LOCUS       NM_152263               7064 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tropomyosin 3 (TPM3), transcript variant Tpm3.12,
            mRNA.
ACCESSION   NM_152263
VERSION     NM_152263.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7064)
  AUTHORS   Geeves,M.A., Hitchcock-DeGregori,S.E. and Gunning,P.W.
  TITLE     A systematic nomenclature for mammalian tropomyosin isoforms
  JOURNAL   J Muscle Res Cell Motil 36 (2), 147-153 (2015)
   PUBMED   25369766
  REMARK    Review article
REFERENCE   2  (bases 1 to 7064)
  AUTHORS   Takeuchi,K., Soda,M., Togashi,Y., Suzuki,R., Sakata,S., Hatano,S.,
            Asaka,R., Hamanaka,W., Ninomiya,H., Uehara,H., Lim Choi,Y.,
            Satoh,Y., Okumura,S., Nakagawa,K., Mano,H. and Ishikawa,Y.
  TITLE     RET, ROS1 and ALK fusions in lung cancer
  JOURNAL   Nat Med 18 (3), 378-381 (2012)
   PUBMED   22327623
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7064)
  AUTHORS   Gunning,P.W., Schevzov,G., Kee,A.J. and Hardeman,E.C.
  TITLE     Tropomyosin isoforms: divining rods for actin cytoskeleton function
  JOURNAL   Trends Cell Biol 15 (6), 333-341 (2005)
   PUBMED   15953552
  REMARK    Review article
REFERENCE   4  (bases 1 to 7064)
  AUTHORS   Lin,J.L., Geng,X., Bhattacharya,S.D., Yu,J.R., Reiter,R.S.,
            Sastri,B., Glazier,K.D., Mirza,Z.K., Wang,K.K., Amenta,P.S.,
            Das,K.M. and Lin,J.J.
  TITLE     Isolation and sequencing of a novel tropomyosin isoform
            preferentially associated with colon cancer
  JOURNAL   Gastroenterology 123 (1), 152-162 (2002)
   PUBMED   12105844
  REMARK    GeneRIF: cloned and sequenced a novel nonmuscle tropomyosin (hTM)
            isoform, TC22, which is strongly associated with colonic neoplasia
            and carcinoma
REFERENCE   5  (bases 1 to 7064)
  AUTHORS   Lamant,L., Dastugue,N., Pulford,K., Delsol,G. and Mariame,B.
  TITLE     A new fusion gene TPM3-ALK in anaplastic large cell lymphoma
            created by a (1;2)(q25;p23) translocation
  JOURNAL   Blood 93 (9), 3088-3095 (1999)
   PUBMED   10216106
REFERENCE   6  (bases 1 to 7064)
  AUTHORS   Laing,N.G., Wilton,S.D., Akkari,P.A., Dorosz,S., Boundy,K.,
            Kneebone,C., Blumbergs,P., White,S., Watkins,H., Love,D.R. et al.
  TITLE     A mutation in the alpha tropomyosin gene TPM3 associated with
            autosomal dominant nemaline myopathy
  JOURNAL   Nat Genet 9 (1), 75-79 (1995)
   PUBMED   7704029
  REMARK    Erratum:[Nat Genet. 1995 Jun;10(2):249. doi: 10.1038/ng0695-249..
            PMID: 7663526]
REFERENCE   7  (bases 1 to 7064)
  AUTHORS   Wilton,S.D., Eyre,H., Akkari,P.A., Watkins,H.C., MacRae,C.,
            Laing,N.G. and Callen,D.C.
  TITLE     Assignment of the human a-tropomyosin gene TPM3 to 1q22-->q23 by
            fluorescence in situ hybridisation
  JOURNAL   Cytogenet Cell Genet 68 (1-2), 122-124 (1995)
   PUBMED   7956350
REFERENCE   8  (bases 1 to 7064)
  AUTHORS   North,K.N. and Ryan,M.M.
  TITLE     Nemaline Myopathy - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301465
REFERENCE   9  (bases 1 to 7064)
  AUTHORS   DeChene,E.T., Kang,P.B. and Beggs,A.H.
  TITLE     Congenital Fiber-Type Disproportion - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301436
REFERENCE   10 (bases 1 to 7064)
  AUTHORS   Clayton,L., Reinach,F.C., Chumbley,G.M. and MacLeod,A.R.
  TITLE     Organization of the hTMnm gene. Implications for the evolution of
            muscle and non-muscle tropomyosins
  JOURNAL   J Mol Biol 201 (3), 507-515 (1988)
   PUBMED   3418707
REFERENCE   11 (bases 1 to 7064)
  AUTHORS   MacLeod,A.R., Houlker,C., Reinach,F.C. and Talbot,K.
