LOCUS       NM_001395978            2101 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens transmembrane phosphoinositide 3-phosphatase and
            tensin homolog 2 (TPTE2), transcript variant 9, mRNA.
ACCESSION   NM_001395978
VERSION     NM_001395978.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2101)
  AUTHORS   Lv,W., Wang,L., Lu,J., Mu,J., Liu,Y. and Dong,P.
  TITLE     Downregulation of TPTE2P1 Inhibits Migration and Invasion of
            Gallbladder Cancer Cells
  JOURNAL   Chem Biol Drug Des 86 (4), 656-662 (2015)
   PUBMED   25676706
  REMARK    GeneRIF: The role of TPTE2 in gallbladder cancer cells
            Erratum:[Chem Biol Drug Des. 2018 Oct;92(4):1816. doi:
            10.1111/cbdd.13401.. PMID: 30267484]
REFERENCE   2  (bases 1 to 2101)
  AUTHORS   Halaszovich,C.R., Leitner,M.G., Mavrantoni,A., Le,A., Frezza,L.,
            Feuer,A., Schreiber,D.N., Villalba-Galea,C.A. and Oliver,D.
  TITLE     A human phospholipid phosphatase activated by a transmembrane
            control module
  JOURNAL   J Lipid Res 53 (11), 2266-2274 (2012)
   PUBMED   22896666
  REMARK    GeneRIF: TPTE2 was originally reported to be a phosphoinositide
            3'-phosphatase, like the tumor suppressor PTEN. Later on, other
            homologous phosphatases, such as Ci-VSP and Dr-VSP, have been
            described. These proteins are 5'-phosphatases. More recently, using
            a chimeric construct, we have shown that the catalytic domain of
            TPTE2 behaves as a 5'-phosphatase as well.
REFERENCE   3  (bases 1 to 2101)
  AUTHORS   Mishra,R.R., Chaudhary,J.K. and Rath,P.C.
  TITLE     Cell cycle arrest and apoptosis by expression of a novel TPIP
            (TPIP-C2) cDNA encoding a C2-domain in HEK-293 cells
  JOURNAL   Mol Biol Rep 39 (7), 7389-7402 (2012)
   PUBMED   22311048
  REMARK    GeneRIF: findings suggest that C2-domain of TPIP-C2 may act as a
            dominant negative effector, which may bind to and arrest the cell
            proliferation signalling complex
REFERENCE   4  (bases 1 to 2101)
  AUTHORS   Mishra,R.R., Chaudhary,J.K., Bajaj,G.D. and Rath,P.C.
  TITLE     A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in
            human and mouse tissues, strongly inhibits cell growth in HeLa
            cells
  JOURNAL   PLoS One 6 (12), e28433 (2011)
   PUBMED   22164291
  REMARK    GeneRIF: the TPIP splice-variant (TPIP-C2) mRNA is expressed in
            human and mouse tissues and strongly inhibits cell growth in HeLa
            cells
REFERENCE   5  (bases 1 to 2101)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   6  (bases 1 to 2101)
  AUTHORS   Tapparel,C., Reymond,A., Girardet,C., Guillou,L., Lyle,R.,
            Lamon,C., Hutter,P. and Antonarakis,S.E.
  TITLE     The TPTE gene family: cellular expression, subcellular localization
            and alternative splicing
  JOURNAL   Gene 323, 189-199 (2003)
   PUBMED   14659893
REFERENCE   7  (bases 1 to 2101)
  AUTHORS   Deocampo,N.D., Huang,H. and Tindall,D.J.
  TITLE     The role of PTEN in the progression and survival of prostate cancer
  JOURNAL   Minerva Endocrinol 28 (2), 145-153 (2003)
   PUBMED   12717346
  REMARK    Review article
REFERENCE   8  (bases 1 to 2101)
  AUTHORS   Walker,S.M., Downes,C.P. and Leslie,N.R.
  TITLE     TPIP: a novel phosphoinositide 3-phosphatase
  JOURNAL   Biochem J 360 (Pt 2), 277-283 (2001)
   PUBMED   11716755
REFERENCE   9  (bases 1 to 2101)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359457.12 and AL590076.4.
