LOCUS       NM_004593               4178 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transformer 2 beta homolog (TRA2B), transcript variant
            1, mRNA.
ACCESSION   NM_004593
VERSION     NM_004593.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4178)
  AUTHORS   Karginov,T.A., Menoret,A., Leclair,N.K., Harrison,A.G.,
            Chandiran,K., Suarez-Ramirez,J.E., Yurieva,M., Karlinsey,K.,
            Wang,P., O'Neill,R.J., Murphy,P.A., Adler,A.J., Cauley,L.S.,
            Anczukow,O., Zhou,B. and Vella,A.T.
  TITLE     Autoregulated splicing of TRA2beta programs T cell fate in response
            to antigen-receptor stimulation
  JOURNAL   Science 385 (6714), eadj1979 (2024)
   PUBMED   39265028
  REMARK    GeneRIF: Autoregulated splicing of TRA2beta programs T cell fate in
            response to antigen-receptor stimulation.
REFERENCE   2  (bases 1 to 4178)
  AUTHORS   Chen,G., Chen,J., Qi,L., Yin,Y., Lin,Z., Wen,H., Zhang,S., Xiao,C.,
            Bello,S.F., Zhang,X., Nie,Q. and Luo,W.
  TITLE     Bulk and single-cell alternative splicing analyses reveal roles of
            TRA2B in myogenic differentiation
  JOURNAL   Cell Prolif 57 (2), e13545 (2024)
   PUBMED   37705195
  REMARK    GeneRIF: Bulk and single-cell alternative splicing analyses reveal
            roles of TRA2B in myogenic differentiation.
REFERENCE   3  (bases 1 to 4178)
  AUTHORS   Ramond,F., Dalgliesh,C., Grimmel,M., Wechsberg,O., Vetro,A.,
            Guerrini,R., FitzPatrick,D., Poole,R.L., Lebrun,M., Bayat,A.,
            Grasshoff,U., Bertrand,M., Witt,D., Turnpenny,P.D., Faundes,V.,
            Santa Maria,L., Mendoza Fuentes,C., Mabe,P., Hussain,S.A.,
            Mullegama,S.V., Torti,E., Oehl-Jaschkowitz,B., Salmon,L.B.,
            Orenstein,N., Shahar,N.R., Hagari,O., Bazak,L., Hoffjan,S.,
            Prada,C.E., Haack,T. and Elliott,D.J.
  TITLE     Clustered variants in the 5' coding region of TRA2B cause a
            distinctive neurodevelopmental syndrome
  JOURNAL   Genet Med 25 (4), 100003 (2023)
   PUBMED   36549593
  REMARK    GeneRIF: Clustered variants in the 5' coding region of TRA2B cause
            a distinctive neurodevelopmental syndrome.
REFERENCE   4  (bases 1 to 4178)
  AUTHORS   Li,M.J., Xiong,D., Wang,S. and Huang,H.
  TITLE     Tra2beta Enhances Cell Proliferation by Inducing the Expression of
            Transcription Factor SP1 in Cervical Cancer
  JOURNAL   Biomed Environ Sci 36 (2), 146-159 (2023)
   PUBMED   36861193
  REMARK    GeneRIF: Tra2beta Enhances Cell Proliferation by Inducing the
            Expression of Transcription Factor SP1 in Cervical Cancer.
REFERENCE   5  (bases 1 to 4178)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4178)
  AUTHORS   Nayler,O., Cap,C. and Stamm,S.
  TITLE     Human transformer-2-beta gene (SFRS10): complete nucleotide
            sequence, chromosomal localization, and generation of a
            tissue-specific isoform
  JOURNAL   Genomics 53 (2), 191-202 (1998)
   PUBMED   9790768
REFERENCE   7  (bases 1 to 4178)
  AUTHORS   Tacke,R., Tohyama,M., Ogawa,S. and Manley,J.L.
