LOCUS       NM_001397346            1956 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens tetrapeptide repeat homeobox 1 (TPRX1), transcript
            variant 1, mRNA.
ACCESSION   NM_001397346
VERSION     NM_001397346.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Zou,Z., Zhang,C., Wang,Q., Hou,Z., Xiong,Z., Kong,F., Wang,Q.,
            Song,J., Liu,B., Liu,B., Wang,L., Lai,F., Fan,Q., Tao,W., Zhao,S.,
            Ma,X., Li,M., Wu,K., Zhao,H., Chen,Z.J. and Xie,W.
  TITLE     Translatome and transcriptome co-profiling reveals a role of TPRXs
            in human zygotic genome activation
  JOURNAL   Science 378 (6615), abo7923 (2022)
   PUBMED   36074823
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Madissoon,E., Jouhilahti,E.M., Vesterlund,L., Tohonen,V.,
            Krjutskov,K., Petropoulos,S., Einarsdottir,E., Linnarsson,S.,
            Lanner,F., Mansson,R., Hovatta,O., Burglin,T.R., Katayama,S. and
            Kere,J.
  TITLE     Characterization and target genes of nine human PRD-like homeobox
            domain genes expressed exclusively in early embryos
  JOURNAL   Sci Rep 6, 28995 (2016)
   PUBMED   27412763
  REMARK    Erratum:[Sci Rep. 2016 Sep 02;6:32053. doi: 10.1038/srep32053..
            PMID: 27586261]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Booth,H.A. and Holland,P.W.
  TITLE     Annotation, nomenclature and evolution of four novel homeobox genes
            expressed in the human germ line
  JOURNAL   Gene 387 (1-2), 7-14 (2007)
   PUBMED   17005330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008745.7.
            
            Summary: Homeobox genes encode DNA-binding proteins, many of which
            are thought to be involved in early embryonic development. Homeobox
            genes encode a DNA-binding domain of 60 to 63 amino acids referred
            to as the homeodomain. This gene is a member of the TPRX homeobox
            gene family. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2148874, SAMEA2158188
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000698655.1/ ENSP00000513863.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC008745.7         84729-84765         c
            38-207              AC008745.7         83718-83887         c
            208-1956            AC008745.7         81446-83194         c
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1956
                     /gene="TPRX1"
                     /gene_synonym="TPRX"
                     /note="tetrapeptide repeat homeobox 1"
                     /db_xref="GeneID:284355"
                     /db_xref="HGNC:HGNC:32174"
                     /db_xref="MIM:611166"
     exon            1..37
                     /gene="TPRX1"
                     /gene_synonym="TPRX"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1413
                     /gene="TPRX1"
                     /gene_synonym="TPRX"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetra-peptide repeat homeobox protein 1; CRX like homeobox
                     2; tetra-peptide repeat homeobox 1"
                     /codon_start=1
                     /product="tetra-peptide repeat homeobox protein 1 isoform
                     1"
                     /protein_id="NP_001384275.1"
                     /db_xref="CCDS:CCDS92654.1"
                     /db_xref="GeneID:284355"
                     /db_xref="HGNC:HGNC:32174"
                     /db_xref="MIM:611166"
                     /translation="MQDPGHLQGPPLALDPPRRQRQERTVYTESQQKVLEFYFQKDQY
                     PNYDQRLNLAEMLSLREQQLQVWFKNRRAKLARERRLQQQPQRVPGQRGRGARAAPLV
