LOCUS       NM_003596               1981 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tyrosylprotein sulfotransferase 1 (TPST1), mRNA.
ACCESSION   NM_003596
VERSION     NM_003596.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1981)
  AUTHORS   Tanaka,S., Nishiyori,T., Kojo,H., Otsubo,R., Tsuruta,M., Kurogi,K.,
            Liu,M.C., Suiko,M., Sakakibara,Y. and Kakuta,Y.
  TITLE     Structural basis for the broad substrate specificity of the human
            tyrosylprotein sulfotransferase-1
  JOURNAL   Sci Rep 7 (1), 8776 (2017)
   PUBMED   28821720
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1981)
  AUTHORS   Jiang,Z., Zhu,J., Ma,Y., Hong,C., Xiao,S. and Jin,L.
  TITLE     Tyrosylprotein sulfotransferase 1 expression is negatively
            correlated with c-Met and lymph node metastasis in human lung
            cancer
  JOURNAL   Mol Med Rep 12 (4), 5217-5222 (2015)
   PUBMED   26238632
  REMARK    GeneRIF: TPST1 was significantly negatively correlated with the
            expression of cMet in lung cancer and may be a negative prognostic
            biomarker of lung cancer.
REFERENCE   3  (bases 1 to 1981)
  AUTHORS   Kim,J.G., Chae,Y.S., Lee,S.J., Kang,B.W., Park,J.Y., Lee,E.J.,
            Jeon,H.S., Park,J.S. and Choi,G.S.
  TITLE     Genetic variation in microRNA-binding site and prognosis of
            patients with colorectal cancer
  JOURNAL   J Cancer Res Clin Oncol 141 (1), 35-41 (2015)
   PUBMED   25079514
  REMARK    GeneRIF: TPST1 rs3757417T>G polymorphisms are associated with
            colorectal cancer.
REFERENCE   4  (bases 1 to 1981)
  AUTHORS   Xu,J., Deng,X., Tang,M., Li,L., Xiao,L., Yang,L., Zhong,J.,
            Bode,A.M., Dong,Z., Tao,Y. and Cao,Y.
  TITLE     Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of
            chemokine receptor 4 are induced by Epstein-Barr virus encoded
            latent membrane protein 1 and associated with the metastatic
            potential of human nasopharyngeal carcinoma
  JOURNAL   PLoS One 8 (3), e56114 (2013)
   PUBMED   23472069
  REMARK    GeneRIF: up-regulation of TPST-1 and tyrosine sulfation of CXCR4 by
            LMP1 might be a potential mechanism contributing to nasopharyngeal
            carcinoma metastasis
REFERENCE   5  (bases 1 to 1981)
  AUTHORS   Saito,A., Kawamoto,M. and Kamatani,N.
  TITLE     Association study between single-nucleotide polymorphisms in 199
            drug-related genes and commonly measured quantitative traits of 752
            healthy Japanese subjects
  JOURNAL   J Hum Genet 54 (6), 317-323 (2009)
   PUBMED   19343046
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1981)
  AUTHORS   Goettsch,S., Goettsch,W., Morawietz,H. and Bayer,P.
  TITLE     Shear stress mediates tyrosylprotein sulfotransferase isoform shift
            in human endothelial cells
  JOURNAL   Biochem Biophys Res Commun 294 (3), 541-546 (2002)
   PUBMED   12056800
  REMARK    GeneRIF: Shear stress-dependent downregulation of TPST1 in human
            endothelium involves protein kinase C
            Erratum:[Biochem Biophys Res Commun 2002 Jul 26;295(4):1033]
REFERENCE   7  (bases 1 to 1981)
  AUTHORS   Popovic,M., Goobie,S., Morrison,J., Ellis,L., Ehtesham,N.,
            Richards,N., Boocock,G., Durie,P.R. and Rommens,J.M.
