LOCUS       NM_001289912            3390 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens TPTEP2-CSNK1E readthrough (TPTEP2-CSNK1E), mRNA.
ACCESSION   NM_001289912
VERSION     NM_001289912.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3390)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   2  (bases 1 to 3390)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   3  (bases 1 to 3390)
  AUTHORS   Chia,R., Haddock,S., Beilina,A., Rudenko,I.N., Mamais,A.,
            Kaganovich,A., Li,Y., Kumaran,R., Nalls,M.A. and Cookson,M.R.
  TITLE     Phosphorylation of LRRK2 by casein kinase 1alpha regulates
            trans-Golgi clustering via differential interaction with ARHGEF7
  JOURNAL   Nat Commun 5, 5827 (2014)
   PUBMED   25500533
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3390)
  AUTHORS   Chen,T.C., Lin,K.T., Chen,C.H., Lee,S.A., Lee,P.Y., Liu,Y.W.,
            Kuo,Y.L., Wang,F.S., Lai,J.M. and Huang,C.Y.
  TITLE     Using an in situ proximity ligation assay to systematically profile
            endogenous protein-protein interactions in a pathway network
  JOURNAL   J Proteome Res 13 (12), 5339-5346 (2014)
   PUBMED   25241761
REFERENCE   5  (bases 1 to 3390)
  AUTHORS   Choksi,D.K., Roy,B., Chatterjee,S., Yusuff,T., Bakhoum,M.F.,
            Sengupta,U., Ambegaokar,S., Kayed,R. and Jackson,G.R.
  TITLE     TDP-43 Phosphorylation by casein kinase Iepsilon promotes
            oligomerization and enhances toxicity in vivo
  JOURNAL   Hum Mol Genet 23 (4), 1025-1035 (2014)
   PUBMED   24105464
  REMARK    GeneRIF: CKI-epsilon is a potent TDP-43 kinase in vivo and in
            vitro.
REFERENCE   6  (bases 1 to 3390)
  AUTHORS   Hino,S., Michiue,T., Asashima,M. and Kikuchi,A.
  TITLE     Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and
            is essential for Wnt-3a-induced accumulation of beta-catenin
  JOURNAL   J Biol Chem 278 (16), 14066-14073 (2003)
   PUBMED   12556519
REFERENCE   7  (bases 1 to 3390)
  AUTHORS   Kishida,M., Hino,Si., Michiue,T., Yamamoto,H., Kishida,S.,
            Fukui,A., Asashima,M. and Kikuchi,A.
  TITLE     Synergistic activation of the Wnt signaling pathway by Dvl and
            casein kinase Iepsilon
  JOURNAL   J Biol Chem 276 (35), 33147-33155 (2001)
   PUBMED   11425858
REFERENCE   8  (bases 1 to 3390)
  AUTHORS   Keesler,G.A., Camacho,F., Guo,Y., Virshup,D., Mondadori,C. and
            Yao,Z.
  TITLE     Phosphorylation and destabilization of human period I clock protein
            by human casein kinase I epsilon
  JOURNAL   Neuroreport 11 (5), 951-955 (2000)
   PUBMED   10790862
REFERENCE   9  (bases 1 to 3390)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 3390)
  AUTHORS   Fish,K.J., Cegielska,A., Getman,M.E., Landes,G.M. and Virshup,D.M.
  TITLE     Isolation and characterization of human casein kinase I epsilon
            (CKI), a novel member of the CKI gene family
  JOURNAL   J Biol Chem 270 (25), 14875-14883 (1995)
   PUBMED   7797465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z97056.1, AK092269.1 and AL020993.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001289912.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring LOC400927 (transmembrane
            phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene) and
            CSNK1E (casein kinase I isoform epsilon) genes on chromosome 22.
            The readthrough transcript encodes the same protein as the
            downstream gene product (casein kinase I isoform epsilon).
