LOCUS       NM_182752               2401 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tumor protein p63 regulated 1 like (TPRG1L), mRNA.
ACCESSION   NM_182752
VERSION     NM_182752.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2401)
  AUTHORS   Korber,C., Horstmann,H., Venkataramani,V., Herrmannsdorfer,F.,
            Kremer,T., Kaiser,M., Schwenger,D.B., Ahmed,S., Dean,C.,
            Dresbach,T. and Kuner,T.
  TITLE     Modulation of Presynaptic Release Probability by the
            Vertebrate-Specific Protein Mover
  JOURNAL   Neuron 87 (3), 521-533 (2015)
   PUBMED   26212709
REFERENCE   2  (bases 1 to 2401)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 2401)
  AUTHORS   Antonini,D., Dentice,M., Mahtani,P., De Rosa,L., Della Gatta,G.,
            Mandinova,A., Salvatore,D., Stupka,E. and Missero,C.
  TITLE     Tprg, a gene predominantly expressed in skin, is a direct target of
            the transcription factor p63
  JOURNAL   J Invest Dermatol 128 (7), 1676-1685 (2008)
   PUBMED   18256694
REFERENCE   4  (bases 1 to 2401)
  AUTHORS   Kremer,T., Kempf,C., Wittenmayer,N., Nawrotzki,R., Kuner,T.,
            Kirsch,J. and Dresbach,T.
  TITLE     Mover is a novel vertebrate-specific presynaptic protein with
            differential distribution at subsets of CNS synapses
  JOURNAL   FEBS Lett 581 (24), 4727-4733 (2007)
   PUBMED   17869247
  REMARK    GeneRIF: mover may act in concert with generally expressed
            scaffolding proteins in distinct sets of presynaptic terminals
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513320.30 and BC019034.2.
            
            On Nov 23, 2018 this sequence version replaced NM_182752.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096427.1, SRR1660809.22235.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378344.7/ ENSP00000367595.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AL513320.30        122867-123125
            260-351             AL513320.30        123276-123367
            352-528             AL513320.30        123565-123741
            529-682             AL513320.30        125352-125505
            683-2369            AL513320.30        126261-127947
            2370-2401           BC019034.2         2135-2166
FEATURES             Location/Qualifiers
     source          1..2401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..2401
                     /gene="TPRG1L"
                     /gene_synonym="FAM79A; h-mover; mover; SVAP30; TPRGL"
                     /note="tumor protein p63 regulated 1 like"
                     /db_xref="GeneID:127262"
                     /db_xref="HGNC:HGNC:27007"
                     /db_xref="MIM:611460"
     exon            1..259
                     /gene="TPRG1L"
                     /gene_synonym="FAM79A; h-mover; mover; SVAP30; TPRGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..877
                     /gene="TPRG1L"
                     /gene_synonym="FAM79A; h-mover; mover; SVAP30; TPRGL"
                     /note="family with sequence similarity 79, member A;
                     RP11-46F15.3; mossy fiber terminal-associated
                     vertebrate-specific presynaptic protein"
                     /codon_start=1
                     /product="tumor protein p63-regulated gene 1-like protein"
                     /protein_id="NP_877429.2"
                     /db_xref="CCDS:CCDS47.1"
                     /db_xref="GeneID:127262"
                     /db_xref="HGNC:HGNC:27007"
                     /db_xref="MIM:611460"
                     /translation="MLQLRDSVDSAGTSPTAVLAAGEEVGAGGGPGGGRPGAGTPLRQ
                     TLWPLSIHDPTRRARVKEYFVFRPGSIEQAVEEIRVVVRPVEDGEIQGVWLLTEVDHW
                     NNEKERLVLVTEQSLLICKYDFISLQCQQVVRIALNAVDTISYGEFQFPPKSLNKREG
                     FGIRIQWDKQSRPSFINRWNPWSTNVPYATFTEHPMAGADEKTASLCQLESFKALLIQ
                     AVKKAQKESPLPGQANGVLILERPLLIETYVGLMSFINNEAKLGYSMTRGKIGF"
     exon            260..351
                     /gene="TPRG1L"
                     /gene_synonym="FAM79A; h-mover; mover; SVAP30; TPRGL"
