LOCUS       NM_012467               1119 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tryptase gamma 1 (TPSG1), mRNA.
ACCESSION   NM_012467
VERSION     NM_012467.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1119)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1119)
  AUTHORS   Xiang,M., Gu,Y., Zhao,F., Lu,H., Chen,S. and Yin,L.
  TITLE     Mast cell tryptase promotes breast cancer migration and invasion
  JOURNAL   Oncol Rep 23 (3), 615-619 (2010)
   PUBMED   20126998
  REMARK    GeneRIF: tryptase promotes breast cancer migration and invasion.
REFERENCE   3  (bases 1 to 1119)
  AUTHORS   Wong,G.W., Foster,P.S., Yasuda,S., Qi,J.C., Mahalingam,S.,
            Mellor,E.A., Katsoulotos,G., Li,L., Boyce,J.A., Krilis,S.A. and
            Stevens,R.L.
  TITLE     Biochemical and functional characterization of human transmembrane
            tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell
            protease that induces airway hyperresponsiveness in vivo via an
            interleukin-13/interleukin-4 receptor alpha/signal transducer and
            activator of transcription (STAT) 6-dependent pathway
  JOURNAL   J Biol Chem 277 (44), 41906-41915 (2002)
   PUBMED   12194977
  REMARK    GeneRIF: TMT is an exocytosed MC neutral protease that induces AHR
            in lungs primarily by activating an
            IL-13/IL-4Ralpha/STAT6-dependent pathway.
REFERENCE   4  (bases 1 to 1119)
  AUTHORS   Caughey,G.H.
  TITLE     New developments in the genetics and activation of mast cell
            proteases
  JOURNAL   Mol Immunol 38 (16-18), 1353-1357 (2002)
   PUBMED   12217407
  REMARK    Review article
REFERENCE   5  (bases 1 to 1119)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   6  (bases 1 to 1119)
  AUTHORS   Caughey,G.H., Raymond,W.W., Blount,J.L., Hau,L.W., Pallaoro,M.,
            Wolters,P.J. and Verghese,G.M.
  TITLE     Characterization of human gamma-tryptases, novel members of the
            chromosome 16p mast cell tryptase and prostasin gene families
  JOURNAL   J Immunol 164 (12), 6566-6575 (2000)
   PUBMED   10843716
REFERENCE   7  (bases 1 to 1119)
  AUTHORS   Wong,G.W., Tang,Y., Feyfant,E., Sali,A., Li,L., Li,Y., Huang,C.,
            Friend,D.S., Krilis,S.A. and Stevens,R.L.
  TITLE     Identification of a new member of the tryptase family of mouse and
            human mast cell proteases which possesses a novel COOH-terminal
            hydrophobic extension
  JOURNAL   J Biol Chem 274 (43), 30784-30793 (1999)
   PUBMED   10521469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120498.2.
            
            On Jun 2, 2019 this sequence version replaced NM_012467.3.
