LOCUS       NM_003292               9636 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens translocated promoter region, nuclear basket protein
            (TPR), mRNA.
ACCESSION   NM_003292
VERSION     NM_003292.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9636)
  AUTHORS   Lv,J., Li,W., Wang,X., Guo,L., Wang,D., Zhang,Y., Yu,J., Chen,T.,
            Niu,B., Wang,X. and Liu,Z.
  TITLE     Identification of MKI67, TPR, and TCHH Mutations as Prognostic
            Biomarkers for Patients With Defective Mismatch Repair Colon Cancer
            Stage II/III
  JOURNAL   Dis Colon Rectum 66 (11), 1481-1491 (2023)
   PUBMED   37643197
  REMARK    GeneRIF: Identification of MKI67, TPR , and TCHH Mutations as
            Prognostic Biomarkers for Patients With Defective Mismatch Repair
            Colon Cancer Stage II/III.
REFERENCE   2  (bases 1 to 9636)
  AUTHORS   Chen,M., Long,Q., Borrie,M.S., Sun,H., Zhang,C., Yang,H., Shi,D.,
            Gartenberg,M.R. and Deng,W.
  TITLE     Nucleoporin TPR promotes tRNA nuclear export and protein synthesis
            in lung cancer cells
  JOURNAL   PLoS Genet 17 (11), e1009899 (2021)
   PUBMED   34793452
  REMARK    GeneRIF: Nucleoporin TPR promotes tRNA nuclear export and protein
            synthesis in lung cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9636)
  AUTHORS   Gunkel,P., Iino,H., Krull,S. and Cordes,V.C.
  TITLE     ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket,
            Resident in a State of Reciprocal Dependence with TPR
  JOURNAL   Cells 10 (8), 1937 (2021)
   PUBMED   34440706
  REMARK    GeneRIF: ZC3HC1 Is a Novel Inherent Component of the Nuclear
            Basket, Resident in a State of Reciprocal Dependence with TPR.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9636)
  AUTHORS   Kosar,M., Giannattasio,M., Piccini,D., Maya-Mendoza,A.,
            Garcia-Benitez,F., Bartkova,J., Barroso,S.I., Gaillard,H.,
            Martini,E., Restuccia,U., Ramirez-Otero,M.A., Garre,M., Verga,E.,
            Andujar-Sanchez,M., Maynard,S., Hodny,Z., Costanzo,V., Kumar,A.,
            Bachi,A., Aguilera,A., Bartek,J. and Foiani,M.
  TITLE     The human nucleoporin Tpr protects cells from RNA-mediated
            replication stress
  JOURNAL   Nat Commun 12 (1), 3937 (2021)
   PUBMED   34168151
  REMARK    GeneRIF: The human nucleoporin Tpr protects cells from RNA-mediated
            replication stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9636)
  AUTHORS   Moon,S.W., Mo,H.Y., Choi,E.J., Yoo,N.J. and Lee,S.H.
  TITLE     Cancer-related SRCAP and TPR mutations in colon cancers
  JOURNAL   Pathol Res Pract 217, 153292 (2021)
   PUBMED   33307343
  REMARK    GeneRIF: Cancer-related SRCAP and TPR mutations in colon cancers.
REFERENCE   6  (bases 1 to 9636)
  AUTHORS   Mitchell,P.J. and Cooper,C.S.
  TITLE     The human tpr gene encodes a protein of 2094 amino acids that has
            extensive coiled-coil regions and an acidic C-terminal domain
  JOURNAL   Oncogene 7 (11), 2329-2333 (1992)
   PUBMED   1437155
REFERENCE   7  (bases 1 to 9636)
  AUTHORS   Mitchell,P.J. and Cooper,C.S.
  TITLE     Nucleotide sequence analysis of human tpr cDNA clones
  JOURNAL   Oncogene 7 (2), 383-388 (1992)
   PUBMED   1549355
REFERENCE   8  (bases 1 to 9636)
  AUTHORS   Greco,A., Pierotti,M.A., Bongarzone,I., Pagliardini,S., Lanzi,C.
            and Della Porta,G.
