LOCUS       NM_004179               4826 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens tryptophan hydroxylase 1 (TPH1), mRNA.
ACCESSION   NM_004179
VERSION     NM_004179.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4826)
  AUTHORS   Zelante,T., Paolicelli,G., Fallarino,F., Gargaro,M., Vascelli,G.,
            De Zuani,M., Fric,J., Laznickova,P., Kohoutkova,M.H.,
            Macchiarulo,A., Dolciami,D., Pieraccini,G., Gaetani,L., Scalisi,G.,
            Trevisan,C., Frossi,B., Pucillo,C., De Luca,A., Nunzi,E.,
            Spaccapelo,R., Pariano,M., Borghi,M., Boscaro,F., Romoli,R.,
            Mancini,A., Gentili,L., Renga,G., Costantini,C., Puccetti,M.,
            Giovagnoli,S., Ricci,M., Antonini,M., Calabresi,P., Puccetti,P., Di
            Filippo,M. and Romani,L.
  TITLE     A microbially produced AhR ligand promotes a Tph1-driven
            tolerogenic program in multiple sclerosis
  JOURNAL   Sci Rep 14 (1), 6651 (2024)
   PUBMED   38509264
  REMARK    GeneRIF: A microbially produced AhR ligand promotes a Tph1-driven
            tolerogenic program in multiple sclerosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4826)
  AUTHORS   Zhang,J., Guo,Z., Xie,Q., Zhong,C., Gao,X. and Yang,Q.
  TITLE     Tryptophan hydroxylase 1 drives glioma progression by modulating
            the serotonin/L1CAM/NF-kappaB signaling pathway
  JOURNAL   BMC Cancer 22 (1), 457 (2022)
   PUBMED   35473609
  REMARK    GeneRIF: Tryptophan hydroxylase 1 drives glioma progression by
            modulating the serotonin/L1CAM/NF-kappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4826)
  AUTHORS   Snarska,J., Fiedorowicz,E., Rozmus,D., Wronski,K., Latacz,M.,
            Kordulewska,N., Plominski,J., Grzybowski,R., Savelkoul,H.F.J.,
            Kostyra,E. and Cieslinska,A.
  TITLE     TPH1 gene polymorphism rs211105 is associated with serotonin and
            tryptophan hydroxylase 1 concentrations in acute pancreatitis
            patients
  JOURNAL   BMC Gastroenterol 21 (1), 426 (2021)
   PUBMED   34772352
  REMARK    GeneRIF: TPH1 gene polymorphism rs211105 is associated with
            serotonin and tryptophan hydroxylase 1 concentrations in acute
            pancreatitis patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4826)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4826)
  AUTHORS   Wang,G.A., Coon,S.L. and Kaufman,S.
  TITLE     Alternative splicing at the 3'-cDNA of human tryptophan hydroxylase
  JOURNAL   J Neurochem 71 (4), 1769-1772 (1998)
   PUBMED   9751214
REFERENCE   6  (bases 1 to 4826)
  AUTHORS   Boularand,S., Darmon,M.C. and Mallet,J.
  TITLE     The human tryptophan hydroxylase gene. An unusual splicing
            complexity in the 5'-untranslated region
  JOURNAL   J Biol Chem 270 (8), 3748-3756 (1995)
   PUBMED   7876115
REFERENCE   7  (bases 1 to 4826)
  AUTHORS   Nielsen,D.A., Dean,M. and Goldman,D.
  TITLE     Genetic mapping of the human tryptophan hydroxylase gene on
            chromosome 11, using an intronic conformational polymorphism
  JOURNAL   Am J Hum Genet 51 (6), 1366-1371 (1992)
   PUBMED   1463016
REFERENCE   8  (bases 1 to 4826)
  AUTHORS   Craig,S.P., Boularand,S., Darmon,M.C., Mallet,J. and Craig,I.W.
  TITLE     Localization of human tryptophan hydroxylase (TPH) to chromosome
            11p15.3----p14 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 56 (3-4), 157-159 (1991)
   PUBMED   2055111
REFERENCE   9  (bases 1 to 4826)
  AUTHORS   Boularand,S., Darmon,M.C., Ganem,Y., Launay,J.M. and Mallet,J.
