LOCUS       NM_007030               5979 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens tubulin polymerization promoting protein (TPPP), mRNA.
ACCESSION   NM_007030
VERSION     NM_007030.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5979)
  AUTHORS   Pehlivanoglu,B., Araya,J.C., Lawrence,S., Roa,J.C., Balci,S.,
            Andersen,J.B., Rashid,A., Hsing,A.W., Zhu,B., Gao,Y.T., Koshiol,J.
            and Adsay,V.
  TITLE     TPPP-BRD9 fusion-related gallbladder carcinomas are frequently
            associated with intracholecystic neoplasia, neuroendocrine
            carcinoma, and a distinctive small tubular-type adenocarcinoma
            commonly accompanied with a syringomatous pattern
  JOURNAL   Hum Pathol 150, 67-73 (2024)
   PUBMED   38972607
  REMARK    GeneRIF: TPPP-BRD9 fusion-related gallbladder carcinomas are
            frequently associated with intracholecystic neoplasia,
            neuroendocrine carcinoma, and a distinctive small tubular-type
            adenocarcinoma commonly accompanied with a syringomatous pattern.
REFERENCE   2  (bases 1 to 5979)
  AUTHORS   Olah,J., Norris,V., Lehotzky,A. and Ovadi,J.
  TITLE     Perspective Strategies for Interventions in Parkinsonism: Remedying
            the Neglected Role of TPPP
  JOURNAL   Cells 13 (4), 338 (2024)
   PUBMED   38391951
  REMARK    GeneRIF: Perspective Strategies for Interventions in Parkinsonism:
            Remedying the Neglected Role of TPPP.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5979)
  AUTHORS   Yan,Q., Wu,X., Zhou,P., Zhou,Y., Li,X., Liu,Z., Tan,H., Yao,W.,
            Xia,Y. and Zhu,F.
  TITLE     HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process
            through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk
  JOURNAL   Viruses 14 (1), 145 (2022)
   PUBMED   35062349
  REMARK    GeneRIF: HERV-W Envelope Triggers Abnormal Dopaminergic Neuron
            Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5979)
  AUTHORS   Olah,J., Lehotzky,A., Szenasi,T. and Ovadi,J.
  TITLE     Anti-Aggregative Effect of the Antioxidant DJ-1 on the
            TPPP/p25-Derived Pathological Associations of Alpha-Synuclein
  JOURNAL   Cells 10 (11), 2909 (2021)
   PUBMED   34831132
  REMARK    GeneRIF: Anti-Aggregative Effect of the Antioxidant DJ-1 on the
            TPPP/p25-Derived Pathological Associations of Alpha-Synuclein.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5979)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5979)
  AUTHORS   Lehotzky,A., Tirian,L., Tokesi,N., Lenart,P., Szabo,B., Kovacs,J.
            and Ovadi,J.
  TITLE     Dynamic targeting of microtubules by TPPP/p25 affects cell survival
  JOURNAL   J Cell Sci 117 (Pt 25), 6249-6259 (2004)
   PUBMED   15564385
  REMARK    GeneRIF: TPPP/p25 has a role in stabilization of physiological
            microtubular ultrastructures and cell survival
REFERENCE   7  (bases 1 to 5979)
  AUTHORS   Tirian,L., Hlavanda,E., Olah,J., Horvath,I., Orosz,F., Szabo,B.,
            Kovacs,J., Szabad,J. and Ovadi,J.
  TITLE     TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle
            formation
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 13976-13981 (2003)
   PUBMED   14623963
REFERENCE   8  (bases 1 to 5979)
  AUTHORS   Hlavanda,E., Kovacs,J., Olah,J., Orosz,F., Medzihradszky,K.F. and
            Ovadi,J.
  TITLE     Brain-specific p25 protein binds to tubulin and microtubules and
            induces aberrant microtubule assemblies at substoichiometric
            concentrations
  JOURNAL   Biochemistry 41 (27), 8657-8664 (2002)
   PUBMED   12093283
REFERENCE   9  (bases 1 to 5979)
  AUTHORS   Martin,C.P., Vazquez,J., Avila,J. and Moreno,F.J.
  TITLE     P24, a glycogen synthase kinase 3 (GSK 3) inhibitor
  JOURNAL   Biochim Biophys Acta 1586 (1), 113-122 (2002)
   PUBMED   11781156
REFERENCE   10 (bases 1 to 5979)
  AUTHORS   Seki,N., Hattori,A., Sugano,S., Suzuki,Y., Nakagawara,A.,
            Muramatsu,M., Hori,T. and Saito,T.
