LOCUS       NM_198485               5482 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tumor protein p63 regulated 1 (TPRG1), mRNA.
ACCESSION   NM_198485 XM_209586
VERSION     NM_198485.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5482)
  AUTHORS   Hong,T., Piao,S., Sun,L., Tao,Y. and Ke,M.
  TITLE     Tumor protein P63 Regulated 1 contributes to inflammation and cell
            proliferation of cystitis glandularis through regulating the
            NF-small ka, CyrillicB/cyclooxygenase-2/prostaglandin E2 axis
  JOURNAL   Bosn J Basic Med Sci 22 (1), 100-109 (2022)
   PUBMED   34998360
  REMARK    GeneRIF: Tumor protein P63 Regulated 1 contributes to inflammation
            and cell proliferation of cystitis glandularis through regulating
            the NF-small ka, CyrillicB/cyclooxygenase-2/prostaglandin E2 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5482)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5482)
  AUTHORS   Cheng,C.Y., Schache,M., Ikram,M.K., Young,T.L., Guggenheim,J.A.,
            Vitart,V., MacGregor,S., Verhoeven,V.J., Barathi,V.A., Liao,J.,
            Hysi,P.G., Bailey-Wilson,J.E., St Pourcain,B., Kemp,J.P.,
            McMahon,G., Timpson,N.J., Evans,D.M., Montgomery,G.W., Mishra,A.,
            Wang,Y.X., Wang,J.J., Rochtchina,E., Polasek,O., Wright,A.F.,
            Amin,N., van Leeuwen,E.M., Wilson,J.F., Pennell,C.E., van
            Duijn,C.M., de Jong,P.T., Vingerling,J.R., Zhou,X., Chen,P., Li,R.,
            Tay,W.T., Zheng,Y., Chew,M., Burdon,K.P., Craig,J.E., Iyengar,S.K.,
            Igo,R.P. Jr., Lass,J.H. Jr., Chew,E.Y., Haller,T., Mihailov,E.,
            Metspalu,A., Wedenoja,J., Simpson,C.L., Wojciechowski,R., Hohn,R.,
            Mirshahi,A., Zeller,T., Pfeiffer,N., Lackner,K.J., Bettecken,T.,
            Meitinger,T., Oexle,K., Pirastu,M., Portas,L., Nag,A.,
            Williams,K.M., Yonova-Doing,E., Klein,R., Klein,B.E.,
            Hosseini,S.M., Paterson,A.D., Makela,K.M., Lehtimaki,T.,
            Kahonen,M., Raitakari,O., Yoshimura,N., Matsuda,F., Chen,L.J.,
            Pang,C.P., Yip,S.P., Yap,M.K., Meguro,A., Mizuki,N., Inoko,H.,
            Foster,P.J., Zhao,J.H., Vithana,E., Tai,E.S., Fan,Q., Xu,L.,
            Campbell,H., Fleck,B., Rudan,I., Aung,T., Hofman,A.,
            Uitterlinden,A.G., Bencic,G., Khor,C.C., Forward,H., Parssinen,O.,
            Mitchell,P., Rivadeneira,F., Hewitt,A.W., Williams,C., Oostra,B.A.,
            Teo,Y.Y., Hammond,C.J., Stambolian,D., Mackey,D.A., Klaver,C.C.,
            Wong,T.Y., Saw,S.M. and Baird,P.N.
  CONSRTM   Consortium for Refractive Error and Myopia; Fuchs' Genetics
            Multi-Center Study Group; Wellcome Trust Case Control Consortium 2;
            Diabetes Control and Complications Trial/Epidemiology of Diabetes
            Interventions, and Complications Research Group
  TITLE     Nine loci for ocular axial length identified through genome-wide
            association studies, including shared loci with refractive error
  JOURNAL   Am J Hum Genet 93 (2), 264-277 (2013)
   PUBMED   24144296
REFERENCE   4  (bases 1 to 5482)
  AUTHORS   Evangelou,E., Maraganore,D.M., Annesi,G., Brighina,L., Brice,A.,
            Elbaz,A., Ferrarese,C., Hadjigeorgiou,G.M., Krueger,R.,
            Lambert,J.C., Lesage,S., Markopoulou,K., Mellick,G.D., Meeus,B.,
            Pedersen,N.L., Quattrone,A., Van Broeckhoven,C., Sharma,M.,
            Silburn,P.A., Tan,E.K., Wirdefeldt,K. and Ioannidis,J.P.
