LOCUS       NM_003595               5653 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tyrosylprotein sulfotransferase 2 (TPST2), transcript
            variant 2, mRNA.
ACCESSION   NM_003595
VERSION     NM_003595.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5653)
  AUTHORS   Guo,X.Y., Gao,X.D. and Fujita,M.
  TITLE     Sulfation of a FLAG tag mediated by SLC35B2 and TPST2 affects
            antibody recognition
  JOURNAL   PLoS One 16 (5), e0250805 (2021)
   PUBMED   33951064
  REMARK    GeneRIF: Sulfation of a FLAG tag mediated by SLC35B2 and TPST2
            affects antibody recognition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5653)
  AUTHORS   Kruize,Z., Maurer,I., Boeser-Nunnink,B.D.M., Booiman,T. and
            Kootstra,N.A.
  TITLE     Genetic variations in the host dependency factors ALCAM and TPST2
            impact HIV-1 disease progression
  JOURNAL   AIDS 34 (9), 1303-1312 (2020)
   PUBMED   32287057
  REMARK    GeneRIF: Genetic variations in the host dependency factors ALCAM
            and TPST2 impact HIV-1 disease progression.
REFERENCE   3  (bases 1 to 5653)
  AUTHORS   Tanaka,S., Nishiyori,T., Kojo,H., Otsubo,R., Tsuruta,M., Kurogi,K.,
            Liu,M.C., Suiko,M., Sakakibara,Y. and Kakuta,Y.
  TITLE     Structural basis for the broad substrate specificity of the human
            tyrosylprotein sulfotransferase-1
  JOURNAL   Sci Rep 7 (1), 8776 (2017)
   PUBMED   28821720
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5653)
  AUTHORS   Marforio,T.D., Giacinto,P., Bottoni,A. and Calvaresi,M.
  TITLE     Computational Evidence for the Catalytic Mechanism of
            Tyrosylprotein Sulfotransferases: A Density Functional Theory
            Investigation
  JOURNAL   Biochemistry 54 (28), 4404-4410 (2015)
   PUBMED   26108987
  REMARK    GeneRIF: Using a quantum mechanics protocol of alanine scanning,
            the study identified unequivocally the role of the amino acids
            involved in the TPST-2 catalytic mechanism.
REFERENCE   5  (bases 1 to 5653)
  AUTHORS   Teramoto,T., Fujikawa,Y., Kawaguchi,Y., Kurogi,K., Soejima,M.,
            Adachi,R., Nakanishi,Y., Mishiro-Sato,E., Liu,M.C., Sakakibara,Y.,
            Suiko,M., Kimura,M. and Kakuta,Y.
  TITLE     Crystal structure of human tyrosylprotein sulfotransferase-2
            reveals the mechanism of protein tyrosine sulfation reaction
  JOURNAL   Nat Commun 4, 1572 (2013)
   PUBMED   23481380
  REMARK    GeneRIF: the first crystal structure of the human tyrosylprotein
            sulfotransferase isoform 2 complexed with a substrate peptide
            (C4P5Y3) derived from complement C4 and
            3'-phosphoadenosine-5'-phosphate at 1.9 A resolution, is reported.
REFERENCE   6  (bases 1 to 5653)
  AUTHORS   Goettsch,S., Goettsch,W., Morawietz,H. and Bayer,P.
  TITLE     Shear stress mediates tyrosylprotein sulfotransferase isoform shift
            in human endothelial cells
  JOURNAL   Biochem Biophys Res Commun 294 (3), 541-546 (2002)
   PUBMED   12056800
  REMARK    GeneRIF: Shear stress-dependent upregulation of TPST2 in human
            endothelium is mediated by a tyrosine kinase-dependent pathway
            Erratum:[Biochem Biophys Res Commun 2002 Jul 26;295(4):1033]
REFERENCE   7  (bases 1 to 5653)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   8  (bases 1 to 5653)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   9  (bases 1 to 5653)
  AUTHORS   Ouyang,Y.B. and Moore,K.L.
  TITLE     Molecular cloning and expression of human and mouse tyrosylprotein
            sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue
            in Caenorhabditis elegans
  JOURNAL   J Biol Chem 273 (38), 24770-24774 (1998)
   PUBMED   9733778
REFERENCE   10 (bases 1 to 5653)
  AUTHORS   Beisswanger,R., Corbeil,D., Vannier,C., Thiele,C., Dohrmann,U.,
            Kellner,R., Ashman,K., Niehrs,C. and Huttner,W.B.
  TITLE     Existence of distinct tyrosylprotein sulfotransferase genes:
            molecular characterization of tyrosylprotein sulfotransferase-2
  JOURNAL   Proc Natl Acad Sci U S A 95 (19), 11134-11139 (1998)
   PUBMED   9736702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z95115.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003595.4.