  TITLE     A novel human gene whose product shares significant homology with
            the bovine brain-specific protein p25 on chromosome 5p15.3
  JOURNAL   J Hum Genet 44 (2), 121-122 (1999)
   PUBMED   10083737
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB478250.2, AB017016.1, BQ066916.1, AW955330.1, AI796918.1,
            DB546894.2 and BU726600.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007030.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA294431.1, AB017016.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2145743,
                                           SAMEA2150585 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360578.7/ ENSP00000353785.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DB478250.2         44-89
            47-3925             AB017016.1         1-3879
            3926-4237           BQ066916.1         363-674
            4238-5065           AB017016.1         4192-5019
            5066-5276           AW955330.1         200-410
            5277-5601           AI796918.1         178-502
            5602-5978           DB546894.2         342-718
            5979-5979           BU726600.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..5979
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..5979
                     /gene="TPPP"
                     /gene_synonym="p24; p25; p25alpha; TPPP/p25; TPPP1"
                     /note="tubulin polymerization promoting protein"
                     /db_xref="GeneID:11076"
                     /db_xref="HGNC:HGNC:24164"
                     /db_xref="MIM:608773"
     exon            1..75
                     /gene="TPPP"
                     /gene_synonym="p24; p25; p25alpha; TPPP/p25; TPPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            76..390
                     /gene="TPPP"
                     /gene_synonym="p24; p25; p25alpha; TPPP/p25; TPPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..739
                     /gene="TPPP"
                     /gene_synonym="p24; p25; p25alpha; TPPP/p25; TPPP1"
                     /note="glycogen synthase kinase 3 (GSK3) inhibitor p24;
                     brain specific protein p25 alpha; p25-alpha; 25 kDa
                     brain-specific protein"
                     /codon_start=1
                     /product="tubulin polymerization-promoting protein"
                     /protein_id="NP_008961.1"
                     /db_xref="CCDS:CCDS3856.1"
                     /db_xref="GeneID:11076"
                     /db_xref="HGNC:HGNC:24164"
                     /db_xref="MIM:608773"
                     /translation="MADKAKPAKAANRTPPKSPGDPSKDRAAKRLSLESEGAGEGAAA
                     SPELSALEEAFRRFAVHGDARATGREMHGKNWSKLCKDCQVIDGRNVTVTDVDIVFSK
                     IKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISS
                     PTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDLVDESGYVSGYKHAGTYDQKVQGG
                     K"
     exon            391..544
                     /gene="TPPP"
                     /gene_synonym="p24; p25; p25alpha; TPPP/p25; TPPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..5979
                     /gene="TPPP"
                     /gene_synonym="p24; p25; p25alpha; TPPP/p25; TPPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5958..5963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPPP"
                     /gene_synonym="p24; p25; p25alpha; TPPP/p25; TPPP1"
                     /note="hexamer: AATAAA"
     polyA_site      5979
                     /gene="TPPP"
                     /gene_synonym="p24; p25; p25alpha; TPPP/p25; TPPP1"
                     /note="major polyA site"
ORIGIN      
        1 agagctccgc tgagcaccgg gtcgcgcgcg gccgagtcgc ggaggcgcct ccgctgcagt
