LOCUS       NM_001330386             781 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens TP53RK binding protein (TPRKB), transcript variant 1,
            mRNA.
ACCESSION   NM_001330386 XM_005264343
VERSION     NM_001330386.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 781)
  AUTHORS   Luo,M., Luo,X., Sun,J., Ao,X., Han,H. and Yang,X.
  TITLE     METTL5 enhances the mRNA stability of TPRKB through m6A
            modification to facilitate the aggressive phenotypes of
            hepatocellular carcinoma cell
  JOURNAL   Exp Cell Res 442 (1), 114219 (2024)
   PUBMED   39182664
  REMARK    GeneRIF: METTL5 enhances the mRNA stability of TPRKB through m[6]A
            modification to facilitate the aggressive phenotypes of
            hepatocellular carcinoma cell.
REFERENCE   2  (bases 1 to 781)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 781)
  AUTHORS   Li,J., Ma,X., Banerjee,S., Chen,H., Ma,W., Bode,A.M. and Dong,Z.
  TITLE     Crystal structure of the human PRPK-TPRKB complex
  JOURNAL   Commun Biol 4 (1), 167 (2021)
   PUBMED   33547416
  REMARK    GeneRIF: Crystal structure of the human PRPK-TPRKB complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 781)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 781)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 781)
  AUTHORS   Braun,D.A., Rao,J., Mollet,G., Schapiro,D., Daugeron,M.C., Tan,W.,
            Gribouval,O., Boyer,O., Revy,P., Jobst-Schwan,T., Schmidt,J.M.,
            Lawson,J.A., Schanze,D., Ashraf,S., Ullmann,J.F.P.,
            Hoogstraten,C.A., Boddaert,N., Collinet,B., Martin,G., Liger,D.,
            Lovric,S., Furlano,M., Guerrera,I.C., Sanchez-Ferras,O., Hu,J.F.,
            Boschat,A.C., Sanquer,S., Menten,B., Vergult,S., De Rocker,N.,
            Airik,M., Hermle,T., Shril,S., Widmeier,E., Gee,H.Y., Choi,W.I.,
            Sadowski,C.E., Pabst,W.L., Warejko,J.K., Daga,A., Basta,T.,
            Matejas,V., Scharmann,K., Kienast,S.D., Behnam,B., Beeson,B.,
            Begtrup,A., Bruce,M., Ch'ng,G.S., Lin,S.P., Chang,J.H., Chen,C.H.,
            Cho,M.T., Gaffney,P.M., Gipson,P.E., Hsu,C.H., Kari,J.A., Ke,Y.Y.,
            Kiraly-Borri,C., Lai,W.M., Lemyre,E., Littlejohn,R.O., Masri,A.,
            Moghtaderi,M., Nakamura,K., Ozaltin,F., Praet,M., Prasad,C.,
            Prytula,A., Roeder,E.R., Rump,P., Schnur,R.E., Shiihara,T.,
            Sinha,M.D., Soliman,N.A., Soulami,K., Sweetser,D.A., Tsai,W.H.,
            Tsai,J.D., Topaloglu,R., Vester,U., Viskochil,D.H.,
            Vatanavicharn,N., Waxler,J.L., Wierenga,K.J., Wolf,M.T.F.,
            Wong,S.N., Leidel,S.A., Truglio,G., Dedon,P.C., Poduri,A., Mane,S.,
            Lifton,R.P., Bouchard,M., Kannu,P., Chitayat,D., Magen,D.,
            Callewaert,B., van Tilbeurgh,H., Zenker,M., Antignac,C. and
            Hildebrandt,F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   7  (bases 1 to 781)
  AUTHORS   Wan,L.C., Maisonneuve,P., Szilard,R.K., Lambert,J.P., Ng,T.F.,
            Manczyk,N., Huang,H., Laister,R., Caudy,A.A., Gingras,A.C.,
            Durocher,D. and Sicheri,F.
  TITLE     Proteomic analysis of the human KEOPS complex identifies C14ORF142
            as a core subunit homologous to yeast Gon7
  JOURNAL   Nucleic Acids Res 45 (2), 805-817 (2017)
   PUBMED   27903914
REFERENCE   8  (bases 1 to 781)
  AUTHORS   Chambers,J.C., Zhang,W., Lord,G.M., van der Harst,P., Lawlor,D.A.,
            Sehmi,J.S., Gale,D.P., Wass,M.N., Ahmadi,K.R., Bakker,S.J.,
            Beckmann,J., Bilo,H.J., Bochud,M., Brown,M.J., Caulfield,M.J.,
            Connell,J.M., Cook,H.T., Cotlarciuc,I., Davey Smith,G., de
            Silva,R., Deng,G., Devuyst,O., Dikkeschei,L.D., Dimkovic,N.,
            Dockrell,M., Dominiczak,A., Ebrahim,S., Eggermann,T., Farrall,M.,
            Ferrucci,L., Floege,J., Forouhi,N.G., Gansevoort,R.T., Han,X.,
            Hedblad,B., Homan van der Heide,J.J., Hepkema,B.G.,
            Hernandez-Fuentes,M., Hypponen,E., Johnson,T., de Jong,P.E.,
            Kleefstra,N., Lagou,V., Lapsley,M., Li,Y., Loos,R.J., Luan,J.,
            Luttropp,K., Marechal,C., Melander,O., Munroe,P.B., Nordfors,L.,
            Parsa,A., Peltonen,L., Penninx,B.W., Perucha,E., Pouta,A.,
            Prokopenko,I., Roderick,P.J., Ruokonen,A., Samani,N.J., Sanna,S.,
            Schalling,M., Schlessinger,D., Schlieper,G., Seelen,M.A.,
            Shuldiner,A.R., Sjogren,M., Smit,J.H., Snieder,H., Soranzo,N.,
            Spector,T.D., Stenvinkel,P., Sternberg,M.J., Swaminathan,R.,
            Tanaka,T., Ubink-Veltmaat,L.J., Uda,M., Vollenweider,P.,
            Wallace,C., Waterworth,D., Zerres,K., Waeber,G., Wareham,N.J.,
            Maxwell,P.H., McCarthy,M.I., Jarvelin,M.R., Mooser,V.,
            Abecasis,G.R., Lightstone,L., Scott,J., Navis,G., Elliott,P. and
            Kooner,J.S.
