LOCUS       NM_173846               1408 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tubulin polymerization promoting protein family member
            2 (TPPP2), mRNA.
ACCESSION   NM_173846
VERSION     NM_173846.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1408)
  AUTHORS   Zhu,F., Yan,P., Zhang,J., Cui,Y., Zheng,M., Cheng,Y., Guo,Y.,
            Yang,X., Guo,X. and Zhu,H.
  TITLE     Deficiency of TPPP2, a factor linked to oligoasthenozoospermia,
            causes subfertility in male mice
  JOURNAL   J Cell Mol Med 23 (4), 2583-2594 (2019)
   PUBMED   30680919
REFERENCE   2  (bases 1 to 1408)
  AUTHORS   Vincze,O., Tokesi,N., Olah,J., Hlavanda,E., Zotter,A., Horvath,I.,
            Lehotzky,A., Tirian,L., Medzihradszky,K.F., Kovacs,J., Orosz,F. and
            Ovadi,J.
  TITLE     Tubulin polymerization promoting proteins (TPPPs): members of a new
            family with distinct structures and functions
  JOURNAL   Biochemistry 45 (46), 13818-13826 (2006)
   PUBMED   17105200
REFERENCE   3  (bases 1 to 1408)
  AUTHORS   Lindersson,E., Lundvig,D., Petersen,C., Madsen,P., Nyengaard,J.R.,
            Hojrup,P., Moos,T., Otzen,D., Gai,W.P., Blumbergs,P.C. and
            Jensen,P.H.
  TITLE     p25alpha Stimulates alpha-synuclein aggregation and is co-localized
            with aggregated alpha-synuclein in alpha-synucleinopathies
  JOURNAL   J Biol Chem 280 (7), 5703-5715 (2005)
   PUBMED   15590652
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB458250.1, BC038970.2, AW135537.1 and AL161668.6.
            
            On Nov 23, 2018 this sequence version replaced NM_173846.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.146997.1,
                                           SRR5189667.197413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321760.11/ ENSP00000317595.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                DB458250.1         32-111
            81-554              BC038970.2         1-474
            555-768             AW135537.1         14-227              c
            769-1408            AL161668.6         85512-86151
FEATURES             Location/Qualifiers
     source          1..1408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1408
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /note="tubulin polymerization promoting protein family
                     member 2"
                     /db_xref="GeneID:122664"
                     /db_xref="HGNC:HGNC:19293"
                     /db_xref="MIM:616956"
     exon            1..88
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /inference="alignment:Splign:2.1.0"
     exon            89..330
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..670
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /note="TPPP/p18; protein p25-beta"
                     /codon_start=1
                     /product="tubulin polymerization-promoting protein family
                     member 2"
                     /protein_id="NP_776245.2"
                     /db_xref="CCDS:CCDS9566.1"
                     /db_xref="GeneID:122664"
                     /db_xref="HGNC:HGNC:19293"
                     /db_xref="MIM:616956"
                     /translation="MASEAEKTFHRFAAFGESSSSGTEMNNKNFSKLCKDCGIMDGKT
                     VTSTDVDIVFSKVKAKNARTITFQQFKEAVKELGQKRFKGKSPDEVLENIYGLMEGKD
                     PATTGATKATTVGAVDRLTDTSKYTGTHKERFDESGKGKGIAGREEMTDNTGYVSGYK
                     GSGTYDKKTK"
     exon            331..484
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /inference="alignment:Splign:2.1.0"
     exon            485..1408
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      739..744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /note="hexamer: AATAAA"
     polyA_site      761
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /note="major polyA site"
     regulatory      1389..1394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /note="hexamer: ATTAAA"
     polyA_site      1408
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
ORIGIN      
        1 attgccacag ccaaccggct cccacatatc tgcacacact taaatacaaa ggccgggaag
       61 ggtcagacca ccatccgggt actctaagtc ctccctcccc cttctccttc acccccaagt
      121 gtctcccacg actgccctcc ccgacctcta gctgaccatg gcatcagagg cagaaaaaac
      181 attccatcgg tttgctgcgt ttggagaatc atcaagcagt ggcactgaaa tgaacaacaa
      241 gaacttctcc aagctgtgca aagactgtgg catcatggat ggcaagacag tcacctccac
      301 ggacgtggac atcgtgttca gcaaagtcaa ggccaagaac gcccgaacca tcacgtttca
      361 acagttcaaa gaggcagtga aggaactggg ccagaagcgc ttcaaaggga agagtccaga
      421 tgaagtcctg gagaacattt atggactcat ggagggcaaa gacccagcca ccactggcgc
      481 tactaaagca acaacagtgg gtgcagtgga ccgtttgaca gacaccagca agtacaccgg
      541 cacccacaag gagcgctttg atgagagtgg caagggcaag ggcattgcgg gacgggaaga
      601 gatgactgac aacacaggct atgtgagtgg ttacaagggt tctggcacct acgataagaa
      661 gaccaagtag agaggagctt catctcagcc tgctagcccc ctgaccctgc atgtttaaca
      721 ccagggagct tggaaaacaa taaacatctg tgtgtgcagc agccaaaatc tctgtctgtg
      781 agggacagat gagcctacta gtgtagagag agggagaaga ggcagcacag gagggtgggt
      841 tctccaccac acacccttcg ctctgcttag ccttatgcct accagccatc agttagcatt
      901 cctcctcaac agctgcttcc aagaacagga tggaagaata tatttggagt aaagagatga
      961 accagatgtg gaggtaaaag tatctactac ttgtgttcac acattactga tatccacctc
     1021 tccaccccca cccctcaaaa gggtgtagca attcctcacg tgatggacta tgactatatc
     1081 acatattaga tccttccctg tccctccacc ttcctcatct gttgcaattc aggttttttg
     1141 ggtggaggag tagaagccag ctaaggttgc ctgacttcta ttacaaattt gttccagagc
     1201 tggggtaagg ggagagtcta ttttcaacac ccagcccaga actaagtttt accccacatc
     1261 acctccatca tggggcacat gggacagaag agcttactga ctgctaaggg tagctcagga
     1321 agatggccag atgaggcagg ctgccaggat tccaagagca ggagttctgg tgcactgaag
     1381 aaaaagcaat taaatcacaa cagagtca
//