                     PAASASAPQRGPSGILPAAEPTICSLHQAWGGPGCRAQKGIPAALSPGPGPIPAPIPG
                     PAQIPGPLPGSIPGPIPGPAQIPSPIPAPIPGPISGPVQIPGPFRGPIPGPISGPAPI
                     PGPISGPFSGPNPGPIPGPNPGPIPGPISGPIPGPISVPIPGPIPGPISGPISGPNPG
                     PIPGPIPGPISGPNPGPIPGPISGPNPGLIPGPIPGPISGPGPIIGPIPSPAQIPGPG
                     RLQGPGPILSPGRMRSPGSLPGLAPILGPGSGPGSGSVPAPIPGPGSLPAPAPLWPQS
                     PDASDFLPDTQLFPHFTELLLPLDPLEGSSVSTMTSQYQEGDDSMGKKHSGSQPQEEG
                     GSVNENHSGPRLLLDL"
     exon            38..207
                     /gene="TPRX1"
                     /gene_synonym="TPRX"
                     /inference="alignment:Splign:2.1.0"
     exon            208..1956
                     /gene="TPRX1"
                     /gene_synonym="TPRX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1924..1929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPRX1"
                     /gene_synonym="TPRX"
                     /note="hexamer: ATTAAA"
     polyA_site      1946
                     /gene="TPRX1"
                     /gene_synonym="TPRX"
                     /note="major polyA site"
ORIGIN      
        1 tcaggactca ggatgcaaga ccctggtcat ctccaaggcc ctcccctggc cctggaccct
       61 ccaaggagac agcggcagga gcgcacggtc tacactgaaa gccagcagaa agtgctagaa
      121 ttttactttc agaaggacca gtacccgaac tacgaccagc gactgaatct ggcggagatg
      181 ctcagcctca gggagcaaca gctgcaggtg tggttcaaga atcgccgcgc caaactagct
      241 cgggagcggc ggctccagca gcagccccag cgcgtccctg ggcagagagg ccgaggagcc
      301 cgcgctgcgc ccctagtccc tgcagcctct gcctccgcac ctcagcgggg cccctcggga
      361 atccttccag cggcggaacc cacgatctgc agcctccacc aggcctgggg tggccctggg
      421 tgcagagccc agaagggcat cccagctgcc ctgagtccag gccctggccc gatccctgcc
      481 ccaatcccag gcccagccca gatcccaggc ccactccctg gctcaattcc aggcccaatt
      541 ccaggcccag ctcagatccc aagcccgatc ccagccccaa tcccaggccc aatttcaggc
      601 ccagtccaga tcccaggccc attccgtggc ccaatcccag gcccaatttc aggcccagcc
      661 ccgatcccag gcccaatctc aggcccattc tcaggcccaa acccaggccc gatcccaggc
      721 ccaaacccag gcccgatccc aggcccaatc tcaggcccga tcccaggccc aatctcagtc
      781 ccgatcccag gcccgatccc aggcccaatc tcaggcccaa tctcaggccc aaacccaggc
      841 ccgatcccag gcccaatccc aggcccaatc tcaggcccga acccaggccc gatcccaggc
      901 ccaatctcag gcccgaaccc aggcctgatc ccaggcccaa tcccaggccc aatctcaggc
      961 ccaggcccaa ttataggccc gattcccagc ccagcccaga tcccaggccc aggcagactc
     1021 caaggcccag gtcccatctt aagtcctggc cggatgcgaa gccctggctc acttccaggc
     1081 ctagccccga ttttaggccc aggctcaggc ccaggctcag gctcagtccc agctccaatc
     1141 ccaggcccag gatcactccc agccccagcc cccttatggc ctcagagccc cgatgcctcc
     1201 gacttcttgc cagacaccca gttattccct cacttcacag agctgctcct acccctagac
     1261 cccttggagg gatcctcagt ctccaccatg acctctcagt accaagaagg ggatgactct
     1321 atgggcaaaa aacactcagg gtctcagccc caagaggagg gtggctctgt gaatgaaaat
     1381 cactcaggcc ccaggttatt actggattta tagggggcct gtgcctgcaa agttcttcag
     1441 atcccagagg gcctggagtg gctgatctac actgctggtg actttctgca gtgaatgcat
     1501 caccctttac ccaccctgct gcaggtggac atttgctgtc ttcactgtgc agctatcaca
     1561 ggtggctctg ctgtgaatgt gcctgcctgt catttgaatt gagcctgagc gtttctctgc
     1621 tgggattgga gtcgctgctc actgggatat ctggcattag tggatgctgc tcgagagctt
     1681 tctaaagggc ttttcccagg gcttctgatg gtcagcatct tccccaacac ttaggattgt
     1741 gagacttttt aatgtttgtc gatccaatga cttgtggttt tgttgtggtt gtaatatcca
     1801 tttccctgat gattgagaag ttaaaccctc acatgttaat tgaaccttag atatcttcat
     1861 aatgtgtatt tgtttacccc ttttccttca tttatttgaa tgtattctta tattctcttg
     1921 gcaattaaag ttctgcagac acctttccta tttgca
//