            [provided by RefSeq, Feb 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK092269.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 1454, 400927
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               Z97056.1           9706-10098          c
            394-1016            AK092269.1         1-623
            1017-1017           AL020993.1         79744-79744         c
            1018-1771           AK092269.1         625-1378
            1772-1772           AL020993.1         71085-71085         c
            1773-2163           AK092269.1         1380-1770
            2164-3390           AL020993.1         67269-68495         c
FEATURES             Location/Qualifiers
     source          1..3390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..3390
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /note="TPTEP2-CSNK1E readthrough"
                     /db_xref="GeneID:102800317"
                     /db_xref="HGNC:HGNC:53829"
     exon            1..478
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            479..532
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            533..586
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            587..748
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            749..847
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            848..935
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     CDS             860..2110
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /EC_number="2.7.11.1"
                     /note="CKI-epsilon; LOC400927-CSNK1E readthrough"
                     /codon_start=1
                     /product="casein kinase I isoform epsilon"
                     /protein_id="NP_001276841.1"
                     /db_xref="GeneID:102800317"
                     /db_xref="HGNC:HGNC:53829"
                     /translation="MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKT
                     KHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSL
                     KTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR
                     THQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKA
                     ATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNL
                     FHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPT
                     GATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSD
                     LTGRQEVSRIPASQTSVPFDHLGK"
     exon            936..1046
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1195
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1424
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1595
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1744
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1937
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2077
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2142
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..3390
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3367..3372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /note="hexamer: AATAAA"
     polyA_site      3390
                     /gene="TPTEP2-CSNK1E"
                     /gene_synonym="LOC400927-CSNK1E"
                     /note="major polyA site"
ORIGIN      
        1 gagcggcggg ccgagggagg gcgcagcagc tgctccctga acactttctg acccaacagt
       61 cccccagcgc cggacgcgcc gcgccctggc ggctctaggg accccccccg cgcctgcact
      121 tagccccgcg cccgaggtga gcccggcccc taaatcctcc gggcgggggt gggggtgcgg
      181 gacgctcctt ttttgttggg ggtcttggag gcgcgaaggc actaggcgcc tcggcagatg
      241 gctgcacccc tcgcttgcgg ctccccgtgt cttttggggg gccgggtgcg ggcgcggaat
      301 ccgggaggtg tccgcacaaa aggccgagaa aactgcgcga ggcctccctc cctccgccct
      361 ccccgccccc tcccctccgc gcccgctcct cctctttcaa acccggccgg cccgagtgga