            
            Summary: TPIP is a member of a large class of membrane-associated
            phosphatases with substrate specificity for the 3-position
            phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000697147.1/ ENSP00000513136.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AL359457.12        26016-26114         c
            100-201             AL359457.12        23610-23711         c
            202-304             AL359457.12        17153-17255         c
            305-358             AL590076.4         87036-87089         c
            359-412             AL590076.4         77260-77313         c
            413-466             AL590076.4         76662-76715         c
            467-526             AL590076.4         66300-66359         c
            527-577             AL590076.4         59385-59435         c
            578-739             AL590076.4         57726-57887         c
            740-859             AL590076.4         51037-51156         c
            860-959             AL590076.4         49277-49376         c
            960-1023            AL590076.4         49067-49130         c
            1024-1088           AL590076.4         48268-48332         c
            1089-1149           AL590076.4         34977-35037         c
            1150-1231           AL590076.4         34075-34156         c
            1232-1320           AL590076.4         33888-33976         c
            1321-1382           AL590076.4         21904-21965         c
            1383-1463           AL590076.4         20038-20118         c
            1464-1569           AL590076.4         16285-16390         c
            1570-1649           AL590076.4         14280-14359         c
            1650-1742           AL590076.4         10237-10329         c
            1743-1813           AL590076.4         8759-8829           c
            1814-2101           AL590076.4         6689-6976           c
FEATURES             Location/Qualifiers
     source          1..2101
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..2101
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /note="transmembrane phosphoinositide 3-phosphatase and
                     tensin homolog 2"
                     /db_xref="GeneID:93492"
                     /db_xref="HGNC:HGNC:17299"
                     /db_xref="MIM:606791"
     exon            1..99
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            100..201
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            202..304
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            305..358
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..1916
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /EC_number="3.1.3.67"
                     /note="isoform gamma is encoded by transcript variant 9;
                     TPTE and PTEN homologous inositol lipid phosphatase; TPIP
                     lipid phosphatase; PTEN-like inositol lipid phosphatase;
                     lipid phosphatase TPIP; phosphatidylinositol
                     3,4,5-trisphosphate 3-phosphatase TPTE2; transmembrane
                     phosphoinositide 3-phosphatase and tensin 2-like protein"
                     /codon_start=1
                     /product="phosphatidylinositol 3,4,5-trisphosphate
                     3-phosphatase TPTE2 isoform gamma"
                     /protein_id="NP_001382907.1"
                     /db_xref="CCDS:CCDS45014.1"
                     /db_xref="GeneID:93492"
                     /db_xref="HGNC:HGNC:17299"
                     /db_xref="MIM:606791"
                     /translation="MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLER
                     LSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKL
                     YIPLEYRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIF
                     FDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFD
                     LDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKH
                     FHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCAL
                     LIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPP
                     RRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYD
                     GPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKI
                     YPPEFAVEILFGEK"
     exon            359..412
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            413..466
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            467..526
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            527..577
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            578..739
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            740..859
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            860..959
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1023
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1088
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1149
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1231
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1320
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1382
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1463
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1569
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1649
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1742
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1813
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2101
                     /gene="TPTE2"
                     /gene_synonym="TPIP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttggctctc cccacttact tcctgataac ctggtagcgg tctcccgcgg gcgtcggggc
       61 ttgcggggag gcgtagcaac tttaggcaac ttcccaaaga gttgacgctg gtgaagacat
      121 tcatgattta aacaccagat cctgaaatgt gttaaatcta ctttgaaatg aatctgcaat
      181 cagtatttca aagcttttct gttagccaca gtcaatgaac aaccccttca gaatggcttt
      241 gaagagctga tcctgtggac aaaagagggg aaactgtggg agttcccagt taacaatgaa
      301 gcagtccacc cacaaatgaa ttatcaggag tgaacccaga ggcacgtatg aatgaaagtc
      361 cacagacaaa cgaatttaaa ggaacaaccg aggaggcacc tgcgaaagaa agcccacaca
      421 caagtgaatt taaaggagca gccctggtgt cacctatcag taaaagtatg ttagaacgac
      481 tttccaagtt tgaagttgaa gatgctgaaa atgttgcttc atatgacagc aagattaaga
      541 aaattgtgca ttcaattgta tcatcctttg catttggaat atttggagtt ttcctggtct
      601 tactggatgt cactctcctc cttgccgacc taattttcac tgacagcaaa ctttatattc
      661 ctttggagta tcgttctatt tctctagcta ttggcttatt ttttctcatg gatgttcttc
      721 ttcgagtatt tgtagaaggg agacagcagt atttttctga cttatttaac attttagata
      781 ctgccattat tgtgattcct ctgctggttg atgtcattta catttttttt gacattaagt
      841 tgcttaggaa tattcccaga tggacacatt tagttcgact tctacgactt attattctga
      901 taagaatttt tcatctgctt catcaaaaaa gacaacttga aaagctgatg agaaggctgg
      961 tttcagaaaa caaaaggcga tacacaaggg atggatttga cctagacctc acttacgtta
     1021 cagaacgtat tattgctatg tcatttccat cttctggaag gcagtctttc tatagaaatc
     1081 caattgagga agttgtgcgg tttctagata agaaacatcg aaaccactat cgagtctaca
     1141 atctatgcag tgaaagagct tatgatccta agcacttcca taatagggtc agtagaatca
     1201 tgattgatga tcataatgtc cccactctac atgagatggt ggttttcacc aaggaagtaa
     1261 atgagtggat ggctcaagat cttgaaaaca tcgtagcgat tcactgtaaa ggaggcaaag
     1321 gaagaaccgg gactatggtt tgtgccctcc ttattgcctc cgaaatattt ttaactgccg
     1381 aggaaagcct atattatttt ggagaaaggc gaaccaataa aacccacagc aataaatttc
     1441 agggagtaga aactccttct cagaatagat atgttggata ttttgcacaa gtgaaacatc
     1501 tctacaactg gaatctccct ccaagacgga tactctttat aaaaagattc attatttatt
     1561 cgattcgtgg tgatgtatgt gatctaaaag tccaagtagt aatggagaaa aaggttgtct
     1621 tttccagtac ttcattagga aattgttcga tattgcatga cattgaaaca gacaaaatat
     1681 taattaatgt atatgacggt ccacctctgt atgatgatgt gaaagtgcag tttttctctt
     1741 cgaatcttcc taaatactat gacaattgtc catttttctt ctggttcaac acgtctttta
     1801 ttcaaaataa caggctttgt ctaccaagaa atgaattgga taatccacat aaacaaaaag
     1861 catggaaaat ttatccacca gaatttgctg tggagatact ttttggcgag aaatgacttc
     1921 caatgatgtt gtagctggat ccgactaagt atagctcccc cttccccttc tgggaaagaa
     1981 ttatgttctt tccaacccct gccacatgtt catgtgtcct aagtcttcct tgatgatgca
     2041 tctatattta tatatgttta tatatgttct tcataaatct attaaatata tatagataaa
     2101 a
//
