LOCUS       NM_003287               2239 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TPD52 like 1 (TPD52L1), transcript variant 1, mRNA.
ACCESSION   NM_003287
VERSION     NM_003287.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2239)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2239)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2239)
  AUTHORS   Couzens,A.L., Knight,J.D., Kean,M.J., Teo,G., Weiss,A.,
            Dunham,W.H., Lin,Z.Y., Bagshaw,R.D., Sicheri,F., Pawson,T.,
            Wrana,J.L., Choi,H. and Gingras,A.C.
  TITLE     Protein interaction network of the mammalian Hippo pathway reveals
            mechanisms of kinase-phosphatase interactions
  JOURNAL   Sci Signal 6 (302), rs15 (2013)
   PUBMED   24255178
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2239)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   5  (bases 1 to 2239)
  AUTHORS   Cao,Q., Chen,J., Zhu,L., Liu,Y., Zhou,Z., Sha,J., Wang,S. and Li,J.
  TITLE     A testis-specific and testis developmentally regulated tumor
            protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52
            family proteins
  JOURNAL   Biochem Biophys Res Commun 344 (3), 798-806 (2006)
   PUBMED   16631610
REFERENCE   6  (bases 1 to 2239)
  AUTHORS   Nourse,C.R., Mattei,M.G., Gunning,P. and Byrne,J.A.
  TITLE     Cloning of a third member of the D52 gene family indicates
            alternative coding sequence usage in D52-like transcripts
  JOURNAL   Biochim Biophys Acta 1443 (1-2), 155-168 (1998)
   PUBMED   9838088
REFERENCE   7  (bases 1 to 2239)
  AUTHORS   Byrne,J.A., Nourse,C.R., Basset,P. and Gunning,P.
  TITLE     Identification of homo- and heteromeric interactions between
            members of the breast carcinoma-associated D52 protein family using
            the yeast two-hybrid system
  JOURNAL   Oncogene 16 (7), 873-881 (1998)
   PUBMED   9484778
REFERENCE   8  (bases 1 to 2239)
  AUTHORS   Byrne,J.A., Mattei,M.G., Basset,P. and Gunning,P.
  TITLE     Identification and in situ hybridization mapping of a mouse Tpd52l1
            (D53) orthologue to chromosome 10A4-B2
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 199-201 (1998)
   PUBMED   9730602
REFERENCE   9  (bases 1 to 2239)
  AUTHORS   Byrne,J.A., Mattei,M.G. and Basset,P.
  TITLE     Definition of the tumor protein D52 (TPD52) gene family through
            cloning of D52 homologues in human (hD53) and mouse (mD52)
  JOURNAL   Genomics 35 (3), 523-532 (1996)
   PUBMED   8812487
REFERENCE   10 (bases 1 to 2239)
  AUTHORS   Byrne,J.A., Tomasetto,C., Garnier,J.M., Rouyer,N., Mattei,M.G.,
            Bellocq,J.P., Rio,M.C. and Basset,P.
  TITLE     A screening method to identify genes commonly overexpressed in
            carcinomas and the identification of a novel complementary DNA
            sequence
  JOURNAL   Cancer Res 55 (13), 2896-2903 (1995)
   PUBMED   7796418
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U44427.1, U44429.1, AL121938.10
            and AI222450.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003287.3.
            
            Summary: This gene encodes a member of a family of proteins that
            contain coiled-coil domains and may form hetero- or homomers. The
            encoded protein is involved in cell proliferation and calcium
            signaling. It also interacts with the mitogen-activated protein
            kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates
            MAP3K5-induced apoptosis. Multiple alternatively spliced transcript
            variants have been observed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.277719.1, U44427.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000534000.6/ ENSP00000434142.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1324              U44427.1           2-1325
            1325-1673           U44429.1           715-1063
            1674-1789           AL121938.10        85540-85655
            1790-2236           U44429.1           1180-1626
            2237-2239           AI222450.1         16-18               c
FEATURES             Location/Qualifiers
     source          1..2239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..2239
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /note="TPD52 like 1"
                     /db_xref="GeneID:7164"
                     /db_xref="HGNC:HGNC:12006"
                     /db_xref="MIM:604069"
     exon            1..198
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..794