  TITLE     The mRNA and RNA-copy pseudogenes encoding TM30nm, a human
            cytoskeletal tropomyosin
  JOURNAL   Nucleic Acids Res 14 (21), 8413-8426 (1986)
   PUBMED   3024106
REFERENCE   12 (bases 1 to 7064)
  AUTHORS   Martin-Zanca,D., Hughes,S.H. and Barbacid,M.
  TITLE     A human oncogene formed by the fusion of truncated tropomyosin and
            protein tyrosine kinase sequences
  JOURNAL   Nature 319 (6056), 743-748 (1986)
   PUBMED   2869410
REFERENCE   13 (bases 1 to 7064)
  AUTHORS   MacLeod,A.R., Houlker,C., Reinach,F.C., Smillie,L.B., Talbot,K.,
            Modi,G. and Walsh,F.S.
  TITLE     A muscle-type tropomyosin in human fibroblasts: evidence for
            expression by an alternative RNA splicing mechanism
  JOURNAL   Proc Natl Acad Sci U S A 82 (23), 7835-7839 (1985)
   PUBMED   3865200
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008425.1, AL590431.11,
            BC050470.1 and AJ573307.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_152263.3.
            
            Summary: This gene encodes a member of the tropomyosin family of
            actin-binding proteins. Tropomyosins are dimers of coiled-coil
            proteins that provide stability to actin filaments and regulate
            access of other actin-binding proteins. Mutations in this gene
            result in autosomal dominant nemaline myopathy and other muscle
            disorders. This locus is involved in translocations with other
            loci, including anaplastic lymphoma receptor tyrosine kinase (ALK)
            and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which
            result in the formation of fusion proteins that act as oncogenes.
            There are numerous pseudogenes for this gene on different
            chromosomes. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (Tpm3.12, also known as variant 1)
            differs in the 5' and 3' UTRs and contains multiple differences in
            the coding region, compared to variant Tpm3.1. It represents use of
            an alternate promoter and initiates translation at an alternate
            start codon. The encoded isoform (Tpm3.12st, also known as Tm sk
            alpha-slow, alpha s Tm1, or isoform 1) is longer and has distinct
            N- and C- termini, compared to isoform Tpm3.1cy. Expression of the
            encoded isoform is enriched in slow-twitch skeletal muscle.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008425.1, X04201.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651641.1/ ENSP00000498577.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1124              BC008425.1         5-1128
            1125-6796           AL590431.11        9476-15147          c
            6797-7063           BC050470.1         1273-1539
            7064-7064           AJ573307.1         337-337
FEATURES             Location/Qualifiers
     source          1..7064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..7064
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /note="tropomyosin 3"
                     /db_xref="GeneID:7170"
                     /db_xref="HGNC:HGNC:12012"
                     /db_xref="MIM:191030"
     exon            1..199
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..940
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /note="isoform Tpm3.12st is encoded by transcript variant
                     Tpm3.12; heat-stable cytoskeletal protein 30 kDa;
                     cytoskeletal tropomyosin TM30; tropomyosin alpha-3 chain;
                     tropomyosin gamma; tropomyosin-5; alpha-tropomyosin, slow
                     skeletal; epididymis secretory sperm binding protein Li
                     82p; epididymis luminal protein 189; tropomyosin 3 nu"
                     /codon_start=1
                     /product="tropomyosin alpha-3 chain isoform Tpm3.12st"