  TITLE     Complete coding sequence of human tryptophan hydroxylase
  JOURNAL   Nucleic Acids Res 18 (14), 4257 (1990)
   PUBMED   2377472
REFERENCE   10 (bases 1 to 4826)
  AUTHORS   Ledley,F.D., Grenett,H.E., Bartos,D.P., van Tuinen,P.,
            Ledbetter,D.H. and Woo,S.L.
  TITLE     Assignment of human tryptophan hydroxylase locus to chromosome 11:
            gene duplication and translocation in evolution of aromatic amino
            acid hydroxylases
  JOURNAL   Somat Cell Mol Genet 13 (5), 575-580 (1987)
   PUBMED   2889273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055860.13 and KF455332.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 5, 2019 this sequence version replaced NM_004179.2.
            
            Summary: This gene encodes a member of the aromatic amino acid
            hydroxylase family. The encoded protein catalyzes the first and
            rate limiting step in the biosynthesis of serotonin, an important
            hormone and neurotransmitter. Mutations in this gene have been
            associated with an elevated risk for a variety of diseases and
            disorders, including schizophrenia, somatic anxiety, anger-related
            traits, bipolar disorder, suicidal behavior, addictions, and
            others.[provided by RefSeq, Apr 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.130127.1,
                                           SRR1803617.132818.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682019.1/ ENSP00000508368.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC055860.13        73435-73463
            30-172              AC055860.13        78916-79058
            173-356             AC055860.13        83562-83745
            357-457             AC055860.13        86330-86430
            458-525             AC055860.13        90125-90192
            526-722             AC055860.13        90343-90539
            723-858             AC055860.13        93079-93214
            859-985             AC055860.13        94003-94129
            986-1081            AC055860.13        95721-95816
            1082-1215           KF455332.1         237-370             c
            1216-4826           AC055860.13        98539-102149
FEATURES             Location/Qualifiers
     source          1..4826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..4826
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /note="tryptophan hydroxylase 1"
                     /db_xref="GeneID:7166"
                     /db_xref="HGNC:HGNC:12008"
                     /db_xref="MIM:191060"
     exon            1..29
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /inference="alignment:Splign:2.1.0"
     exon            30..172
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1390
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /EC_number="1.14.16.4"
                     /note="tryptophan hydroxylase (tryptophan
                     5-monooxygenase); L-tryptophan hydroxylase; indoleacetic
                     acid-5-hydroxylase; tryptophan 5-monooxygenase 1"
                     /codon_start=1
                     /product="tryptophan 5-hydroxylase 1"
                     /protein_id="NP_004170.1"
                     /db_xref="CCDS:CCDS7829.1"
                     /db_xref="GeneID:7166"
                     /db_xref="HGNC:HGNC:12008"
                     /db_xref="MIM:191060"
                     /translation="MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVN
                     LLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGM
                     ETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDP
                     IPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVS
                     NFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLG
                     HVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGL
                     LSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKT
                     IKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI"
     exon            173..356
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /inference="alignment:Splign:2.1.0"
     exon            357..457
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /inference="alignment:Splign:2.1.0"
     exon            458..525
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /inference="alignment:Splign:2.1.0"
     exon            526..722
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /inference="alignment:Splign:2.1.0"
     exon            723..858
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /inference="alignment:Splign:2.1.0"
     exon            859..985
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1081
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1215
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..4826
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4797..4802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /note="hexamer: AATAAA"
     regulatory      4801..4806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /note="hexamer: AATGAA"
     polyA_site      4817
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
     polyA_site      4826
                     /gene="TPH1"
                     /gene_synonym="TPRH; TRPH"
                     /note="major polyA site"
ORIGIN      
        1 gacccagcct gcacctactg gcgcccgagt tttagagaat tactccaaat tcatcatgat
       61 tgaagacaat aaggagaaca aagaccattc cttagaaagg ggaagagcaa gtctcatttt
      121 ttccttaaag aatgaagttg gaggacttat aaaagccctg aaaatctttc aggagaagca
      181 tgtgaatctg ttacatatcg agtcccgaaa atcaaaaaga agaaactcag aatttgagat
      241 ttttgttgac tgtgacatca acagagaaca attgaatgat atttttcatc tgctgaagtc
      301 tcataccaat gttctctctg tgaatctacc agataatttt actttgaagg aagatggtat
      361 ggaaactgtt ccttggtttc caaagaagat ttctgacctg gaccattgtg ccaacagagt
      421 tctgatgtat ggatctgaac tagatgcaga ccatcctggc ttcaaagaca atgtctaccg
      481 taaacgtcga aagtattttg cggacttggc tatgaactat aaacatggag accccattcc
      541 aaaggttgaa ttcactgaag aggagattaa gacctgggga accgtattcc aagagctcaa
      601 caaactctac ccaacccatg cttgcagaga gtatctcaaa aacttacctt tgctttctaa
      661 atattgtgga tatcgggagg ataatatccc acaattggaa gatgtctcca actttttaaa
      721 agagcgtaca ggtttttcca tccgtcctgt ggctggttac ttatcaccaa gagatttctt
      781 atcaggttta gcctttcgag tttttcactg cactcaatat gtgagacaca gttcagatcc
      841 cttctatacc ccagagccag atacctgcca tgaactctta ggtcatgtcc cgcttttggc
      901 tgaacctagt tttgcccaat tctcccaaga aattggcttg gcttctcttg gcgcttcaga
      961 ggaggctgtt caaaaactgg caacgtgcta ctttttcact gtggagtttg gtctatgtaa
     1021 acaagatgga cagctaagag tctttggtgc tggcttactt tcttctatca gtgaactcaa
     1081 acatgcactt tctggacatg ccaaagtaaa gccctttgat cccaagatta cctgcaaaca
     1141 ggaatgtctt atcacaactt ttcaagatgt ctactttgta tctgaaagtt ttgaagatgc
     1201 aaaggagaag atgagagaat ttaccaaaac aattaagcgt ccatttggag tgaagtataa
     1261 tccatataca cggagtattc agatcctgaa agacaccaag agcataacca gtgccatgaa
     1321 tgagctgcag catgatctcg atgttgtcag tgatgccctt gctaaggtca gcaggaagcc
     1381 gagtatctaa cagtagccag tcatccagga acatttgagc atcaattcgg aggtctgggc
     1441 catctcttgc tttccttgaa cacctgatcc tggagggaca gcatcttctg gccaaacaat
     1501 attatcgaat tccactactt aaggaatcac tagtctttga aaatttgtac ctggatattc
     1561 tatttaccac ttattttttt gtttagtttt atttcttttt ttttttggta gcagctttaa
     1621 tgagacaatt tatataccat acaagccact gaccacccat ttttaataga gaagttgttt
     1681 gacccaatag atagatctaa tctcagccta actctatttt ccccaatcct ccttgagtaa
     1741 aatgaccctt taggatcgct tagaataact tgaggagtat tatggcgctg actcatattg