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /note="isoform 1 is encoded by transcript variant 1; tumor
                     protein D53; tumor protein D52 like 1"
                     /codon_start=1
                     /product="tumor protein D53 isoform 1"
                     /protein_id="NP_003278.1"
                     /db_xref="CCDS:CCDS5130.1"
                     /db_xref="GeneID:7164"
                     /db_xref="HGNC:HGNC:12006"
                     /db_xref="MIM:604069"
                     /translation="MEAQAQGLLETEPLQGTDEDAVASADFSSMLSEEEKEELKAELV
                     QLEDEITTLRQVLSAKERHLVEIKQKLGMNLMNELKQNFSKSWHDMQTTTAYKKTHET
                     LSHAGQKATAAFSNVGTAISKKFGDMSYSIRHSISMPAMRNSPTFKSFEERVETTVTS
                     LKTKVGGTNPNGGSFEEVLSSTAHASAQSLAGGSRRTKEEELQC"
     exon            199..314
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     exon            315..463
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     exon            464..565
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     exon            566..604
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     exon            605..665
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     exon            666..2239
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1307..1312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /note="hexamer: ATTAAA"
     polyA_site      1326
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /note="major polyA site"
     regulatory      2209..2214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /note="hexamer: AGTAAA"
     polyA_site      2239
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
ORIGIN      
        1 agaagcggct agtggcggct gcctgcgtcc ccaaccccct ccgcgcagcg ctcgcgacac
       61 gcgtgccagg agtgggagcg agcggcgggg ccagctgcgt tctgagcctg ggcgcagctg
      121 ccatctgctc tgggaagcac cagggtgtcc ccgccgccct cagctcgaag tcagccacca
      181 tggaggcgca ggcacaaggt ttgttggaga ctgaaccgtt gcaaggaaca gacgaagatg
      241 cagtagccag tgctgacttc tctagcatgc tctctgagga ggaaaaggaa gagttaaaag
      301 cagagttagt tcagctagaa gacgaaatta caacactacg acaagttttg tcagcgaaag
      361 aaaggcatct agttgagata aaacaaaaac tcggcatgaa cctgatgaat gaattaaaac
      421 agaacttcag caaaagctgg catgacatgc agactaccac tgcctacaag aaaacacatg
      481 aaaccctgag tcacgcaggg caaaaggcaa ctgcagcttt cagcaacgtt ggaacggcca
      541 tcagcaagaa gttcggagac atgagttact ccattcgcca ttccataagt atgcctgcta
      601 tgaggaattc tcctactttc aaatcatttg aggagagggt tgagacaact gtcacaagcc
      661 tcaagacgaa agtaggcggt acgaacccta atggaggcag ttttgaggag gtcctcagct
      721 ccacggccca tgccagtgcc cagagcttgg caggaggctc ccggcggacc aaggaggagg
      781 agctgcagtg ctaagtccag ccagcgtgca gctgcatcca gaaaccggcc actacccagc
      841 ccatctctgc ctgtgcttat ccagataaga agaccaaaat cccgctggga aaaacccagg
      901 ccttgacatt gttattcaaa tggcccctcc agaaagttta atgatttcca tttgtatttg
      961 tgttgatgat ggaccacttg accatcacat ttcagtattc atagatgact gtcacatttt
     1021 aaaatgttcc cacttgagca ggtacacaac tggtcataat tcctgtctgt gtaattcgat
     1081 gtatattttt ccaaacatgt agctattgtt tgctttgatt tttgcttggc ctcctttatg
     1141 atgtgcatgt ccttgaaggc tgaatgaaca gtccctttca gttcagcaga tcaacaggat
     1201 ggagctcttc atgactgtct ccagcaatag gatgatttac tataaatttc atccaactac
     1261 ttgtgatctc tctcacctac atcaattatg tatgttaatt tcagcaatta aaagaattga
     1321 ttttaatgac tttgaattct taatttcttt gtcttaaaag ttgctagtta tgattttaca
     1381 gatgcaattt taaatcaact tttagccagg tgcggcggct cacacctgta atcccaacta
     1441 ttttggatgc caaggtgaga ggattgcttg aggccaggag ttaaagatca gcctgggcaa
     1501 cacagaccct gtctctacaa aaaaagaaaa aaattagcca gacatagtgt tgcttgcctg
     1561 tagtcccagc tactctagag gctgaggcag gaggattgca tgagcctagg agttcgaaac
     1621 tgcagtgagc tatgattgca ccactgcact actccagcct gggtgacaga gtgggacact
     1681 gtctccaaaa atagtaataa taagtagtca acttttactg ctaatttggt gaacatgaga
     1741 gaggatatga aaataaatat tacctcagct atcctaggat gttaaaataa tctccaattt
     1801 taaaattctc tccaatctac atacagtagt agttagtcag ataaaggata tccaaaaaag
     1861 agatagctag aaaatgggag aagcagagtt ctgcaacccc tttcagtttg taaattgttc
     1921 acatgtatga aaataactgg tatttatcaa tccactcaga tttctgcact aacttttatc
     1981 ttatatatca tatgtatctc ttttcttttt ctaaatggga acatatattt gttattaggt
     2041 ggcagagata tagccttaag atatatttgt aaaatgcaca ctgaatagac atccaaccta
     2101 aaaaaaatca ctatttaaaa agcccatata atatatacat atttgttagc atgctaattg
     2161 ttcatgtttt gtgtttatta aatagaagtg atatatatga cattttgaag taaagcacat
     2221 ctgaaaaatt ctactcaaa
//
