LOCUS       NM_199261               2142 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transmembrane phosphatase with tensin homology (TPTE),
            transcript variant 1, mRNA.
ACCESSION   NM_199261 NM_013315
VERSION     NM_199261.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Zainodini,N., Abolhasani,M., Mohsenzadegan,M., Farajollahi,M.M. and
            Rismani,E.
  TITLE     Overexpression of Transmembrane Phosphatase with Tensin homology
            (TPTE) in prostate cancer is clinically significant, suggesting its
            potential as a valuable biomarker
  JOURNAL   J Cancer Res Clin Oncol 150 (3), 165 (2024)
   PUBMED   38546751
  REMARK    GeneRIF: Overexpression of Transmembrane Phosphatase with Tensin
            homology (TPTE) in prostate cancer is clinically significant,
            suggesting its potential as a valuable biomarker.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2142)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 2142)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2142)
  AUTHORS   Kuemmel,A., Simon,P., Breitkreuz,A., Rohlig,J., Luxemburger,U.,
            Elsasser,A., Schmidt,L.H., Sebastian,M., Sahin,U., Tureci,O. and
            Buhl,R.
  TITLE     Humoral immune responses of lung cancer patients against the
            Transmembrane Phosphatase with TEnsin homology (TPTE)
  JOURNAL   Lung Cancer 90 (2), 334-341 (2015)
   PUBMED   26350112
  REMARK    GeneRIF: TPTE sero-reactivity has moderate sensitivity.
REFERENCE   5  (bases 1 to 2142)
  AUTHORS   Ostensson,M., Monten,C., Bacelis,J., Gudjonsdottir,A.H.,
            Adamovic,S., Ek,J., Ascher,H., Pollak,E., Arnell,H., Browaldh,L.,
            Agardh,D., Wahlstrom,J., Nilsson,S. and Torinsson-Naluai,A.
  TITLE     A possible mechanism behind autoimmune disorders discovered by
            genome-wide linkage and association analysis in celiac disease
  JOURNAL   PLoS One 8 (8), e70174 (2013)
   PUBMED   23936387
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2142)
  AUTHORS   Guipponi,M., Tapparel,C., Jousson,O., Scamuffa,N., Mas,C.,
            Rossier,C., Hutter,P., Meda,P., Lyle,R., Reymond,A. and
            Antonarakis,S.E.
  TITLE     The murine orthologue of the Golgi-localized TPTE protein provides
            clues to the evolutionary history of the human TPTE gene family
  JOURNAL   Hum Genet 109 (6), 569-575 (2001)
   PUBMED   11810268
REFERENCE   7  (bases 1 to 2142)
  AUTHORS   Wu,Y., Dowbenko,D., Pisabarro,M.T., Dillard-Telm,L., Koeppen,H. and
            Lasky,L.A.
  TITLE     PTEN 2, a Golgi-associated testis-specific homologue of the PTEN
            tumor suppressor lipid phosphatase
  JOURNAL   J Biol Chem 276 (24), 21745-21753 (2001)
   PUBMED   11279206
REFERENCE   8  (bases 1 to 2142)
  AUTHORS   Guipponi,M., Yaspo,M.L., Riesselman,L., Chen,H., De Sario,A.,
            Roizes,G. and Antonarakis,S.E.
  TITLE     Genomic structure of a copy of the human TPTE gene which
            encompasses 87 kb on the short arm of chromosome 21
  JOURNAL   Hum Genet 107 (2), 127-131 (2000)
   PUBMED   11030409
REFERENCE   9  (bases 1 to 2142)
  AUTHORS   Chen,H., Rossier,C., Morris,M.A., Scott,H.S., Gos,A., Bairoch,A.
            and Antonarakis,S.E.
  TITLE     A testis-specific gene, TPTE, encodes a putative transmembrane
            tyrosine phosphatase and maps to the pericentromeric region of
            human chromosomes 21 and 13, and to chromosomes 15, 22, and Y
  JOURNAL   Hum Genet 105 (5), 399-409 (1999)
   PUBMED   10598804
REFERENCE   10 (bases 1 to 2142)
  AUTHORS   Antonarakis,S.E.
  TITLE     10 years of Genomics, chromosome 21, and Down syndrome
  JOURNAL   Genomics 51 (1), 1-16 (1998)
   PUBMED   9693027
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF254983.3 and AL078471.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_199261.3.