  TITLE     TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK
            genes in human papillary thyroid carcinomas
  JOURNAL   Oncogene 7 (2), 237-242 (1992)
   PUBMED   1532241
REFERENCE   9  (bases 1 to 9636)
  AUTHORS   Galland,F., Stefanova,M., Lafage,M. and Birnbaum,D.
  TITLE     Localization of the 5' end of the MCF2 oncogene to human chromosome
            15q15----q23
  JOURNAL   Cytogenet Cell Genet 60 (2), 114-116 (1992)
   PUBMED   1611909
REFERENCE   10 (bases 1 to 9636)
  AUTHORS   Gonzatti-Haces,M., Seth,A., Park,M., Copeland,T., Oroszlan,S. and
            Vande Woude,G.F.
  TITLE     Characterization of the TPR-MET oncogene p65 and the MET
            protooncogene p140 protein-tyrosine kinases
  JOURNAL   Proc Natl Acad Sci U S A 85 (1), 21-25 (1988)
   PUBMED   3277171
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X66397.1, U69668.1, AL596220.9,
            AL133553.9 and AA688415.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003292.2.
            
            Summary: This gene encodes a large coiled-coil protein that forms
            intranuclear filaments attached to the inner surface of nuclear
            pore complexes (NPCs). The protein directly interacts with several
            components of the NPC. It is required for the nuclear export of
            mRNAs and some proteins. Oncogenic fusions of the 5' end of this
            gene with several different kinase genes occur in some neoplasias.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69668.1, SRR14038197.730469.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367478.9/ ENSP00000356448.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               X66397.1           73-209
            138-2559            U69668.1           1-2422
            2560-3938           X66397.1           2632-4010
            3939-5819           U69668.1           3802-5682
            5820-5820           AL596220.9         4304-4304           c
            5821-7462           U69668.1           5684-7325
            7463-9237           AL133553.9         16076-17850
            9238-9636           AA688415.1         20-418              c
FEATURES             Location/Qualifiers
     source          1..9636
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.1"
     gene            1..9636
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /note="translocated promoter region, nuclear basket
                     protein"
                     /db_xref="GeneID:7175"
                     /db_xref="HGNC:HGNC:12017"
                     /db_xref="MIM:189940"
     exon            1..376
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..7317
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /note="nuclear pore complex-associated protein TPR; tumor
                     potentiating region; translocated promoter region (to
                     activated MET oncogene); megator; NPC-associated
                     intranuclear protein; translocated promoter region
                     protein"
                     /codon_start=1
                     /product="nucleoprotein TPR"
                     /protein_id="NP_003283.2"
                     /db_xref="CCDS:CCDS41446.1"
                     /db_xref="GeneID:7175"
                     /db_xref="HGNC:HGNC:12017"
                     /db_xref="MIM:189940"
                     /translation="MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHE
                     KFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIA
                     QDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKG
                     ELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNE
                     ILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH
                     NELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQS
                     KDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG
                     MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKA
                     VASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELE
                     EARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRER
                     EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGV
                     AIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENY
                     KKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREIT
                     SLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRL
                     SQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE
                     NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQ
                     VASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSL
                     EESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESME
                     QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELML
                     HAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV
                     CRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR
                     REKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEEL
                     MKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM
                     LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRL
                     KAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKK
                     IGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLE
                     SQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEK
                     TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI
                     SRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTAN
                     IKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQ
                     EAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHP
                     QIEPANQELSSNIVEVVQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEA
                     SDQVSDDTVEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQ
                     GDYTPMEDSEETSQSLQIDLGPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDEN
                     DGEHEDYEEDEEDDDDDEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGT
                     ETEESMGGGEGNHRAADSQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRAPQSP
                     RRPPHPLPPRLTIHAPPQELGPPVQRIQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDR
                     TVPSTPTLVVPHRTDGFAEAIHSPQVAGVPRFRFGPPEDMPQTSSSHSDLGQLASQGG
                     LGMYETPLFLAHEEESGGRSVPTTPLQVAAPVTVFTESTTSDASEHASQSVPMVTTST
                     GTLSTTNETATGDDGDEVFVEAESEGISSEAGLEIDSQQEEEPVQASDESDLPSTSQD
                     PPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQFNRQRGVSHAMGGRGGINRGNIN"
     exon            377..481
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            482..555
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            556..652
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            653..756
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            757..921
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1014
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1095
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1183
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1324
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1416
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1614
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1722
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1949
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2113
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2247
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2396
