LOCUS       NM_016140               1112 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens tubulin polymerization promoting protein family member
            3 (TPPP3), transcript variant 1, mRNA.
ACCESSION   NM_016140
VERSION     NM_016140.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1112)
  AUTHORS   Xu,X., Hou,Y., Long,N., Jiang,L., Yan,Z., Xu,Y., Lv,Y., Xiang,X.,
            Yang,H., Liu,J., Qi,X. and Chu,L.
  TITLE     TPPP3 promote epithelial-mesenchymal transition via Snail1 in
            glioblastoma
  JOURNAL   Sci Rep 13 (1), 17960 (2023)
   PUBMED   37863960
  REMARK    GeneRIF: TPPP3 promote epithelial-mesenchymal transition via Snail1
            in glioblastoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1112)
  AUTHORS   Xiao,T., Lin,F., Zhou,J. and Tang,Z.
  TITLE     The expression and role of tubulin polymerization-promoting protein
            3 in oral squamous cell carcinoma
  JOURNAL   Arch Oral Biol 143, 105519 (2022)
   PUBMED   36058091
  REMARK    GeneRIF: The expression and role of tubulin
            polymerization-promoting protein 3 in oral squamous cell carcinoma.
REFERENCE   3  (bases 1 to 1112)
  AUTHORS   Olah,J., Lehotzky,A., Szenasi,T., Berki,T. and Ovadi,J.
  TITLE     Modulatory Role of TPPP3 in Microtubule Organization and Its Impact
            on Alpha-Synuclein Pathology
  JOURNAL   Cells 11 (19), 3025 (2022)
   PUBMED   36230985
  REMARK    GeneRIF: Modulatory Role of TPPP3 in Microtubule Organization and
            Its Impact on Alpha-Synuclein Pathology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1112)
  AUTHORS   Shen,A., Tong,X., Li,H., Chu,L., Jin,X., Ma,H. and Ouyang,Y.
  TITLE     TPPP3 inhibits the proliferation, invasion and migration of
            endometrial carcinoma targeted with miR-1827
  JOURNAL   Clin Exp Pharmacol Physiol 48 (6), 890-901 (2021)
   PUBMED   33644928
  REMARK    GeneRIF: TPPP3 inhibits the proliferation, invasion and migration
            of endometrial carcinoma targeted with miR-1827.
REFERENCE   5  (bases 1 to 1112)
  AUTHORS   Yang,Z., Li,X., Li,J., Su,Q., Qiu,Y., Zhang,Z., Zhang,L. and Mo,W.
  TITLE     TPPP3 Associated with Prognosis and Immune Infiltrates in Head and
            Neck Squamous Carcinoma
  JOURNAL   Biomed Res Int 2020, 3962146 (2020)
   PUBMED   33083464
  REMARK    GeneRIF: TPPP3 Associated with Prognosis and Immune Infiltrates in
            Head and Neck Squamous Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1112)
  AUTHORS   Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Rewerts,C.,
            Maccarrone,G., Dias-Neto,E. and Turck,C.W.
  TITLE     Prefrontal cortex shotgun proteome analysis reveals altered calcium
            homeostasis and immune system imbalance in schizophrenia
  JOURNAL   Eur Arch Psychiatry Clin Neurosci 259 (3), 151-163 (2009)
   PUBMED   19165527
  REMARK    GeneRIF: Using shotgun mass spectrometry, we found this protein
            differentially expressed in the dorsolateral prefrontal cortex from
            patients with schizophrenia.
REFERENCE   7  (bases 1 to 1112)
  AUTHORS   Vincze,O., Tokesi,N., Olah,J., Hlavanda,E., Zotter,A., Horvath,I.,
            Lehotzky,A., Tirian,L., Medzihradszky,K.F., Kovacs,J., Orosz,F. and
            Ovadi,J.
  TITLE     Tubulin polymerization promoting proteins (TPPPs): members of a new
            family with distinct structures and functions
  JOURNAL   Biochemistry 45 (46), 13818-13826 (2006)
   PUBMED   17105200
REFERENCE   8  (bases 1 to 1112)
  AUTHORS   Lindersson,E., Lundvig,D., Petersen,C., Madsen,P., Nyengaard,J.R.,
            Hojrup,P., Moos,T., Otzen,D., Gai,W.P., Blumbergs,P.C. and
            Jensen,P.H.
  TITLE     p25alpha Stimulates alpha-synuclein aggregation and is co-localized
            with aggregated alpha-synuclein in alpha-synucleinopathies
  JOURNAL   J Biol Chem 280 (7), 5703-5715 (2005)
   PUBMED   15590652
REFERENCE   9  (bases 1 to 1112)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1112)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI754230.1 and BC000691.2.
