LOCUS       NM_001277053            1814 bp    mRNA    linear   PRI 06-SEP-2020
DEFINITION  Homo sapiens TraB domain containing 2A (TRABD2A), transcript
            variant 1, mRNA.
ACCESSION   NM_001277053
VERSION     NM_001277053.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Dong J, Liang G and Shang H.
  TITLE     Inhibition of Metalloprotease TRABD2A Facilitates the Study of
            HIV-1 Replication in Resting CD4(+) T Cells
  JOURNAL   J. Virol. 94 (5), e01655-19 (2020)
   PUBMED   31801864
  REMARK    GeneRIF: Inhibition of Metalloprotease TRABD2A Facilitates the
            Study of HIV-1 Replication in Resting CD4(+) T Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Liu M, Dong J, Ouyang J, Zhao L, Liang G and Shang H.
  TITLE     Metalloprotease TRABD2A Restriction of HIV-1 Production in
            Monocyte-Derived Dendritic Cells
  JOURNAL   AIDS Res. Hum. Retroviruses 35 (10), 887-889 (2019)
   PUBMED   31282173
  REMARK    GeneRIF: Metalloprotease TRABD2A Restriction of HIV-1 Production in
            Monocyte-Derived Dendritic Cells.
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Reis AH, Macdonald B, Feistel K, Brito JM, Amado NG, Xu C, Abreu JG
            and He XI.
  TITLE     Expression and evolution of the Tiki1 and Tiki2 genes in
            vertebrates
  JOURNAL   Int. J. Dev. Biol. 58 (5), 355-362 (2014)
   PUBMED   25354456
REFERENCE   4  (bases 1 to 1814)
  AUTHORS   Zhang X, Abreu JG, Yokota C, MacDonald BT, Singh S, Coburn KL,
            Cheong SM, Zhang MM, Ye QZ, Hang HC, Steen H and He X.
  TITLE     Tiki1 is required for head formation via Wnt cleavage-oxidation and
            inactivation
  JOURNAL   Cell 149 (7), 1565-1577 (2012)
   PUBMED   22726442
  REMARK    GeneRIF: Tiki1 antagonizes Wnt function in embryos and human cells
            via a TIKI homology domain that is conserved from bacteria to
            mammals and acts likely as a protease to cleave eight
            amino-terminal residues of a Wnt protein, resulting in oxidized Wnt
            oligomers that exhibit normal secretion but minimized
            receptor-binding capability.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010087.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001277053.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296608.1, SRR1660807.253656.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409520.7/ ENSP00000387075.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC010087.3         5700-5852
            154-714             AC010087.3         15999-16559
            715-861             AC010087.3         44777-44923
            862-1036            AC010087.3         47461-47635
            1037-1127           AC010087.3         54639-54729
            1128-1379           AC010087.3         62580-62831
            1380-1814           AC010087.3         64684-65118
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..1814
                     /gene="TRABD2A"
                     /gene_synonym="C2orf89; TIKI1"
                     /note="TraB domain containing 2A"
                     /db_xref="GeneID:129293"
                     /db_xref="HGNC:HGNC:27013"
                     /db_xref="MIM:614912"
     exon            1..153
                     /gene="TRABD2A"
                     /gene_synonym="C2orf89; TIKI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1563
                     /gene="TRABD2A"
                     /gene_synonym="C2orf89; TIKI1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; UPF0632 protein C2orf89; TRAB domain-containing
                     protein 2A; metalloprotease TIKI1"
                     /codon_start=1
                     /product="metalloprotease TIKI1 isoform 1 precursor"
                     /protein_id="NP_001263982.1"
                     /db_xref="CCDS:CCDS62946.1"
                     /db_xref="GeneID:129293"
                     /db_xref="HGNC:HGNC:27013"
                     /db_xref="MIM:614912"
                     /translation="MSPWSWFLLQTLCLLPTGAASRRGAPGTANCELKPQQSELNSFL
                     WTIKRDPPSYFFGTIHVPYTRVWDFIPDNSKEAFLQSSIVYFELDLTDPYTISALTSC