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2559
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2694
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2835
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..3001
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3168
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3321
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3438
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3642
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3827
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3975
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            3976..4113
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            4114..4245
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            4246..4376
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            4377..4587
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            4588..4731
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            4732..4930
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            4931..5136
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            5137..5198
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            5199..5407
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            5408..5680
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            5681..5829
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            5830..5913
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            5914..6114
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            6115..6246
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            6247..6337
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            6338..6522
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            6523..6591
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            6592..6686
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            6687..6793
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            6794..6889
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            6890..7046
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            7047..7165
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            7166..7261
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     exon            7262..9636
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7438..7443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /note="hexamer: AATAAA"
     polyA_site      7462
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /note="major polyA site"
     regulatory      8902..8907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /note="hexamer: AATAAA"
     polyA_site      8929
                     /gene="TPR"
                     /gene_synonym="MRT79"
     regulatory      9613..9618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPR"
                     /gene_synonym="MRT79"
                     /note="hexamer: AGTAAA"
     polyA_site      9636
                     /gene="TPR"
                     /gene_synonym="MRT79"
ORIGIN      
        1 cttcggtcgc gggcggtgag gtgctgttgc tgaaacgctg ccgctgaggg tggactcgat
       61 ttcccagggt cccgccgcgg gagtctccgg cgggcgggcg cgcgcgagcc accgagcgag
      121 gtgatagagg cggcggccca ggcgtctggg tcctgctggt cttcgccttt cttctccgct
      181 tctaccccgt cggccgctgc cactggggtc cctggcccca ccgacatggc ggcggtgttg
      241 cagcaagtcc tggagcgcac ggagctgaac aagctgccca agtctgtcca gaacaaactt
      301 gaaaagttcc ttgctgatca gcaatccgag atcgatggcc tgaaggggcg gcatgagaaa
      361 tttaaggtgg agagcgaaca acagtatttt gaaatagaaa agaggttgtc ccacagtcag
      421 gagagacttg tgaatgaaac ccgagagtgt caaagcttgc ggcttgagct agagaaactc
      481 aacaatcaac tgaaggcact aactgagaaa aacaaagaac ttgaaattgc tcaggatcgc