  TITLE     Human Tra2 proteins are sequence-specific activators of pre-mRNA
            splicing
  JOURNAL   Cell 93 (1), 139-148 (1998)
   PUBMED   9546399
REFERENCE   8  (bases 1 to 4178)
  AUTHORS   Imai,Y., Matsuo,N., Ogawa,S., Tohyama,M. and Takagi,T.
  TITLE     Cloning of a gene, YT521, for a novel RNA splicing-related protein
            induced by hypoxia/reoxygenation
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 33-40 (1998)
   PUBMED   9473574
REFERENCE   9  (bases 1 to 4178)
  AUTHORS   Beil,B., Screaton,G. and Stamm,S.
  TITLE     Molecular cloning of htra2-beta-1 and htra2-beta-2, two human
            homologs of tra-2 generated by alternative splicing
  JOURNAL   DNA Cell Biol 16 (6), 679-690 (1997)
   PUBMED   9212162
REFERENCE   10 (bases 1 to 4178)
  AUTHORS   Matsuo,N., Ogawa,S., Imai,Y., Takagi,T., Tohyama,M., Stern,D. and
            Wanaka,A.
  TITLE     Cloning of a novel RNA binding polypeptide (RA301) induced by
            hypoxia/reoxygenation
  JOURNAL   J Biol Chem 270 (47), 28216-28222 (1995)
   PUBMED   7499316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA164444.1, BC000160.2,
            U61267.1 and AC009247.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004593.2.
            
            Summary: This gene encodes a nuclear protein which functions as
            sequence-specific serine/arginine splicing factor which plays a
            role in mRNA processing, splicing patterns, and gene expression.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.73674.1,
                                           SRR1803617.17285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267755, SAMN03267759
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453386.7/ ENSP00000416959.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA164444.1         123-133
            12-1408             BC000160.2         1-1397
            1409-1992           U61267.1           1376-1959
            1993-4168           AC009247.13        96073-98248         c
            4169-4178           AC009247.13        96063-96072         c
FEATURES             Location/Qualifiers
     source          1..4178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.2"
     gene            1..4178
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /note="transformer 2 beta homolog"
                     /db_xref="GeneID:6434"
                     /db_xref="HGNC:HGNC:10781"
                     /db_xref="MIM:602719"
     exon            1..190
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1021
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transformer-2 protein homolog beta; TRA-2 beta;
                     transformer-2 protein homolog B; protein phosphatase 1,
                     regulatory subunit 156; splicing factor,
                     arginine/serine-rich 10 (transformer 2 homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transformer-2 protein homolog beta isoform 1"
                     /protein_id="NP_004584.1"
                     /db_xref="CCDS:CCDS33905.1"
                     /db_xref="GeneID:6434"
                     /db_xref="HGNC:HGNC:10781"
                     /db_xref="MIM:602719"
                     /translation="MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSR
                     RSRSKSRSRSESRSRSRRSSRRHYTRSRSRSRSHRRSRSRSYSRDYRRRHSHSHSPMS
                     TRRRHVGNRANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIADVSIVYDQQSRRSRG
                     FAFVYFENVDDAKEAKERANGMELDGRRIRVDFSITKRPHTPTPGIYMGRPTYGSSRR
                     RDYYDRGYDRGYDDRDYYSRSYRGGGGGGGGWRAAQDRDQIYRRRSPSPYYSRGGYRS