  TITLE     Fine mapping of the locus for Shwachman-Diamond syndrome at 7q11,
            identification of shared disease haplotypes, and exclusion of TPST1
            as a candidate gene
  JOURNAL   Eur J Hum Genet 10 (4), 250-258 (2002)
   PUBMED   12032733
  REMARK    GeneRIF: results exclude TPST1 as the causative gene for
            Shwachman-Diamond syndrome
REFERENCE   8  (bases 1 to 1981)
  AUTHORS   Ouyang,Y.B. and Moore,K.L.
  TITLE     Molecular cloning and expression of human and mouse tyrosylprotein
            sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue
            in Caenorhabditis elegans
  JOURNAL   J Biol Chem 273 (38), 24770-24774 (1998)
   PUBMED   9733778
REFERENCE   9  (bases 1 to 1981)
  AUTHORS   Ouyang,Yb., Lane,W.S. and Moore,K.L.
  TITLE     Tyrosylprotein sulfotransferase: purification and molecular cloning
            of an enzyme that catalyzes tyrosine O-sulfation, a common
            posttranslational modification of eukaryotic proteins
  JOURNAL   Proc Natl Acad Sci U S A 95 (6), 2896-2901 (1998)
   PUBMED   9501187
REFERENCE   10 (bases 1 to 1981)
  AUTHORS   Marchese,P., Murata,M., Mazzucato,M., Pradella,P., De Marco,L.,
            Ware,J. and Ruggeri,Z.M.
  TITLE     Identification of three tyrosine residues of glycoprotein Ib alpha
            with distinct roles in von Willebrand factor and alpha-thrombin
            binding
  JOURNAL   J Biol Chem 270 (16), 9571-9578 (1995)
   PUBMED   7721887
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC013188.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003596.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013188.1, SRR1803616.185557.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304842.6/ ENSP00000302413.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1981              BC013188.1         38-2018
FEATURES             Location/Qualifiers
     source          1..1981
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..1981
                     /gene="TPST1"
                     /gene_synonym="TANGO13A"
                     /note="tyrosylprotein sulfotransferase 1"
                     /db_xref="GeneID:8460"
                     /db_xref="HGNC:HGNC:12020"
                     /db_xref="MIM:603125"
     exon            1..189
                     /gene="TPST1"
                     /gene_synonym="TANGO13A"
                     /inference="alignment:Splign:2.1.0"
     exon            190..1135
                     /gene="TPST1"
                     /gene_synonym="TANGO13A"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1403
                     /gene="TPST1"
                     /gene_synonym="TANGO13A"
                     /EC_number="2.8.2.20"
                     /note="TPST-1; transport and golgi organization 13 homolog
                     A"
                     /codon_start=1
                     /product="protein-tyrosine sulfotransferase 1"
                     /protein_id="NP_003587.1"
                     /db_xref="CCDS:CCDS5533.1"
                     /db_xref="GeneID:8460"
                     /db_xref="HGNC:HGNC:12020"
                     /db_xref="MIM:603125"
                     /translation="MVGKLKQNLLLACLVISSVTVFYLGQHAMECHHRIEERSQPVKL
                     ESTRTTVRTGLDLKANKTFAYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETR
                     VIPRILALKQMWSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKD
                     PFALKSLTYLSRLFPNAKFLLMVRDGRASVHSMISRKVTIAGFDLNSYRDCLTKWNRA
                     IETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNHSVLHHEEMIGKAG
