LOCUS       NM_003295               4548 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens tumor protein, translationally-controlled 1 (TPT1),
            transcript variant 2, mRNA.
ACCESSION   NM_003295
VERSION     NM_003295.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4548)
  AUTHORS   Sharma,D., Pawar,S.N., Sulkshane,P., Waghole,R., Yasser,M.,
            Pawar,S.S., Kannan,S., Chaudhary,N., Kalwar,A., Patil,R., Nair,S.,
            Dalal,S.N. and Teni,T.
  TITLE     Elevated translationally controlled tumour protein promotes oral
            cancer progression and poor outcome
  JOURNAL   J Oral Pathol Med 52 (9), 849-859 (2023)
   PUBMED   37573872
  REMARK    GeneRIF: Elevated translationally controlled tumour protein
            promotes oral cancer progression and poor outcome.
REFERENCE   2  (bases 1 to 4548)
  AUTHORS   Ni,H., Liang,C., Zhou,Z., Jiang,B., Li,Y., Shang,H. and Yu,X.
  TITLE     METTL13 promotes nasopharyngeal carcinoma progression through
            regulating the ZEB1/TPT1 axis
  JOURNAL   J Gene Med 25 (5), e3476 (2023)
   PUBMED   36735630
  REMARK    GeneRIF: METTL13 promotes nasopharyngeal carcinoma progression
            through regulating the ZEB1/TPT1 axis.
REFERENCE   3  (bases 1 to 4548)
  AUTHORS   Morais de Castro,E., Barbosa,L.V., Simoneti Fonseca,A.,
            Nagashima,S., Busatta Vaz de Paula,C., Zeni,R., Panini do
            Carmo,L.A., Cavalli,L.R., Bleggi Torres,L.F., Senff Ribeiro,A., de
            Noronha,L. and Machado-Souza,C.
  TITLE     Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas
  JOURNAL   ASN Neuro 15, 17590914231153481 (2023)
   PUBMED   36714975
  REMARK    GeneRIF: Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas.
REFERENCE   4  (bases 1 to 4548)
  AUTHORS   Pinkaew,D., Martinez-Hackert,E., Jia,W., King,M.D., Miao,F.,
            Enger,N.R., Silakit,R., Ramana,K., Chen,S.Y. and Fujise,K.
  TITLE     Fortilin interacts with TGF-beta1 and prevents TGF-beta receptor
            activation
  JOURNAL   Commun Biol 5 (1), 157 (2022)
   PUBMED   35197550
  REMARK    GeneRIF: Fortilin interacts with TGF-beta1 and prevents TGF-beta
            receptor activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4548)
  AUTHORS   Yarm,F.R.
  TITLE     Plk phosphorylation regulates the microtubule-stabilizing protein
            TCTP
  JOURNAL   Mol Cell Biol 22 (17), 6209-6221 (2002)
   PUBMED   12167714
  REMARK    GeneRIF: Human TCTP was identified as a putative Plk-interacting
            clone by a two-hybrid screen. Plk phosphorylates TCTP on two serine
            residues in vitro and cofractionates with the majority of kinase
            activity toward TCTP in mitotic cell lysates.
REFERENCE   6  (bases 1 to 4548)
  AUTHORS   Bommer,U.A., Borovjagin,A.V., Greagg,M.A., Jeffrey,I.W.,
            Russell,P., Laing,K.G., Lee,M. and Clemens,M.J.
  TITLE     The mRNA of the translationally controlled tumor protein P23/TCTP
            is a highly structured RNA, which activates the dsRNA-dependent
            protein kinase PKR
  JOURNAL   RNA 8 (4), 478-496 (2002)
   PUBMED   11991642
  REMARK    GeneRIF: The mRNA of the translationally controlled tumor protein
            P23/TCTP is a highly structured RNA, which activates the
            dsRNA-dependent protein kinase PKR (TCTP PROTEIN)
REFERENCE   7  (bases 1 to 4548)
  AUTHORS   Sanchez,J.C., Schaller,D., Ravier,F., Golaz,O., Jaccoud,S.,
            Belet,M., Wilkins,M.R., James,R., Deshusses,J. and Hochstrasser,D.
