt gagacgtatt gagatggagc ttgaggttaa ttaaagatga agcatttggg
     4381 taaacagtcc aggcacctga ccgtgtgccc agatctgtgc caggcactga gccaagaagg
     4441 taaattaatg cagcttgtaa ttactgagca catgcaatgc caggctctgt attagagctg
     4501 aatctaacca ctctccttgg cccagaggaa ctcattatca agatgggaca agcagtgcaa
     4561 tgctagatta cgtcgtcctg gcccctaact tcaggaagat tcagccttag tctttcccag
     4621 atccctcctc tgggcatatt aggggatcct aaactctccc ttaccctaat tcaagtgttt
     4681 aaagaaagat ggctagacta accgatggag tagacatgta cctacaggag agcaagagcc
     4741 aatgtggtca gacatctgtt gccaaagttc actgatctct gaggaccacc agctggccag
     4801 ggtctgaaat gaactcaact tgctgactta tgacccaaaa gacttgaggc acatatgcag
     4861 gaatctgcat gtctggggca cttgaattct ctcatcctgg gccagagaac caccattcca
     4921 taagcagcaa cccacacctt tgacacgatc tatccaccac taactgacat ttcttccaga
     4981 aacgttcttt gtgcccagcc tcataaaatg ctcctgttgc tctgagaaat ttgtgtgcac
     5041 ttcttagact tttctgtttg actgtgaggc aggcaggaaa gatgaaaggt ctgagaccca
     5101 gcaggtaaag tgatctgctt aaggtcgggc agcatgttat tgtggccctg ggtcctctac
     5161 ctctcacgaa agctgactgt gtgatgaagg gctctctggg gcatgttgga atggccatgt
     5221 ccccaggtct tcctccagtg gtgggtctga tgcaccagca gccagatgaa gacagggaga
     5281 gccctgtcat ccacagtgga gggagaagaa tcaggctgcc agggagctgc aaagggctgc
     5341 tgaggatgcc tccagtcctg agagtcaaag atctgggatc taggaagcat ggaaccttgt
     5401 gctggttatg aacaaatttg tccttgcatt gaaagaccct aagcatattt tcttcatgct
     5461 aaataatgtg ttatctacaa cttcctggcc tcggctagac ctggacaagc ctaggtgctc
     5521 aggccccttg tcccacttgc ctaatctcca gcccagggcc attgtcacag tggatcccaa
     5581 agaggaggga aagtccttct accaaaagga aagtctattg aaaatgctgt gaaggacaag
     5641 agaagttctc cagggaattg cagctttgat ggcatcctgt gtggcagaca gcagaattgg
     5701 ggctggtgat agtttttcag tgactgtgag ataagaacca gagtcctcag cctcaccctg
     5761 aagtgtccgc tagacccttc gtgacccaac cctgctgacc agccacgtct ctcatgtctc
     5821 ttaccctgtg cctggccagc gtgatgtgca gtcatctcta gaatagacag gatgtttcac
     5881 acatgctgct ccctacccct ggaaactccc ttctctcccc tgtaactgct catccattga
     5941 ggatcaacac agatagcact tcctccagga agccccctcc cattcctttg tgctttctta
     6001 gcatctatca caatacccac tgcccagtgt tgtgactatc tagtgtgtat ctgctcctct
     6061 cggactgtga gcagcttaat ggcaggggtc atgtaaattt gtttttgtac cctcatctga
     6121 cacaaaggtg gtgctcaaca gatgtgtaga gagagaaagg aagggaagga agctgaagga
     6181 aggggaggaa gaaaggaatg aaggcagaaa agaaggagag aggcagacct tagttccacc
     6241 agtggcataa tttccaccaa gccaaagctg tctggggatg gcccggagcc cccaagggtg
     6301 gcaggtttcc catcgggaga ggtgtttgag caggggcagt gtgcccactg gctgaagaag
     6361 tggtaggaga gttgacatct tgccaagggc ctggtgtaga tgacattgag ggtccctcct
     6421 ggctctgcaa tgatcaagtt ctatgaacat tgttattttt ccagaaattc atctgagcag
     6481 ccaaaaaaaa tcaccccgct ggctgtctaa accagtaagg ttcaggaata agtccagcct
     6541 ccccactcca cccacaacca ccaccacccc tcacagcgcc cccttcaatg acccagctgg
     6601 gcttgactgc tgcctttggg tgggggaact tctgaaaggt ggaggaggag tgaactggaa
     6661 cccaggcctg cagcccagcc cagagctcct tcccgctctg ccccactccc tgaccccagg
     6721 ggaggaaagg gttcacgaga actgattgac cccctacttg gctctttcca gggagcatcg
     6781 gctatcctca ccctttctcc aagtgggagc tgggctcttc ctttccggag atactctgga
     6841 tactccttca ctttgctgga tgaccttggg caagttcctg tccctctctg agccttcact
     6901 tcctcatctg tcaaatgaag accttgattc ctgcctgggc agttctaggg ctggagggca
     6961 ggggtgacat ggacaatctt gggcctccat ggagatgagg tgcttggctt tcttcccagg
     7021 acccacaggc tgccatggga ttgaaagcat gtggaggtgg gaaaggtgac agagtagcat
     7081 gcctccaagg cccccttcat cccagtcctg ctgtggggaa agtgggcttt gaacgggatc
     7141 caagtctaag atgtttccgg tgagctgcca gggacaaagg gctctcagac atcttgggtc
     7201 cccagtggct ggggtgggca ggggctgatt cagccaaagg aggctctagc ccagaacaga
     7261 ggaagccaga gcccctgccc cattcttgag cctcacagag cttgtccccg agttgattca
     7321 ctgtgcaaca caggcttcag attcatgtat ttgaaaggta ttcatgatgt tgttctctta
     7381 tcacctctgc ccctcacctc tgtgaattat catgaagagt cctttaagag tataaataga
     7441 agacaaagaa agatgctatt aatgttattt tgccaaaaat atttttgtag cataatatat
     7501 taataaaaga tattatgaat tcaa
//