                     /protein_id="NP_689476.2"
                     /db_xref="CCDS:CCDS41403.1"
                     /db_xref="GeneID:7170"
                     /db_xref="HGNC:HGNC:12012"
                     /db_xref="MIM:191030"
                     /translation="MMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDEL
                     AAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDR
                     AQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD
                     RKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQK
                     EDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELD
                     HALNDMTSI"
     exon            200..325
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /inference="alignment:Splign:2.1.0"
     exon            326..459
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /inference="alignment:Splign:2.1.0"
     exon            460..577
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /inference="alignment:Splign:2.1.0"
     exon            578..648
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /inference="alignment:Splign:2.1.0"
     exon            649..724
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /inference="alignment:Splign:2.1.0"
     exon            725..787
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /inference="alignment:Splign:2.1.0"
     exon            788..857
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /inference="alignment:Splign:2.1.0"
     exon            858..936
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /inference="alignment:Splign:2.1.0"
     exon            937..7064
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1107..1112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /note="hexamer: ATTAAA"
     polyA_site      1135
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /note="major polyA site"
     regulatory      1381..1386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /note="hexamer: ATTAAA"
     polyA_site      1412
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
     regulatory      1611..1616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /note="hexamer: AATACA"
     polyA_site      1633
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
     regulatory      7044..7049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
                     /note="hexamer: AATAAA"
     polyA_site      7064
                     /gene="TPM3"
                     /gene_synonym="CAPM1; CFTD; CMYO4A; CMYO4B; CMYP4A;
                     CMYP4B; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5;
                     TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK"
ORIGIN      
        1 actcaggcag cagccccttc tttcttgccc cagtctccag ttctccagtg ttcacaggtg
       61 agcctaccaa cagccactgc tcatgatgga ggccatcaag aaaaagatgc agatgctgaa
      121 gttagacaag gagaatgctc tggatcgggc agagcaagct gaagctgagc agaagcaggc
      181 agaagaaaga agtaaacagc tggaggatga gctggcagcc atgcagaaga agctgaaagg
      241 gacagaggat gagctggaca agtattctga agctttgaag gatgcccagg agaagctgga
      301 actggcagag aagaaggctg ctgatgctga ggctgaggtg gcctccttga accgtaggat
      361 ccagctggtt gaagaagagc tggaccgtgc tcaggagcgc ctggccactg ccctgcaaaa
      421 gctggaagaa gctgaaaaag ctgctgatga gagtgagaga ggtatgaagg ttattgaaaa
      481 ccgggcctta aaagatgaag aaaagatgga actccaggaa atccaactca aagaagctaa
      541 gcacattgca gaagaggcag ataggaagta tgaagaggtg gctcgtaagt tggtgatcat
      601 tgaaggagac ttggaacgca cagaggaacg agctgagctg gcagagtcta agtgttctga
      661 gctggaggag gagctgaaga atgtcaccaa caacctcaag tctcttgagg ctcaggcgga
      721 gaagtactct caaaaagaag ataaatatga ggaagaaatc aagattctta ctgataaact
      781 caaggaggca gagacccgtg ctgagtttgc tgagagatcg gtagccaagc tggaaaagac
      841 aattgatgac ctggaagatg agctctatgc ccagaaactg aagtacaagg ccattagcga