  CONSRTM   Genetic Epidemiology of Parkinson's Disease (GEOPD) Consortium
  TITLE     Non-replication of association for six polymorphisms from
            meta-analysis of genome-wide association studies of Parkinson's
            disease: large-scale collaborative study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (1), 220-228 (2010)
   PUBMED   19475631
  REMARK    GeneRIF: Meta-analysis of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104669.6, AK125682.1, BC101550.1, AC112909.4 and CR737485.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198485.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125682.1, ERR279824.6917.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345063.8/ ENSP00000341031.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC104669.6         78470-78472         c
            4-76                AK125682.1         2-74
            77-77               AC104669.6         78396-78396         c
            78-102              AK125682.1         76-100
            103-1082            BC101550.1         1-980
            1083-3493           AC112909.4         72469-74879
            3494-3660           CR737485.1         9-175               c
            3661-5482           AC112909.4         75047-76868
FEATURES             Location/Qualifiers
     source          1..5482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28"
     gene            1..5482
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /note="tumor protein p63 regulated 1"
                     /db_xref="GeneID:285386"
                     /db_xref="HGNC:HGNC:24759"
     exon            1..161
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /inference="alignment:Splign:2.1.0"
     exon            162..380
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..998
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /note="family with sequence similarity 79, member B"
                     /codon_start=1
                     /product="tumor protein p63-regulated gene 1 protein"
                     /protein_id="NP_940887.1"
                     /db_xref="CCDS:CCDS3292.1"
                     /db_xref="GeneID:285386"
                     /db_xref="HGNC:HGNC:24759"
                     /translation="MSTIGSFEGFQAVSLKQEGDDQPSETDHLSMEEEDPMPRQISRQ
                     SSVTESTLYPNPYHQPYISRKYFATRPGAIETAMEDLKGHVAETSGETIQGFWLLTKI
                     DHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDK
                     RQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSK
                     LVPAIQNAHKNSTGSGRGKKLMVLTEPILIETYTGLMSFIGNRNKLGYSLARGSIGF"
     exon            381..472
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /inference="alignment:Splign:2.1.0"
     exon            473..649
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /inference="alignment:Splign:2.1.0"
     exon            650..803
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /inference="alignment:Splign:2.1.0"
     exon            804..5482
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1218..1223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /note="hexamer: AATAAA"
     polyA_site      1242
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /note="major polyA site"
     regulatory      3639..3644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /note="hexamer: ATTAAA"
     polyA_site      3660
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
     regulatory      5453..5458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
                     /note="hexamer: AATAAA"