                     /inference="alignment:Splign:2.1.0"
     exon            352..528
                     /gene="TPRG1L"
                     /gene_synonym="FAM79A; h-mover; mover; SVAP30; TPRGL"
                     /inference="alignment:Splign:2.1.0"
     exon            529..682
                     /gene="TPRG1L"
                     /gene_synonym="FAM79A; h-mover; mover; SVAP30; TPRGL"
                     /inference="alignment:Splign:2.1.0"
     exon            683..2401
                     /gene="TPRG1L"
                     /gene_synonym="FAM79A; h-mover; mover; SVAP30; TPRGL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2379..2384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPRG1L"
                     /gene_synonym="FAM79A; h-mover; mover; SVAP30; TPRGL"
                     /note="hexamer: ATTAAA"
     polyA_site      2401
                     /gene="TPRG1L"
                     /gene_synonym="FAM79A; h-mover; mover; SVAP30; TPRGL"
                     /note="major polyA site"
ORIGIN      
        1 ggctgcggcg acggcggtcg cgtcggcgtc agggtcgggg tcggtaaggg gtgcggcaat
       61 gctgcaactg cgggactcgg tggactcggc cggtacgagc cccacggcgg tgctggcggc
      121 cggcgaggag gtgggggcag gcggcggccc gggcgggggg cggccggggg cggggacgcc
      181 gctgcgccag acactctggc ctctcagcat ccacgacccc acgcgccgcg cccgcgtcaa
      241 ggagtacttc gtgttccggc ccggcagcat cgagcaggca gtggaggaga tccgcgtggt
      301 ggtgcggccc gtggaggacg gcgagatcca gggagtgtgg ctgcttaccg aggtggatca
      361 ctggaacaat gagaaggagc ggctggtgct ggtcacggag cagtccctgc ttatctgtaa
      421 atacgacttc atcagtctcc agtgccagca ggtggtgcgg atagcgctca acgcagtaga
      481 caccatttcc tacggagaat tccagtttcc ccctaaatcg ctcaacaagc gagaaggttt
      541 tgggattcga attcagtggg acaagcaaag tcgtccttcc ttcataaaca gatggaatcc
      601 ctggtctacc aacgtgccct atgccacttt cacagaacac ccgatggctg gcgcagatga
      661 gaagacagca tctctgtgtc agttggaaag cttcaaggct ctgttaatcc aagctgtcaa
      721 aaaagcccaa aaagaaagcc ctttgccagg acaggcgaat ggcgtgctga tcctggagcg
      781 ccccctgctc atcgagacct acgtgggact catgtccttc attaacaacg aggcgaaact
      841 gggctactcc atgaccaggg gcaaaatagg cttttagccg ctgcgttctg ggagctcctc
      901 ccccttctgg gagctcctcc ccctccccag aaggccaagg gatgtggggg ctgggggact
      961 gggaggcctg gcagtcttca tgctgccctg ctgctgctgg aaggatgggg atctttcacc
     1021 tttagggatc tcagcacaat tagaatcgta aagtgaattc tatctattta attggatatt
     1081 ggactctgct catataagct acagacaaaa gccaaaagac tctcgctgtc cctgtgctgc
     1141 tggtatttca ttctctgtaa cttcagttct ggtgttttcc ttgagtatct acttggcttc
     1201 tcgtggtttt tcccacccca gctgccccag cacgcgggac ccatagcaca ccccttagcg
     1261 cttgcctagg ttgctgaaaa cagggaggca cctggtatct cgagtgcctg cagttgcaag
     1321 tatgtttaca cctggtgtcc aattttgtat tttaaaatgt aatccatttt tacttcagct
     1381 catccaaaag cagccagcag accggttgac tgagaccggt ctgtggctgt gggccccttg
     1441 gtgacccgct gctcttttgg aaatgggtga cctgaagtga cactttttcc acaattaacc
     1501 caagttgtgt taatacttca ggtctgtttc ccagacccag aaagctttac agaaaatcat
     1561 tgtaagacaa tttattaatt tgagaaagtc accttgacag ttctttgcac acaagtttta
     1621 cacctctctg gattcgaagt ttgtattgta ttcatagtta aagggaatcg ggtactttgc
     1681 ttgttgaata atgcacttta aaacaaggaa ccgtatcagg ccagcatggt ggctcatgcc
     1741 tgtaatccca gcattttggg aggctcaggc agacaaatcg ctctagctca gaagttgcag
     1801 agcagcctgg gcaacatggt gaaacccgtc tctaccaaac agacaaaaag cagccaggcg
     1861 tggtggcaca tctgtggtcc cagctacttg agaggctgag ccaggaggat cgcttgagcc
     1921 caggaggcgg aggttgcagt gagctgagat ggcaccactt attgcactcc agcccgggcg
     1981 acagagcgag actccatcta ccagatcctt atgacgcagc tgatgcctgc cttggttcct
     2041 accactctgg tgtagacaga ggactttgtc caagtctcac actaaacatg cccgggcttc
     2101 gatgtgcctg gaggatttcc ccacagggac ccacgcacct ccctgtatct gcgcagcttg
     2161 ctcgtgtggc tggaagcgct gtcgataagc ttcacgcact ggcttgccag ttcttcagct
     2221 ctaggacttg tagctttaag caaacggtgt ggcatgggtt gagtgtggcc acctgcagga
     2281 tgtgcagggc tgcctcagaa gctggctggg gactctagcc tctgtgttca taaagacatt
     2341 aagaagtgga tggatgttgt tccttttttg aagttgtcat taaagtaggt gcaacaacca
     2401 a
//