      541 aatattgcca ttcagagcca atttacaaga acaaaggaag aattagaagc tgagaaaaga
      601 gacttaatta gaaccaatga gagactatct caagaacttg aatacttaac agaggatgtt
      661 aaacgtctga atgaaaaact taaagaaagc aatacaacaa agggtgaact tcagttaaaa
      721 ttggatgaac ttcaagcttc tgatgtttct gttaagtatc gagaaaaacg cttggagcaa
      781 gaaaaggaat tgctacatag tcagaataca tggctgaata cagagttgaa aaccaaaact
      841 gatgaacttc tggctcttgg aagagaaaaa gggaatgaga ttctagagct taaatgtaat
      901 cttgaaaata aaaaagaaga ggtttctaga ctggaagaac aaatgaatgg cttaaaaaca
      961 tcaaatgaac atcttcaaaa gcatgtggag gatctgttga ccaaattaaa agaggccaag
     1021 gaacaacagg ccagtatgga agagaaattc cacaatgaat taaatgccca cataaaactt
     1081 tctaatttgt acaagagtgc cgctgatgac tcagaagcaa agagcaatga actaacccgg
     1141 gcagtagagg aactacacaa acttttgaaa gaagctggtg aagccaacaa agcaatacaa
     1201 gatcatcttc tagaggtgga gcaatccaaa gatcaaatgg aaaaagaaat gcttgagaaa
     1261 atagggagat tggagaagga attagagaat gcaaatgacc ttctttctgc cacaaaacgt
     1321 aaaggagcca tattgtctga agaagagctt gccgccatgt ctcctactgc agcagctgta
     1381 gctaagatag tgaaacctgg gatgaaacta actgagctct ataatgctta tgtggaaact
     1441 caggatcagt tgcttttgga gaaactagag aacaaaagaa ttaataagta cctagatgaa
     1501 atagtgaaag aagtggaagc caaagcacca attttgaaac gccagcgtga ggaatatgaa
     1561 cgtgcacaga aagctgtagc aagtttatct gttaagcttg aacaagctat gaaggagatt
     1621 cagcgattgc aggaggacac tgataaagcc aacaagcaat catctgtact tgagagagat
     1681 aatcgaagaa tggaaataca agtaaaagat ctttcacaac agattagagt gcttttgatg
     1741 gaacttgaag aagcaagggg taaccacgta attcgtgatg aggaagtaag ctctgctgat
     1801 ataagtagtt catctgaggt aatatcacag catctagtat cttacagaaa tattgaagag
     1861 cttcaacaac aaaatcaacg tctcttagtg gcccttagag agcttgggga aaccagagaa
     1921 agagaagaac aagaaacaac ttcatccaaa atcactgagc ttcagctcaa acttgagagt
     1981 gcccttactg aactagaaca actccgcaaa tcacgacagc atcaaatgca gcttgttgat
     2041 tccatagttc gtcagcgtga tatgtaccgt attttattgt cacaaacaac aggagttgcc
     2101 attccattac atgcttcaag cttagatgat gtttctcttg catcaactcc aaaacgtcca
     2161 agtacatcac agactgtttc cactcctgct ccagtacctg ttattgaatc aacagaggct
     2221 atagaggcta aggctgccct taaacagttg caggaaattt ttgagaacta caaaaaagaa
     2281 aaagcagaaa atgaaaaaat acaaaatgag cagcttgaga aacttcaaga acaagttaca
     2341 gatttgcgat cacaaaatac caaaatttct acccagctag attttgcttc taaacgttat
     2401 gaaatgctgc aagataatgt tgaaggatat cgtcgagaaa taacatcact tcatgagaga
     2461 aatcagaaac tcactgccac aactcaaaag caagaacaga ttatcaatac gatgactcaa
     2521 gatttgagag gagcaaatga gaagctagct gtcgcagaag taagagcaga aaatttgaag
     2581 aaggaaaagg aaatgcttaa attgtctgaa gttcgtcttt ctcagcaaag agagtctttg
     2641 ttagctgaac aaagggggca aaacttactg ctaactaatc tgcaaacaat tcagggaata
     2701 ctggagcgat ctgaaacaga aaccaaacaa aggcttagta gccagataga aaaactggaa
     2761 catgagatct ctcatctaaa gaagaagttg gaaaatgagg tggaacaaag gcatacactt
     2821 actagaaatc tagatgttca acttttagat acaaagagac aactggatac agagacaaat
     2881 cttcatctta acacaaaaga actattaaaa aatgctcaaa aagaaattgc cacattgaaa
     2941 cagcacctca gtaatatgga agtccaagtt gcttctcagt cttcacagag aactggtaaa
     3001 ggtcagccta gcaacaaaga agatgtggat gatcttgtga gtcagctaag acagacagaa
     3061 gagcaggtga atgacttaaa ggagagactc aaaacaagta cgagcaatgt ggaacaatat
     3121 caagcaatgg ttactagttt agaagaatcc ctgaacaagg aaaaacaggt gacagaagaa
     3181 gtgcgtaaga atattgaagt tcgtttaaaa gagtcagctg aatttcagac acagttggaa
     3241 aagaagttga tggaagtaga gaaggaaaaa caagaacttc aggatgataa aagaagagcc
     3301 atagagagca tggaacaaca gttatctgaa ttgaagaaaa cactttctag tgttcagaat
     3361 gaagtacaag aagctcttca gagagcaagc acagctttaa gtaatgagca gcaagccaga
     3421 cgtgactgtc aggaacaagc taaaatagct gtggaagctc agaataagta tgagagagaa
     3481 ttgatgctgc atgctgctga tgttgaagct ctacaagctg cgaaggagca ggtttcaaaa