            
            Summary: The protein encoded by this gene catalyzes the O-sulfation
            of tyrosine residues within acidic regions of proteins. The encoded
            protein is a type II integral membrane protein found in the Golgi
            body. Alternative splicing produces multiple transcript variants
            encoding distinct isoforms. [provided by RefSeq, May 2018].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.188158.1,
                                           SRR1803611.210681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338754.9/ ENSP00000339813.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                Z95115.1           87519-87598         c
            81-152              Z95115.1           42072-42143         c
            153-1082            Z95115.1           38257-39186         c
            1083-1281           Z95115.1           33756-33954         c
            1282-1332           Z95115.1           30163-30213         c
            1333-1381           Z95115.1           25682-25730         c
            1382-5653           Z95115.1           19464-23735         c
FEATURES             Location/Qualifiers
     source          1..5653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.1"
     gene            1..5653
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /note="tyrosylprotein sulfotransferase 2"
                     /db_xref="GeneID:8459"
                     /db_xref="HGNC:HGNC:12021"
                     /db_xref="MIM:603126"
     exon            1..80
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /inference="alignment:Splign:2.1.0"
     exon            81..152
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /inference="alignment:Splign:2.1.0"
     exon            153..1082
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1374
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /EC_number="2.8.2.20"
                     /note="isoform 1 is encoded by transcript variant 2;
                     protein-tyrosine sulfotransferase 2; transport and golgi
                     organization 13 homolog B; tyrosylprotein
                     phosphotransferase 2"
                     /codon_start=1
                     /product="protein-tyrosine sulfotransferase 2 isoform 1"
                     /protein_id="NP_003586.3"
                     /db_xref="CCDS:CCDS13839.1"
                     /db_xref="GeneID:8459"
                     /db_xref="HGNC:HGNC:12021"
                     /db_xref="MIM:603126"
                     /translation="MRLSVRRVLLAAGCALVLVLAVQLGQQVLECRAVLAGLRSPRGA
                     MRPEQEELVMVGTNHVEYRYGKAMPLIFVGGVPRSGTTLMRAMLDAHPEVRCGEETRI
                     IPRVLAMRQAWSKSGREKLRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDP
                     FTLKSSVYLSRLFPNSKFLLMVRDGRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAI
                     EVMYAQCMEVGKEKCLPVYYEQLVLHPRRSLKLILDFLGIAWSDAVLHHEDLIGKPGG
                     VSLSKIERSTDQVIKPVNLEALSKWTGHIPGDVVRDMAQIAPMLAQLGYDPYANPPNY
                     GNPDPFVINNTQRVLKGDYKTPANLKGYFQVNQNSTSSHLGSS"
     exon            1083..1281
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1332
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1381
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..5653
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /note="hexamer: AATAAA"
     polyA_site      1876
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /note="major polyA site"
     regulatory      3548..3553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /note="hexamer: GATAAA"
     polyA_site      3567
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