                     GVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQDMAVIAPMLAKLGYDPYANPPN
                     YGKPDPKIIENTRRVYKGEFQLPDFLKEKPQTEQVE"
     exon            1136..1334
                     /gene="TPST1"
                     /gene_synonym="TANGO13A"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1385
                     /gene="TPST1"
                     /gene_synonym="TANGO13A"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1432
                     /gene="TPST1"
                     /gene_synonym="TANGO13A"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1981
                     /gene="TPST1"
                     /gene_synonym="TANGO13A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1958..1963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPST1"
                     /gene_synonym="TANGO13A"
                     /note="hexamer: AATAAA"
     polyA_site      1981
                     /gene="TPST1"
                     /gene_synonym="TANGO13A"
                     /note="major polyA site"
ORIGIN      
        1 agacgctgct gaggcggctt cggttgcggg tcggaacggc gctgctctgc ggggccggtc
       61 caggctggca gctgccggcg cttggcggtg agggcgggct cccgagtggc cccccaccga
      121 aggcggtggg accagcggct gaggccagga tgccgtccag gcggcgcggc ggctcctcac
      181 tcatcccaga tgttggttat ctttctgaag tagactgtcc atggcctgaa cattttccga
      241 aaatcatttt gagcaaaata tctgtttaat aacaagataa ccacatcaag atggttggaa
      301 agctgaagca gaacttacta ttggcatgtc tggtgattag ttctgtgact gtgttttacc
      361 tgggccagca tgccatggaa tgccatcacc ggatagagga acgtagccag ccagtcaaat
      421 tggagagcac aaggaccact gtgagaactg gcctggacct caaagccaac aaaacctttg
      481 cctatcacaa agatatgcct ttaatattta ttggaggtgt gcctcggagt ggaaccacac
      541 tcatgagggc catgctggac gcacatcctg acattcgctg tggagaggaa accagggtca
      601 ttccccgaat cctggccctg aagcagatgt ggtcacggtc aagtaaagag aagatccgcc
      661 tggatgaggc tggtgttact gatgaagtgc tggattctgc catgcaagcc ttcttactag
      721 aaattatcgt taagcatggg gagccagccc cttatttatg taataaagat ccttttgccc
      781 tgaaatcttt aacttacctt tctaggttat tccccaatgc caaatttctc ctgatggtcc
      841 gagatggccg ggcatcagta cattcaatga tttctcgaaa agttactata gctggatttg
      901 atctgaacag ctatagggac tgtttgacaa agtggaatcg tgctatagag accatgtata
      961 accagtgtat ggaggttggt tataaaaagt gcatgttggt tcactatgaa caacttgtct
     1021 tacatcctga acggtggatg agaacactct taaagttcct ccagattcca tggaaccact
     1081 cagtattgca ccatgaagag atgattggga aagctggggg agtgtctctg tcaaaagtgg
     1141 agagatctac agaccaagta atcaagccag tcaatgtagg agctctatca aaatgggttg
     1201 ggaagatacc gccagatgtt ttacaagaca tggcagtgat tgctcctatg cttgccaagc
     1261 ttggatatga cccatatgcc aacccaccta actacggaaa acctgatccc aaaattattg
     1321 aaaacactcg aagggtctat aagggagaat tccaactacc tgactttctt aaagaaaaac
     1381 cacagactga gcaagtggag tagcagaacc aggagcctct tccatacatg aggaaagatt
     1441 gctgcctttt cagcagaagg gaaattccta ggattggctg tcccctgcca agcttggtgg
     1501 agcgtctgca ccttggctgc gccgcctgtg catttgccag tttcctccca ctgagaggat
     1561 ggaggtgtcc gcacagcttt gggcctcgtg agggatctgc ctcctgagca aagagctctt
     1621 gatcccgatt tcatgcacag ccctgcagta aggagcccag aaggaacatg tgtttcctgt
     1681 taaaactcct cttgttctct tttcttacat tatgacgttt gttttcaagg agagggttta
     1741 aaaatgggat cctgtaagca gacttgggca gtctcctttt gaaataggtt gtctgtacat
     1801 gttctaatgt tttgtagaac acgtgtgcct gtttaagtgt attgatgtga ataatattaa
     1861 atatcctaat tatttaattc attgtattgt ttctgagaag ttgggaaatt accattatac
     1921 atttacaacc taatgacttt tgtattttat ttttcaaaat aaaagctttc aatgtgaagc
     1981 a
//
