LOCUS       NM_001320485            2305 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens TraB domain containing (TRABD), transcript variant 3,
            mRNA.
ACCESSION   NM_001320485
VERSION     NM_001320485.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2305)
  AUTHORS   Zhou,C., Li,Z., Li,Y., Li,Y., Wang,W., Shang,W., Liu,J.P., Wang,L.
            and Tong,C.
  TITLE     TRABD modulates mitochondrial homeostasis and tissue integrity
  JOURNAL   Cell Rep 43 (6), 114304 (2024)
   PUBMED   38843396
REFERENCE   2  (bases 1 to 2305)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2305)
  AUTHORS   Wu,D., Jia,H., Zhang,Z. and Li,S.
  TITLE     STAT3-induced HLA-F-AS1 promotes cell proliferation and stemness
            characteristics in triple negative breast cancer cells by
            upregulating TRABD
  JOURNAL   Bioorg Chem 109, 104722 (2021)
   PUBMED   33618253
REFERENCE   4  (bases 1 to 2305)
  AUTHORS   Liang,Q., Yao,X., Tang,S., Zhang,J., Yau,T.O., Li,X., Tang,C.M.,
            Kang,W., Lung,R.W., Li,J.W., Chan,T.F., Xing,R., Lu,Y., Lo,K.W.,
            Wong,N., To,K.F., Yu,C., Chan,F.K., Sung,J.J. and Yu,J.
  TITLE     Integrative identification of Epstein-Barr virus-associated
            mutations and epigenetic alterations in gastric cancer
  JOURNAL   Gastroenterology 147 (6), 1350-62 (2014)
   PUBMED   25173755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU902575.1 and AL449244.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001320485.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (b)
            has the same N- and C-termini but is shorter compared to isoform a.
            Variants 2, 3, and 4 all encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.926816.1,
                                           SRR7346977.1053258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380909.9/ ENSP00000370295.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-724               BU902575.1         2-725
            725-2305            AL449244.1         732-2312
FEATURES             Location/Qualifiers
     source          1..2305
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..2305
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /note="TraB domain containing"
                     /db_xref="GeneID:80305"
                     /db_xref="HGNC:HGNC:28805"
     exon            1..64
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /inference="alignment:Splign:2.1.0"
     exon            65..131
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1229
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /note="isoform b is encoded by transcript variant 3; traB
                     domain-containing protein"
                     /codon_start=1
                     /product="traB domain-containing protein isoform b"
                     /protein_id="NP_001307414.1"
                     /db_xref="CCDS:CCDS14086.1"
                     /db_xref="GeneID:80305"
                     /db_xref="HGNC:HGNC:28805"
                     /translation="MDGEEQQPPHEANVEPVVPSEASEPVPRVLSGDPQNLSDVDAFN
                     LLLEMKLKRRRQRPNLPRTVTQLVAEDGSRVYVVGTAHFSDDSKRDVVKTIREVQPDV
                     VVVELCQYRVSMLKMDESTLLREAQELSLEKLQQAVRQNGLMSGLMQMLLLKVSAHIT
                     EQLGMAPGGEFREAFKEASKVPFCKFHLGDRPIPVTFKRAIAALSFWQKVRLAWGLCF
                     LSDPISKDDVERCKQKDLLEQMMAEMIGEFPDLHRTIVSERDVYLTYMLRQAARRLEL
                     PRASDAEPRKCVPSVVVGVVGMGHVPGIEKNWSTDLNIQEIMTVPPPSVSGRVSRLAV
                     KAAFFGLLGYSLYWMGRRTASLVLSLPAAQYCLQRVTEARHK"
     exon            132..210
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /inference="alignment:Splign:2.1.0"
     exon            211..377
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /inference="alignment:Splign:2.1.0"