      901 ggagctggac cacgccctca atgacatgac ctctatataa ttatcaccgt ttctgctctg
      961 ttctggatct gcccccttta ctcctcgggg aacccaaggc cccactctcg ctctggattc
     1021 catttgggtc agcctggctg gtccccaagg cattaggatg ggggagcaaa aagcaactta
     1081 tgtattttct tccaccccca ccccaaatta aaatgttaag ctgctggaaa cctcatgcca
     1141 ccctgcattt gtgtcattga caaagctgtt gctgtcccta agaaggagcc ttgggggtgt
     1201 gatgtgggga agagctattg taggctcccc ctcctctgac ttatgtaatc aaagccactt
     1261 ttgtgtgtgt ctattttttc ttgacattta aactcagctg atctgattct accagagtga
     1321 tggatttagt acaggttact caggatagta attttagtta tactcctcaa gctgaacaag
     1381 attaaattcc ttatttccag gttcttaaat catcctgcct gcagtgtttc cattctctct
     1441 tcaggtattc ctcctttggt gtggtgtcat tgagaagcca ttgaagtgac tctcaataca
     1501 cattctgtac ccttttaccg gtggttcaaa tggtgcatcc tcagaacacc cagtgaaccc
     1561 aatacattat tgctaagatt gactaattat gtcaactcca gtcacagaaa aatacacaat
     1621 ggatagaatt ctggacggtt tttttacttt ttcttcttta aacctttctt acatatttga
     1681 gacttgctac catttgcctg ctagtgtgtg actagtggga tataagataa gtgataaatt
     1741 attattggga aaactaaaat gaccaatcat gcatatttca aataatgtgc atatgaggct
     1801 aatgatttat tacatacata aatttctgct agtaaaattt tccttggttc atattgtgga
     1861 attaaatatc aacattttag aaattcccat tataggccgg gcgtggtagc tcacgcctat
     1921 aatcccagca ctttgggagg ctggggcagg tggatcacct gaggtcatga gttcgagacc
     1981 agctcggcca acatggtgaa accccgtctc tactaaaaat acaaaaatta gctgggcatg
     2041 gtgggtgggt gcctgtaatc ccagctactc gggaggctga ggcaggagaa tcgcttgcac
     2101 ctgggaggcg gaggttgcag tgagcggaga tcgcgccact gcattccagc ctgggcaaca
     2161 gagagactcc atctcaaaaa aaaaaaagga attcgcattc caatttacac agcagagatt
     2221 tcttaatagt atagctgtga attatactaa tccaagcacg taagtgttgt tcacttagta
     2281 ctttagtttc ccagcagggt atgtatttaa aatttgcttt tcttttagct gggtgcaatg
     2341 gcacttgcct gtactgcctg tagcttcttg ggaggctgag gcaggaggat tgcttgagcc
     2401 caggagttct gcactgtagt gtgctatgca ggtcagatgt cctcactaaa tttggcatca
     2461 gtatggtgac ctcctgggag tggagaacaa caaggttgcc taagaagggg tgaactggcc
     2521 caggtcggaa atggagcagg tcaaaattcc tgtgctgatc agtagtggga ttgcacctat
     2581 aaatagccac tgtagtactc cagcctgggc aacacagcaa gattccatct gttaaaaaca
     2641 cttttgctct tcttttaaac agatataatc aggtagggaa gttttcctta atctaaaact
     2701 ttaagtcata tcaaattcac gtttcctttt gtccattcca tttcttactg ccgcatagcc
     2761 tttgagatta aggttcagat tcatttattc agctgacact tcctggtatc ttctaggtat
     2821 aggatattaa gatggagaca gaaataaaga tggaggcacc attcctactc tcaagttgct
     2881 tagaatctac taggagagaa aacatacata aagctacaga tactgtgtga tgaatgccac
     2941 aaataatagt gttatgggaa ttgagtagag gggacgagat tgatcctagt gggaatgaat
     3001 tggaaaaact catggaagaa ggcatgtaat gggtacttca taaacatgtt aaaacttttt
     3061 tctttttttc tttttttttt tttttttgag acggagtttg actcttgtca cctaggctgg
     3121 agttcagtgg cctgatctca gctcactgca acctctgcct cctgggttca agcagttctc
     3181 ccacctcagc ctcccgagta gctgagatca caggcgcctg ccaccacacc cagctaattt
     3241 ttgtattatt agtagaggtg aggtttcacc atgttggcca ggctggtctg gaactcctga
     3301 cctcaagtga tccacccacc tcagcctccc aaagtgatgg gattacaggc ttgagccact
     3361 gcgcccagcc aacatgttaa acttgcatat tcatttttat tgggttccaa aagtggattt
     3421 ttgacaagca gagttgggtt gtgggatagt gaatattgag cattccatta tttatttatt
     3481 tttctctttt tgagatggag tctcgctctg tcacccaggc tggatggagt gcagtggtga
     3541 gatcatggct cactgcaacc tctgcttctt gagttcaagc gattctcctg tctcagcttc
     3601 ccgaggagct gtgattacag atacccacca ccatgcccag ctgatttttg tatttttagt
     3661 acggacgggg tttcagcatg ttggccaggc tggtcgcgaa ctcctgacct caagtgatcc
     3721 acccgcctct gcctcccaaa gtgttgggat tacaggcgtg agccactgca cctggcctga
     3781 gcattccatt taaagagaaa caaaataata aaggcattga tagagatgag aaggccacaa
     3841 tagctctaaa ggtagattta gacagagtag ggaacaggtt gtgtcttaaa atgaggctga
     3901 ggagttataa ttttacttgg agttaatggg gatgccactg gagattttga ataggatatg
     3961 ttgtgatctg aataacatat aagaagaatt aatttggtaa ctaatttgca gattagcaaa
