LOCUS       NM_033513               1114 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tubulin polyglutamylase complex subunit 1 (TPGS1),
            mRNA.
ACCESSION   NM_033513 XM_042012
VERSION     NM_033513.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1114)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   2  (bases 1 to 1114)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   3  (bases 1 to 1114)
  AUTHORS   Regnard,C., Fesquet,D., Janke,C., Boucher,D., Desbruyeres,E.,
            Koulakoff,A., Insina,C., Travo,P. and Edde,B.
  TITLE     Characterisation of PGs1, a subunit of a protein complex
            co-purifying with tubulin polyglutamylase
  JOURNAL   J Cell Sci 116 (Pt 20), 4181-4190 (2003)
   PUBMED   12972506
  REMARK    GeneRIF: Isolation and functional characterization of the mouse
            PGs1 ortholog, and comparison to the human protein.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM846833.1 and BC009520.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033513.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.92786.1,
                                           SRR1163655.241914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359315.6/ ENSP00000352265.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               BM846833.1         1-114
            115-1114            BC009520.1         1-1000
FEATURES             Location/Qualifiers
     source          1..1114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1114
                     /gene="TPGS1"
                     /gene_synonym="C19orf20; GTRGEO22; PGs1"
                     /note="tubulin polyglutamylase complex subunit 1"
                     /db_xref="GeneID:91978"
                     /db_xref="HGNC:HGNC:25058"
                     /db_xref="MIM:620709"
     exon            1..348
                     /gene="TPGS1"
                     /gene_synonym="C19orf20; GTRGEO22; PGs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..883
                     /gene="TPGS1"
                     /gene_synonym="C19orf20; GTRGEO22; PGs1"
                     /note="gene trap ROSA b-geo 22; polyglutamylase subunit 1"
                     /codon_start=1
                     /product="tubulin polyglutamylase complex subunit 1"
                     /protein_id="NP_277048.2"
                     /db_xref="CCDS:CCDS42454.1"
                     /db_xref="GeneID:91978"
                     /db_xref="HGNC:HGNC:25058"
                     /db_xref="MIM:620709"
                     /translation="MAAVEKRRQAVPPPAGFTDSGRQSVSRAAGAAESEEDFLRQVGV
                     TEMLRAALLKVLEARPEEPIAFLAHYFENMGLRSPVNGGAGEPPGQLLLQQQRLGRAL
                     WHLRLAHHSQRAAFNNNVSVAYECLSAGGRRKRPGLDGRTYSELLRRICRDGQAPEEV
                     VAPLLRKVQCRDHEAVPLSVFRAGTLTCFVLLEFVARAGALFQLLEDSAAAVADRRVG
                     QAVLDTLEGALQASDAAAPARFLEAGSRLGPDSLALALDRAVGGRRPSAPMTREEFLE
                     RAAALFIAKVKPVG"
     exon            349..1114
                     /gene="TPGS1"
                     /gene_synonym="C19orf20; GTRGEO22; PGs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1092..1097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPGS1"
                     /gene_synonym="C19orf20; GTRGEO22; PGs1"
                     /note="hexamer: AATAAA"
     polyA_site      1114
                     /gene="TPGS1"
                     /gene_synonym="C19orf20; GTRGEO22; PGs1"
                     /note="major polyA site"
ORIGIN      
        1 ctcagcgaag atggcggcag tggagaagcg gcggcaagcg gtaccaccgc cggccggttt
       61 cacggacagc ggccgccagt cggtatcccg ggcggcgggg gcggccgaga gcgaggagga
      121 cttcctgcgg caggtcggcg tgacggaaat gctacgtgcg gccctgctga aggtgctgga
      181 ggcgcggccc gaggagccga tcgccttcct ggctcactac ttcgagaaca tgggcctgcg
      241 ctcgcctgta aacggcggcg ccggggagcc cccgggccag ctcctgctgc agcagcagcg
      301 cctgggccgc gcgctatggc accttcgcct ggcccaccac tcccagaggg ccgccttcaa
      361 caacaacgtg agcgtggcct acgagtgcct gagcgccggc gggcgcagga agaggccggg
      421 gctggacggg cgcacctaca gcgagctgct caggcgcatc tgccgggacg gccaagcccc
      481 cgaggaggtg gtggcgccgc tgctgcgcaa ggtgcagtgc cgtgaccacg aggcggtgcc
      541 gctgagcgtc ttccgcgcgg gcacactcac ctgcttcgtg ctgctggagt tcgtggcgcg
      601 cgccggcgcg ctcttccagc tgctggagga ctcggccgcc gccgtggccg accgccgcgt
      661 gggccaggcc gtgctggaca ccctggaggg cgcgctgcag gccagcgacg ccgccgcgcc
      721 cgcgcgcttc ctggaggccg gctcgcgctt ggggcccgac agcctggcgc tggcgctgga
      781 ccgcgccgtc ggggggcggc ggcccagcgc gcccatgacc cgcgaggagt ttctggagag
      841 ggccgccgcg ctcttcatcg cgaaggtcaa gccggtgggc tgaggcccgt gggccgcgcg
      901 gatccgggat ctgcgctggg gggtccccgc gtgcggggcg cgcggagcct tcccttcgcc
      961 ctggtgaggc cctgccataa ccaggcgccc agccctgcgg aggaggccgg ggctcccagg
     1021 aagcggacgc ccggtcccca cacagcgccg cggccgcccc tccacccccg cgggagcccc
     1081 tgccccacgc taataaaatg tgttgcgagg ctga
//