       61 cgctgcgtct ccaagcaaca tggctgacaa ggccaagcct gccaaagctg ccaacaggac
      121 gccccccaag tccccggggg acccctcgaa ggaccgggca gccaagaggc tgtcgctgga
      181 atcggagggt gctggtgagg gggcagccgc atcccctgag ctcagtgccc tggaggaggc
      241 cttccggcgc tttgccgtgc acggggacgc cagggccacc gggagggaga tgcacggcaa
      301 gaactggtcg aagctgtgca aggactgcca ggtgatcgac ggcaggaacg tgaccgtcac
      361 tgacgtggac atcgtcttca gcaagatcaa agggaagtct tgccggacca tcacctttga
      421 gcagttccag gaggcgctgg aggagctcgc caagaagcga ttcaaagaca agagcagcga
      481 ggaggccgtt cgcgaggtgc acaggctcat cgagggcaag gcgcccatca tctcaggggt
      541 gacgaaagcc atctcgtcgc ccacagtgtc gaggctcacg gacaccacca agttcacggg
      601 ctcccacaag gagcgcttcg acccctctgg caagggcaag ggcaaggctg gccgcgtgga
      661 tctggtggac gagtcaggct atgtgtccgg ctacaagcac gcaggcacct acgaccagaa
      721 ggtgcaaggg ggcaagtagc ccccgctcca tgcctcgcgg cactgccggt gtccccagag
      781 cagggactct gtcacctcgc acttcattac attcctgtac taactggggc agaactcaga
      841 cgggtgcccc agagggggct ggggggcggc caggcccagg cctccctcct gcccctcctc
      901 ctaccggatg cccccagcac tcccctctca aaccaggttt gggccccagt tcgctgaccc
      961 tcctaataca cctgcctcgt cctcagccat ttccaaagtg tctcgcggat cacaccacac
     1021 tgggcacgtg gtttgcaggt caaaggggcg ttttaaagca gctggctgtc atggcaacag
     1081 gaggctgtgc tgacctcctg agcggcagac accttccagg agccctgagg gtggcaggag
     1141 ctaaccccaa ccagcaggca actaacacgg aattggcccc acaccggacg tgggaggtgt
     1201 ctgtggggcc cgaggcctgt cctgtgtgca gcggacacca cggggccttc ctgctttcct
     1261 gggcagaggg cagagtgagg ccacctggcg ggggtgctgg gcgcctggca catgtgtggg
     1321 gaagccggtc acatggacac acctgtgcac acatgcctac aggccagctc tgtgccaagg
     1381 gcaacctagg taaaacgaaa gccgtcaggg gcagtgggcg gcttcccggc tgaccacagt
     1441 ggcttggact gtgagggtag agtaggctcg ctttgctttc ctgagaagat gcggtggctg
     1501 cctatgttct cagagcgggt ctgggaagat tcagaatgtc cggtccctgt ggtgttgcca
     1561 ggcaagagac acgaagtgcc gagacactcc tcgcctcacc gcgtgacaga gcctctgccc
     1621 ggccctcccg ttcgcccgtc ctcactagct gcaccctgtt tgctcgcaga cctcccattg
     1681 ccacagccca agcaccttct tcaactctcc caaaatggct cagcctaacc tctcctggcc
     1741 aatccccccc gccggagagc aggacactag ggaggacccc cagtcctgca gtgtctgtgg
     1801 gggtttctct gccagcaggg ggctgagcag agcccatcca ggacactcca cactgccagg
     1861 acacacccag gcggcccgcc cttgcctgtc tgcacctggg gagaagccgg cgctcctgct
     1921 ccctcctggg gaggctgacg ggtgtggcca cccgctgtca caatggcaca ctgccactgt
     1981 cccttggcac gcacacagcc acagccacac gtgtgacctg ctgggccgtg gttctggagt
     2041 ctacctgcgg atgagcctgc ggcagtcctg gggaaacttt tccagagcct gttagcccgt
     2101 ggctacggtc aggctctggc cagggcagag ggctgcccag ggccaggctc acagtacagg
     2161 agggtggcga ggcccctccc tcactggcac gcatgagcac cacccgcctc cccgactccc
     2221 aagagtgcac ctgctgcggc cacagctccg tggaaggact ccccctacct gagcagagca
     2281 gaagccccag ggcggagctc ccagccagca tggtccgctg agggctgggg ggcggtctcc
     2341 gaggcccctc aacagagaag cctccacctg aggatgggga ggacctggca ggcagcttcc
     2401 acggcagggc tgggaagttc agtgcctgga aataaagagc aaggaaaaat ggacctcagg
     2461 cttcgtggct cctttaggat gtcacctcac cggcctgggg aaggcggggg gtgcccaagc
     2521 ccagccctgt gcccccgctg aacctggctg gaccgcgtgt gaaaggcaga actaacgtgc
     2581 ggaaacattt gaaaacaact ctgaatgtgc ggttcggaat cacccgatca cagacgagcg
     2641 gtcaccggaa tcgcccggtc acagacgagc agtcatcgga ctcacccgat cacagacgag
     2701 cggtcaccgg aatcgcccga tcacagacga gcggccaccg gaatcgccca atcacagaca
     2761 agcagtcatc ggaatcaccc gatcacagac gagcagtcat cggactcacc cgatcacaga
     2821 cgagcggtca ccagactcgc ccgatcacag acgagcagtc atcggaatca cccgatcaca
     2881 gacgagcagt catcggactc acccgatcac agacgagcgg tcaccagaat cgcccgatca
     2941 cagacgagca gtcatcggaa tcacccgatc acagacgagt ggccaccgga atcacccgat