  TITLE     Genetic loci influencing kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 373-375 (2010)
   PUBMED   20383145
REFERENCE   9  (bases 1 to 781)
  AUTHORS   Miyoshi,A., Kito,K., Aramoto,T., Abe,Y., Kobayashi,N. and Ueda,N.
  TITLE     Identification of CGI-121, a novel PRPK (p53-related protein
            kinase)-binding protein
  JOURNAL   Biochem Biophys Res Commun 303 (2), 399-405 (2003)
   PUBMED   12659830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092653.3.
            
            On Aug 13, 2020 this sequence version replaced NM_001330386.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1612357.1,
                                           SRR14038194.461637.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA2142853 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC092653.3         147435-147478       c
            45-207              AC092653.3         144562-144724       c
            208-324             AC092653.3         142717-142833       c
            325-447             AC092653.3         142296-142418       c
            448-624             AC092653.3         140693-140869       c
            625-781             AC092653.3         140006-140162       c
FEATURES             Location/Qualifiers
     source          1..781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..781
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
                     /note="TP53RK binding protein"
                     /db_xref="GeneID:51002"
                     /db_xref="HGNC:HGNC:24259"
                     /db_xref="MIM:608680"
     exon            1..44
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
                     /inference="alignment:Splign:2.1.0"
     exon            45..207
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..711
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
                     /note="isoform a is encoded by transcript variant 1; PRPK
                     (p53-related protein kinase)-binding protein; EKC/KEOPS
                     complex subunit TPRKB"
                     /codon_start=1
                     /product="EKC/KEOPS complex subunit TPRKB isoform a"
                     /protein_id="NP_001317315.1"
                     /db_xref="CCDS:CCDS82471.1"
                     /db_xref="GeneID:51002"
                     /db_xref="HGNC:HGNC:24259"
                     /db_xref="MIM:608680"
                     /translation="MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLIN
                     PTVFHSCCPGWSAMARSWLTATSASRVQAIVLPQPPELLGLQIVDPFQILVAANKAVH
                     LYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEY
                     LISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL"
     exon            208..324
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
                     /inference="alignment:Splign:2.1.0"
     exon            325..447
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
                     /inference="alignment:Splign:2.1.0"
     exon            448..624
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
                     /inference="alignment:Splign:2.1.0"
     exon            625..781
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      743..748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
                     /note="hexamer: ATTAAA"
     regulatory      747..752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
                     /note="hexamer: AAGAAA"
     polyA_site      764
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
                     /note="major polyA site"
     polyA_site      781
                     /gene="TPRKB"
                     /gene_synonym="CGI-121; CGI121; GAMOS5"
ORIGIN      
        1 gtttcggagc gggagctctt ccgagacgca ctgggggccg gatgtagaat cctgcttatc
       61 tgtgaaatgc agttaacaca tcagctggac ctatttcccg aatgcagggt aacccttctg
      121 ttatttaaag atgtaaaaaa tgcgggagac ttgagaagaa aggccatgga aggcaccatc
      181 gatggatcac tgataaatcc tacagtgttt cactcttgtt gcccaggctg gagtgcaatg
      241 gcgcgatctt ggctcacggc aacctctgcc tcccgggttc aagcaattgt cctgcctcag
      301 cctcctgagt tgctgggatt acagattgtt gatccatttc agatacttgt ggcagcaaac
      361 aaagcagttc acctctacaa actgggaaaa atgaagacaa gaactctatc tactgaaatt
      421 attttcaacc tttccccaaa taacaatatt tcagaggctt tgaaaaaatt tggtatctca
      481 gcaaatgaca cttcaattct aattgtttac attgaagagg gagaaaaaca aataaatcaa
      541 gaatacctaa tatctcaagt agaaggtcat caggtttctc tgaaaaatct tcctgaaata
      601 atgaatatta cagaagtcaa aaagatatat aaactctctt cacaagaaga aagtattggg
      661 acattattgg atgctatcat ttgtagaatg tcaacaaaag atgttttatg aaatgtcaga
      721 aatattaaca aaaattctca gcattaaaga aaacattgat tttcctttcc tgactataaa
      781 a
//