     regulatory      5631..5636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
                     /note="hexamer: AATAAA"
     polyA_site      5653
                     /gene="TPST2"
                     /gene_synonym="TANGO13B; TPST-2"
ORIGIN      
        1 cctccccctt ccccggctgg ggcggctgga gagccgggag tcgctgggtg cgtggggctg
       61 cctcgccgcg tctcgccacg ggctctgcca gcagacagcc ttggcacaca ggcacaaggg
      121 ctggagccca gagatgagag tgcccaaggg agatgtgagc ctggcgggct gcccgctaac
      181 ctgtcgctga agccccagaa gcgggccctc aggccaggcc taccctgcct ccggcccagc
      241 atgcgcctgt cggtgcggag ggtgctgctg gcagccggct gcgccctggt cctggtgctg
      301 gcggttcagc tgggacagca ggtgctagag tgccgggcgg tgctggcggg cctgcggagc
      361 ccccgggggg ccatgcggcc tgagcaggag gagctggtga tggtgggcac caaccacgtg
      421 gaataccgct atggcaaggc catgccgctc atcttcgtgg gtggcgtgcc tcgcagtggc
      481 accacgttga tgcgcgccat gctggacgcg caccccgagg tgcgctgcgg cgaggagacc
      541 cgcatcatcc cgcgcgtgct ggccatgcgc caggcctggt ccaagtctgg ccgtgagaag
      601 ctgcggctgg atgaggcggg ggtgacggat gaggtgctgg acgccgccat gcaggccttc
      661 atcctggagg tgattgccaa gcacggagag ccggcccgcg tgctctgcaa caaggaccca
      721 tttacgctca agtcctcggt ctacctgtcg cgcctgttcc ccaactccaa gttcctgctg
      781 atggtgcggg acggccgggc ctccgtgcac tccatgatca cgcgcaaagt caccattgcg
      841 ggctttgacc tcagcagcta ccgtgactgc ctcaccaagt ggaacaaggc catcgaggtg
      901 atgtacgccc agtgcatgga ggtaggcaag gagaagtgcc tgcctgtgta ctacgagcag
      961 ctggtgctgc accccaggcg ctcactcaag ctcatcctcg acttcctcgg catcgcctgg
     1021 agcgacgctg tcctccacca tgaagacctc attggcaagc ccggtggtgt ctccctgtcc
     1081 aagatcgagc ggtccacgga ccaggtcatc aagcctgtta acctggaagc gctctccaag
     1141 tggactggcc acatccctgg ggatgtggtg cgggacatgg cccagatcgc ccccatgctg
     1201 gctcagctcg gctatgaccc ttatgcaaac ccccccaact atggcaaccc tgaccccttc
     1261 gtcatcaaca acacacagcg ggtcttgaaa ggggactata aaacaccagc caatctgaaa
     1321 ggatattttc aggtgaacca gaacagcacc tcctcccact taggaagctc gtgatttcca
     1381 gatctccgca aatgacttca ttgccaagaa gagaagaaaa tgcatttaag tggaaatcgg
     1441 acctctaatc caagcatatt gcttgctatt aatcgccaaa acaggactgc tgatgaggaa
     1501 tgtatttgca tatgtttgca aaagctgaat cattgaaaac gtaccttgaa actctctatc
     1561 tctggacact ccagggtaga gaatgaaggg tatggaagta gtccggcttt tgaaacttag
     1621 gtattttata tttttcccct caagaacttt tttttaagag acagatttgc catcctcctt
     1681 aatttgcagg actgccttgg tggctttgtt tgctgggaca aggcccacaa cctgtgcctc
     1741 tcctattgac ccttactttg aattcaaaga atctatttaa gagtttaata tatgaggctt
     1801 tctttgattc ctcctcagtt ctacctagtt tcacagagga aaaaaatact ctttgaataa
     1861 agtgaacaga ggctcatttg tttgtgcctt actttactga atgaataggg tttttttttt
     1921 ctttccatac tggattttgt caggtagatt tgtgatgagc aaaaagctgg agaatatagg
     1981 tgcatgtaag gcacagctga attcctgtgt cagggtcccc agggccaccc ccaggatcga
     2041 tgattggcta gaagaactca gaattcagaa gagctattat ccttatggtt atggtttatt
     2101 acagcaaaag gataaacatt aaaatcagca aaagaggccg ggtggagtgg ctcacgcctg
     2161 taatcccagc actttgggag gccaaggcag gcagatcgcc tgaggtcagg agttcgagac
     2221 cagcctggcc aacatggtga aaccccgtct ctactaaaaa tacaaaaatt acctgggcgt
     2281 ggtggtgtgc acctgtaatc ccagctactc aggaggcttg aacctgggag gcggaggttg
     2341 cagtgagcgg agatcgtgcc attatactcc agcctgggtg acagagcaag actccatctc
     2401 aaaataaaat caacaaaaga aaaaggtgca tagggcagag tccgggagag accggcctca
     2461 agcttccagt tgtcatctcc tggtagagtc ttacagacac acttaatttt cccagcaatg
     2521 atatgtgaca acacgtacta aatattacca gccagaaagc tcaccctagc cttggggtct
     2581 aggtttttat tgcatgtcag tcacataggg caatcacatg accgacttta gttacttaat
     2641 caccagctgc tccagaggtc aaaatgatac agcatggccc aaggtcccca ccataaatca
     2701 cattattagc acaaactatc tggcctggta tggcccaagg cctgaggtat acaaagacac