                     QMLPQGENLQDVLPRDIYCRLKRHLEYVKLMMPLWMTPDQRGKGLYADYLFNAIAGNW
                     ERKRPVWVMLMVNSLTEVDIKSRGVPVLDLFLAQEAERLRKQTGAVEKVEEQCHPLNG
                     LNFSQVIFALNQTLLQQESLRAGSLQIPYTTEDLIKHYNCGDLSSVILSHDSSQVPNF
                     INATLPPQERITAQEIDSYLRRELIYKRNERIGKRVKALLEEFPDKGFFFAFGAGHFM
                     GNNTVLDVLRREGYEVEHAPAGRPIHKGKSKKTSTRPTLSTIFAPKVPTLEVPAPEAV
                     SSGHSTLPPLVSRPGSADTPSEAEQRFRKKRRRSQRRPRLRQFSDLWVRLEESDIVPQ
                     LQVPVLDRHISTELRLPRRGHSHHSQMVASSACLSLWTPVFWVLVLAFQTETPLL"
     exon            154..714
                     /gene="TRABD2A"
                     /gene_synonym="C2orf89; TIKI1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..861
                     /gene="TRABD2A"
                     /gene_synonym="C2orf89; TIKI1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1036
                     /gene="TRABD2A"
                     /gene_synonym="C2orf89; TIKI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1127
                     /gene="TRABD2A"
                     /gene_synonym="C2orf89; TIKI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1379
                     /gene="TRABD2A"
                     /gene_synonym="C2orf89; TIKI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1814
                     /gene="TRABD2A"
                     /gene_synonym="C2orf89; TIKI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1809..1814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRABD2A"
                     /gene_synonym="C2orf89; TIKI1"
                     /note="hexamer: AATAAA"
     polyA_site      1814
                     /gene="TRABD2A"
                     /gene_synonym="C2orf89; TIKI1"
                     /note="major polyA site"
ORIGIN      
        1 actccttccc tccgcgttcc gggcctcgga gccgccttga ggaggatgag tccctggagc
       61 tggttcctgc tgcagaccct ctgcctcctg cccacgggcg cagcttcgcg gcgcggggcg
      121 cccggcaccg ccaactgcga gctcaagccc caacaaagcg agctgaattc cttcttgtgg
      181 accattaagc gagacccacc atcttacttc tttggcacaa tccatgtccc gtacacccga
      241 gtttgggact tcatccccga caactctaag gaggctttcc tgcagagcag cattgtgtac
      301 tttgagttgg atctcacaga cccctatacc atctcagctc tcaccagctg tcagatgctg
      361 ccacagggcg agaacctcca agatgtgctc cccagggaca tctactgccg cctcaagcgc
      421 cacctggagt atgtcaagct catgatgccc ttgtggatga ccccagacca gcgcggcaag
      481 gggctctacg cagactacct cttcaatgct attgccggaa actgggagcg caagaggcct
      541 gtctgggtga tgctcatggt caactccctg actgaagtgg acattaagtc ccgtggagtg
      601 cctgtcttag acctgttcct tgcccaggag gctgagcggc tgaggaaaca gactggggca
      661 gtggaaaagg tggaagagca gtgccatcca ttgaatgggt tgaacttttc acaggtcatc
      721 tttgctttga accagaccct cctgcagcag gaaagcctgc gagcaggcag tcttcagatc
      781 ccctacacga cggaggatct catcaaacac tataactgcg gggacctcag ctccgtcatc
      841 ctcagccatg acagctccca ggttcccaat tttattaatg ccacgctacc acctcaggag
      901 cgcatcactg ctcaggagat tgacagctac ttacgccggg agctgatcta caagcggaat
      961 gagagaatag ggaagcgggt gaaggccctt ttggaggagt tccctgacaa aggcttcttc
     1021 tttgcctttg gagctggtca tttcatgggc aacaacacag tgctggatgt tttgcggcgt
     1081 gaaggctatg aggtagaaca cgcccctgct ggacgaccca tccacaaagg gaagagtaaa
     1141 aagacctcca cacggcccac tctgtccacc atctttgctc caaaagtccc taccctggaa
     1201 gtaccggcac cagaagccgt atcctcaggg cactcaacgc tgcctcccct tgtgtcccgg
     1261 cctggaagtg ccgacacgcc cagtgaggcc gaacagaggt tccggaagaa gcggaggcgg
     1321 tcacagcgga ggccgcgact ccggcaattc agcgatctgt gggtccgcct ggaggagagt
     1381 gacatagtcc cgcaactcca ggtccctgtc ctggacaggc acatctccac tgaactgcgg
     1441 ctccctcgcc gtgggcattc ccaccacagc cagatggtgg ccagcagtgc ctgcctgtct
     1501 ctctggactc ctgtgttctg ggtgctggtg ctggctttcc aaacagagac acccctcctg
     1561 taacgactgg aagcaccagg ctaagaacct gacccctcgg acttgaagaa tggccattcc
     1621 tgtactccac attctggtct agccttgttg ggcccaatcc agaagagact gctcttgaaa
     1681 aagcggccca gtgttgattc ttctctttcc aaggaatgtg actttgggtt atccaacttt
     1741 gggggcaggt gtacagtttt gtaacatagt gagttgtgtg aaaataaatt ataaatgagt
     1801 tgtatgaaaa taaa
//