  TITLE     Translationally controlled tumor protein: a protein identified in
            several nontumoral cells including erythrocytes
  JOURNAL   Electrophoresis 18 (1), 150-155 (1997)
   PUBMED   9059837
REFERENCE   8  (bases 1 to 4548)
  AUTHORS   MacDonald,S.M., Rafnar,T., Langdon,J. and Lichtenstein,L.M.
  TITLE     Molecular identification of an IgE-dependent histamine-releasing
            factor
  JOURNAL   Science 269 (5224), 688-690 (1995)
   PUBMED   7542803
REFERENCE   9  (bases 1 to 4548)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   10 (bases 1 to 4548)
  AUTHORS   Gross,B., Gaestel,M., Bohm,H. and Bielka,H.
  TITLE     cDNA sequence coding for a translationally controlled human tumor
            protein
  JOURNAL   Nucleic Acids Res 17 (20), 8367 (1989)
   PUBMED   2813067
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP215975.1, X16064.1 and
            AL138963.20.
            
            On Jun 2, 2019 this sequence version replaced NM_003295.3.
            
            Summary: This gene encodes a protein that is a regulator of
            cellular growth and proliferation. Its mRNA is highly structured
            and contains an oligopyrimidine tract (5'-TOP) in its 5'
            untranslated region that functions to repress its translation under
            quiescent conditions. The encoded protein is involved in a variety
            of cellular pathways, including apoptosis, protein synthesis and
            cell division. It binds to and stabilizes microtubules, and removal
            of this protein through phosphorylation is required for progression
            through mitotic and meiotic cell divisions. This gene is known to
            play a role in carcinogenesis, and is upregulated in some cancer
            cells. Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. The encoded isoform (2) has a shorter C-terminus than
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.93147.1,
                                           SRR1660803.95732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530705.6/ ENSP00000431872.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BP215975.1         102-122
            22-850              X16064.1           2-830
            851-4548            AL138963.20        139252-142949       c
FEATURES             Location/Qualifiers
     source          1..4548
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.13"
     gene            1..4548
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /note="tumor protein, translationally-controlled 1"
                     /db_xref="GeneID:7178"
                     /db_xref="HGNC:HGNC:12022"
                     /db_xref="MIM:600763"
     exon            1..142
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..633
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     fortilin; translationally-controlled tumor protein;
                     histamine-releasing factor"
                     /codon_start=1
                     /product="translationally-controlled tumor protein isoform
                     2"
                     /protein_id="NP_003286.1"
                     /db_xref="CCDS:CCDS9397.1"
                     /db_xref="GeneID:7178"
                     /db_xref="HGNC:HGNC:12022"
                     /db_xref="MIM:600763"
                     /translation="MIIYRDLISHDEMFSDIYKIREIADGLCLEVEGKMVSRTEGNID
                     DSLIGGNASAEGPEGEGTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGK
                     LEEQRPERVKPFMTGAAEQIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYM
                     IFFKDGLEMEKC"
     exon            143..216
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /inference="alignment:Splign:2.1.0"
     exon            217..407
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /inference="alignment:Splign:2.1.0"
     exon            408..513
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /inference="alignment:Splign:2.1.0"
     exon            514..630
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /inference="alignment:Splign:2.1.0"
     exon            631..4548
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      822..827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /note="hexamer: AATAAA"
     polyA_site      842
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /note="major polyA site"
     regulatory      1124..1129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /note="hexamer: AATAAA"
     polyA_site      1149
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /note="major polyA site"
     polyA_site      1367
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /note="hexamer: AATACA"
     polyA_site      1714
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
     regulatory      4514..4519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
                     /note="hexamer: AATAAA"
     polyA_site      4548
                     /gene="TPT1"
                     /gene_synonym="HRF; p02; p23; TCTP"
ORIGIN      
        1 cttttccgcc cgctcccccc tccccccgag cgccgctccg gctgcaccgc gctcgctccg
       61 agtttcaggc tcgtgctaag ctagcgccgt cgtcgtctcc cttcagtcgc catcatgatt
      121 atctaccggg acctcatcag ccacgatgag atgttctccg acatctacaa gatccgggag
      181 atcgcggacg ggttgtgcct ggaggtggag gggaagatgg tcagtaggac agaaggtaac
      241 attgatgact cgctcattgg tggaaatgcc tccgctgaag gccccgaggg cgaaggtacc
      301 gaaagcacag taatcactgg tgtcgatatt gtcatgaacc atcacctgca ggaaacaagt
      361 ttcacaaaag aagcctacaa gaagtacatc aaagattaca tgaaatcaat caaagggaaa
      421 cttgaagaac agagaccaga aagagtaaaa ccttttatga caggggctgc agaacaaatc
      481 aagcacatcc ttgctaattt caaaaactac cagttcttta ttggtgaaaa catgaatcca
      541 gatggcatgg ttgctctatt ggactaccgt gaggatggtg tgaccccata tatgattttc
      601 tttaaggatg gtttagaaat ggaaaaatgt taacaaatgt ggcaattatt ttggatctat
      661 cacctgtcat cataactggc ttctgcttgt catccacaca acaccaggac ttaagacaaa
      721 tgggactgat gtcatcttga gctcttcatt tattttgact gtgatttatt tggagtggag
      781 gcattgtttt taagaaaaac atgtcatgta ggttgtctaa aaataaaatg catttaaact
      841 catttgagag aatgcctttt agtttaatgc atatttaaac taaattgatc ctgtagtgtt
      901 cctggagaag ctagagcctg attgtaggct actactcatc aattaacttc tacagtggag
      961 actacttctg ggactggaat ataaaaaaga atcaaaggtt ctgattttga gttgcaataa
     1021 agggaaagac catgctcata gcagtgccaa catctgaagt gtggagcctt acccatttca
     1081 tcacctacaa cggaagtagt taactggaag agattaccaa gagaataaaa agagactcat
     1141 tcagtggaag caactttgtc tcagcttatt tcacataaag agagcgaagt cttttgggat
     1201 gaatgttaat taaactccct ggtaactaga acagggactg gcaaactagc ctatctgacc
     1261 acctgttttg tacactttaa ggtggttggt tgccttttta aatggttgag gggaaaagaa
     1321 taccttgtgg gatatggaat ttaagttcga gtccagtttt attggaacgt ggctatgctt
     1381 attcatttat ggattgactg tggctgttgt cagtgcatga gcagagttgt gtctaacaga
     1441 ctagagcctg caagtttgcc agcccctgat ttaaaagatg aaggtacaca gaatgtgggc
     1501 tggctggtgg gcaaaggggt aaaaatgttc tctatattgt atctgaaaag atggggtgtc
     1561 tgaataagaa aatgcatcta tttgacagac ctggagcagt tgctatctgc tgctatggtt
     1621 tccaccacag atgcaagaag aacatgtcct tgcgctttcc gtctgtctaa ttgtggcagc
