LOCUS       NM_001397347            1127 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens tetrapeptide repeat homeobox 2 (TPRX2), transcript
            variant 1, mRNA.
ACCESSION   NM_001397347
VERSION     NM_001397347.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1127)
  AUTHORS   Zou,Z., Zhang,C., Wang,Q., Hou,Z., Xiong,Z., Kong,F., Wang,Q.,
            Song,J., Liu,B., Liu,B., Wang,L., Lai,F., Fan,Q., Tao,W., Zhao,S.,
            Ma,X., Li,M., Wu,K., Zhao,H., Chen,Z.J. and Xie,W.
  TITLE     Translatome and transcriptome co-profiling reveals a role of TPRXs
            in human zygotic genome activation
  JOURNAL   Science 378 (6615), abo7923 (2022)
   PUBMED   36074823
REFERENCE   2  (bases 1 to 1127)
  AUTHORS   Lewin,T.D., Royall,A.H. and Holland,P.W.H.
  TITLE     Dynamic Molecular Evolution of Mammalian Homeobox Genes:
            Duplication, Loss, Divergence and Gene Conversion Sculpt PRD Class
            Repertoires
  JOURNAL   J Mol Evol 89 (6), 396-414 (2021)
   PUBMED   34097121
REFERENCE   3  (bases 1 to 1127)
  AUTHORS   Madissoon,E., Jouhilahti,E.M., Vesterlund,L., Tohonen,V.,
            Krjutskov,K., Petropoulos,S., Einarsdottir,E., Linnarsson,S.,
            Lanner,F., Mansson,R., Hovatta,O., Burglin,T.R., Katayama,S. and
            Kere,J.
  TITLE     Characterization and target genes of nine human PRD-like homeobox
            domain genes expressed exclusively in early embryos
  JOURNAL   Sci Rep 6, 28995 (2016)
   PUBMED   27412763
  REMARK    Erratum:[Sci Rep. 2016 Sep 02;6:32053. doi: 10.1038/srep32053..
            PMID: 27586261]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024582.7.
            
            On Nov 10, 2021 this sequence version replaced NM_001397347.1.
            
            Summary: Homeobox genes encode DNA-binding proteins, many of which
            are thought to be involved in early embryonic development. Homeobox
            genes encode a DNA-binding domain of 60 to 63 amino acids referred
            to as the homeodomain. This pseudogene is a member of the TPRX
            homeobox gene family. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: LN901405.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535362.3/ ENSP00000514106.1
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC024582.7         19367-19403
            38-207              AC024582.7         20245-20414
            208-1127            AC024582.7         20934-21853
FEATURES             Location/Qualifiers
     source          1..1127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1127
                     /gene="TPRX2"
                     /gene_synonym="TPRX2P; TPRX2P1; TPRXP1"
                     /note="tetrapeptide repeat homeobox 2"
                     /db_xref="GeneID:503627"
                     /db_xref="HGNC:HGNC:32175"
                     /db_xref="MIM:620360"
     exon            1..37
                     /gene="TPRX2"
                     /gene_synonym="TPRX2P; TPRX2P1; TPRXP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..918
                     /gene="TPRX2"
                     /gene_synonym="TPRX2P; TPRX2P1; TPRXP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetra-peptide repeat homeobox pseudogene 1; tetra-peptide
                     repeat homeobox 1 pseudogene; tetra-peptide repeat
                     homeobox 2 pseudogene; tetrapeptide repeat homeobox 2,
                     pseudogene; Tetrapeptide repeat homeobox protein 2"
                     /codon_start=1
                     /product="tetrapeptide repeat homeobox protein 2 isoform
                     1"
                     /protein_id="NP_001384276.1"
                     /db_xref="CCDS:CCDS92655.1"
                     /db_xref="GeneID:503627"
                     /db_xref="HGNC:HGNC:32175"
                     /db_xref="MIM:620360"
                     /translation="MQDPGHLQGPPLALDPPRRQRQERTVYTESQQKVLEFYFQKDQY
                     PNYDQRLNLAEMLSLREQQLQVWFKNRRAKLARERRLQQQPQRVPGQRGRGARAAPLV
                     PVAAASFPGGPEFPQGRGSWISPQPGPWGVLPAAEPKIYSLPRTWGGPECGTQEGLKA
                     VPAPGPGPIPAPIPGPAQIPGPVPGPAPNLGPMSGPLSVSIPGPIPAPISCPGPIPDP
                     VLGRTLMPGPGSLPTPAPGALWPQSPYASNLSPDTQLYPDFTKLLPLLDRFEESSLST
                     TTSQYKEEDGFVDKNHSVPRSLLDL"
     exon            38..207
                     /gene="TPRX2"
                     /gene_synonym="TPRX2P; TPRX2P1; TPRXP1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..1127
                     /gene="TPRX2"
                     /gene_synonym="TPRX2P; TPRX2P1; TPRXP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcaggactca ggatgcaaga ccctggtcat ctccaaggcc ctcccctggc cctggaccct
       61 ccaaggagac agcggcagga gcgcacggtc tacactgaaa gccagcagaa agtgctagaa
      121 ttttactttc agaaggacca gtacccgaac tacgaccagc gactgaatct ggcggagatg
      181 ctcagcctca gggagcaaca gctgcaggtg tggttcaaga atcgccgcgc caaactagct
      241 cgggagcggc ggctccagca gcagccccag cgcgtccctg ggcagagagg ccgaggagcc
      301 cgcgctgcgc ccctagtccc tgtagccgct gcctccttcc ctgggggtcc tgagttcccg
      361 cagggcaggg gttcctggat ctcccctcag ccgggcccct ggggagtcct cccagcagca
      421 gaaccgaaga tctacagcct cccccggacc tggggtggcc ctgagtgtgg aacacaggag
      481 ggcctcaagg ctgtcccggc tccaggccct ggcccaatcc cagcccctat cccaggccca
      541 gcccagatcc caggcccagt cccaggccca gccccgaatt taggcccaat gtcaggccca
      601 ctgtcagtct cgatccccgg tccaatacca gcccccatct cttgcccagg cccaatccca
      661 gacccagtcc taggccgaac cctgatgcca ggcccaggat cactcccaac cccagcccca
      721 ggcgccttgt ggcctcagag cccctatgcc tccaacttgt cgccagacac ccagttatac
      781 cctgacttca ccaagctgct cccgctccta gaccggttcg aggaatcctc actctccacc
      841 acgacgtctc agtacaaaga ggaggatggc ttcgtggaca aaaatcactc agtccccagg
      901 tcattactgg atttataggg ggcctgtgcc tgcaaagttc ttcagatccc agagggcctg
      961 gagtggctga tctacactgc tggtgacttt ctgcagtgaa tgcatcaccc tttacccacc
     1021 ctgctgcagg tggacatttg ctgtcttcac tgtgcagcca tcacaggtgg ctctgctgtg
     1081 aatgtgcctg cctgtcattt gaattgagcc tgagcgtttc tctgctg
//