     3001 aacagcccat cacaactcca aagcccttgt gttgaaaagg ccgaggacga gtggtcacca
     3061 aacagggtgg ctccccaggt cccgaagcct gagacccgga aggccctggc acccttacac
     3121 cctcggactc ctgccctcct cggcctccct ggccccagcg cggctccacc ctgggctgcg
     3181 tctcctggtc acaggctgcg tttctccttt ctgtccgtgg gcagcccagt ccccacagtc
     3241 acggccaagc cacgcagaac gaacatgact ccagaggacc tcgccctgga gctgagcctg
     3301 gcgccgggtc aggacggagg gaagggcggg ttggggtccg cgggtcctca caccgcacgg
     3361 caggcacaga ggctcgccag gccctgatcc ggtctgtggg gacgagggac actgaggaga
     3421 ggtgctgggc accaggacgc tgcctcctgg tccctggttg gcctcagaca agcacggcct
     3481 cgagaaaaga gccaagcgca tcgggagcac accagaaacc ggccctgagc acgagaagag
     3541 cctccgcccg gcccgggcac cacccgacct cgcagggagc aggccctgtc accgacgggt
     3601 cacctcgccc acacggccag caccgactca ccacagccct tcccagacct ggctggagtg
     3661 gccggagcgg cggggctcat ggctcccatc ttggcccctg gaggtgagct cattcacaga
     3721 agtggtccct tcactctgag agagaaaatc gtggcgtgca tcccaaaccc taggccacgc
     3781 ctgtgggttt cgtgaatgag atcgaggctg ctgtggcacc ctgcccgtcc tggcctggag
     3841 caccctggga tcctggaggg agaggcccca cgcccccact ctccctccac acttccaggg
     3901 ttggtgccca cgagttagag gcacgccctc ccccagcggc cctcaggctt ttctcagaca
     3961 tgcgggagcc aggagagcac ccttctccac tcagctccaa agcgaatctt tgaaaacacc
     4021 cactcggctc ccatctctgt cacctagcca ggaggggtag caaaaataaa gtcacgagga
     4081 catagtggtc accactgtca gttacaactt gtctgtggaa tccgtaattg catctgtgtg
     4141 ccgcctccga acacagaaca ttgtttggac ggcagcccca ctgcacataa cagacccgtg
     4201 catcttcctc agtcagtttc tgaatattgt gaattcaggc aggtgtgtgt tctcttctgc
     4261 atgtttttat gcactgccaa ttagcttcta ctaaccacgg ttcaacagaa aataaatgtg
     4321 tatttgtgaa taacaaactg cacaacctgc aaaccaggag agagggacag gttctgtcag
     4381 gggtgacacc aggacacagg gacaggttct gtcgggggtg acaccaggac acagggacag
     4441 gttctgtcat gggtgacacg aggacacagg gacaggttct atcatgggtg acaccaggag
     4501 agagggacag gttctgttgg gggtgacaag aggagacagg gacaggttct gtcgggggtg
     4561 acaccaggag agagggacag gttctgtcag gggtgacacc aggagagagg gacaggttct
     4621 gttgggggtg acaccaggac acaggaatag gttctgtcgg gaggacagtg ctgatcgtgt
     4681 ctcagcatca ggaaaggaga aaggcagagg gagagcgctg agaagactgt tcacgccaga
     4741 gtgcttattt atttttaatt tactgctata ggataagcaa ccaggtagtg ttcctaacaa
     4801 ttagcgttac caaaattaaa gttcaaatta tatgtttaaa atattgtaga agatatatat
     4861 ttatactgga ctacttttac accttctaat atcctgtcca agtttgggcg cagatggtgg
     4921 agttgggctg gcatcatgtc ctgtggccgc cccacttgcc tgttggtgcc actccatccc
     4981 gggccccagg gatgccagct cagggctgac cacagcagcc ctgcgtgggc atcacctcct
     5041 accccagccc ccatcctggg ctgctgcggc cgcctgcttt tgtgaatggt gttttgttgg
     5101 cacagggcct gtcctgtgtt ttcacacagg cctgtggctc ctgctgtaca agtggagtgg
     5161 ggaggagttg agatggagat gccttggccc tggacactta cctgtccctc tactggccca
     5221 gctcatctcc tcctgtgggc aatcacgcgt gcactggcca ccctcccacc ccacagcaca
     5281 caccacgagg ggatggcaca gggggaagat gaggctggac cgtgatgtta tcaataggct
     5341 agaacgtcct tcaaacactg aacctgcatc tttcctcctc ttactactga acactttgtg
     5401 agctctggtg gtccagggtg cagcgtttgt ccctgggcat gtgatgggga gtcctgggca
     5461 catcgagatg ctttacttct ttctttcgac ctcttaaaaa actaaaccaa gccaaaccac
     5521 aaaggaaatc tgcacaactt aagagaaact tgaaagggat cgtgtaacta ctagtttgta
     5581 ctaagttttt ttcaagaaag ggaaacaaat ttatatatat atatatatat atatatgtgc
     5641 aatatatttt tacactgtgt gattaacatt agggagtact gagtgcatca ctttatcagt
     5701 gtgacgggtg atgtccacgt catggctgtt ctgactctga aagccacttc tgctgatgtc
     5761 taaaccgcac tcaccgcgga cgtccgcggg gtggggtggc cctgctgttc ctcctgcagg
     5821 tgagaggtgt ggtgttgcct gttggacttg ctgttgagcc tggcttgcaa acctgtagtg
     5881 aaacagctcg tgtctgtgtg cacactgctc ctgtgtctgc tgtcgttaac attgtgtgtc
     5941 aagttggtaa agtgacaaat aaaggtgtta aaacatgga
//