     4021 gtgattcact aacatggtgt ttctcacatt tcagccattt atgttaccat ttttgatggc
     4081 tttttccata ttcattgctg cctacattgt tttcttcaga tctactcatt tccagattta
     4141 ttttgttctt acttgacaca attctatttt gaaatcaaag ttttgatgtg ttagtgtttt
     4201 ttcctaatca cattaaagta actatagcag tgaatacacc acactttgga aaaaattggg
     4261 ttaggttaat ttagttttct aggagagaat aatcagggtc tgagctagag tagtggcagg
     4321 agagatagca ctaaataaag acaggcattg tgaaaggcct ggccacttga tgtgaggagg
     4381 aaagacaagg atgactggtt tttagagtag gagaattagc cgggtgcagt ggctcatgcc
     4441 tgtaatccct gcactttagg aggctgaggt gagaggattt cttgaatcca ggagttcgag
     4501 accagcctgg caataaagtg agaacctgtc tctacaaaat ataaaaactt agccaaacat
     4561 ggtggtgcgt gcctgcagtc ctatctactt ggagggccga agccagagga tcctttgagc
     4621 ccaggagtct gaggctgcag caagctgtga tcacactgct gcactccatc ctgggtggca
     4681 gaatgagacc ccccccaaaa aaagagtagg aaagtggtgg ggttaaagat gtagggagat
     4741 catgttgtcc tggtttgggg agctggggga agggaaagaa gatacggctg acaatctggc
     4801 aggtatctgg gtgaaaacaa aattctaggg cgtgaggcag agaggttgac ataagagagt
     4861 tgggaatcca tatggggtac aggtagttta tgccatggag gtaaattaga accatgaagg
     4921 acaattgcaa atacaaaaaa aagaggccag gcacggtggc tcacgcctgt aatcccagca
     4981 ctttgggagg ccgaggtggg cggatcacga ggtcaggaga tcaagaccat cctggctgac
     5041 acgttgaaac cccgtctcta ctaaaaatac aaaaaattag ctgggcgtgg ttgcgggcac
     5101 ctgtagtccc aactacttgg gaggctgagg caggagaatg gcgtgaaccc gggaggcgga
     5161 gcttgtagtg agctgagatt gtgccacggc attccagcct gggtgacaga gcaagactct
     5221 gtctcaaaaa aaaattaaac aatgaggaaa acgttatgta agaggaggaa ccaaatggaa
     5281 ctgattggag ggaaagaaga cggttgagta gttctttaaa aagttccggg ttggatgctt
     5341 tctagtggtt tttcaacaga gaggctaaga aggaagataa ctgaaaatgg gacatgcatt
     5401 gatactttag taatttgagg gtacattttg agtgttaaga agtgaagagg aggagtcatt
     5461 ttcaggggca aaagagtgta ttggtaggaa gattatatag gcaatataat ttactttaga
     5521 gcagggcttt ccaacagaac ttttggtaat gatgtctagt acattagcca catgtggcag
     5581 tcaagcactc aaaacatggc tagtgtggct gaggggctaa aatttaattg tatttcattg
     5641 tagttcattt aaatttggct acctgtggct agtggctatt atattggaca atgcatttct
     5701 aaatattcag atcctgggca gaagttggct ttgacatgaa gaaagacttc ttagaaagga
     5761 aggaagtaga ccgggcatgg tggctcatgc ctgtaatccc aacactttgg gaagccgagg
     5821 caggtggatc acaaggtcaa gagatcaaga ccatcctggc caacgtggtg aaaacctgtc
     5881 tctactaaaa atacaaaaat tagctggaca tggtggcaca tgcctgtagt cccaactact
     5941 cgagaggctg aggcaggaga gaaaaaaaag aaggaaataa gagggagatt gggagaaaag
     6001 taaggtgtta tagctctgat ctgtggtatc tcctgttttc cttgcggtat gactagtgtg
     6061 agccaaggat agagaccaac aaactggggt accaaagtgg acaatgaagt actatgtaat
     6121 tagtgctaat gctaaattca ttcctttgtt taaggcttaa tatccttgca gaagccatcc
     6181 tgtgttactt gagcctggac tagtattggg gtgaagtcaa gcatcagagt aaaacatttg
     6241 tccccttaat gttaccccct cttaatttct aagaaccaca ggcccatttt gcccttcctt
     6301 gttaccatca ttgagataag gaataagatg tagtaacccc aagttatctg ataggtacaa
     6361 ctgacctatt ctgtttggca gctttatctt agacctattc tgtttggcag ctttatctta
     6421 gccccaacca aatctcttcc tttcacatgg tgttggttga atactatcca actccatggg
     6481 gttggtttgt gttttttttt tttttttttt ttgagacgga gtcttgctct gttgcccagg
     6541 ctggagtgcg gtggtgtgat cttggctcac tgcaagctcc gcctcctggg tttaagtgat
     6601 cctcctgcct cagcctcctg aatagctggg attacaggca cgtgcaacca agcccggcta
     6661 atttttgtgt ttttagtaga gactaggttt caacatgtta ggctgatctc aaactcctga
     6721 cctcgtgatc tgcccgcctc ggccttccaa agtgctgggg ttacagactt gagccactgc
     6781 acctggccat ggggttgttt cttaattaga tatagctgaa aagaacgcta gaccaaatag
     6841 gttctctgcc ttgccttttc gtttgttttg ttttagctat tatcagggaa ccaaaaactt
     6901 taaggagcta gtactggtct taatttttaa taactagaga tagcagagtt agaaactaag
     6961 ttcaaagtga gagaacagct gcatttgtct ttctgacctc atgcaattcc taggaaactc
     7021 tgtgttctgt gatttagtca ggcaataaaa tgctctcact cctt
//