     1801 ttacctaaga tccccttatt tctaaagtat ctgttactta ttgctgaatt tgtgccaagc
     1861 tcaatcacat tcacactaaa atttaacagg agaccctgct gtctttgttg ctagcatgag
     1921 caaaagtata gaggcctttg cacatggagg atacctagta aagagcaagt agtctagttt
     1981 caagtgtagt atcttgtagg gaaatgggag tagctaagcc tggaaaggtt gaatggggca
     2041 taatcattaa gactaggcta aaaattcgag actttatttt ttaggcatta gggagcccct
     2101 tcccaagtga ctatcttcct tgaaactttg ttttctttca atgacatcac acgatactgg
     2161 ttttattctg gactatctat cctactcatg ggtccaaggg aaacttagta gagatgcgac
     2221 ttgcatgggg ctgtactcag acatgtggtc ctaggtatta taatgggatt gtccccagat
     2281 taacaggaag cattgttatc aaaggaagag ttcaaactga gatagataag agaagcacaa
     2341 agtaaaagat agaaaaaaca gtgctgagta ctttatttct aaggtataag gtgaggccat
     2401 aaacagaaag gtatgcaatg agagtagagg ctgcagaaaa ggggaggaaa tagaatgtca
     2461 gaaaggtcaa gaagagtggt ttaggactga gactgtaagt aatgtaagga ttgccaagga
     2521 atggttttta tgcagagtca gctgtgtagc acagggagta agcagtcctg ttataaatgg
     2581 gtgaagctga actccaaaat acaaacttat gtctctttaa tttgcccctt tcctccctct
     2641 agtcactaaa tgaagatgtt cttcaagttt ctgtctttgc acttctactc tttttgccat
     2701 ctcttcatgg ggaatgtcac ccagatacat gacttcagtt cttattttga atgactcctc
     2761 tatttgcagt tataaccctg acatctttct tgaatttttt tgccccttaa ttccaacgaa
     2821 ctcctggatg tctatgtaga tgtctcataa tttaggccaa tgctgtacaa cttcatgtgg
     2881 catcatccac atagaatgaa taggggttgt tcaatatgac agccctgcca agcatctcaa
     2941 attgaacagg tctataaagg aactcagaat cacttgaata tcacagtcca tcagcttcct
     3001 ttcccagtaa tttaatttcc attaatggta tattaaacat cgtattttca atcattttta
     3061 ggtttagtca gctacttaaa aataggcttt ttcttcacat aaataaattg tataccattt
     3121 aatgtgtttt atttcaacag actaatagat cttttaacac ttcttagtcc tcaaaataaa
     3181 ttattaaaaa ctttgtattt catgtcatat tatataagga aatagaattt tgaagaataa
     3241 ttcatgctgt tttaaatttt tacattgtac attttaatag ctaatcaact cttaagtata
     3301 catttgatgg taaatagatg ctagctaatc tagaatcatt tgaaatattg attatctgat
     3361 ttatagtttg gttgcaagga aatctactgt aagcaaatca taatagatag caaatcttag
     3421 aacatgtaga aaaaaagaaa ttaaaaaaag caaatcttag aacatgtaga aaaaggaaat
     3481 taaaaaatag atagcaaata acacaaatta tgcatactat atgtggttat tttcatacaa
     3541 ctttgataac ggtgaagaat catacttatt gaattttaaa atgatgatgt ttaaaatcac
     3601 tctatgacta aagcacatga gaataaatgt taaaggcaca gccttataat ccacaacttc
     3661 agaacaatgg aatttttttt tttttttttt tttttttttt tttttttttt tttttgagac
     3721 ggagtcttgc tctgtcgccc aggctggagt gcagtggtgc gatcttggct cactgcaagc
     3781 tccacctccc aggttcacgg cattctcctg cctctgtctc ctgagtagct gggactacag
     3841 gcgcccgcca ccacgtccgg ctcatttttt gtatttttag tagagacaag gtttcaccgt
     3901 gttagccagg atggtttcaa tctcctgaca ttgtgatctg cccacctcgg cctcccaaag
     3961 tgctgggatt acaggcgtga gccactgcac ccggccaaac attggaaatt tttaatgatg
     4021 gatttcagtt cttctcacct ctgggtattt gtaatatttg gtaaatcagg agtcctgaga
     4081 gtcttagaat tttcatgcat tttaaatata tgtcttcaaa gcacctagga atatgtaaat
     4141 agttacccaa atgtgagaac agaattgaac taaaagcttc gtttataatt tttttttttt
     4201 tttgagacag agtctcactc tgttgcccag gctggagcgc agttgcgtga tttcagctcg
     4261 ctgcaacctg ggactgcagg cgtgcttcac catgccccgc taatttttgt ttttttagta
     4321 gagatggggt ttcgccatgt tggccaggct ggtctcgaac ttctgaccgc aggtgatcca
     4381 tccgcctcgg cctcccaaag tgctgggatt acaagcatga gccaccatgc ccagccggtt
     4441 aataattctt aatcagtaaa tcattattca aagacatagt taatatcttc atgacttctt
     4501 aaggatgctc aaaagctggt cttcagaata cctacatttc tttatctaca tattctgtca
     4561 tttggagtta tacaagtagt aatgacacac caaaatgtaa ataattattg ttagctttta
     4621 agttggcttc caaattcaaa aaagaaaaaa atcctgaatt ctctaaagga acatatgata
     4681 gagtccatat gttaattcat aggaagtgtt taaggtacta tggtctattt tggtctaatc
     4741 tttgttttac tatgtaatat atatttatga tttacaagtt tgttattcag tgggataata
     4801 aatgaacaca aaatttatgt tctcaa
//