     polyA_site      5482
                     /gene="TPRG1"
                     /gene_synonym="FAM79B"
ORIGIN      
        1 ctacttggtg aagtgagatt cagactgagt ggggtcacag cacagggcac tgtcttgcct
       61 ggctttatct gagccaatca cacctctcct ggccactatc tgtggtctag ccccctttgt
      121 gcagaaagag aaagaagagc cttgaggacc agcctagtca ggctgaagaa atgtcaacaa
      181 ttgggagttt tgaaggattc caggctgtgt ctctgaagca agagggagat gaccaaccct
      241 ctgagactga ccacctatcg atggaggaag aggacccgat gccaagacag atttcaaggc
      301 agtcaagtgt gaccgaatca actctttacc ccaatcctta tcatcagcct tatatctcac
      361 ggaagtactt tgctacacgg ccgggggcca ttgagactgc catggaagac ttgaaaggtc
      421 acgtagctga gacttctgga gagaccattc aaggcttctg gctcttgaca aagatagacc
      481 actggaacaa tgagaaggag agaattctac tggtcacaga caagactctc ttgatctgca
      541 aatacgactt catcatgctg agttgtgtgc agctgcagcg gattcctctg agcgctgtct
      601 atcgcatctg cctgggcaag ttcaccttcc ctgggatgtc cctggacaag agacaaggag
      661 aaggccttag gatctactgg gggagtccgg aggagcagtc tcttctgtcc cgctggaacc
      721 catggtccac tgaagttcct tatgctactt tcactgagca tcctatgaaa tacaccagtg
      781 agaaattcct tgaaatttgc aagttgtctg ggttcatgtc taagcttgtt ccagctatcc
      841 agaatgccca caagaattca actggatctg gaagaggaaa gaaactgatg gtgttaactg
      901 aacccatttt gattgagacc tacacagggc tgatgtcatt cattggaaac cgcaacaaac
      961 ttggctattc ccttgcccgt gggagtattg gtttttgaga gtctttttgg taccataagc
     1021 atatcatcca cagatatgtc actttgaaaa ttccagtttg acccacgcta tttttggact
     1081 gaaacaatta attattttta aatgacgctt tatgatttag aaatttagta tttccgaaaa
     1141 tttaaaagct tgattggact gatagataca cactttagac ctcatacaag aataatcaaa
     1201 ttttcttaaa actagaaaat aaatgctgct gagcctatca aatactgtta tcaaatgagt
     1261 gcctgatcat caactcagga aagaagactc taagtcctgt tgcttcagct ctctaaatgt
     1321 aggctttttt tttttttttt ttttaggtct tggtcttcag ccctcttatc ctgatttatt
     1381 ctctcattgg ggtctcactg tctctagtat tttagctacc acttgataag gatgacttcc
     1441 aaatttatat tcccattccc aatatttatt ccaagactca gttttgcatt tctgactgct
     1501 aatcatctat atatcagtgt cccagtggcc tcttaattga gcattatcaa aatcctgtgg
     1561 tatttatatg gtcccagtta tccatccctg aagtctgtca attttgattt ctctaaattc
     1621 cttgccatga catcctatat atgatcacat ctctatacgg cttagcattg tattccgatg
     1681 cccagatgtc aaacttgaag ctcattctct tatcaaaatt gttcatgtat tcctcctttc
     1741 cattcttata gctgtattat tagatcaggt ttttaattct gctcaaccaa ttattaccac
     1801 agcctgttaa atggaatccc tactccaagg ctgactgttt caatctatcc tacacttggt
     1861 ttctagctca tttacttata ccatcttttg ttcaaatata tattttttaa taacagacct
     1921 ttttcttcta aagaaatctt ttgtagaagc agcatatacg aagcagataa aagtaggttc
     1981 aatgcggttg gagtgaagat gagaatgcca caggcatctt tctttctagg cctcagaggt
     2041 gctgcatatg gaatgtccat ggatcgcaga gggttttgaa gaccatgttt tcaaaaacac
     2101 tgtcttaaca ctctattgtc attgctcttt tccctcttat ttcctctttg tctcttcccg
     2161 acttagatct aattttcaac aacccaggaa attatctcat atgtttgcat ctctcaagtt
     2221 tcttttcttt tttctttcag agtcttattt tatctaaatt tatgtagaaa aaaaagcttt
     2281 gaatgttgac tacatagaca ttactacaat aagctttttg cctttcccaa gactcaaaat
     2341 tgacacatct ttgttgatgt ttaagttgaa attccagcca actttttttt gacttttatg
     2401 tgaagtttaa agtcttttct ttgaaaagct tgcttcctca atttcaaaga tttgtcctct
     2461 gatatattta taaacatcaa tttaatgcag acattcaaac cctaaacctt gaataactct
     2521 tattttattt tgtctttgtt tacttccatt aatttttttt tctttccctc tcttccgcct
     2581 ttacagcacc cactttttct tccccccatg atggcaaata ttgttatagt ccccaaggca
     2641 gggaacttct attcagactg taaaaggaaa tgttgaaatc catagctgtc ctgtcaacag