     exon            378..518
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /inference="alignment:Splign:2.1.0"
     exon            519..629
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /inference="alignment:Splign:2.1.0"
     exon            630..769
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /inference="alignment:Splign:2.1.0"
     exon            770..942
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1054
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..2305
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2285..2290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /note="hexamer: AATAAA"
     polyA_site      2305
                     /gene="TRABD"
                     /gene_synonym="LP6054; PP2447"
                     /note="major polyA site"
ORIGIN      
        1 gccccgtccg ttgagggccc gcgccgcatg gaggccggct gaggagcgcc gctgcctcgc
       61 ctcggctccc cacaggtgca ggaagccgcc gcccagccat ggacggggag gagcagcagc
      121 caccgcacga ggccaacgtg gaacctgttg tgccgtcaga ggcttcagag ccggtgccca
      181 gggtgctttc tggagacccc cagaacctgt ccgacgtgga cgccttcaac ctgctcctgg
      241 agatgaagct gaagcggcgg cgtcagcggc ccaacctgcc gcgcactgtg acccagttgg
      301 tggctgagga cgggagcagg gtgtacgtgg tggggacagc ccacttcagc gacgacagca
      361 agagggacgt tgtgaagacc atccgggagg tgcagcctga cgtggtggtc gtggagctct
      421 gccaatatcg tgtgtccatg ctgaagatgg acgagagcac gctgctgcgg gaggcccagg
      481 agctcagcct ggagaagctg cagcaggccg tgaggcagaa cgggctcatg tcggggctga
      541 tgcagatgct gctgctgaag gtgtctgcac acatcaccga gcagctgggc atggccccag
      601 gtggcgagtt cagggaggcc ttcaaggagg ccagcaaggt gcctttctgc aagttccacc
      661 tgggtgaccg acccatcccc gtcaccttca agagggccat cgcagcgctc tccttctggc
      721 agaaggtcag gctggcttgg ggcctgtgct tcctgtcaga ccccatcagc aaggatgacg
      781 tggaacgctg caagcagaag gacctactgg agcagatgat ggccgagatg attggcgagt
      841 tcccagacct gcaccgcacc atcgtctcgg agcgcgacgt ctacctaacc tacatgctgc
      901 gccaggccgc gcggcgcctc gagctgcctc gggcctctga cgccgagccc aggaagtgcg
      961 tcccctccgt ggtcgtgggc gtcgtgggca tgggccacgt gcctggcatc gagaagaact
     1021 ggagcaccga cctcaacatc caggagatca tgaccgtgcc cccgccgtcc gtctccggca
     1081 gagtgtctcg gttggccgtg aaggccgcct tcttcggcct gctgggctac agcctgtact
     1141 ggatgggccg ccgcaccgcg agcctggtcc tgtcgctgcc cgccgcgcag tactgcctgc
     1201 agagggtgac cgaggcccgg cacaagtagg agactgctcc ccgcccgctc gggcccctga
     1261 ggagccagtg cccccgcggc acttctgggt gccaggtgca tcctagcccg cccgaggccc
     1321 ctgccacccc ccatgggggt ctgggcccgg cctcgcctgc cctcctgggc cagtcacccc
     1381 tcccccagcc cacccaaata aaggattatt taactgtctg agctcaggcc tcccggcagc
     1441 ccctcccctc ccacactgca ggggccgttc cccagcttct ggacaagaca cccagctccg
     1501 agggggcagg ggcttatagg aggggccgag gcgtgcgctg ccctctcagc cctggtggca
     1561 ggcgggggac aatggccact gtccctacct cactgtgcct tcctgtgctc cggccacagg
     1621 agcgtcggcc caggggcggc tcctgggggc tccagggcag gcgagactgg gaaaggccca
     1681 gccctggagc tccagccgac cccaccgtgc ccctggcatc ctggccctgg ccgccacctc
     1741 cctggcaccg tctgcctgca gggattctgt gtttttggct tttttaatgt cttaaaatct
     1801 tttactcagg taattttaat ttcagagaga aaaactgaag taaatgtcaa aaaacaccag
     1861 ccttaaatcc aaagggagag aattcgtgtt cttgggtctg tcccgagtgg gctcgcgtgc
     1921 agccaaacat cagctctggg tccaggcgtg gcctcagctg ggagcctgtg tcctgagccc
     1981 ccggagcgaa ggggtgcctg gggcatcttg gccctctctg ggcagacaat gtgtgcacct
     2041 atgtggaagg ccaaggacat gggctgtggc caggcctgtc ccgctcaggc cccctgcccg
     2101 gcggccgtct gtgtgcgggg cctccctcct ggctgtccag gacacagccc gtgcagcccc
     2161 agcctggacc caggccatct ctggttgtgt ctgtgccgac tcggtgttga atcaaatcag
     2221 gtgtgcgtca ggagccggct gtgtccttcc tgccacactc ggggattcat tccttagaaa
     2281 ctgaaataaa ttctaatttt ggaaa
//