            
            Summary: Tryptases comprise a family of trypsin-like serine
            proteases, the peptidase family S1. Tryptases are enzymatically
            active only as heparin-stabilized tetramers, and they are resistant
            to all known endogenous proteinase inhibitors. Several tryptase
            genes are clustered on chromosome 16p13.3. There is uncertainty
            regarding the number of genes in this cluster. Currently four
            functional genes - alpha I, beta I, beta II and gamma I - have been
            identified. And beta I has an allelic variant named alpha II, beta
            II has an allelic variant beta III, also gamma I has an allelic
            variant gamma II. Beta tryptases appear to be the main isoenzymes
            expressed in mast cells; whereas in basophils, alpha-tryptases
            predominant. This gene differs from other members of the tryptase
            gene family in that it has C-terminal hydrophobic domain, which may
            serve as a membrane anchor. Tryptases have been implicated as
            mediators in the pathogenesis of asthma and other allergic and
            inflammatory disorders. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2153946
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234798.5/ ENSP00000234798.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC120498.2         104135-104196       c
            63-89               AC120498.2         103530-103556       c
            90-261              AC120498.2         102351-102522       c
            262-527             AC120498.2         101580-101845       c
            528-673             AC120498.2         101124-101269       c
            674-1119            AC120498.2         100579-101024       c
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1119
                     /gene="TPSG1"
                     /gene_synonym="PRSS31; TMT; trpA"
                     /note="tryptase gamma 1"
                     /db_xref="GeneID:25823"
                     /db_xref="HGNC:HGNC:14134"
                     /db_xref="MIM:609341"
     exon            1..62
                     /gene="TPSG1"
                     /gene_synonym="PRSS31; TMT; trpA"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..982
                     /gene="TPSG1"
                     /gene_synonym="PRSS31; TMT; trpA"
                     /EC_number="3.4.21.59"
                     /note="tryptase gamma I; tryptase gamma II; serine
                     protease 31; transmembrane tryptase"
                     /codon_start=1
                     /product="tryptase gamma preproprotein"
                     /protein_id="NP_036599.4"
                     /db_xref="CCDS:CCDS10430.1"
                     /db_xref="GeneID:25823"
                     /db_xref="HGNC:HGNC:14134"
                     /db_xref="MIM:609341"
                     /translation="MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAA
                     PAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSP
                     HFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCW
                     VTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDAC
                     QDDSGGPLVCQVNGAWVQAGTVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSE
                     SGYPRLPLLAGFFLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD"
     exon            63..89
                     /gene="TPSG1"
                     /gene_synonym="PRSS31; TMT; trpA"
                     /inference="alignment:Splign:2.1.0"
     exon            90..261
                     /gene="TPSG1"
                     /gene_synonym="PRSS31; TMT; trpA"
                     /inference="alignment:Splign:2.1.0"
     exon            262..527
                     /gene="TPSG1"
                     /gene_synonym="PRSS31; TMT; trpA"
                     /inference="alignment:Splign:2.1.0"
     exon            528..673
                     /gene="TPSG1"
                     /gene_synonym="PRSS31; TMT; trpA"
                     /inference="alignment:Splign:2.1.0"
     exon            674..1119
                     /gene="TPSG1"
                     /gene_synonym="PRSS31; TMT; trpA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtgggca gacaccatgg cccttggggc ctgtggcctc ctgctgctcc tggctgtgcc
       61 cggtgtgtcc ctcaggactt tgcagccagg gtgtggccgg ccgcaggttt cggatgcagg
      121 cggccggatc gtggggggtc acgctgcccc ggccggcgca tggccatggc aggccagcct
      181 ccgcctgcgg agggtgcacg tgtgcggcgg gtcactgctc agcccccagt gggtgctcac
      241 agctgcccac tgcttctccg ggtccctgaa ctcatccgac taccaggtgc acctggggga
      301 actggagatc actctgtctc cccacttctc caccgtgagg cagatcatcc tgcactccag
      361 cccctcagga cagccgggga ccagcgggga catcgccctg gtggagctca gtgtccccgt
      421 gaccctctcc agccggatcc tgcccgtctg cctcccggag gcctcagatg acttctgccc
      481 tgggatccgg tgctgggtga ccggctgggg ctatacgcgg gagggagagc ctctgccacc
      541 cccgtacagc ctgcgggagg tgaaagtctc cgtggtggac acagagacct gccgccggga
      601 ctatcccggc cccgggggca gcatccttca gcccgacatg ctgtgtgccc ggggccccgg
      661 ggatgcctgc caggacgact ccggggggcc tctggtctgc caggtgaacg gtgcctgggt
      721 gcaggctggc actgtgagct ggggtgaggg ctgcggccgc cccaacaggc cgggagtcta
      781 cactcgtgtc cctgcctacg tgaactggat ccgccgccac atcacagcat cagggggctc
      841 agagtctggg taccccaggc tccccctcct ggctggcttc ttcctccccg gcctcttcct
      901 tctgctagtc tcctgtgtcc tgctggccaa gtgcctgctg cacccatctg cggatggtac
      961 tcccttcccc gcccctgact gatggcagga atccaagtgc atttcttaaa taagttacta
     1021 tttattccgc tccgccccct ccctctccct tgagaagctg agtcttctgc atcagattat
     1081 tgcaacattt aacctgaatt taaaagcaca cgaaacaaa
//