     2701 tagtggaatg aaaagtcgtt ggattgtttt ggcactggtt ctgaagcagg cataattggc
     2761 aaattattat aatactgctg cccgaaaatc cccatttgcc tcaagatagt ggcatttatt
     2821 ggcagaagcc tctgaaatgt ccagcacatt cttttgagtt accatttaag gatcagcctg
     2881 acaatcgact tctctctgca catttgcccc ctttgtaacc taagccagac tgttcccaaa
     2941 tgaccttcta aaggacacag tgcaccatca tcaatggaaa cagttcagaa aggatgacag
     3001 gagggagatg tttcttagtt ctgagagcca gtctgtaaca atgggataag catttaatgg
     3061 aatcaaagct gttttgcata aagagtgaac tcagagacga caagagggtc tttatgaatt
     3121 cccttcacat tttgtaaaaa ctgtcatata taggctatcc ccttaattga taaatgggat
     3181 ctagaaagcg gtattatgac cagagggtga gaagatttag gaatttggat agcagttcaa
     3241 gataagaaag aacttcttat agttataaat tttcaatgat ggaatgggtt gcttctttaa
     3301 acagtgagcc caccatcact tggtatgttc aaggaaagac tagataaagt cgatattgtg
     3361 agaggaattg ctgtatgata ccgtttggag aaatgattga cataatcttt taaggccggt
     3421 gaccctatca ttttccaaat aattgttgct agtacttagt taattagacc catttttttc
     3481 ttaggaaaga gttggatcaa tcatgggaga ccctgaaaaa tttccttacc tttcctaagg
     3541 tttaatttcc tcttctgcga aatggagaca attatattac ttttgcttat ttcataaaga
     3601 tcttgtgagg attcaatgaa atgaggttaa attcttttat taaacagaaa gttttgagta
     3661 tttgcctaga gagtgatgtg acttttgcag cagaaggtgg gaaaacatcc aagggaacta
     3721 catttcctcc agaaattgtt tcttcattac catcgaccta ctgattatgg ttttctcatt
     3781 ttacacttgg tgttcttact tgggatcttt gtccttaagc tcaacaggga gccacaaccc
     3841 aggggaccta tgtgtacact tggagttttt atcagactat catttgaact taccactaca
     3901 gtttagcaaa tggcatgatg agtttgattg ataataggag tagacgcaag atacattaag
     3961 tagagtacaa agcatttcat aaccaaaatg tcatggttgg aggtcttcat tattcggtct
     4021 ttatctcatt caggaatttc cacttgaaaa atctctgata agctttattt cagaaactgc
     4081 ttgaacagct ccactgacaa atgcctcact atcttctgat acatcgtagg cagttctgag
     4141 ggtgagaaag ttcaaagcag atagatgttt taacacaaca ggaggacttt taaacaatca
     4201 ccaggactca ctcctcggtg gtcaattggg cctgtttgga ggcctgacct ttggtcatct
     4261 taaggtcatc taaggcagaa aagagaagct cacttataag ttggcacttc tgaatcattt
     4321 gccttgaggt ccatttttta ttcagccttt gtttaaacct tcttaggaag ccagtttgta
     4381 gagttctggg gataagaagg cagaaaaacc atgtcaattc agtgctttta tttcacagaa
     4441 aatgaagcaa aggcctagaa actagaaaga catttctcaa aaagaagatg gtgaactttt
     4501 ggaaatactg agattagact acattttcca atttctatcc ctagcccact gctctttcca
     4561 atataatatc tgtattccat gggaaagaca tgccatctga attgatgtat cgtagttgtt
     4621 gagataattt tgaaatgaga aaacaatagg gcacagtcgt ttgggaagaa tttccagaaa
     4681 ttgccatcat tttcttaaag gctaaggaca cttatagagc tctccgattt cctatctgat
     4741 aaaaaaagcc caaacaaagc tgcggaagct ggcagagcca gcagatattt tgtaaggcag
     4801 cttcacctct gctggcattt tgtggggcag gagaggggga gggcaaaggt attaaattta
     4861 ggcttaaaag ctcctcagaa attctttaca cacaagagac caagttggag aaaagaagat
     4921 gacttgtgcc aaggggaaga aagagagaga ctaatgcctg tggttttcaa aggttaacaa
     4981 caacataaaa aagccaaggt atttgcacag ggatgaatgc tcattggctc ttggccaaca
     5041 attatacaag ggcttgtgcc cacatcctgt agctgtggtt tagggacgct gctcatgagt
     5101 gacttcttat gcttagtggc aggaaacttt agtcactgat gtgtaaactc acctttggtc
     5161 tgcacctccc acaacgtgct ccgaaagcag ttaggggact aggcctcttg atttccttgt
     5221 agataccagt tccccagaag ctaaggaaaa actctgaggc cttggagtta ctgagagtgg
     5281 accaatactt gtcttattct acctgatttt ggcaactgct tagggttctt ctgtatccac
     5341 aaaaaggaat tatgatatcc tctgctaaac cctctcttta gcctcaaagc ccaagaccaa
     5401 aaaaaatgag ccatatttca ttgcaggcct gctgccaatg tgaaatataa ggaataaagt
     5461 catgagactg cttctcaacc ta
//
