LOCUS       NP_036349                242 aa            linear   PRI 28-APR-2025
DEFINITION  tryptase delta precursor [Homo sapiens].
ACCESSION   NP_036349
VERSION     NP_036349.1
DBSOURCE    REFSEQ: accession NM_012217.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 242)
  AUTHORS   Tsuchiya,M., Fukushima,K., Takata,K., Ohashi,Y., Uchiyama,K.,
            Takahira,N., Saito,H., Tsukada,A., Inoue,G., Takaso,M. and
            Uchida,K.
  TITLE     Increase in TPSB2 and TPSD1 Expression in Synovium of Hip
            Osteoarthritis Patients Who Are Overweight
  JOURNAL   Int J Mol Sci 24 (14), 11532 (2023)
   PUBMED   37511292
  REMARK    GeneRIF: Increase in TPSB2 and TPSD1 Expression in Synovium of Hip
            Osteoarthritis Patients Who Are Overweight.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 242)
  AUTHORS   Trivedi,N.N., Tamraz,B., Chu,C., Kwok,P.Y. and Caughey,G.H.
  TITLE     Human subjects are protected from mast cell tryptase deficiency
            despite frequent inheritance of loss-of-function mutations
  JOURNAL   J Allergy Clin Immunol 124 (5), 1099-105 (2009)
   PUBMED   19748655
REFERENCE   3  (residues 1 to 242)
  AUTHORS   Jackson,N.E., Wang,H.W., Bryant,K.J., McNeil,H.P., Husain,A.,
            Liu,K., Tedla,N., Thomas,P.S., King,G.C., Hettiaratchi,A.,
            Cairns,J. and Hunt,J.E.
  TITLE     Alternate mRNA splicing in multiple human tryptase genes is
            predicted to regulate tetramer formation
  JOURNAL   J Biol Chem 283 (49), 34178-34187 (2008)
   PUBMED   18854315
REFERENCE   4  (residues 1 to 242)
  AUTHORS   Trivedi,N.N., Raymond,W.W. and Caughey,G.H.
  TITLE     Chimerism, point mutation, and truncation dramatically transformed
            mast cell delta-tryptases during primate evolution
  JOURNAL   J Allergy Clin Immunol 121 (5), 1262-1268 (2008)
   PUBMED   18325577
REFERENCE   5  (residues 1 to 242)
  AUTHORS   Trivedi,N.N., Tong,Q., Raman,K., Bhagwandin,V.J. and Caughey,G.H.
  TITLE     Mast cell alpha and beta tryptases changed rapidly during primate
            speciation and evolved from gamma-like transmembrane peptidases in
            ancestral vertebrates
  JOURNAL   J Immunol 179 (9), 6072-6079 (2007)
   PUBMED   17947681
REFERENCE   6  (residues 1 to 242)
  AUTHORS   Caughey,G.H.
  TITLE     New developments in the genetics and activation of mast cell
            proteases
  JOURNAL   Mol Immunol 38 (16-18), 1353-1357 (2002)
   PUBMED   12217407
  REMARK    Review article
REFERENCE   7  (residues 1 to 242)
  AUTHORS   Soto,D., Malmsten,C., Blount,J.L., Muilenburg,D.J. and Caughey,G.H.
  TITLE     Genetic deficiency of human mast cell alpha-tryptase
  JOURNAL   Clin Exp Allergy 32 (7), 1000-1006 (2002)
   PUBMED   12100045
REFERENCE   8  (residues 1 to 242)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   9  (residues 1 to 242)
  AUTHORS   Min,H.K., Kambe,N. and Schwartz,L.B.
  TITLE     Human mouse mast cell protease 7-like tryptase genes are
            pseudogenes
  JOURNAL   J Allergy Clin Immunol 107 (2), 315-321 (2001)
   PUBMED   11174199
REFERENCE   10 (residues 1 to 242)
  AUTHORS   Pallaoro,M., Fejzo,M.S., Shayesteh,L., Blount,J.L. and Caughey,G.H.
  TITLE     Characterization of genes encoding known and novel human mast cell
            tryptases on chromosome 16p13.3
  JOURNAL   J Biol Chem 274 (6), 3355-3362 (1999)
   PUBMED   9920877
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120498.2.
            
            Summary: Tryptases comprise a family of trypsin-like serine
            proteases, the peptidase family S1. Tryptases are enzymatically
            active only as heparin-stabilized tetramers, and they are resistant
            to all known endogenous proteinase inhibitors. Several tryptase
            genes are clustered on chromosome 16p13.3. These genes are
            characterized by several distinct features. They have a highly
            conserved 3' UTR and contain tandem repeat sequences at the 5'
            flank and 3' UTR which are thought to play a role in regulation of
            the mRNA stability. Although this gene may be an exception, most of
            the tryptase genes have an intron immediately upstream of the
            initiator Met codon, which separates the site of transcription
            initiation from protein coding sequence. This feature is
            characteristic of tryptases but is unusual in other genes.
            Tryptases have been implicated as mediators in the pathogenesis of
            asthma and other allergic and inflammatory disorders. This gene was
            once considered to be a pseudogene, although it is now believed to
            be a functional gene that encodes a protein. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000211076.5/ ENSP00000211076.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..242
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     Protein         1..242
                     /product="tryptase delta precursor"
                     /EC_number="3.4.21.59"
                     /note="mast cell tryptase; mMCP-7-like-2; mMCP-7-like-1;
                     hmMCP-3-like tryptase III; mMCP-7-like delta II tryptase;
                     tryptase-3; delta-tryptase"
                     /calculated_mol_wt=24468
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2134
     Region          38..242
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            38
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(81,128,231)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            139
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9BZJ3.2)"
     CDS             1..242
                     /gene="TPSD1"
                     /gene_synonym="MCP7-LIKE; MCP7L1; MMCP-7L"
                     /coded_by="NM_012217.3:213..941"
                     /db_xref="CCDS:CCDS10432.1"
                     /db_xref="GeneID:23430"
                     /db_xref="HGNC:HGNC:14118"
                     /db_xref="MIM:609272"
ORIGIN      
        1 mlllapqmls llllalpvla spayvapapg qalqqtgivg gqeaprskwp wqvslrvrgp
       61 ywmhfcggsl ihpqwvltaa hcvepdikdl aalrvqlreq hlyyqdqllp vsriivhpqf
      121 yiiqtgadia lleleepvni sshihtvtlp pasetfppgm pcwvtgwgdv dnnvhlpppy
      181 plkevevpvv enhlcnaeyh tglhtghsfq ivrddmlcag senhdscqgd sggplvckvn
      241 gt
//