                     RSRSRSYSPRRY"
     exon            191..324
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            325..487
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            488..676
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            677..792
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            793..876
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            877..936
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1010
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..4178
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1389..1394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /note="hexamer: AATAAA"
     polyA_site      1408
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /note="major polyA site"
     regulatory      1589..1594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /note="hexamer: AATACA"
     polyA_site      1612
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
     regulatory      1969..1974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /note="hexamer: AATAAA"
     regulatory      1985..1990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /note="hexamer: AAGAAA"
     polyA_site      1992
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
     polyA_site      2014
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
     regulatory      2810..2815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /note="hexamer: ATTAAA"
     polyA_site      2830
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
     regulatory      4145..4150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
                     /note="hexamer: AATATA"
     polyA_site      4178
                     /gene="TRA2B"
                     /gene_synonym="Htra2-beta; PPP1R156; SFRS10; SRFS10;
                     TRA2-BETA; TRAN2B"
ORIGIN      
        1 agagcccgtg cggaggcggt gcggagcatt tcggctctga gcggctgggc gaccggcgcg
       61 tcgtgcgggg ctgcggcgga gcctccttaa ggaaggtgca agaggttggc agcttcgatt
      121 gaagcacatc gaccggcgac agcagccagg agtcatgagc gacagcggcg agcagaacta
      181 cggcgagcgg gaatcccgtt ctgcttccag aagtggaagt gctcacggat cggggaaatc
      241 tgcaaggcat acccctgcaa ggtctcgctc caaggaagat tccaggcgtt ccagatcaaa
      301 gtccaggtcc cgatctgaat ctaggtctag atccagaaga agctcccgaa ggcattatac
      361 ccggtcacgg tctcgctccc gctcccatag acgatcacgt agcaggtctt acagtcgaga
      421 ttatcgtaga cggcacagcc acagccattc tcccatgtct actcgcaggc gtcatgttgg
      481 gaatcgggca aatcctgatc ctaactgttg tcttggagta tttgggctga gcttgtacac
      541 cacagaaaga gatctaagag aagtgttctc taaatatggt cccattgccg atgtgtctat
      601 tgtatatgac cagcagtcta ggcgttcaag aggatttgcc tttgtatatt ttgaaaatgt
      661 agatgatgcc aaggaagcta aagaacgtgc caatggaatg gagcttgatg ggcgtaggat
      721 cagagttgat ttctctataa caaaaagacc acatacgcca acaccaggaa tttacatggg
      781 gagacctacc tatggcagct ctcgccgtcg ggattactat gacagaggat atgatcgggg
      841 ctatgatgat cgggactact atagcagatc atacagagga ggaggtggag gaggaggagg
      901 atggagagct gcccaagaca gggatcagat ttatagaagg cggtcacctt ctccttacta
      961 tagtcgtgga ggatacagat cacgttccag atctcgatca tactcacctc gtcgctatta
     1021 aagcatgaag actttctgaa acctgcccta gagctgggat attgtttgtg ggcaatattt
     1081 tttattgtct cttgtttaaa aagtgaacag tgcctagtga agttaggtga cttttacacc
     1141 ttttacgatg actacttttg gtggagttga aatgctgttt tcattctgca tttgtgtagt
     1201 ttggtgcttt gttccaagtt aagtgttttc agaaaagtat gttttgcatg tattttttta
     1261 cagtctaaat tttgactgct gagaagtttc tattgtacaa aacttcattt aaaaggtttt