     3541 atggcatcag tccgtcagca tttggaagaa acaacacaga aagcagaatc acagttgttg
     3601 gagtgtaaag catcttggga ggaaagagag agaatgttaa aggatgaagt ttccaaatgt
     3661 gtatgtcgct gtgaagatct ggagaaacaa aacagattac ttcatgatca gatcgaaaaa
     3721 ttaagtgaca aggtcgttgc ctctgtgaag gaaggtgtac aaggtccact gaatgtatct
     3781 ctcagtgaag aaggaaaatc tcaagaacaa attttggaaa ttctcagatt tatacgacga
     3841 gaaaaagaaa ttgctgaaac taggtttgag gtggctcagg ttgagagtct gcgttatcga
     3901 caaagggttg aacttttaga aagagagctg caggaactgc aagatagtct aaatgctgaa
     3961 agggagaaag tccaggtaac tgcaaaaaca atggctcagc atgaagaact gatgaagaaa
     4021 actgaaacaa tgaatgtagt tatggagacc aataaaatgc taagagaaga gaaggagaga
     4081 ctagaacagg atctacagca aatgcaagca aaggtgagga aactggagtt agatatttta
     4141 cccttacaag aagcaaatgc tgagctgagt gagaaaagcg gtatgttgca ggcagagaag
     4201 aagctcttag aagaggatgt caaacgttgg aaagcacgta accagcatct agtaagtcaa
     4261 cagaaagatc cagatacaga agaatatcgg aagctccttt ctgaaaagga agttcatact
     4321 aagcgtattc aacaattgac agaagaaatt ggtagactta aagctgaaat tgcaagatca
     4381 aatgcatctt tgactaacaa ccagaactta attcagagtc tgaaggaaga tctaaataaa
     4441 gtaagaactg aaaaggaaac catccagaag gacttagatg ccaaaataat tgatatccaa
     4501 gaaaaagtca aaactattac tcaagttaag aaaattggac gtaggtacaa gactcaatat
     4561 gaagaactta aagcacaaca ggataaggtt atggagacat cggctcagtc ctctggagac
     4621 catcaggagc agcatgtttc agtccaggaa atgcaggaac tcaaagaaac gctcaaccaa
     4681 gctgaaacaa aatcaaaatc acttgaaagt caagtagaga atctgcagaa gacattatct
     4741 gaaaaagaga cagaagcaag aaatctccag gaacagactg tgcaacttca gtctgaactt
     4801 tcacgacttc gtcaggatct tcaagataga accacacagg aggagcagct ccgacaacag
     4861 ataactgaaa aggaagaaaa aaccagaaag gctattgtag cagcaaagtc aaaaattgca
     4921 cacttagctg gtgtaaaaga tcagctaact aaagaaaatg aggagcttaa acaaaggaat
     4981 ggagccttag atcagcagaa agatgaattg gatgttcgca ttactgcgct aaagtcccaa
     5041 tatgaaggtc gaattagtcg cttggaaaga gaactcaggg agcatcaaga gagacacctt
     5101 gagcagagag atgagcctca agaaccttct aataaggtcc ctgaacagca gagacagatc
     5161 acattgaaaa caactccagc ttctggtgaa agaggaattg ccagcacatc agacccacca
     5221 acagccaata tcaagccaac tcctgttgtg tctactccaa gtaaagtgac agctgcagct
     5281 atggctggaa ataagtcaac acccagggct agtatccgcc caatggttac acctgcaact
     5341 gttacaaatc ccactactac cccaacagct acagtgatgc ccactacaca agtggaatca
     5401 caggaagcta tgcagtcaga agggcctgtg gaacatgttc cagtttttgg aagcacaagt
     5461 ggatccgttc gttctactag tcctaatgtc cagccttcta tctctcaacc tattttaact
     5521 gttcagcaac aaacacaggc tacagctttt gtgcaaccca ctcaacagag tcatcctcag
     5581 attgagcctg ccaatcaaga gttatcttca aacatagtag aggttgttca gagttcacca
     5641 gttgagcggc cttctacttc cacagcagta tttggcacag tttcggctac ccccagttct
     5701 tctttgccaa agcgtacacg tgaagaggaa gaggatagca ccatagaagc atcagaccaa
     5761 gtctctgatg atacagtgga aatgcctctt ccaaagaagt tgaaaagtgt cacacctgta
     5821 ggaactgagg aagaagttat ggcagaagaa agtactgatg gagaggtaga gactcaggta
     5881 tacaaccagg attctcaaga ttccattgga gaaggagtta cccagggaga ttatacacct
     5941 atggaagaca gtgaagaaac ctctcagtct ctacaaatag atcttgggcc acttcaatca
     6001 gatcagcaga cgacaacttc atcccaggat ggtcaaggca aaggagatga tgtcattgta
     6061 attgacagtg atgatgaaga agaggatgat gatgaaaatg atggagaaca tgaggattat
     6121 gaagaggatg aggaagatga tgatgatgat gaagatgaca cagggatggg agatgagggt
     6181 gaagatagta atgaaggaac tggtagtgcc gatggcaatg atggttatga agctgatgat
     6241 gctgagggtg gtgatgggac tgatccaggt acagaaacag aagaaagtat gggtggaggt
     6301 gaaggtaatc acagagctgc tgattctcaa aacagtggtg aaggaaatac aggtgctgca
     6361 gaatcttctt tttctcagga ggtttctaga gaacaacagc catcatcagc atctgaaaga
     6421 caggcccctc gagcacctca gtcaccgaga cgcccaccac atccacttcc cccaagactg
     6481 accattcatg ccccacctca ggagttggga ccaccagttc agagaattca gatgacccga
     6541 aggcagtctg taggacgtgg ccttcagttg actccaggaa taggtggcat gcaacagcat