      421 gtcagctcag tcccggcagc cgccgcgcga ggaaatggcc gaggggccgg agccacagtc
      481 cacagacaaa cgaatttaaa ggagcaaccg aggaggcacc tgcgaaagaa agcccacaca
      541 caggtgaatt taaaggagca gccctggtgt cacctatcag taaaagacta tttggagttt
      601 tcctcgtctt actggatgtc actctcgtcc ttgccgacct aattttcact gacagcaaac
      661 tttatattcc tttggagtat cgttctattt ctctagctat tgccttattt tttctcatgg
      721 atgttcttct tcgagtattt gtagaagggt gttggagcgg gccggagaga agtagagtgg
      781 gctgcgagga gaaggaaaca ggcctttcgg aggctcctca tccctcggag gtcatccctt
      841 actccagcaa gagtgagcca tggagctacg tgtggggaac aagtaccgcc tgggacggaa
      901 gatcgggagc gggtccttcg gagatatcta cctgggtgcc aacatcgcct ctggtgagga
      961 agtcgccatc aagctggagt gtgtgaagac aaagcacccc cagctgcaca tcgagagcaa
     1021 gttctacaag atgatgcagg gtggcgtggg gatcccgtcc atcaagtggt gcggagctga
     1081 gggcgactac aacgtgatgg tcatggagct gctggggcct agcctcgagg acctgttcaa
     1141 cttctgttcc cgcaaattca gcctcaagac ggtgctgctc ttggccgacc agatgatcag
     1201 ccgcatcgag tatatccact ccaagaactt catccaccgg gacgtcaagc ccgacaactt
     1261 cctcatgggg ctggggaaga agggcaacct ggtctacatc atcgacttcg gcctggccaa
     1321 gaagtaccgg gacgcccgca cccaccagca cattccctac cgggaaaaca agaacctgac
     1381 cggcacggcc cgctacgctt ccatcaacac gcacctgggc attgagcaaa gccgtcgaga
     1441 tgacctggag agcctgggct acgtgctcat gtacttcaac ctgggctccc tgccctggca
     1501 ggggctcaaa gcagccacca agcgccagaa gtatgaacgg atcagcgaga agaagatgtc
     1561 aacgcccatc gaggtcctct gcaaaggcta tccctccgaa ttctcaacat acctcaactt
     1621 ctgccgctcc ctgcggtttg acgacaagcc cgactactct tacctacgtc agctcttccg
     1681 caacctcttc caccggcagg gcttctccta tgactacgtc tttgactgga acatgctgaa
     1741 attcggtgca gcccggaatc ccgaggatgt ggaccgggag cggcgagaac acgaacgcga
     1801 ggagaggatg gggcagctac gggggtccgc gacccgagcc ctgccccctg gcccacccac
     1861 gggggccact gccaaccggc tccgcagtgc cgccgagccc gtggcttcca cgccagcctc
     1921 ccgcatccag ccggctggca atacttctcc cagagcgatc tcgcgggtcg accgggagag
     1981 gaaggtgagt atgaggctgc acaggggtgc gcccgccaac gtctcctcct cagacctcac
     2041 tgggcggcaa gaggtctccc ggatcccagc ctcacagaca agtgtgccat ttgaccatct
     2101 cgggaagtga ggagagcccc cattggacca gtgtttgctt agtgtcttca ctgtattttc
     2161 tttaaaaaaa aaaaaaaaaa aaaaaaggca aaaataaacc actcaaaaga acaacaaaaa
     2221 aacccagcac aaaaccgacg atggagtttg tttctttgat ttctttgcca atggcaagaa
     2281 gatgagatgc cctcagcact gaggattctt gcccccttgt ggtgcccgct gcccccaacc
     2341 ttcaggctgc cagatgctcc cctgacaaca ccaggctaca ggagccagac gccagggcct
     2401 gcccggcctc ctgttcctgc ccccacccac cacctgcctg gagaggaacg ggtcgggtcc
     2461 gtgtcggaga agtgacaggt cccagagcca aagccggccc tcaagcatca tcagggagtg
     2521 gtgtagtcag ttgaaggcag ttcccaccga gttttccgag cctcagaatc caggagatac
     2581 gcacagcccc acccactctg agatgacagt ggctgacttc ccgtgctggg cttttccatt
     2641 gtccccctgg cctccaggct cctcctctgc ctctccatgg agtgggtggg gaggtggtgg
     2701 gggccggcgt cccctgcgtg tgtgtgtgtg tgtgtgtgtg tggatgtatt gacctgtgtt
     2761 tcccaagaca gcaggtgcca cggcccgccc cgcctgccag cccgaattcc cgttctcctg
     2821 tgtctactaa caaggacatg ggggtgggcg gtgacctccg catccctcag agctcagagg
     2881 gtcctcgctg ccaccggtcc ccccctagcc cgtcatcagc cggtggcagc tccatcttcc
     2941 attcctggtt ttagggcaga atccatggag actgcttcca gaaggcatct ggctctgagt
     3001 tataaattac ttccctggtc ctgacagtca cctggggtcc cccctctccc tggttccacc
     3061 tttctgagga ggagcctgga gtcagggctg ggttttggat taacccatcc ttcctagtta
     3121 acaccttttt gtttttattt tattttattt ttgtttgttt tctccgtgtg tgtgttttcc
     3181 taatttattt acctctgttt cccctttttc cttttttttt ttaattaaag agcaaagctt
     3241 tttattactt tgtaatttaa aaaactgaaa aaaaaaaaac tgaagaactt tggggggaat
     3301 tttgtacttt tttcctgtgt aaatattgga cttttttgag ctttatcgtg gttgttaatt
     3361 tgaagtaata aagtagaaaa gataaagtga
//