     1321 tctactgaat ccagggtatt ctgaagatcg aagcctgtgt aaaatgctac caaatggcaa
     1381 aaagcaacaa taaacagttt gatttttact tttctttcta acatatcaat gcttagcaga
     1441 actattcaga ttgtcagtag taaatttaaa gacaaatgcc cgttttcctc cagtccatga
     1501 aacataccat acttatatac ctgcaactaa gtgtttaaaa ttatgctctg taactctgta
     1561 ctgctagtat tagaactaaa aatcttaaaa tacagccagt gcttaatgct tatatcaatg
     1621 tggatttgtc ggcttttatg taatctgtaa tatgtatagc aggaaatacg aagagttaca
     1681 cagtgtatgc cttaaaaggc tgtttcttaa aggtgttaca aggggataat ggtatttcaa
     1741 ctagttatca gcaagtgaca atacattcca ccacaaatac actcttgttc ttctagcttt
     1801 tagactatat gaaaaaaccg ggtgcttcaa agtacatgat aagggaacac tatacctgtc
     1861 atggatgaac tgaagacttt gcctgttcat tttttaaata ttattttcag gtcctttgct
     1921 taccaaagga ggcccaattt cactcaaatg ttttgagaac tgtgtttaaa taaacgcaaa
     1981 tgaaaagaaa aatgttggtg cagctgttca caaagaagtg ttcttgttct attataatta
     2041 gagttcttct gtagtttaat cgttagggca gtgtgttcct tgggctgagg tgtatctttg
     2101 ctattttggg ctgggttgag ggggggatga atttctgtat tcctggaaaa ttcagagtgc
     2161 ataactaggt attagagtga tctccatttg gggatggagt tacagtaaat aactagactg
     2221 cgggtacttt aatacatgtt cttattattt tgcatttaag taattttcat gaccaattgt
     2281 agggatgttg ctacaggtgg gttattttgt tgccttgcta acctttatcg catctaggta
     2341 ttagtatgtt tcaggtactt tgggaagaac tttacatata atctttagca atgaaatgat
     2401 gtagagtaac ttaccttagt tcaaatagct gtttaagtgg caatgccacg atctgaattg
     2461 aacctaggtg atcttagtcc acagttctct tgatcatgat gtctcaaatc tgggtacctg
     2521 ggtgatggaa aataccagta atggagcata ggcagtattg gcaggtctta atttgtaaaa
     2581 cttactgtcc agggtgtttt cagtgtttgc caacttgtgg taaattaata tgcttagaga
     2641 actaccctta ggtttgtttc tgataagcat gtggaaacaa cttagtatat gcctgatggg
     2701 ttatttcaaa ttgttctcaa tgagttttga aacaagaatt tgtagtattt atatataaag
     2761 ttgagtttta gggtgtggtc ccagaggggg ttgtgttatg gatggataca ttaaaggctg
     2821 agaaacctgg ttttatcgtg gtagtatata caggcatcct ttcctgaagt aactacattc
     2881 tccaccattt tctccccaac caaacctctc cccatcagtt aactgatggc ttgcgagttc
     2941 acactcctga taatctcgaa cataaccctc ggtttctatc ctaaagcctg agttttagcc
     3001 ctttagttgt gtagccatcc tttatcctgc tgattgaaag tttccttttt taggctagtt
     3061 tgagttgttt tctggctttt agatttgaaa gaattttagc catttgacat ggctacaaag
     3121 agtgttaaca ggcaaaagac tgaggaaaat ttggaatttt accaagttga gatagactga
     3181 gaagtagtga gacaaagtgg tagtcttttg atgtgctgta atgctagtcg ccagtttcat
     3241 gaaagggagg cagcagttac ccgtaggtaa cccctaggta actgctgcca tgggcagctg
     3301 aatcagacaa aagccatggg aaaggataaa tttgagtctt aaagttactg cctcaaggca
     3361 aagggacttg gaggctttta tatgccaata caaacaatcc atttcttata gctgtagggc
     3421 tgagactact aaaaccaaat gtaaagttca tttggaagat tgctaagtta aatagtttta
     3481 tactaggctt ttgtgaaact tctcaggaaa tcaacagggt cccagcaagt ggaaataagg
     3541 ctgtgtcaaa agatttgtag acctgggagc aggggtttcc gatctcctgg ccatggattg
     3601 cctgagctcc gccgcctgtc agatcagcaa cagcagattt tcatagcagg aatcctattg
     3661 tgaagtgcgc ttgagaggga tctagcttgc acatttcctt atggaaatct aactacatgt
     3721 tagagaatgc tcaaggtctg caatgtttac attgttgccc ctacataagg aatatatgcc
     3781 ttaagataaa actaatagct cttagccctc ttacaccatt gactaggatt ccaattctgc
     3841 aaggcccagg aggagaaatt gagaattaga agtttcaccg agaagaaata aaaagatttg
     3901 gtttgcatta tcaaaatttc tgtaaattat atggaaattt tgaggatgga ttaggctgga
     3961 tttattagca gtggacacgc ctccaatatt ccttcagcat gccatctcag tggattttga
     4021 ttggctcttg taggattgga cttaatgcta gcttatgcca aatgtcatca aaaagccaga
     4081 atgctactac agtaatgtaa aggattattg tatatagtgt aaaggattat tatgtgtaat
     4141 ctttaatata taatgtaaag acttaaaagt gacaagaa
//