            
            Summary: This gene encodes a PTEN-related tyrosine phosphatase
            which may play a role in the signal transduction pathways of the
            endocrine or spermatogenic function of the testis. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF007118.1, AK314285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618007.5/ ENSP00000484403.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AF254983.3         35617-35728         c
            113-221             AF254983.3         32623-32731         c
            222-279             AL078471.2         1907-1964
            280-333             AL078471.2         13233-13286
            334-387             AL078471.2         15664-15717
            388-441             AL078471.2         16947-17000
            442-495             AL078471.2         17881-17934
            496-555             AL078471.2         27209-27268
            556-606             AL078471.2         34046-34096
            607-768             AL078471.2         35582-35743
            769-888             AL078471.2         42222-42341
            889-988             AL078471.2         43989-44088
            989-1052            AL078471.2         44235-44298
            1053-1117           AL078471.2         45037-45101
            1118-1178           AL078471.2         52012-52072
            1179-1260           AL078471.2         52889-52970
            1261-1349           AL078471.2         53069-53157
            1350-1411           AL078471.2         65014-65075
            1412-1492           AL078471.2         66845-66925
            1493-1598           AL078471.2         70534-70639
            1599-1678           AL078471.2         72567-72646
            1679-1771           AL078471.2         76610-76702
            1772-1842           AL078471.2         78114-78184
            1843-2142           AL078471.2         79969-80268
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21p11.2"
     gene            1..2142
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /note="transmembrane phosphatase with tensin homology"
                     /db_xref="GeneID:7179"
                     /db_xref="HGNC:HGNC:12023"
                     /db_xref="MIM:604336"
     exon            1..112
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            113..221
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..279
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..333
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..1978
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /EC_number="3.1.3.48"
                     /note="isoform alpha is encoded by transcript variant 1;
                     cancer/testis antigen 44; PTEN-related tyrosine
                     phosphatase; tensin, putative protein-tyrosine
                     phosphatase; tumor antigen BJ-HCC-5"
                     /codon_start=1
                     /product="putative tyrosine-protein phosphatase TPTE
                     isoform alpha"
                     /protein_id="NP_954870.3"
                     /db_xref="CCDS:CCDS74771.1"
                     /db_xref="GeneID:7179"
                     /db_xref="HGNC:HGNC:12023"
                     /db_xref="MIM:604336"
                     /translation="MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESPHTS
                     EFKGAARVSPISESVLARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFGVFLV
                     LLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFNI
                     LDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKL
                     IRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHR
                     NHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIV
                     AIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVKTPSQKR
                     YVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGK
                     CSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRL
                     YLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD"
     exon            334..387
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..441
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..495
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..555
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..606
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..768
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..888
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..988
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1052
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1117
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1178
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1260
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1349
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1411
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1492
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1598
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1678
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1771
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1842
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2142
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /note="hexamer: CATAAA"
     regulatory      2122..2127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /note="hexamer: ATTACA"
     polyA_site      2137
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /note="major polyA site"
     polyA_site      2142
                     /gene="TPTE"
                     /gene_synonym="CT44; PTEN2; TPTE1"
                     /note="major polyA site"
ORIGIN      
        1 acaacagctg ctacctgaac agtttctgac ccaacagtta cccagcgccg gactcgctgc
       61 gccccggcgg ctctagggac ccccggcgcc tacacttagc tccgcgcccg agagaatgtt
      121 ggaccgacga cacaagacct cagacttgtg ttattctagc agctgaacac accccaggct
      181 cttctgcccg gcagtggctc tggaagcagt ctggtgtata gagttatgga ttcactacca
      241 gattctactg tatgctcttg acaactatga ccacaatggt ccacccacaa atgaattatc
      301 aggagtgaac ccagaggcac gtatgaatga aagtcctgat ccgactgacc tggcgggagt
      361 catcattgag ctcggcccca atgacagtcc acagacaagt gaatttaaag gagcaaccga
      421 ggaggcacct gcgaaagaaa gcccacacac aagtgaattt aaaggagcag cccgggtgtc
      481 acctatcagt gaaagtgtgt tagcacgact ttccaagttt gaagttgaag atgctgaaaa
      541 tgttgcttca tatgacagca agattaagaa aattgtgcat tcaattgtat catcctttgc
      601 atttggacta tttggagttt tcctggtctt actggatgtc actctcatcc ttgccgacct
      661 aattttcact gacagcaaac tttatattcc tttggagtat cgttctattt ctctagctat
      721 tgccttattt tttctcatgg atgttcttct tcgagtattt gtagaaagga gacagcagta
      781 tttttctgac ttatttaaca ttttagatac tgccattatt gtgattcttc tgctggttga
      841 tgtcgtttac attttttttg acattaagtt gcttaggaat attcccagat ggacacattt
      901 acttcgactt ctacgactta ttattctgtt aagaattttt catctgtttc atcaaaaaag
      961 acaacttgaa aagctgataa gaaggcgggt ttcagaaaac aaaaggcgat acacaaggga
     1021 tggatttgac ctagacctca cttacgttac agaacgtatt attgctatgt catttccatc
     1081 ttctggaagg cagtctttct atagaaatcc aatcaaggaa gttgtgcggt ttctagataa
     1141 gaaacaccga aaccactatc gagtctacaa tctatgcagt gaaagagctt acgatcctaa
     1201 gcacttccat aatagggtcg ttagaatcat gattgatgat cataatgtcc ccactctaca
     1261 tcagatggtg gttttcacca aggaagtaaa tgagtggatg gctcaagatc ttgaaaacat
     1321 cgtagcgatt cactgtaaag gaggcacaga tagaacagga actatggttt gtgccttcct
     1381 tattgcctct gaaatatgtt caactgcaaa ggaaagcctg tattattttg gagaaaggcg
     1441 aacagataaa acccacagcg aaaaatttca gggagtaaaa actccttctc agaagagata
     1501 tgttgcatat tttgcacaag tgaaacatct ctacaactgg aatctccctc caagacggat
     1561 actctttata aaacacttca ttatttattc gattcctcgt tatgtacgtg atctaaaaat
     1621 ccaaatagaa atggagaaaa aggttgtctt ttccactatt tcattaggaa aatgttcggt
     1681 acttgataac attacaacag acaaaatatt aattgatgta ttcgacggtc tacctctgta
     1741 tgatgatgtg aaagtgcagt ttttctattc gaatcttcct acatactatg acaattgctc
     1801 attttacttc tggttgcaca catcttttat tgaaaataac aggctttatc taccaaaaaa
     1861 tgaattggat aatctacata aacaaaaagc acggagaatt tatccatcag attttgccgt
     1921 ggagatactt tttggcgaga aaatgacttc cagtgatgtt gtagctggat ccgattaagt
     1981 atagctcccc cttccccttc tgggaaagaa ttatgttctt tccaaccctg ccacatgttc
     2041 atatatccta aatctatcct aaatgttcct tgaagtattt atttatgttt atatatgttt
     2101 atatatgttc ttcataaatc tattacatat atatagataa aa
//