     1681 tgagattgaa tagaggaata caggaggaaa aaaagcggga agagtttttg aggcaggtcg
     1741 gtcacccagg cttgtagtgc agtggcacaa gcaactcact gcattctctg catcctgtgc
     1801 tcaagccatt ttcccacctc agtctcacta gttgctggga ctgcaggcat gcacccctat
     1861 gcccagctaa tttttgtaga gaccgagtat cgcttagttg cccagggtgg tctcaactcc
     1921 tgggctcaag gagatctgcc cacctcagcc tcccaaagtg caggcctagc ctgggagggg
     1981 aattttcaaa acgtgagttt tgggaaatag tctatcagcc ttacctggtt gattacactt
     2041 gtaaaagaaa gattaaaagc aggccagtga ctctggtctg cttgaacatg tgaatgtagt
     2101 ggtttgagca atctggagtt tgccctagtg tcaaattcca gactgtccat agtgtccaaa
     2161 acctgaggca gatactaatg ttaaccccca gcaccccgtg attggaaaca aacctaaata
     2221 cgtattggga acttaatagc aattttaagc attctgatag attttttgta gggatggggt
     2281 catgccatgt ggcccaggct ggtctgaaaa ctctggcctc aagtgatctc aagctttggc
     2341 cttctaaagt gttgggatta caggtgtgag gcattgcacc tggcttagcg ttctgatttg
     2401 acattgtaat gaaaagtgtg agtctcatct acagggcctt ttgtcctctg aaatgatagc
     2461 aggaagggaa ttttcaggca gtggtcaaag ctggggaaac caggatagtg aagaaggcct
     2521 tgaggtgaga gatggaagct aattggtgaa ctagccttgg aagcctgaaa cagacaagta
     2581 gcaattcaga gactttgtgg gctccactgc tccaacttgt tttgaagatt ttcagttctg
     2641 cagaagaggt atttccccag ttgtcctttc agtgctctta gctgttttcc caacatccag
     2701 atccaatcaa ggctgggaca tagcatttta tcatgtctat ttaagtcaga agtgatgaac
     2761 cccagctgtt tacctcatgg taaacctttg aagattccag gtagaatctt ctcagacttt
     2821 gaagactgtc tcattttata tctttttctc gttattccta gggtcaagac gttttgggca
     2881 agaataagga tgtgaacatc agaaagctca taacattttg tttttgatgc taagtttaac
     2941 aaaggcatgc tttagtagcc tgtgggccct agggtttgtt aaagtgtgga gaacaactga
     3001 gtggagcaag aggacttttc taggaaggtc cttgtaatgt gacatttgaa aacaaatgaa
     3061 ggtgtggaag taggccatgt ggatatcagg acaaaccatt ccaggccaag acaacagcag
     3121 ttagtctgga gtgtgatgtg ttctgggaaa aaagtggcca ctttgctaac ccaagaagac
     3181 aggaagggtt gtaaagcagt gggagtgtgc aaggaaggaa gaccagacct caaggaaacc
     3241 acaggcgctc tgagcagaag agttacatga tatgactcaa atttttaaag gatcactttg
     3301 gctgccaggt ggcagggtaa aagcatagaa taattgtgta taatgtgttt ttaaggcaaa
     3361 gatagtggct tagtctaggg tagtagactg aggtggtagg aaatgaagat agagacaaca
     3421 ggatatgctg gtgggtgagg atggatttaa tgttgataca agtattttgg tctgagcgtt
     3481 tggaagaaag ttggcactga ggtgggaagt cgagtttagt tttgttagtt ttggatgtgt
     3541 taagtttgag atgctgattc ttcagagaag tctaagctgg agaactatat agagagtgga
     3601 aagataacaa tagacattga aagccatgat acaggataag gtcatttgga gagaggatag
     3661 actgcattcc aacatgagat tggttgacaa agagaaacca acaaaggtaa ttaagaggtg
     3721 ctcccactgc acttgtactc agaaggctga ggtaggattg ttagaggcca gcctgggcac
     3781 cacagggaga ccccatctct aaaatttagc caggaaccat ggctcatgcc tgtagcccca
     3841 ggaatttggg aggctgagtg gggaggatcg cttgaggtca ggagtttgag accagcctgg
     3901 gcaacatagg gagacctaaa aaaattaatt gggcatctgt agtcccagct actcaggcgg
     3961 ctgagctgag aggatggctt gagtccgaga gattgagggt gcagtgagct gtgatcatac
     4021 cactgcactc cagcctgggc ggcagtgaga cactatctga aaaaagttta aaaattttaa
     4081 aaaagaagga actgcccctg aggtaagaac caagggaggg cctcccagag gtcaggtgga
     4141 aaaagtttta ggaaggagga agtagtcaac agggttacct gttgcaaagt acttaagtaa
     4201 tatgaggcct gatagtggta aacttgacta ccgttggatt tcactagtgg gaaaggaagt
     4261 ctaattaaaa tgcactcaag agactaacag tcgcaggcat gaaatacaat acaggtacat
     4321 ggttttttat tatgtgtgca tctgcttcag taataggtgt gaattactca tttggatcat
     4381 taggagtttc aaaatctagt taaatgacta gatttttgtt gatgtaaatt ctgtcattct
     4441 gaactgcagg gattgtcagt aacttaactg caaactaaac tggtgataat tatggtaaaa
     4501 ttgcaagacg agcaataaat ctcaaccaac ttgagagaac actgataa
//