     2761 ccctacttgg gaggatattc caaggactta gaggttatct cccaggagcc cattaaggcc
     2821 agttttttct ttgagatgtg ctgggtttgg acacttcaag cctgctgagt taacccttat
     2881 agcacagtcc ccaaatgctg agggaccaac tgggcctaca ataagtttgt atctttaagg
     2941 gttaaggtgt tttacccata cctccttgcc ttatatctca tgataatatg aggcttttgg
     3001 aaggcagtga cttattgtgg cttggggcat gggtttttgg agtcaggctg acctactggc
     3061 tgtatggctt gagactttgt ctcttcatct gtaaaatggg gaagttaaaa cttcatggtg
     3121 tgtatgtgtg tatgtgtgtg tttagacaga atctcgctct gtcactcagg ctagagtaca
     3181 gtggcgtgat catagctcac tgcagcctcg gtctcctagg gtcaggtgat cctcccatct
     3241 tagcctcctg agtagctggg catgtgccac cacacctggc tactttttaa attttttttt
     3301 ttctgtagag acgaggtctt tctatgctgt tcaggctgaa cttcatgggt ttattgggga
     3361 tggctaatgg atgacattgg cggtggtcct tgataccaga taagccctca gtgtgaagca
     3421 gctcttattt ttccttgtct tgagattgct ctggaatgga aattaggctt ttttgaaggt
     3481 gtgacccttt ttgttcattt cttcagcagt tactttttat tttttaaatg tttgacacac
     3541 agtctctgat aaatgatcat tcaccaatca ccgattactc tccttgctct gttaagtgtg
     3601 acactgtccc tttgagaatc tggcgacagc tatgtatccc atcaccacac accccaaaaa
     3661 aaaaatttat gtctggttcc aggagttacc ttttatgaga agtccatctg tgaagaccct
     3721 ggatgttcag agaacttcct gggaaaacac tgaaagaaaa taaagaggcc gggcccggtg
     3781 gctcatgctt gtaatcccag cactttggga ggctgaggtg ggcagataag ctgaggtcag
     3841 gagttccaga ccagcctggc caacgtggcg aaaccccatc tactaaaaat acaaaaatta
     3901 gctgggcgtc gtggcgcatg cctgtagttg cagctacttg ggaggctgag gcaggagaat
     3961 tgcttgaacc caggaggcag aggttgcagt gaaccaagat catgctagta cactccagcc
     4021 tgggcaacag agtgagactc catctcaaaa ataaaataaa taaaacaaaa taaaataaat
     4081 acaatttctg tttctagccc ctaagtggta gcactgggtc ttgttccctg aaaaaaacta
     4141 ggctcagaat ccactctcat ttcatctccc ctgatttgat ctgaaaagat tttgtttaga
     4201 gtactacatg aatatattat aaaacatggg acaatcagaa ttgatagtaa gaaggcaagt
     4261 ggctctattt gtacttcctc tcaatagctc ctaaaggtaa tgctaccatt ttctgtttgt
     4321 acatagtctt ccagacttta aatttttgaa catataaata ttatcatctt aaagacgtat
     4381 ggaaaaaacc attttgaata ggttattcca aaatgtaatt taacagattg ctctggagga
     4441 ttgtttgttt gtttgttttg gagacagagt cccgcttggt tgctcaggct gcagtgcagt
     4501 ggcacaaaca cagctcactg caacctctaa ctcctgcaaa cacagctcac tgcaacctct
     4561 aactcctgca aacacagctc actgcaacct ctaactcctg caaacacagc tcactgcaac
     4621 ctctaactcc tgcaaacaca gctcactgca acctctaact cctgggctca agcagtcctt
     4681 tcacctcagc ctcctgagta gctggaccat gacacctacc taacttttta ttttttgtaa
     4741 agaggggaat cactatgttg cccaggctgg tctcaaactc ctgggctcaa gcaatccttc
     4801 ctcagcctct caaagagttg ggtttacagg cgtgagccac cgcacctggc tcctggagca
     4861 tttctgatgt gaacatgtgc tgatctaaca ccactccttt taccagctgc ctgttctaga
     4921 gcaaaccatc ttttttgagc attccacttt ggctaggccc ttaggctgtt agcagttttc
     4981 atcgctactg gcaaagctgc agtggacgtt ctcctgcaca tataacctct tgatgccact
     5041 gtatgagtga gtctctgcaa aatgagaagt agaattgctg gggtgaaagg catacatact
     5101 aacttttttg attaattcca cccatgtacc ctgatttggg cagaatttta atctcactgt
     5161 gaaatcagag ctttgttcta gagcctttct tgggggttcc atggatcagt gggtcagccg
     5221 tcacttgtgc cctggcccat cctctgtcca gcttgggcag catgcatcat tcattctgat
     5281 tccttaattt gccatatgtg aaaacatggt aatctataca ttacttgggt gctattatta
     5341 tatataacta gctttggagt cagaattagc gtctcatcct ggctctacca ctttccaact
     5401 gtgcgactgt ggccaagtga ctccccttct ctgagcctca gttttcctct tctgtaaaat
     5461 gggggtaaag ggataagaac tataggggga tctcagggga tggttaagag aaatccatga
     5521 gataagcaaa cacattatct agtttagtaa agctaagcaa tgaagactta acagccccat
     5581 ggtgaaggct taatacatgg tagctataat gattactatt aatattgtga aataaaaggt
     5641 tgtgatgaac caa
//