     6601 ttttttgatg atgaagacag aacagttcca agtactccaa ctcttgtggt gccacatcgt
     6661 actgatggat ttgctgaagc aattcattcg ccgcaggttg ctggtgtccc tagattccgg
     6721 tttgggccac ctgaagatat gccacaaaca agttctagtc actctgatct tggccagctt
     6781 gcttctcaag gaggtttagg aatgtatgaa acacccctgt tcctagctca tgaagaagag
     6841 tcaggtggcc gaagtgttcc cactactcca ctacaagtag cagccccagt gactgtattt
     6901 actgagagca ccacctctga tgcttcggaa catgcctctc aatctgttcc aatggtgact
     6961 acatccactg gcactttatc tacaacaaat gaaacagcaa caggtgatga tggagatgaa
     7021 gtatttgtgg aggcagaatc tgaaggtatt agttcagaag caggcctaga aattgatagc
     7081 cagcaggaag aagagccggt tcaagcatct gatgagtcag atctcccctc caccagccag
     7141 gatcctcctt ctagctcatc tgtagatact agtagtagtc aaccaaagcc tttcagacga
     7201 gtaagacttc agacaacatt gagacaaggt gtccgtggtc gtcagtttaa cagacagaga
     7261 ggtgtgagcc atgcaatggg agggagagga ggaataaaca gaggaaatat taattaaatg
     7321 gtctgtaaac aataacaact gtgaataaga ttatcaaatc tgttttagtg taatgattgt
     7381 caagtttaaa aacattttta tatataaact ggtatactca tgtcaatatt ctttattaat
     7441 aaaatgtttt tcagtgtcaa aatttattat tcatttcttc attagttgac tcctcctttg
     7501 ctcatcagtc taaggacagt tgtaccagac tttggataag gtctgcccag aacgagtagt
     7561 aattgctctt gctgttctac taggcacatc aatgttatag tattgatcta aatggaagag
     7621 aaaacatttt tttagttaaa aagaaaacaa tgcccaaact aaaaaataac ttatgttgac
     7681 tattatgctc aaagacaatg tttatcattt taatagagat gtttttacta attaatttga
     7741 actttataac aaaaagaaaa acaattgcct agacttttca gcttttttga tgtttcaaaa
     7801 gattgacatt tcaccatctt tttgtaaaat caggttcagc tctcctttat gaagtaaaca
     7861 ttaaagagta accaagtttg aaaaataatt tacttggggt tattcctttt aaaaaataca
     7921 tgccaatgtc attcatatta tgaaattaca ggcagaataa cttagatttc tgggcatttc
     7981 aaagaaaagc atcctgagta atataattta attaataaaa ttagtttctc aggaacttct
     8041 ttctgatctt acagactctg cagtgatgca aatcattata accttgtgcc aaacaaggta
     8101 tctgttaaat gccacaaatg atagaagtaa aatactattg tcagtagcaa gtttactcta
     8161 gtaactggat gttttatcgt aatctcatga aggttagagc agaattgaat tgcagtgcca
     8221 tcattttaat tgaaattaaa gcaaaagtct taactctttt ccacagcaat tagaataagt
     8281 accgtagtgt aacttctcac attcagtcat cattgcagcc agcattttta ctttatcttc
     8341 atgttttcac aaatgatatc acctccttgg gaaactgtta gttaatacct tacctttaga
     8401 aaaggcatag taatcatagc cgtcaggttt tctgatgttg ggcagtgata tagctgaggt
     8461 aaccacattt ggaagtcctc tccacagtat actcacttta acttcattat gaaggacacc
     8521 tgtaagtggc atgtttaata aaagatacca gattaaaagg caatgtacta tcttggaaag
     8581 agccagacat ctgagtttta atctcagttt tagccctctg atgtagaact attgagggtt
     8641 atagactggt atataatgtt cttggtaaga agtacttgat aaatagtatt ggttataact
     8701 aacaaacctg aacaaactgc tttacttacc cacaaggaaa aagaaagtat tggtctttgg
     8761 ttattcacta aggcaagtgg atgagttttt catcagtaag cttaaattat tagggctgtt
     8821 tgatcagtat ccatatttca taagccttac tgtataagaa actgtattac atctacttat
     8881 gtttaaggat ttttttaaca caataaaaat gttacctttg tcttgataag ccagtctggc
     8941 aggtgaatat tgaattctga tggtgtgtgt ttgagaaggt cctatagcac gttcaaagcg
     9001 acgtctccta acctgtgtcg tttctccata cactggataa tttagagcag gccttcttcc
     9061 agggcacttc tgtacaggtt cctgtttata aatatactgc tgaatgctgc cacctgttat
     9121 gtattagaat atcacatgga aaatgaaaat taattttaat accctcagaa aaggtggaaa
     9181 acaactttta caatgtatag gaaacagttt tgttctcatt tttcatataa tatattgata
     9241 ttaataatgg ctattagtca agggtattat aaaaataatt attaaactga aatacttgtt
     9301 gaatgaatag atgcagcaaa ttacatagtt atatatttaa tttcaattga aagtgacaag
     9361 tgctcagttt ggcagcacat atactaaaac tggaatgata cagagattag catggccctt
     9421 gtgcaaggat gacatgcaca tttgtgaagc gaaagtaaat gacattctat cagtgacctg
     9481 aaaactcaaa tgaattgtga cttgcctgtg aagaaatgaa aataaaaatt gagggcaata
     9541 agaatactac cctcaatatt gatttttttc actgaaaata tttgatttca gccattaaag
     9601 atatcttttg acagtaaagt caataataaa tgaaaa
//