            
            On Jun 1, 2019 this sequence version replaced NM_016140.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279839.7590.1,
                                           SRR7410570.624822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147596, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-669               BI754230.1         21-689
            670-1112            BC000691.2         563-1005
FEATURES             Location/Qualifiers
     source          1..1112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1112
                     /gene="TPPP3"
                     /gene_synonym="CGI-38; p20; p25gamma; TPPP/p20"
                     /note="tubulin polymerization promoting protein family
                     member 3"
                     /db_xref="GeneID:51673"
                     /db_xref="HGNC:HGNC:24162"
                     /db_xref="MIM:616957"
     exon            1..119
                     /gene="TPPP3"
                     /gene_synonym="CGI-38; p20; p25gamma; TPPP/p20"
                     /inference="alignment:Splign:2.1.0"
     exon            120..210
                     /gene="TPPP3"
                     /gene_synonym="CGI-38; p20; p25gamma; TPPP/p20"
                     /inference="alignment:Splign:2.1.0"
     exon            211..404
                     /gene="TPPP3"
                     /gene_synonym="CGI-38; p20; p25gamma; TPPP/p20"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..747
                     /gene="TPPP3"
                     /gene_synonym="CGI-38; p20; p25gamma; TPPP/p20"
                     /note="brain specific protein"
                     /codon_start=1
                     /product="tubulin polymerization-promoting protein family
                     member 3"
                     /protein_id="NP_057224.2"
                     /db_xref="CCDS:CCDS10835.1"
                     /db_xref="GeneID:51673"
                     /db_xref="HGNC:HGNC:24162"
                     /db_xref="MIM:616957"
                     /translation="MAASTDMAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKV
                     ADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQL
                     VAGKEPANVGVTKAKTGGAVDRLTDTSRYTGSHKERFDESGKGKGIAGRQDILDDSGY
                     VSAYKNAGTYDAKVKK"
     exon            405..558
                     /gene="TPPP3"
                     /gene_synonym="CGI-38; p20; p25gamma; TPPP/p20"
                     /inference="alignment:Splign:2.1.0"
     exon            559..1112
                     /gene="TPPP3"
                     /gene_synonym="CGI-38; p20; p25gamma; TPPP/p20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1090..1095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPPP3"
                     /gene_synonym="CGI-38; p20; p25gamma; TPPP/p20"
                     /note="hexamer: AATAAA"
     polyA_site      1112
                     /gene="TPPP3"
                     /gene_synonym="CGI-38; p20; p25gamma; TPPP/p20"
                     /note="major polyA site"
ORIGIN      
        1 agtcccaccc gggagccggc agggagcgga gctgcggagc cgcctggtct cccgcgtcca
       61 tcggtccatt cctgcgtcgt tctgtccttc cgaacgcaca cttcaggagc agccgcgagg
      121 agtgagcact gcacgcagga tccgcccagt gcttgggcca agcaccctgt ggcatccaag
      181 ctcccctgga cgttaccctt ggtgaaccaa ggtggcatgg cagcgagcac agacatggct
      241 gggctggagg agagcttccg caagtttgcc atccatggtg accccaaggc cagtgggcaa
      301 gagatgaatg gcaagaactg ggccaagctg tgcaaggact gcaaggtggc tgacggaaag
      361 tccgtgacag ggaccgatgt ggacatcgtc ttctccaaag tcaaggggaa gtctgctcgg
      421 gtcatcaact atgaggagtt caagaaggcc ctggaagagc tggcgaccaa gagattcaag
      481 gggaagagca aggaggaggc cttcgatgcc atctgccagc tggtggcagg caaagagcca
      541 gccaatgtgg gcgtcactaa agcaaaaaca gggggtgctg tagaccggct gacggacacc
      601 agcagataca cgggctccca caaggagcgc ttcgatgaga gcggcaaggg caagggcatt
      661 gcgggacggc aggacatcct ggacgacagt ggctacgtga gcgcctacaa gaatgcaggc
      721 acctacgatg ccaaggtgaa gaagtgaggc ttgggaagac cgccctgcca agtgcggctg
      781 cccctgccag aggctcaggc ctgggtctaa ggggcacgtg gagcaagaga tcctggtccc
      841 ctccctgctg gacctgccac ccagagcttc ctgcctagtc ccactgggct ggcccaccag
      901 gcctctgacc caggctgctc tgcggcccct tcctcctcct cttcctgctc caacttctgt
      961 ccacctgggg acagtctgtg cctgtagcct catgacccca acccagcccc aggcatggct
     1021 aacccctgac tgcttgcctc atatttaagc tgctgctctg gccaagtgcc taattttaac
     1081 ccagacctca ataaagacac cttttgtacc aa
//
